{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:42:00Z","timestamp":1784068920239,"version":"3.55.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jad-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jad.2015.04.056","type":"journal-article","created":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T13:25:17Z","timestamp":1431177917000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Serotonin gene polymorphisms and lifetime mood disorders in predicting interferon-induced depression in chronic hepatitis C"],"prefix":"10.1016","volume":"183","author":[{"given":"Raffaele","family":"Cozzolongo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Porcelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Cariola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Giannuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Lanzilotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Sonnante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioacchino","family":"Leandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2015.04.056_bib1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/j.1440-1746.2011.07035.x","article-title":"Effect of pegylated interferon-\u03b1-2a treatment on mental health during recent Hepatitis C Virus infection","volume":"27","author":"Alavi","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jad.2015.04.056_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1192\/bjp.bp.110.087924","article-title":"War exposure, 5-HTTLPR genotype and lifetime risk of depression","volume":"199","author":"Artero","year":"2011","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.04.056_bib3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1136\/thoraxjnl-2012-202040","article-title":"Interventions to improve symptoms and quality of life of patients with fibrotic interstitial lung disease: a systematic review of the literature","volume":"68","author":"Bajwah","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.jad.2015.04.056_bib4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000348587","article-title":"A biopsychosocial model of interferon-alpha-induced depression in patients with chronic hepatitis C infection","volume":"82","author":"Baranyi","year":"2013","journal-title":"Psychother. Psychosom."},{"key":"10.1016\/j.jad.2015.04.056_bib5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00004714-200202000-00014","article-title":"Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system","volume":"22","author":"Bonaccorso","year":"2002","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2015.04.056_bib6","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s00702-005-0391-4","article-title":"Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation","volume":"112","author":"Canli","year":"2005","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.jad.2015.04.056_bib7","doi-asserted-by":"crossref","first-page":"817","DOI":"10.4088\/JCP.08m04230","article-title":"Pegylated interferon and ribavirin-induced depression in chronic hepatitis C: role of personality","volume":"70","author":"Castellvi","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2015.04.056_bib8","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1365-2036.2006.03107.x","article-title":"Impact on adherence and sustained virological response of psychiatric side effects during peginterferon and ribavirin therapy for chronic hepatitis C","volume":"24","author":"Castera","year":"2006","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2015.04.056_bib9","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1017\/S0033291710000516","article-title":"Association of the 5-HTTLPR genotype and unipolar depression: a meta-analysis","volume":"40","author":"Clarke","year":"2010","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2015.04.056_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.phrs.2010.10.009","article-title":"Effects of PEG-interferon alpha plus ribavirin on tryptophan metabolism in patients with chronic hepatitis C","volume":"63","author":"Comai","year":"2011","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jad.2015.04.056_bib11","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1038\/ajg.2009.428","article-title":"Epidemiology of HCV Infection in the general population: a survey in a Southern Italian town","volume":"104","author":"Cozzolongo","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jad.2015.04.056_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/brbi.2000.0613","article-title":"Cytokine-induced sickness behavior: where do we stand","volume":"15","author":"Dantzer","year":"2001","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2015.04.056_bib13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2015.04.056_bib14","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1056\/NEJM198911303212203","article-title":"Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized, controlled trial. Hepatitis Interventional Therapy Group","volume":"321","author":"Davis","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jad.2015.04.056_bib15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1176\/appi.psy.44.2.104","article-title":"A prospective study of neuropsychiatric symptoms associated with interferon-alpha-2b and ribavirin therapy for patients with chronic hepatitis C","volume":"44","author":"Dieperink","year":"2003","journal-title":"Psychosomatics"},{"key":"10.1016\/j.jad.2015.04.056_bib16","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1038\/ajg.2009.528","article-title":"Prospective analysis of depression during peginterferon and ribavirin therapy of chronic hepatitis C: results of the Virahep-C study","volume":"104","author":"Evon","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jad.2015.04.056_bib17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.genhosppsych.2011.09.002","article-title":"Screening inventories to detect depression in chronic hepatitis C patients","volume":"34","author":"F\u00e0bregas","year":"2012","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jad.2015.04.056_bib18","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1161\/STROKEAHA.110.598672","article-title":"Serotonin transporter gene polymorphism in Chinese patients with poststroke depression: a case-control study","volume":"42","author":"Fang","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.jad.2015.04.056_bib19","series-title":"Organizzazioni Speciali","article-title":"SCID-I \u2013 Structured Clinical Interview for DSM-IV axis I disorders","author":"First","year":"2000"},{"key":"10.1016\/j.jad.2015.04.056_bib20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jad.2014.10.010","article-title":"Depression is not a consistent syndrome: an investigation of unique symptom patterns in the STAR\u204eD study","volume":"172","author":"Fried","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.04.056_bib21","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1056\/NEJMoa020047","article-title":"Peginterferon alfa-2a plus ribavirin for chronic Hepatitis C Virus infection","volume":"347","author":"Fried","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jad.2015.04.056_bib22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.psym.2010.11.004","article-title":"Interferon-alpha as an appropriate model of substance-induced depression","volume":"52","author":"Galv\u00e3o-de Almeida","year":"2011","journal-title":"Psychosomatics"},{"key":"10.1016\/j.jad.2015.04.056_bib23","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.bbi.2011.06.001","article-title":"Lack of association of indoleamine 2,3-dioxygenase polymorphisms with interferon-alpha-related depression in hepatitis C","volume":"25","author":"Galv\u00e3o-de Almeida","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2015.04.056_bib24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.genhosppsych.2013.12.007","article-title":"Serotonin-1A receptor CC genotype is associated with persistent depression related to interferon-alpha in hepatitis C patients","volume":"36","author":"Galv\u00e3o-de Almeida","year":"2014","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jad.2015.04.056_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jad.2007.07.005","article-title":"The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression","volume":"107","author":"Gizatullin","year":"2008","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.04.056_bib26","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jad.2009.12.022","article-title":"Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients","volume":"124","author":"Grassi","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.04.056_bib27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jad.2011.03.004","article-title":"Subtyping depression in the medically ill by cluster analysis","volume":"132","author":"Guidi","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.04.056_bib28","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1097\/01.psy.0000145824.82125.a8","article-title":"Biopsychosocial predictors of health-related quality of life in patients with chronic hepatitis C","volume":"66","author":"H\u00e4user","year":"2004","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2015.04.056_bib29","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.neuroscience.2005.03.051","article-title":"The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity","volume":"135","author":"Hayley","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.jad.2015.04.056_bib30","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0024-3205(02)02482-7","article-title":"Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration","volume":"72","author":"Hensler","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.jad.2015.04.056_bib31","first-page":"157","article-title":"Influence of psychiatric diagnoses on interferon-alpha treatment for chronic hepatitis C in a veteran population","volume":"96","author":"Ho","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jad.2015.04.056_bib32","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.neubiorev.2008.03.006","article-title":"Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease","volume":"32","author":"Holmes","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2015.04.056_bib33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1192\/bjp.bp.108.062521","article-title":"Moderation of antidepressant response by the serotonin transporter gene","volume":"195","author":"Huezo-Diaz","year":"2009","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.04.056_bib34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tins.2012.01.001","article-title":"Serotonin transporter gene, stress and raphe\u2013raphe interactions: a molecular mechanism of depression","volume":"35","author":"Jasinska","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jad.2015.04.056_bib35","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11920-007-0028-4","article-title":"Interferon-induced depression in hepatitis C: an update","volume":"9","author":"Keefe","year":"2007","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.jad.2015.04.056_bib36","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","article-title":"The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)","volume":"289","author":"Kessler","year":"2003","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.jad.2015.04.056_bib37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00406-012-0337-4","article-title":"The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder","volume":"263","author":"Kishi","year":"2013","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2015.04.056_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/YPG.0b013e328335112b","article-title":"Association between major depressive disorder and a functional polymorphism of the 5-hydroxytryptamine (serotonin) transporter gene: a meta-analysis","volume":"20","author":"Kiyohara","year":"2010","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.jad.2015.04.056_bib39","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1001\/jama.2014.7085","article-title":"Treatment of hepatitis C. A systematic review","volume":"312","author":"Kohli","year":"2014","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.jad.2015.04.056_bib40","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1053\/j.gastro.2007.02.053","article-title":"Serotonin-1A receptor gene HTR1A variation predicts interferon-induced depression in chronic hepatitis C","volume":"132","author":"Kraus","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jad.2015.04.056_bib41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1056\/NEJM200107053450107","article-title":"Hepatitis C Virus infection","volume":"345","author":"Lauer","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jad.2015.04.056_bib42","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/infdis\/jis385","article-title":"Chronic Hepatitis C Virus infection increases mortality from hepatic and extrahepatic diseases: a community-based long-term prospective study","volume":"206","author":"Lee","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jad.2015.04.056_bib43","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1017\/S1461145704004699","article-title":"Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response","volume":"7","author":"Lemonde","year":"2004","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2015.04.056_bib44","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1523\/JNEUROSCI.23-25-08788.2003","article-title":"Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide","volume":"23","author":"Lemonde","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2015.04.056_bib45","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.274.5292.1527","article-title":"Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region","volume":"274","author":"Lesch","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jad.2015.04.056_bib46","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3109\/09540261.2013.813442","article-title":"Cytokines as biomarkers in depressive disorder: current standing and prospects","volume":"25","author":"Lichtblau","year":"2013","journal-title":"Int. Rev. Psychiatry"},{"key":"10.1016\/j.jad.2015.04.056_bib47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jpsychores.2012.10.012","article-title":"Vulnerability to somatic symptoms of depression during interferon-alpha therapy for hepatitis C: a 16-week prospective study","volume":"74","author":"Loftis","year":"2013","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.jad.2015.04.056_bib48","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.2174\/138161212803523680","article-title":"Inflammatory cytokines, growth factors, and depression","volume":"18","author":"Lotrich","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jad.2015.04.056_bib49","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/npp.2012.263","article-title":"Brain-derived neurotrophic factor serum levels and genotype: association with depression during interferon-alpha treatment","volume":"38","author":"Lotrich","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2015.04.056_bib50","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.biopsych.2008.08.009","article-title":"Risk for depression during interferon-alpha treatment is affected by the serotonin transporter polymorphism","volume":"65","author":"Lotrich","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.04.056_bib51","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jpsychores.2007.05.013","article-title":"Depression following pegylated interferon-alpha: characteristics and vulnerability","volume":"63","author":"Lotrich","year":"2007","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.jad.2015.04.056_bib52","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000026485","article-title":"Interferon-alpha induced depression in chronic hepatitis C patients: comparison between different types of interferon alpha","volume":"37","author":"Malaguarnera","year":"1998","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.jad.2015.04.056_bib81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1037\/a0017336","article-title":"Association between depression severity and neurocognitive function in major depressive disorder: a review and synthesis","volume":"24","author":"McClintock","year":"2010","journal-title":"Neuropsychology"},{"key":"10.1016\/j.jad.2015.04.056_bib53","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.04.056_bib54","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.26141","article-title":"Global epidemiology of Hepatitis C Virus infection: new estimates of age-specific antibody to HCV seroprevalence","volume":"57","author":"Mohd Hanafiah","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jad.2015.04.056_bib55","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/1099-1077(200008)15:6<397::AID-HUP212>3.0.CO;2-L","article-title":"A review of the role of serotonin receptors in psychiatric disorders","volume":"15","author":"Naughton","year":"2000","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.jad.2015.04.056_bib56","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jad.2009.12.026","article-title":"Is the serotonin transporter polymorphism (5-HTTLPR) a potential marker for suicidal behavior in bipolar disorder patients","volume":"125","author":"Neves","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.04.056_bib57","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1111\/j.1440-1746.2011.06965.x","article-title":"Evaluation of the adverse effect of premature discontinuation of pegylated interferon a-2b and ribavirin treatment for chronic Hepatitis C Virus infection: results from Kyushu University Liver Disease Study","volume":"27","author":"Ogawa","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jad.2015.04.056_bib58","first-page":"137","article-title":"A functional serotonin transporter gene polymorphism and depressive effects associated with interferon-alpha treatment","volume":"51","author":"Pierucci-Lagha","year":"2010","journal-title":"Psychosomatics"},{"key":"10.1016\/j.jad.2015.04.056_bib59","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/01.pra.0000358313.06858.ea","article-title":"Psychiatric problems in patients infected with hepatitis C before and during antiviral treatment with interferon-alpha: a review","volume":"15","author":"Quelhas","year":"2009","journal-title":"J. Psychiatr. Pract."},{"key":"10.1016\/j.jad.2015.04.056_bib60","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4088\/JCP.v66n0106","article-title":"Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and prediction","volume":"66","author":"Raison","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2015.04.056_bib62","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.jhep.2012.07.037","article-title":"Hepatitis C infection, antiviral treatment and mental health: a European expert consensus statement","volume":"57","author":"Sch\u00e4fer","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jad.2015.04.056_bib63","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jpsychires.2008.06.005","article-title":"Seretonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls","volume":"43","author":"Serretti","year":"2009","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2015.04.056_bib64","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.psychres.2011.02.001","article-title":"Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia","volume":"189","author":"Serretti","year":"2011","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2015.04.056_bib65","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2147\/NDT.S13917","article-title":"Risk factors for the development of depression in patients with hepatitis C taking interferon","volume":"7","author":"Smith","year":"2011","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.jad.2015.04.056_bib66","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/hep.20659","article-title":"Impact of hepatitis C on health related quality of life: a systematic review and quantitative assessment","volume":"41","author":"Spiegel","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jad.2015.04.056_bib67","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/jgh.12028","article-title":"Current prospects for interferon-free treatment of hepatitis C in 2012","volume":"28","author":"Stedman","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jad.2015.04.056_bib68","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00702-003-0072-0","article-title":"Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits","volume":"110","author":"Strobel","year":"2003","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.jad.2015.04.056_bib69","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.pnpbp.2009.02.020","article-title":"Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response","volume":"33","author":"Tsai","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.04.056_bib70","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/FPC.0b013e3282fb02cb","article-title":"Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment","volume":"18","author":"Tzvetkov","year":"2008","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.jad.2015.04.056_bib71","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.4088\/JCP.12r07694","article-title":"Interferon-induced depression in chronic hepatitis C: a systematic review and meta-analysis","volume":"73","author":"Udina","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2015.04.056_bib72","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.psyneuen.2013.03.007","article-title":"Serotonin and interleukin-6: the role of genetic polymorphisms in IFN-induced neuropsychiatric symptoms","volume":"38","author":"Udina","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2015.04.056_bib73","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11920-005-0042-3","article-title":"Neurobehavioral effects of interferon therapy","volume":"7","author":"Valentine","year":"2005","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.jad.2015.04.056_bib74","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1741-7015-10-156","article-title":"Data-driven subtypes of major depressive disorder: a systematic review","volume":"10","author":"van Loo","year":"2012","journal-title":"BMC Med."},{"key":"10.1016\/j.jad.2015.04.056_bib75","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0006-2952(03)00556-2","article-title":"A unique central tryptophan hydroxylase isoform","volume":"66","author":"Walther","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jad.2015.04.056_bib76","first-page":"1","article-title":"Chronic hepatitis C: future treatment","volume":"6","author":"Wendt","year":"2014","journal-title":"Clin. Pharmacol."},{"key":"10.1016\/j.jad.2015.04.056_bib77","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1017\/S1461145702003103","article-title":"The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans","volume":"5","author":"Wichers","year":"2002","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2015.04.056_bib78","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1001\/archpsyc.62.10.1109","article-title":"Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations","volume":"62","author":"Zhou","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.04.056_bib79","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The Hospital Anxiety And Depression Scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2015.04.056_bib80","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.comppsych.2014.09.007","article-title":"How many different ways do patients meet the diagnostic criteria for major depressive disorder","volume":"56","author":"Zimmerman","year":"2015","journal-title":"Comp. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503271500289X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503271500289X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T17:48:58Z","timestamp":1566668938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503271500289X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":80,"alternative-id":["S016503271500289X"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2015.04.056","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serotonin gene polymorphisms and lifetime mood disorders in predicting interferon-induced depression in chronic hepatitis C","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2015.04.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}