{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:06:58Z","timestamp":1782122818777,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jad-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.jad.2013.04.008","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T06:16:26Z","timestamp":1368080186000},"page":"295-299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["The change of insulin levels after six weeks antidepressant use in drug-na\u00efve major depressive patients"],"prefix":"10.1016","volume":"150","author":[{"given":"Hui Hua","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Hung","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Hui","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin Chun","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po Wu","family":"Gean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen Kuang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Band","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po See","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2013.04.008_bib1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1176\/appi.ajp.2008.08071065","article-title":"Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus","volume":"166","author":"Andersohn","year":"2009","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2013.04.008_bib2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.diabres.2007.07.009","article-title":"Type of antidepressant therapy and risk of type 2 diabetes in people with depression","volume":"79","author":"Brown","year":"2008","journal-title":"Diabetes Research and Clinical Practice"},{"key":"10.1016\/j.jad.2013.04.008_bib3","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/aje\/kwg172","article-title":"Symptoms of depression as a risk factor for incident diabetes: findings from the National Health and Nutrition Examination Epidemiologic Follow-up Study, 1971\u20131992","volume":"158","author":"Carnethon","year":"2003","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.jad.2013.04.008_bib4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbi.2011.07.239","article-title":"Treatment response and cognitive impairment in major depression: association with C-reactive protein","volume":"26","author":"Chang","year":"2012","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.jad.2013.04.008_bib5","doi-asserted-by":"crossref","first-page":"573594","DOI":"10.1155\/2010\/573594","article-title":"Antidepressant effects on insulin sensitivity and proinflammatory cytokines in the depressed males","volume":"2010","author":"Chen","year":"2010","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/j.jad.2013.04.008_bib6","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s00125-006-0442-x","article-title":"Prevalent and incident depression in community-dwelling elderly persons with diabetes mellitus: results from the ZARADEMP project","volume":"49","author":"de Jonge","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.jad.2013.04.008_bib7","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.2337\/diacare.19.10.1097","article-title":"Depression and risk for onset of type II diabetes. A prospective population-based study","volume":"19","author":"Eaton","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2013.04.008_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jpsychores.2006.07.009","article-title":"The role of depression and anxiety in onset of diabetes in a large population-based study","volume":"62","author":"Engum","year":"2007","journal-title":"Journal of Psychosomatic Research"},{"key":"10.1016\/j.jad.2013.04.008_bib9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/ebmh.12.1.24","article-title":"Bidirectional association between elevated depressive symptoms and type 2 diabetes","volume":"12","author":"Everson-Rose","year":"2009","journal-title":"Evidence-Based Mental Health"},{"key":"10.1016\/j.jad.2013.04.008_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1471-4159.1976.tb01598.x","article-title":"The relevance of both plasma free tryptophan and insulin to rat brain tryptophan concentration","volume":"27","author":"Fernando","year":"1976","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.jad.2013.04.008_bib11","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1126\/science.178.4059.414","article-title":"Brain serotonin content: physiological regulation by plasma neutral amino acids","volume":"178","author":"Fernstrom","year":"1972","journal-title":"Science"},{"key":"10.1016\/j.jad.2013.04.008_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0026-0495(72)90078-9","article-title":"Elevation of plasma tryptophan by insulin in rat","volume":"21","author":"Fernstrom","year":"1972","journal-title":"Metabolism: Clinical and Experimental"},{"key":"10.1016\/j.jad.2013.04.008_bib13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.biopsych.2009.09.019","article-title":"Fasting glucose, diagnosis of type 2 diabetes, and depression: the Vietnam experience study","volume":"67","author":"Gale","year":"2010","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jad.2013.04.008_bib14","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1001\/archpsyc.1976.01770120066006","article-title":"Total and free plasma tryptophan levels in patients with affective disorders: effects of a peripheral decarboxylase inhibitor","volume":"33","author":"Garfinkel","year":"1976","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jad.2013.04.008_bib15","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nm0710-756","article-title":"Pregnancy hormones boost beta cells via serotonin","volume":"16","author":"Georgia","year":"2010","journal-title":"Nature Medicine"},{"key":"10.1016\/j.jad.2013.04.008_bib16","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/01.jcp.0000132441.27854.0d","article-title":"Comparing the effects of 8-week treatment with fluoxetine and imipramine on fasting blood glucose of patients with major depressive disorder","volume":"24","author":"Ghaeli","year":"2004","journal-title":"Journal of Clinical Psychopharmacology"},{"key":"10.1016\/j.jad.2013.04.008_bib17","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/PSY.0b013e318197a4d5","article-title":"Lifetime history of major depression predicts the development of the metabolic syndrome in middle-aged women","volume":"71","author":"Goldbacher","year":"2009","journal-title":"Psychosomatic Medicine"},{"key":"10.1016\/j.jad.2013.04.008_bib18","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1001\/jama.299.23.2751","article-title":"Examining a bidirectional association between depressive symptoms and diabetes","volume":"299","author":"Golden","year":"2008","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/j.jad.2013.04.008_bib19","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1176\/appi.ajp.2009.09050629","article-title":"Long-term antidepressant use and risk for diabetes: cause for concern and optimism","volume":"166","author":"Jindal","year":"2009","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2013.04.008_bib20","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.2337\/diacare.22.7.1071","article-title":"Depressive symptoms and occurrence of type 2 diabetes among Japanese men","volume":"22","author":"Kawakami","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2013.04.008_bib21","doi-asserted-by":"crossref","first-page":"e500","DOI":"10.1542\/peds.2004-1921","article-title":"Homeostasis model assessment is more reliable than the fasting glucose\/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents","volume":"115","author":"Keskin","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.jad.2013.04.008_bib22","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nm.2173","article-title":"Serotonin regulates pancreatic beta cell mass during pregnancy","volume":"16","author":"Kim","year":"2010","journal-title":"Nature Medicine"},{"key":"10.1016\/j.jad.2013.04.008_bib23","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.biopsych.2011.07.008","article-title":"Antidepressant medication use and risk of hyperglycemia and diabetes mellitus: a noncausal association?","volume":"70","author":"Kivimaki","year":"2011","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jad.2013.04.008_bib24","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.2337\/dc10-1187","article-title":"Antidepressant medication use, weight gain, and risk of type 2 diabetes: a population-based study","volume":"33","author":"Kivimaki","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2013.04.008_bib25","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.2337\/dc09-2359","article-title":"Antidepressant use before and after the diagnosis of type 2 diabetes: a longitudinal modeling study","volume":"33","author":"Kivimaki","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2013.04.008_bib26","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4088\/JCP.v69n0202","article-title":"Metabolic syndrome predisposes to depressive symptoms: a population-based 7-year follow-up study","volume":"69","author":"Koponen","year":"2008","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.jad.2013.04.008_bib27","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.nucmedbio.2008.08.004","article-title":"In vivo imaging of vesicular monoamine transporter 2 in pancreas using an (18)F epoxide derivative of tetrabenazine","volume":"35","author":"Kung","year":"2008","journal-title":"Nuclear Medicine and Biology"},{"key":"10.1016\/j.jad.2013.04.008_bib28","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.mcn.2007.05.009","article-title":"Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases","volume":"36","author":"Levkovitz","year":"2007","journal-title":"Molecular and Cellular Neurosciences"},{"key":"10.1016\/j.jad.2013.04.008_bib29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2337\/dc06-1769","article-title":"Factors influencing glycemic control in type 2 diabetes during acute- and maintenance-phase treatment of major depressive disorder with bupropion","volume":"30","author":"Lustman","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2013.04.008_bib30","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1176\/appi.ajp.2010.10020243","article-title":"Depression and diabetes: more on what the relationship might be","volume":"167","author":"Lyketsos","year":"2010","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2013.04.008_bib31","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.2337\/dc11-1223","article-title":"Elevated depressive symptoms, antidepressant use, and diabetes in a large multiethnic national sample of postmenopausal women","volume":"34","author":"Ma","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2013.04.008_bib32","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1001\/archinte.167.11.1137","article-title":"Diabetes mellitus, glycemic control, and incident depressive symptoms among 70- to 79-year-old persons: the health, aging, and body composition study","volume":"167","author":"Maraldi","year":"2007","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.jad.2013.04.008_bib33","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.jad.2013.04.008_bib34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1517\/14740338.5.1.157","article-title":"The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms","volume":"5","author":"McIntyre","year":"2006","journal-title":"Expert Opinion on Drug Safety"},{"key":"10.1016\/j.jad.2013.04.008_bib35","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0140-6736(07)61415-9","article-title":"Depression, chronic diseases, and decrements in health: results from the World Health Surveys","volume":"370","author":"Moussavi","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2013.04.008_bib36","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.2337\/db10-1192","article-title":"Convergence of the insulin and serotonin programs in the pancreatic beta-cell","volume":"60","author":"Ohta","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.jad.2013.04.008_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2009.05356.x","article-title":"Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism","volume":"1199","author":"Oxenkrug","year":"2010","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.jad.2013.04.008_bib38","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2337\/dc11-2055","article-title":"Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies","volume":"35","author":"Pan","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2013.04.008_bib39","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1001\/archinternmed.2010.356","article-title":"Bidirectional association between depression and type 2 diabetes mellitus in women","volume":"170","author":"Pan","year":"2010","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.jad.2013.04.008_bib40","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/ijo.2011.111","article-title":"Bidirectional association between depression and obesity in middle-aged and older women","volume":"36","author":"Pan","year":"2012","journal-title":"International Journal of Obesity"},{"key":"10.1016\/j.jad.2013.04.008_bib41","doi-asserted-by":"crossref","first-page":"e1000229","DOI":"10.1371\/journal.pbio.1000229","article-title":"Intracellular serotonin modulates insulin secretion from pancreatic \u03b2-cells by protein serotonylation","volume":"7","author":"Paulmann","year":"2009","journal-title":"PLoS Biology"},{"key":"10.1016\/j.jad.2013.04.008_bib42","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.2337\/dc11-0107","article-title":"Depressive symptoms, antidepressant medication use, and insulin resistance","volume":"34","author":"Pyykk\u00f6nen","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2013.04.008_bib43","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.2337\/dc10-1033","article-title":"Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study","volume":"33","author":"Rubin","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2013.04.008_bib44","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/PSY.0b013e31824d0865","article-title":"A neural circuitry linking insulin resistance to depressed mood","volume":"74","author":"Ryan","year":"2012","journal-title":"Psychosomatic Medicine"},{"key":"10.1016\/j.jad.2013.04.008_bib45","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10735-008-9195-9","article-title":"Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas","volume":"39","author":"Saisho","year":"2008","journal-title":"Journal of Molecular Histology"},{"key":"10.1016\/j.jad.2013.04.008_bib46","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/ije\/19.2.303","article-title":"Fat distribution in European women: a comparison of anthropometric measurements in relation to cardiovascular risk factors","volume":"19","author":"Seidell","year":"1990","journal-title":"International Journal of Epidemiology"},{"key":"10.1016\/j.jad.2013.04.008_bib47","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archgenpsychiatry.2009.50","article-title":"Major depressive disorder and hypothalamic-pituitary\u2013adrenal axis activity: results from a large cohort study","volume":"66","author":"Vreeburg","year":"2009","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jad.2013.04.008_bib48","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/MOL.0b013e3283462273","article-title":"Role of peripheral serotonin in glucose and lipid metabolism","volume":"22","author":"Watanabe","year":"2011","journal-title":"Current Opinion in Lipidology"},{"key":"10.1016\/j.jad.2013.04.008_bib49","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neulet.2009.03.049","article-title":"Inhibitory effect of selective serotonin reuptake inhibitors on the vesicular monoamine transporter 2","volume":"454","author":"Yasumoto","year":"2009","journal-title":"Neuroscience Letters"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032713002632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032713002632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:25:02Z","timestamp":1539649502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032713002632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0165032713002632"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2013.04.008","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The change of insulin levels after six weeks antidepressant use in drug-na\u00efve major depressive patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2013.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}