{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:43:02Z","timestamp":1791200582751,"version":"4.2.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jad-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.jad.2014.06.054","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T16:18:20Z","timestamp":1404922700000},"page":"197-204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Commingling analysis of age-of-onset in bipolar I disorder and the morbid risk for major psychoses in first degree relatives of bipolar I probands"],"prefix":"10.1016","volume":"168","author":[{"given":"Maria","family":"Grigoroiu-Serbanescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Rietschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr M.","family":"Czerski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Herms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Wickramaratne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Elston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2014.06.054_bib1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1109\/TAC.1974.1100705","article-title":"A new look at the statistical model identification","volume":"AC-19","author":"Akaike","year":"1974","journal-title":"IEEE Trans. Automat. Contr."},{"key":"10.1016\/j.jad.2014.06.054_bib2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.wpsyc.2012.01.006","article-title":"Age at onset versus family history and clinical outcomes in 1665 international bipolar-I disorder patients","volume":"11","author":"Baldessarini","year":"2012","journal-title":"World Psychiatry"},{"key":"10.1016\/j.jad.2014.06.054_bib3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.neuroscience.2009.03.080","article-title":"The genetics of bipolar disorder","volume":"164","author":"Barnett","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.jad.2014.06.054_bib4","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1001\/archpsyc.58.5.510","article-title":"Admixture analysis of age at onset in bipolar I affective disorder","volume":"58","author":"Bellivier","year":"2001","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.054_bib5","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1176\/appi.ajp.160.5.999","article-title":"Age at onset in bipolar I affective disorder: Further evidence for three subgroups","volume":"160","author":"Bellivier","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.054_bib6","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/ajmg.b.31172","article-title":"Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder","volume":"156B","author":"Belmonte Mahon","year":"2011","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.jad.2014.06.054_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.2517-6161.1964.tb00553.x","article-title":"An analysis of transformations (with discussion)","volume":"26","author":"Box","year":"1964","journal-title":"J. R. Statist. Soc., Ser. B"},{"key":"10.1016\/j.jad.2014.06.054_bib8","doi-asserted-by":"crossref","first-page":"s19","DOI":"10.1192\/bjp.181.43.s19","article-title":"Family history of psychiatric disorders and age at first contact in schizophrenia: an epidemiological study","volume":"43","author":"Byrne","year":"2002","journal-title":"Br. J. Psychiatry Suppl."},{"key":"10.1016\/j.jad.2014.06.054_bib9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jad.2012.08.031","article-title":"Age of onset and the prospectively observed course of illness in bipolar disorder","volume":"146","author":"Coryell","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2014.06.054_bib10","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1136\/jmg.36.8.585","article-title":"Genetics of bipolar disorder","volume":"36","author":"Craddock","year":"1999","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.jad.2014.06.054_bib11","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/schbul\/sbp020","article-title":"Psychosis genetics: modeling the relationship between schizophrenia, bipolar disorder, and mixed (or \u201cschizoaffective\u201d) psychoses","volume":"35","author":"Craddock","year":"2009","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jad.2014.06.054_bib12","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0140-6736(12)62129-1","article-title":"Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis","volume":"381","author":"Cross-Disorder Group of the Psychiatric Genomics Consortium","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2014.06.054_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1001\/archpsyc.1988.01800280038006","article-title":"A controlled family study of chronic psychoses. schizophrenia and schizoaffective disorder","volume":"45","author":"Gershon","year":"1982","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.054_bib14","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ajmg.10047","article-title":"Different familial transmission patterns in bipolar I disorder with onset before and after age 25","volume":"105B","author":"Grigoroiu-Serbanescu","year":"2001","journal-title":"Am. J. Med. Genet.( B) - Neuropsychiatr. Genet."},{"key":"10.1016\/j.jad.2014.06.054_bib15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/ajmg.b.30133","article-title":"Family history influences age of onset in bipolar I disorder in females but not in males","volume":"133B","author":"Grigoroiu-Serbanescu","year":"2005","journal-title":"Am. J. Med. Genet. (B) \u2013 Neuropsychiatr. Genet."},{"issue":"Suppl 1","key":"10.1016\/j.jad.2014.06.054_bib16","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/S0924-9338(10)71414-0","article-title":"Two or three age-of-onset groups in bipolar I disorder? Findings of commingling analysis in Romanian and German bipolar I patients","volume":"25","author":"Grigoroiu-Serbanescu","year":"2010","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.054_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jad.2008.10.021","article-title":"Age-at-onset in bipolar-I disorder: mixture analysis of 1369 cases identifies three distinct clinical sub-groups","volume":"116","author":"Hamshere","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2014.06.054_bib500","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jad.2012.12.013","article-title":"A three generations nation-wide population study of family load estimates in bipolar disorder with different age at onset","volume":"150","author":"Helenius","year":"2013","journal-title":"J Affect Disord."},{"key":"10.1016\/j.jad.2014.06.054_bib18","first-page":"16","article-title":"Ethnicity and age at onset in bipolar spectrum disorders","author":"Javaid","year":"2011","journal-title":"C.N.S. Spectr."},{"key":"10.1016\/j.jad.2014.06.054_bib19","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1017\/S0033291704003307","article-title":"Incidence and distribution of first-episode mania by age: results from a 35-year study","volume":"35","author":"Kennedy","year":"2005","journal-title":"Psychol. Med."},{"issue":"9659","key":"10.1016\/j.jad.2014.06.054_bib20","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0140-6736(09)60072-6","article-title":"Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study","volume":"373","author":"Lichtenstein","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2014.06.054_bib21","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1176\/appi.ajp.163.2.240","article-title":"Clinical correlates and familial aggregation of age at onset in bipolar disorder","volume":"163","author":"Lin","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.054_bib22","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2307\/2529760","article-title":"Skeness in commingled distributions","volume":"32","author":"MacLean","year":"1976","journal-title":"Biometrics"},{"key":"10.1016\/j.jad.2014.06.054_bib23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1399-5618.2007.00572.x","article-title":"Age at onset in Sardinian bipolar I patients: evidence for three subgroups","volume":"10","author":"Manchia","year":"2008","journal-title":"Bipolar. Disord."},{"key":"10.1016\/j.jad.2014.06.054_bib24","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1001\/archpsyc.1993.01820230041004","article-title":"Continuity and discontinuity of affective disorders and schizophrenia. Results of a controlled family study","volume":"50","author":"Maier","year":"1993","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.054_bib25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archgenpsychiatry.2011.12","article-title":"Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative","volume":"68","author":"Merikangas","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.054_bib26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0165-0327(01)00476-1","article-title":"Evidence for a late onset bipolar-I disorder sub-group from 50 years","volume":"73","author":"Moorhead","year":"2003","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2014.06.054_bib27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.psychres.2010.10.033","article-title":"An admixture analysis of the age at index episodes in bipolar disorder","volume":"188","author":"Ortiz","year":"2011","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.jad.2014.06.054_bib28","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.schres.2009.10.024","article-title":"Age at onset in Canadian Schizophrenia patients: admixture analysis","volume":"122","author":"Panariello","year":"2010","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jad.2014.06.054_bib29","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/ajmg.b.32093","article-title":"Dissecting the genetic heterogeneity of depression through age at onset","volume":"159B","author":"Power","year":"2012","journal-title":"Am. J. Med. Genet (B) \u2013 Neuropsychiatr. Genet."},{"key":"10.1016\/j.jad.2014.06.054_bib30","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/mp.2011.8","article-title":"Genome-wide survey implicates the influence of copy number variants (CNVs) on the development of early-onset bipolar disorder","volume":"17","author":"Priebe","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.054_bib31","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1001\/archpsyc.1987.01800170063009","article-title":"The familial transmission of bipolar illness","author":"Rice","year":"1987","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.054_bib32","unstructured":"S.A.G.E., 2012. Statistical Analysis for Genetic Epidemiology, Release 6.3.\u3008http:\/\/darwin.cwru.edu\u3009."},{"key":"10.1016\/j.jad.2014.06.054_bib33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ajmg.c.20013","article-title":"Family, twin, and adoption studies of bipolar disorder","volume":"123C","author":"Smoller","year":"2003","journal-title":"Am. J. Med. Genet. (C) \u2013 Semin. Med. Genet."},{"key":"10.1016\/j.jad.2014.06.054_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0165-0327(00)00372-4","article-title":"A family study of early-onset bipolar I disorder","volume":"70","author":"Somanath","year":"2002","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2014.06.054_bib35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/archpsyc.1981.01780260060006","article-title":"Early- and late-onset bipolar illness","volume":"38","author":"Taylor","year":"1981","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2014.06.054_bib36","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1600-0447.2009.01523.x","article-title":"Age at onset in 3014 Sardinian bipolar and major depressive disorder patients","volume":"121","author":"Tondo","year":"2010","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2014.06.054_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.psychres.2009.11.025","article-title":"Admixture analysis of age at onset in bipolar disorder","volume":"185","author":"Tozzi","year":"2011","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.jad.2014.06.054_bib38","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/archpsyc.1984.01790230022003","article-title":"Onset of major depression in early adulthood. Increased familial loading and specificity","volume":"41","author":"Weissman","year":"1984","journal-title":"Arch. Gen. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032714004303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032714004303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T12:39:14Z","timestamp":1716986354000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032714004303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":39,"alternative-id":["S0165032714004303"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2014.06.054","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Commingling analysis of age-of-onset in bipolar I disorder and the morbid risk for major psychoses in first degree relatives of bipolar I probands","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2014.06.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}