{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:27:23Z","timestamp":1786991243552,"version":"build-2736575974"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.jad.2014.06.039","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T20:01:55Z","timestamp":1404417715000},"page":"136-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Efficacy of olanzapine in the treatment of bipolar mania with mixed features defined by DSM-5"],"prefix":"10.1016","volume":"168","author":[{"given":"Mauricio","family":"Tohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenobu","family":"Kanba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Fujikoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2014.06.039_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2194-7511-1-12","article-title":"Bipolar disorders in DSM-5: Strengths, problems and perspectives","volume":"1","author":"Angst","year":"2013","journal-title":"Int. J. Bipolar Disord."},{"key":"10.1016\/j.jad.2014.06.039_bib2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-244X-9-33","article-title":"Mixed states vs. pure mania in the French sample of the EMBLEM study: results at baseline and 24 months-European mania in bipolar longitudinal evaluation of medication","volume":"9","author":"Azorin","year":"2009","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00004714-200304000-00005","article-title":"Acute dysphoric mania: treatment response to olanzapine versus placebo","volume":"23","author":"Baker","year":"2003","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2014.06.039_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1192\/bjp.187.1.87","article-title":"\u2018Bipolarity\u2019 in bipolar disorder: distribution of manic and depressive symptoms in a treated population","volume":"187","author":"Bauer","year":"2005","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib5","doi-asserted-by":"crossref","first-page":"692","DOI":"10.4088\/JCP.09m05291gre","article-title":"Subsyndromal depressive symptoms after symptomatic recovery from mania are associated with delayed functional recovery","volume":"72","author":"Gitlin","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1176\/appi.ajp.2008.08050746","article-title":"Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD","volume":"166","author":"Goldberg","year":"2009","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib7","doi-asserted-by":"crossref","first-page":"671","DOI":"10.4088\/JCP.09m05483yel","article-title":"Poor long-term prognosis in mixed bipolar patients: 10-year outcomes in the Vitoria prospective naturalistic study in Spain","volume":"72","author":"Gonz\u00e1lez-Pinto","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib8","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jad.2011.12.046","article-title":"Prevalence and clinical significance of subsyndromal manic symptoms, including irritability and psychomotor agitation, during bipolar major depressive episodes","volume":"138","author":"Judd","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2014.06.039_bib9","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jad.2011.10.045","article-title":"Efficacy and safety of olanzapine in the treatment of Japanese patients with bipolar I disorder in a current manic or mixed episode: a randomized, double-blind, placebo- and haloperidol-controlled study","volume":"136","author":"Katagiri","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2014.06.039_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1744-859X-11-7","article-title":"Number of prior episodes and the presence of depressive symptoms are associated with longer length of stay for patients with acute manic episodes","volume":"11","author":"Martin-Carrasco","year":"2012","journal-title":"Ann. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib11","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jad.2013.04.025","article-title":"DSM-5 mixed specifier for manic episodes: evaluating the effect of depressive features on severity and treatment outcome using asenapine clinical trial data","volume":"150","author":"McIntyre","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2014.06.039_bib12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1399-5618.2009.00698.x","article-title":"Clinical predictors of functional outcome of bipolar patients in remission","volume":"11","author":"Rosa","year":"2009","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2014.06.039_bib13","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1399-5618.2007.00357.x","article-title":"Manic symptoms and impulsivity during bipolar depressive episodes","volume":"9","author":"Swann","year":"2007","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2014.06.039_bib14","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1001\/archpsyc.1990.01810240026005","article-title":"Outcome in mania. A 4-year prospective follow-up of 75 patients utilizing survival analysis","volume":"47","author":"Tohen","year":"1990","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib15","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1176\/ajp.156.5.702","article-title":"Olanzapine versus placebo in the treatment of acute mania","volume":"156","author":"Tohen","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib16","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1001\/archpsyc.57.9.841","article-title":"Efficacy of olanzapine in acute bipolar mania. A double-blind, placebo-controlled study","volume":"57","author":"Tohen","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib17","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1176\/appi.ajp.159.6.1011","article-title":"Olanzapine versus divalproex in the treatment of acute mania","volume":"159","author":"Tohen","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib18","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1001\/archpsyc.60.11.1079","article-title":"Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression","volume":"60","author":"Tohen","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib19","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1192\/bjp.bp.105.020321","article-title":"Influence of sub-syndromal symptoms after remission from manic or mixed episodes","volume":"189","author":"Tohen","year":"2006","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib20","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1192\/bjp.bp.112.108357","article-title":"Randomised, double-blind, placebo-controlled study of olanzapine in patients with bipolar I depression","volume":"201","author":"Tohen","year":"2012","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jad.2009.12.019","article-title":"Prevalence of mixed mania using 3 definitions","volume":"125","author":"Vieta","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2014.06.039_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jad.2013.03.007","article-title":"Mixed states in DSM-5: implications for clinical care, education, and research","volume":"148","author":"Vieta","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2014.06.039_bib23","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jad.2013.12.031","article-title":"Phenomenology of manic episodes according to the presence or absence of depressive features as defined in DSM-5: results from the IMPACT self-reported online survey","volume":"156","author":"Vieta","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2014.06.039_bib24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br J. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.039_bib25","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.4088\/JCP.v63n1210","article-title":"A comparison of the efficacy, safety, and tolerabilty of divalproex sodium and olanzapine in the treatment of bipolar disorder","volume":"63","author":"Zajecka","year":"2002","journal-title":"J. Clin. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032714004078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032714004078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:14:00Z","timestamp":1759022040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032714004078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":25,"alternative-id":["S0165032714004078"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2014.06.039","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of olanzapine in the treatment of bipolar mania with mixed features defined by DSM-5","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2014.06.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}