{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:09:46Z","timestamp":1790708986647,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GV0611"],"award-info":[{"award-number":["01GV0611"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GV0615"],"award-info":[{"award-number":["01GV0615"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jad.2015.05.052","type":"journal-article","created":{"date-parts":[[2015,6,7]],"date-time":"2015-06-07T07:51:48Z","timestamp":1433663508000},"page":"182-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Separating depressive comorbidity from panic disorder: A combined functional magnetic resonance imaging and machine learning approach"],"prefix":"10.1016","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-4012","authenticated-orcid":false,"given":"Ulrike","family":"Lueken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Straube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Beesdo-Baum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Ulrich","family":"Wittchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Konrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Str\u00f6hle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Wittmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Gerlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1238-6225","authenticated-orcid":false,"given":"Bettina","family":"Pfleiderer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Arolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilo","family":"Kircher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2015.05.052_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuroimage.2013.03.007","article-title":"Perforant pathway stimulation as a conditioned stimulus for active avoidance learning triggers BOLD responses in various target regions of the hippocampus: a combined fMRI and electrophysiological study","volume":"75","author":"Angenstein","year":"2013","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2015.05.052_bib2","series-title":"Panic and Agoraphobia Scale (PAS)","author":"Bandelow","year":"1999"},{"key":"10.1016\/j.jad.2015.05.052_bib3","series-title":"Beck Depression Inventory","author":"Beck","year":"1996"},{"key":"10.1016\/j.jad.2015.05.052_bib4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1037\/0033-295X.108.1.4","article-title":"A modern learning theory perspective on the etiology of panic disorder","volume":"108","author":"Bouton","year":"2001","journal-title":"Psychol. Rev."},{"key":"10.1016\/j.jad.2015.05.052_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0005-7916(94)90063-9","article-title":"Measuring emotion \u2013 the self-assessment mannequin and the semantic differential","volume":"25","author":"Bradley","year":"1994","journal-title":"J. Behav. Ther. Exp. Psychiatry"},{"key":"10.1016\/j.jad.2015.05.052_bib6","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrn894","article-title":"How do you feel? Interoception: the sense of the physiological condition of the body","volume":"3","author":"Craig","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2015.05.052_bib7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1037\/a0025738","article-title":"Elevated responding to safe conditions as a specific risk factor for anxiety vs. depressive disorders: evidence from a longitudinal investigation","volume":"121","author":"Craske","year":"2012","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.jad.2015.05.052_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00702-012-0811-1","article-title":"Revise the revised? New dimensions of the neuroanatomical hypothesis of panic disorder","volume":"120","author":"Dresler","year":"2012","journal-title":"J. Neural Transm."},{"issue":"4","key":"10.1016\/j.jad.2015.05.052_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/da.22353","article-title":"Updated meta-analysis of classical fear conditioning in the anxiety disorders","volume":"32","author":"Duits","year":"2015","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2015.05.052_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000335246","article-title":"Depression does not affect the treatment outcome of CBT for panic and agoraphobia: results from a multicenter randomized trial","volume":"81","author":"Emmrich","year":"2012","journal-title":"Psychother. Psychosom."},{"key":"10.1016\/j.jad.2015.05.052_bib11","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1176\/appi.ajp.2007.07030504","article-title":"Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia","volume":"164","author":"Etkin","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.05.052_bib12","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.neuroimage.2006.03.062","article-title":"Reducing inter-scanner variability of activation in a multicenter fMRI study: role of smoothness equalization","volume":"32","author":"Friedman","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2015.05.052_bib13","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1037\/a0023584","article-title":"Psychological treatment for panic disorder with agoraphobia: a randomized controlled trial to examine the role of therapist-guided exposure in situ in CBT","volume":"79","author":"Gloster","year":"2011","journal-title":"J. Consult. Clin. Psychol."},{"key":"10.1016\/j.jad.2015.05.052_bib14","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.euroneuro.2005.04.006","article-title":"The epidemiology of panic disorder and agoraphobia in Europe","volume":"15","author":"Goodwin","year":"2005","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2015.05.052_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jad.2014.04.019","article-title":"Neural response to reward anticipation in those with depression with and without panic disorder","volume":"164","author":"Gorka","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.05.052_bib16","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1002\/hbm.22380","article-title":"Amygdala excitability to subliminally presented emotional faces distinguishes unipolar and bipolar depression: an fMRI and pattern classification study","volume":"35","author":"Grotegerd","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jad.2015.05.052_bib17","doi-asserted-by":"crossref","unstructured":"Guy, W., 1976. ECDEU Assessment Manual for Psychopharmacology.\u00a0U.S. National Institute of Health, Psychopharmacology Research Branch, Rev. Rockville, MD.","DOI":"10.1037\/e591322011-001"},{"key":"10.1016\/j.jad.2015.05.052_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1001\/jamapsychiatry.2014.1741","article-title":"Predicting treatment response to cognitive behavioral therapy in panic disorder with agoraphobia by integrating local neural information","volume":"72","author":"Hahn","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2015.05.052_bib19","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/da.20663","article-title":"Impaired fear inhibition is a biomarker of PTSD but not depression","volume":"27","author":"Jovanovic","year":"2010","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2015.05.052_bib20","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1001\/archpsyc.63.4.415","article-title":"The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication","volume":"63","author":"Kessler","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.05.052_bib21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.pnpbp.2012.12.022","article-title":"Comparison of panic disorder with and without comorbid major depression by using brain structural magnetic resonance imaging","volume":"43","author":"Kim","year":"2013","journal-title":"Prog. Neuro\u2013Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.05.052_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.biopsych.2012.07.026","article-title":"Effect of cognitive behavioural therapy on neural correlates of fear conditioning in panic disorder","volume":"73","author":"Kircher","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.05.052_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pscychresns.2006.11.006","article-title":"Neural correlates of trauma script-imagery in posttraumatic stress disorder with and without comorbid major depression: a functional MRI investigation","volume":"155","author":"Lanius","year":"2007","journal-title":"Psychiatry Res. \u2013 Neuroimaging"},{"key":"10.1016\/j.jad.2015.05.052_bib24","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1523\/JNEUROSCI.08-07-02517.1988","article-title":"Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear","volume":"8","author":"LeDoux","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2015.05.052_bib25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1176\/appi.ajp.2009.09030410","article-title":"Overgeneralization of conditioned fear as a pathogenic marker of panic disorder","volume":"167","author":"Lissek","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.05.052_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.brat.2008.10.017","article-title":"Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder","volume":"47","author":"Lissek","year":"2009","journal-title":"Behav. Res. Ther."},{"key":"10.1016\/j.jad.2015.05.052_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00702-014-1272-5","article-title":"Diagnostic classification of specific phobia subtypes using structural MRI data: a machine-learning approach","volume":"122","author":"Lueken","year":"2015","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.jad.2015.05.052_bib28","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1176\/appi.ajp.2013.12111484","article-title":"Neural substrates of treatment response to cognitive-behavioral therapy in panic disorder with agoraphobia","volume":"170","author":"Lueken","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.05.052_bib29","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1017\/S0033291713000792","article-title":"Altered top-down and bottom-up processing of fear conditioning in panic disorder with agoraphobia","volume":"44","author":"Lueken","year":"2014","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2015.05.052_bib30","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S1053-8119(03)00169-1","article-title":"An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets","volume":"19","author":"Maldjian","year":"2003","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2015.05.052_bib31","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1176\/jnp.9.3.471","article-title":"Limbic\u2013cortical dysregulation: a proposed model of depression","volume":"9","author":"Mayberg","year":"1997","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2015.05.052_bib32","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.neuron.2005.02.014","article-title":"Deep brain stimulation for treatment-resistant depression","volume":"45","author":"Mayberg","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2015.05.052_bib33","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1469-8986.2007.00560.x","article-title":"Startle reflex modulation and autonomic responding during anxious apprehension in panic disorder patients","volume":"44","author":"Melzig","year":"2007","journal-title":"Psychophysiology"},{"key":"10.1016\/j.jad.2015.05.052_bib34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1037\/0021-843X.110.1.40","article-title":"Misunderstanding analysis of covariance","volume":"110","author":"Miller","year":"2001","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.jad.2015.05.052_bib35","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.neuroimage.2005.06.070","article-title":"Classifying brain states and determining the discriminating activation patterns: support vector machine on functional MRI data","volume":"28","author":"Mourao-Miranda","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2015.05.052_bib36","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.biopsych.2010.05.026","article-title":"Learning as a model for neural plasticity in major depression","volume":"68","author":"Nissen","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.05.052_bib37","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.neubiorev.2012.01.004","article-title":"Using support vector machine to identify imaging biomarkers of neurological and psychiatric disease: a critical review","volume":"36","author":"Orru","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2015.05.052_bib38","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.biopsych.2006.03.042","article-title":"An insular view of anxiety","volume":"60","author":"Paulus","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.05.052_bib39","series-title":"Anxiety Sensitivty Index Manual","author":"Peterson","year":"1992"},{"key":"10.1016\/j.jad.2015.05.052_bib40","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00406-010-0099-9","article-title":"Neural correlates of aversive conditioning: development of a functional imaging paradigm for the investigation of anxiety disorders","volume":"260","author":"Reinhardt","year":"2010","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2015.05.052_bib41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1192\/bjp.176.3.229","article-title":"Lifetime panic-depression comorbidity in the National Comorbidity Survey\u2010Association with symptoms, impairment, course and help-seeking","volume":"176","author":"Roy-Byrne","year":"2000","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.05.052_bib42","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1111\/j.1460-9568.2012.08048.x","article-title":"Perceived helplessness is associated with individual differences in the central motor output system","volume":"35","author":"Salomons","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jad.2015.05.052_bib43","doi-asserted-by":"crossref","first-page":"e5865","DOI":"10.1371\/journal.pone.0005865","article-title":"Human fear conditioning and extinction in neuroimaging: a systematic review","volume":"4","author":"Sehlmeyer","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2015.05.052_bib44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1109\/TSMCA.2009.2029559","article-title":"RUSBoost: a hybrid approach to alleviating class imbalance","volume":"40","author":"Seiffert","year":"2010","journal-title":"IEEE Trans. Syst. Man Cybern. A"},{"key":"10.1016\/j.jad.2015.05.052_bib45","series-title":"Helplessness: On Development, Depression, and Death","author":"Seligman","year":"1992"},{"key":"10.1016\/j.jad.2015.05.052_bib46","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.tics.2013.09.007","article-title":"Interoceptive inference, emotion, and the embodied self","volume":"17","author":"Seth","year":"2013","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.jad.2015.05.052_bib47","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/da.1033","article-title":"Reliability and validity of a structured interview guide for the Hamilton Anxiety Rating Scale (SIGH-A)","volume":"13","author":"Shear","year":"2001","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2015.05.052_bib48","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0926-6410(03)00082-X","article-title":"Distinct prefrontal cortex activity associated with item memory and source memory for visual shapes","volume":"17","author":"Slotnick","year":"2003","journal-title":"Brain Res. Cogn. Brain Res."},{"key":"10.1016\/j.jad.2015.05.052_bib49","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1176\/ajp.2007.164.2.318","article-title":"Increased amygdala and insula activation during emotion processing in anxiety-prone subjects","volume":"164","author":"Stein","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.05.052_bib50","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.janxdis.2010.09.010","article-title":"Differential activity of subgenual cingulate and brainstem in panic disorder and PTSD","volume":"25","author":"Tuescher","year":"2011","journal-title":"J. Anxiety Disord."},{"key":"10.1016\/j.jad.2015.05.052_bib51","series-title":"DIA-X Interview","author":"Wittchen","year":"1997"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032715003584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032715003584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T13:12:00Z","timestamp":1668604320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032715003584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":51,"alternative-id":["S0165032715003584"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2015.05.052","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Separating depressive comorbidity from panic disorder: A combined functional magnetic resonance imaging and machine learning approach","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2015.05.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}