{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:16:28Z","timestamp":1789438588400,"version":"build-2803163510"},"reference-count":66,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.jad.2013.06.054","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T17:00:41Z","timestamp":1375808441000},"page":"582-589","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["The long-term outcomes of heroin dependent-treatment-resistant patients with bipolar 1 comorbidity after admission to enhanced methadone maintenance"],"prefix":"10.1016","volume":"151","author":[{"given":"Angelo Giovanni Icro","family":"Maremmani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Rovai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bacciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Rugani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pacini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier","family":"Paolo Pani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana Dell'","family":"Osso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagop","family":"Akiskal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Icro","family":"Maremmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2013.06.054_bib1","series-title":"Diagnostic and Statistical Manual of Mental Disorders, DSM-IV","author":"A.P.A.","year":"1994"},{"key":"10.1016\/j.jad.2013.06.054_bib2","first-page":"CD005031","article-title":"Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification","volume":"9","author":"Amato","year":"2011","journal-title":"Cochrane Database System Review"},{"key":"10.1016\/j.jad.2013.06.054_bib3","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/cpt1975173258","article-title":"Disposition of methadone in methadone maintenance","volume":"17","author":"\u00c4ngg\u00e5rd","year":"1974","journal-title":"Clinical Pharmacology & Therapeutics"},{"key":"10.1016\/j.jad.2013.06.054_bib4","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/add.12153","article-title":"Characterizing the longitudinal patterns of substance use among individuals diagnosed with serious mental illness after psychiatric hospitalization","volume":"108","author":"Bahorik","year":"2013","journal-title":"Addiction"},{"key":"10.1016\/j.jad.2013.06.054_bib5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/YCO.0b013e3283523d3d","article-title":"Managing patients with dual diagnosis in psychiatric practice","volume":"25","author":"Baigent","year":"2012","journal-title":"Current Opinion in Psychiatry"},{"key":"10.1016\/j.jad.2013.06.054_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0740-5472(98)00031-2","article-title":"Methadone maintenance. Does dose determine differences in outcome?","volume":"16","author":"Blaney","year":"1999","journal-title":"Journal of Substance Abuse Treatment"},{"key":"10.1016\/j.jad.2013.06.054_bib7","first-page":"19","article-title":"The relationship between substance abuse and bipolar disorder","volume":"56","author":"Brady","year":"1995","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.jad.2013.06.054_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1300\/J069v24n03_03","article-title":"Methadone dosage and retention: An examination of the 60mg\/day threshold","volume":"24","author":"Brady","year":"2005","journal-title":"Journal of Addictive Diseases"},{"key":"10.1016\/j.jad.2013.06.054_bib9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0376-8716(00)00148-4","article-title":"The relationship of psychiatric comorbidity to treatment outcomes in methadone maintained patients","volume":"61","author":"Cacciola","year":"2001","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.jad.2013.06.054_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jad.2003.10.014","article-title":"Proposal for a bipolar-stimulant spectrum: temperament, diagnostic validation and therapeutic outcomes with mood stabilizers","volume":"85","author":"Camacho","year":"2005","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2013.06.054_bib11","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.2217\/pgs.11.103","article-title":"Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients","volume":"12","author":"Chen","year":"2011","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.jad.2013.06.054_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0376-8716(98)00091-X","article-title":"Retention in treatment of heroin users in Italy: The role of treatment type and of methadone maintenance dosage","volume":"52","author":"D\u2019Ippoliti","year":"1998","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.jad.2013.06.054_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.psychres.2007.12.007","article-title":"Patterns of major depression and drug-related problems amongst heroin users across 36 months","volume":"166","author":"Darke","year":"2009","journal-title":"Psychiatry Research"},{"key":"10.1016\/j.jad.2013.06.054_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1749-6632.1978.tb16775.x","article-title":"Long term outcome of patients treated with methadone maintenance","volume":"311","author":"Dole","year":"1978","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.jad.2013.06.054_bib15","article-title":"Methadone maintenance at different dosages for opioid dependence","volume":"3","author":"Faggiano","year":"2003","journal-title":"Cochrane Database System Review"},{"key":"10.1016\/j.jad.2013.06.054_bib16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/10550880903183042","article-title":"High dose versus moderate dose methadone maintenance: is there a better outcome?","volume":"28","author":"Fareed","year":"2009","journal-title":"Journal of Addictive Diseases"},{"key":"10.1016\/j.jad.2013.06.054_bib17","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0306-4603(98)00075-6","article-title":"Substance misuse and psychiatric comorbidity: an overview of the OPCS national psychiatric morbidity survey","volume":"23","author":"Farrell","year":"1998","journal-title":"Addictive Behaviors"},{"key":"10.1016\/j.jad.2013.06.054_bib18","first-page":"228","article-title":"Influence of psychiatric disorders in the effectiveness of a long-term methadone maintenance treatment","volume":"29","author":"Fernandez Miranda","year":"2001","journal-title":"Actas Luso-Espanolas de Neurologia, Psiquiatria y Ciencias Afines"},{"key":"10.1016\/j.jad.2013.06.054_bib19","series-title":"Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Clinician Version","author":"First","year":"1997"},{"key":"10.1016\/j.jad.2013.06.054_bib20","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1046\/j.1365-2125.1999.00921.x","article-title":"Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4","volume":"47","author":"Foster","year":"1999","journal-title":"British Jornal of Clinical Pharmacology"},{"key":"10.1016\/j.jad.2013.06.054_bib21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0376-8716(02)00323-X","article-title":"Predictors of follow-up health status in the Drug Abuse Treatment Outcome Study (DATOS)","volume":"69","author":"Friedmann","year":"2003","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.jad.2013.06.054_bib22","first-page":"126","article-title":"Does psychiatric comorbidity affect drug abuse treatment outcome? A prospective assessment of drug abuse, treatment tenure and infectious diseases in an israeli methadone maintenance clinic","volume":"43","author":"Gelkopf","year":"2006","journal-title":"Israel Journal of Psychiatry and Related Sciences"},{"key":"10.1016\/j.jad.2013.06.054_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.drugalcdep.2003.11.017","article-title":"Buprenorphine versus methadone for opioid dependence: Predictor variables for treatment outcome","volume":"75","author":"Gerra","year":"2004","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.jad.2013.06.054_bib24","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jad.2009.11.005","article-title":"Different profile of substance abuse in relation to predominant polarity in bipolar disorder: The Vitoria long-term follow-up study","volume":"124","author":"Gonzalez-Pinto","year":"2010","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2013.06.054_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.pharmtox.42.111901.111051","article-title":"Regulation of CYP3A gene transcription by the Pregnane X receptor","volume":"42","author":"Goodwin","year":"2002","journal-title":"Annual Review of Pharmacology and Toxicology"},{"key":"10.1016\/j.jad.2013.06.054_bib26","series-title":"ECDEU Assessment Manual for Psychopharmacology. Clinical Global Impressions","author":"Guy","year":"1976"},{"key":"10.1016\/j.jad.2013.06.054_bib27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1176\/ps.2009.60.1.50","article-title":"Substance use disorders as risk factors for psychiatric hospitalization in bipolar disorder","volume":"60","author":"Hoblyn","year":"2009","journal-title":"Psychiatric Services"},{"key":"10.1016\/j.jad.2013.06.054_bib28","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jcph.1","article-title":"Role of cytochrome P4502B6 in methadone metabolism and clearance","volume":"53","author":"Kharasch","year":"2013","journal-title":"Journal of Clinical Pharmacology"},{"key":"10.1016\/j.jad.2013.06.054_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/10550880802545010","article-title":"Opioid dependence as a chronic disease: The interrelationships between length of stay, methadone dose, and age on treatment outcome at an urban opioid treatment program","volume":"28","author":"Kritz","year":"2009","journal-title":"Journal of Addictive Diseases"},{"key":"10.1016\/j.jad.2013.06.054_bib30","first-page":"5","article-title":"Ethnicity and drug addiction. A comparison between Italian and Slovenian heroin addicts","volume":"14","author":"Lovrecic","year":"2012","journal-title":"Heroin Addiction and Related Clinical Problems"},{"key":"10.1016\/j.jad.2013.06.054_bib31","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1176\/appi.ajp.160.12.2134","article-title":"Agitated depression in bipolar I disorder: prevalence, phenomenology, and a outcome","volume":"160","author":"Maj","year":"2003","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2013.06.054_bib32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/ADT.0b013e31824c5d1b","article-title":"Natural history of addiction in psychotic heroin addicted patients at their first Agonist Opioid Treatment","volume":"12","author":"Maremmani","year":"2013","journal-title":"Addictive Disorders and Their Treatment"},{"key":"10.1016\/j.jad.2013.06.054_bib33","first-page":"11","article-title":"Heroin addicts' psychopathological subtypes. Correlations with the natural history of illness","volume":"14","author":"Maremmani","year":"2012","journal-title":"Heroin Addiction and Related Clinical Problems"},{"key":"10.1016\/j.jad.2013.06.054_bib34","first-page":"1","article-title":"Correlations between awareness of illness (insight) and history of addiction in heroin-addicted patients","volume":"3 (61)","author":"Maremmani","year":"2012","journal-title":"Frontiers in Psychiatry"},{"key":"10.1016\/j.jad.2013.06.054_bib37","article-title":"Clinical presentations of substance abuse in bipolar heroin addicts at time of treatment entry","volume":"11 (23)","author":"Maremmani","year":"2012","journal-title":"Annals of General Psychiatry"},{"key":"10.1016\/j.jad.2013.06.054_bib35","first-page":"179","article-title":"Heroin dependence and bipolar disorders","volume":"X","author":"Maremmani","year":"1994","journal-title":"New Trends in Experimental and Clinical Psychiatry"},{"key":"10.1016\/j.jad.2013.06.054_bib36","series-title":"DAH-Q: Drug Addiction Questionnaire","author":"Maremmani","year":"1989"},{"key":"10.1016\/j.jad.2013.06.054_bib38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1017\/S1092852900027346","article-title":"Mood stabilizers in the treatment of substance use disorders","volume":"15","author":"Maremmani","year":"2010","journal-title":"CNS Spectrums"},{"key":"10.1016\/j.jad.2013.06.054_bib39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jad.2007.03.015","article-title":"Cocaine abuse and the bipolar spectrum in 1090 heroin addicts: Clinical observations and a proposed pathophysiologic model","volume":"106","author":"Maremmani","year":"2008","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2013.06.054_bib40","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jad.2009.01.007","article-title":"Affective temperaments in heroin addiction","volume":"117","author":"Maremmani","year":"2009","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2013.06.054_bib41","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000104742","article-title":"Is the bipolar spectrum the psychopathological substrate of suicidality in heroin addicts?","volume":"40","author":"Maremmani","year":"2007","journal-title":"Psychopathology"},{"key":"10.1016\/j.jad.2013.06.054_bib42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jsat.2006.11.009","article-title":"Substance use and quality of life over 12 months among buprenorphine maintenance-treated and methadone maintenance-treated heroin-addicted patients","volume":"33","author":"Maremmani","year":"2007","journal-title":"Journal of Substance Abuse Treatment"},{"key":"10.1016\/j.jad.2013.06.054_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2006.02.022","article-title":"Toward a unitary perspective on the bipolar spectrum and substance abuse: Opiate addiction as a paradigm","volume":"93","author":"Maremmani","year":"2006","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2013.06.054_bib44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1300\/J069v19n02_03","article-title":"Methadone dose and retention during treatment of heroin addicts with Axis I psychiatric comorbidity","volume":"19","author":"Maremmani","year":"2000","journal-title":"Journal of Addictive Diseases"},{"key":"10.1016\/j.jad.2013.06.054_bib45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jad.2008.08.019","article-title":"Clinical features, response to treatment and functional outcome of bipolar disorder patients with and without co-occurring substance use disorder: 1-year follow-up","volume":"115","author":"Mazza","year":"2009","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jad.2013.06.054_bib46","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0022-3565(24)29471-4","article-title":"Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation","volume":"298","author":"Oda","year":"2001","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.jad.2013.06.054_bib47","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0376-8716(00)80006-X","article-title":"Buprenorphine: a controlled clinical trial in the treatment of opioid dependence","volume":"60","author":"Pani","year":"2000","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.jad.2013.06.054_bib48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0376-8716(97)00115-4","article-title":"Psychiatric severity and treatment response in a comprehensive methadone maintenance treatment program","volume":"48","author":"Pani","year":"1997","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.jad.2013.06.054_bib49","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.drugalcdep.2009.09.013","article-title":"15-Year survival and retention of patients in a general hospital-affiliated methadone maintenance treatment (MMT) center in Israel","volume":"107","author":"Peles","year":"2010","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.jad.2013.06.054_bib50","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1111\/j.1475-6773.2008.00870.x","article-title":"Dosage patterns in methadone treatment: results from a national survey, 1988\u20132005","volume":"43","author":"Pollack","year":"2008","journal-title":"Health Services Research"},{"key":"10.1016\/j.jad.2013.06.054_bib51","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1747-597X-6-28","article-title":"Chronic disease and recent addiction treatment utilization among alcohol and drug dependent adults","volume":"6","author":"Reif","year":"2011","journal-title":"Substance Abuse Treatment, Prevention, and Policy"},{"key":"10.1016\/j.jad.2013.06.054_bib52","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0022-3956(81)90005-4","article-title":"Diagnostic concordance in a follow-up study of opiate addicts","volume":"16","author":"Rounsaville","year":"1981","journal-title":"Journal of Psychiatric Research"},{"key":"10.1016\/j.jad.2013.06.054_bib53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archpsyc.1982.04290020027006","article-title":"Heterogeneity of psychiatric diagnosis in treated opiate addicts","volume":"39","author":"Rounsaville","year":"1982","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jad.2013.06.054_bib54","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.comppsych.2008.06.008","article-title":"Predictors of nonadherence among individuals with bipolar disorder receiving treatment in a community mental health clinic","volume":"50","author":"Sajatovic","year":"2009","journal-title":"Comprehensive Psychiatry"},{"key":"10.1016\/j.jad.2013.06.054_bib55","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.3109\/10826081003791932","article-title":"Effectiveness of therapies for heroin addiction in retaining patients in treatment: results from the VEdeTTE study","volume":"45","author":"Salamina","year":"2010","journal-title":"Substance Use & Misuse"},{"key":"10.1016\/j.jad.2013.06.054_bib56","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000274177","article-title":"Effects of psychiatric comorbidity on treatment outcome in patients undergoing diamorphine or methadone maintenance treatment","volume":"43","author":"Schafer","year":"2010","journal-title":"Psychopathology"},{"key":"10.1016\/j.jad.2013.06.054_bib57","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000092113","article-title":"Methadone treatment in clinical practice in Italy: need for improvement","volume":"12","author":"Schifano","year":"2006","journal-title":"European Addiction Research"},{"key":"10.1016\/j.jad.2013.06.054_bib58","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1017\/S0033291709991231","article-title":"Social anxiety disorder and alcohol use disorder co-morbidity in the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"40","author":"Schneier","year":"2010","journal-title":"Psychological Medicine"},{"key":"10.1016\/j.jad.2013.06.054_bib59","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0376-8716(02)00320-4","article-title":"Cytochrome P4503A4 metabolic activity, methadone blood concentrations, and methadone doses","volume":"69","author":"Shinderman","year":"2003","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.jad.2013.06.054_bib60","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3109\/10826087709027267","article-title":"Comparison of the effect of high and low doses of methadone on treatment outcome","volume":"12","author":"Siassi","year":"1977","journal-title":"International Journal of the Addictions"},{"key":"10.1016\/j.jad.2013.06.054_bib61","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0376-8716(93)90052-R","article-title":"Methadone dose and treatment outcome","volume":"33","author":"Strain","year":"1993","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.jad.2013.06.054_bib62","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/NMD.0b013e31819292a6","article-title":"Does cannabis use affect treatment outcome in bipolar disorder? A longitudinal analysis","volume":"197","author":"van Rossum","year":"2009","journal-title":"Journal of Nervous and Mental Diseases"},{"key":"10.1016\/j.jad.2013.06.054_bib63","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/cpt1975182180","article-title":"Methadone in man: Pharmacokinetic and excretion studies in acute and chronic treatment","volume":"18","author":"Verebely","year":"1975","journal-title":"Clinical Pharmacology & Therapeutics"},{"key":"10.1016\/j.jad.2013.06.054_bib64","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1124\/dmd.31.6.742","article-title":"Involvement of CYP3A4, CYP2C8 and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro","volume":"31","author":"Wang","year":"2003","journal-title":"Drug Metabolism and Disposition"},{"key":"10.1016\/j.jad.2013.06.054_bib65","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF02353475","article-title":"Cytochrome P4503A (CYP3A) metabolism: Prediction of in vivo activity in humans","volume":"24","author":"Wilkinson","year":"1996","journal-title":"Journal of Pharmacokinetics and Biopharmaceutics"},{"key":"10.1016\/j.jad.2013.06.054_bib66","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2147\/SAR.S15151","article-title":"Gender and racial\/ethnic differences in addiction severity, HIV risk, and quality of life among adults in opioid detoxification: results from the National Drug Abuse Treatment Clinical Trials Network","volume":"2010","author":"Wu","year":"2010","journal-title":"Substance Abuse and Rehabilitation"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503271300534X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503271300534X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:12:39Z","timestamp":1759021959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503271300534X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S016503271300534X"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2013.06.054","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The long-term outcomes of heroin dependent-treatment-resistant patients with bipolar 1 comorbidity after admission to enhanced methadone maintenance","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2013.06.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}