{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:24:23Z","timestamp":1767338663022,"version":"3.44.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009885","name":"Regione Piemonte","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009885","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.jad.2015.03.013","type":"journal-article","created":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T01:32:12Z","timestamp":1426296732000},"page":"188-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Neurokinin (NK)-1 receptor expression in monocytes from bipolar disorder patients: A pilot study"],"prefix":"10.1016","volume":"178","author":[{"given":"Angela","family":"Amoruso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Bardelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo Ignazio","family":"Cattaneo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigia Grazia","family":"Fresu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Manzetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Brunelleschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2015.03.013_bib1","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.lfs.2007.07.017","article-title":"Quantification of PPAR-\u03b3 protein in monocyte\/macrophages from healthy smokers and non-smokers: a possible direct effect of nicotine","volume":"81","author":"Amoruso","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.jad.2015.03.013_bib2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/bjp.2008.50","article-title":"A novel activity for substance P: stimulation of peroxisome proliferator-activated receptor-\u03b3 protein expression in human monocytes and macrophages","volume":"154","author":"Amoruso","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jad.2015.03.013_bib3","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.jpsychires.2013.08.019","article-title":"Altered intracellular signaling cascades in peripheral blood mononuclear cells from BD patients","volume":"47","author":"Barbosa","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2015.03.013_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.phrs.2012.10.022","article-title":"Recurrent major depressive disorder: imbalance of neurokinin (NK)-1 and NK-2 receptor expression in monocytes","volume":"68","author":"Bardelli","year":"2013","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jad.2015.03.013_bib5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.bjp.0706198","article-title":"Expression of functional NK-1 receptors in human alveolar macrophages: superoxide anion production, cytokine release and involvement of NF-\u03baB pathway","volume":"145","author":"Bardelli","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jad.2015.03.013_bib6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/978-3-642-25758-2_13","article-title":"Nicotinic receptors and functional regulation of GABE cell microcircuitry in bipolar disorder and schizophrenia","volume":"213","author":"Benes","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.jad.2015.03.013_bib7","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1189\/jlb.0212100","article-title":"The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes","volume":"92","author":"Beumer","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jad.2015.03.013_bib8","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0006-3223(02)01544-5","article-title":"Substance P serum levels are increased in major depression: preliminary results","volume":"53","author":"Bondy","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.03.013_bib9","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.pnpbp.2008.01.006","article-title":"TNF-\u03b1 as a molecular target in bipolar disorder","volume":"32","author":"Brietzke","year":"2008","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.03.013_bib10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0006-3223(99)00264-4","article-title":"Substance P (NK1) receptors in the cingulated cortex in unipolar and bipolar mood disorder and schizophrenia","volume":"47","author":"Burnet","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.03.013_bib11","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.bbi.2011.03.013","article-title":"The activation of monocyte and T cell networks in patients with bipolar disorder","volume":"25","author":"Drexhage","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2015.03.013_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1586\/ern.09.144","article-title":"The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder","volume":"10","author":"Drexhage","year":"2010","journal-title":"Expert. Rev. Neurother."},{"key":"10.1016\/j.jad.2015.03.013_bib13","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1017\/S1461145710000799","article-title":"Inflammatory gene expression in monocytes of patients with schizophrenia: overlap and difference with bipolar disorder. A study in naturalistically treated patients","volume":"13","author":"Drexhage","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2015.03.013_bib14","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2174\/138161209788168074","article-title":"Tachykinin receptors as therapeutic targets in stress-related disorders","volume":"15","author":"Ebner","year":"2009","journal-title":"Curr. Pharm. Des."},{"year":"1994","series-title":"SCID-I\/P. Version 2.0. Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition","author":"First","key":"10.1016\/j.jad.2015.03.013_bib15"},{"key":"10.1016\/j.jad.2015.03.013_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/bdi.12142","article-title":"Relationship between clinical features and inflammation-related monocyte gene expression in bipolar disorder \u2013 towards a better understanding of psychoimmunological interactions","volume":"16","author":"Haarman","year":"2014","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2015.03.013_bib17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2015.03.013_bib18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.biopsych.2005.07.013","article-title":"Lack of efficacy of the substance P (neurokinin 1 receptor) antagonist aprepitant in the treatment of major depressive disorder","volume":"59","author":"Keller","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.03.013_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jad.2007.02.018","article-title":"Imbalance between pro-inflammatory and anti-inflammatory cytokines in bipolar disorder","volume":"104","author":"Kim","year":"2007","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.03.013_bib20","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1126\/science.281.5383.1640","article-title":"Distinct mechanism for antidepressant activity by blockade of central substance P receptors","volume":"281","author":"Kramer","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jad.2015.03.013_bib21","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0165-5728(98)00025-3","article-title":"Human lymphocytes express substance P and its receptor","volume":"86","author":"Lai","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jad.2015.03.013_bib22","doi-asserted-by":"crossref","first-page":"7771","DOI":"10.1073\/pnas.0602563103","article-title":"Full-length and truncated neurokinin-1 receptor expression and function during monocyte\/macrophage differentiation","volume":"103","author":"Lai","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jad.2015.03.013_bib23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.pnpbp.2013.10.018","article-title":"Impact of inflammation on neurotransmitter changes in major depression: an insight into the action of antidepressants","volume":"48","author":"Leonard","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psych."},{"key":"10.1016\/j.jad.2015.03.013_bib24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/da.20800","article-title":"Proof of concept trials in bipolar disorder and major depressive disorder: a translational perspective in the search for improved treatments","volume":"28","author":"Machado-Vieira","year":"2011","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2015.03.013_bib25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0306-4530(94)00066-J","article-title":"The monocyte\/T-lymphocyte hypothesis of major depression","volume":"20","author":"Maes","year":"1995","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2015.03.013_bib26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1017\/S1461145705005444","article-title":"Patient-control association study of substance P-related genes in unipolar and bipolar affective disorders","volume":"8","author":"Mendlewicz","year":"2005","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2015.03.013_bib27","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jpsychires.2013.05.018","article-title":"Cytokines in bipolar disorder vs healthy control subjects: a systematic review and meta-analysis","volume":"47","author":"Munkholm","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2015.03.013_bib28","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/sj.bjp.0706561","article-title":"Distribution and pharmacological characterization of primate NK-1 and NK-3 tachykinin receptors in the central nervous system of rhesus monkey","volume":"147","author":"Nagano","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jad.2015.03.013_bib29","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1001\/jamapsychiatry.2014.176","article-title":"Identification of pathways for bipolar disorder: a meta-analysis","volume":"71","author":"Nurnberg","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2015.03.013_bib30","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/sj.mp.4001547","article-title":"Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomic approach","volume":"9","author":"Ogden","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2015.03.013_bib31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1001\/archpsyc.65.4.395","article-title":"A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes","volume":"65","author":"Padmos","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.03.013_bib32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/archgenpsychiatry.2007.15","article-title":"Family-based association of lithium-related and other candidate genes in bipolar disorder","volume":"65","author":"Perlis","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.03.013_bib33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jad.2014.08.052","article-title":"General medical conditions in 347 bipolar disorder patients: clinical correlates of metabolic and autoimmune-allergic disorders","volume":"170","author":"Perugi","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.03.013_bib34","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1399-5618.2007.00361.x","article-title":"Chronic treatment of rats with sodium valproate downregulates frontal cortex NF-\u03baB DNA binding activity and COX-2 mRNA","volume":"9","author":"Rao","year":"2007","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2015.03.013_bib35","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/mp.2009.47","article-title":"Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients","volume":"15","author":"Rao","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2015.03.013_bib36","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/glia.10034","article-title":"Expression of functional NK-1 receptors in murine microglia","volume":"37","author":"Rasley","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.jad.2015.03.013_bib37","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ajmg.b.32241","article-title":"Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome","volume":"165","author":"Sharp","year":"2014","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet. B"},{"key":"10.1016\/j.jad.2015.03.013_bib38","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0006-8993(99)01976-9","article-title":"The substance P antagonist L-760,735 inhibits stress-induced NK1 receptor internalization in the basolateral amygdale","volume":"848","author":"Smith","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.jad.2015.03.013_bib39","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0306-9877(92)90117-U","article-title":"A comprehensive macrophage-T lymphocyte theory of schizophrenia","volume":"39","author":"Smith","year":"1992","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.jad.2015.03.013_bib40","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1399-5618.2011.00961.x","article-title":"Hippocampal \u03b17 nicotinic acetylcholine receptor levels in patients with schizophrenia, bipolar disorder, or major depressive disorder","volume":"13","author":"Thomsen","year":"2011","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2015.03.013_bib41","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032715001421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032715001421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:15:02Z","timestamp":1759022102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032715001421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":41,"alternative-id":["S0165032715001421"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2015.03.013","relation":{},"ISSN":["0165-0327"],"issn-type":[{"type":"print","value":"0165-0327"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurokinin (NK)-1 receptor expression in monocytes from bipolar disorder patients: A pilot study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2015.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}