{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:06:53Z","timestamp":1788278813592,"version":"build-2803163510"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jad-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.jad.2015.08.027","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:48:59Z","timestamp":1441673339000},"page":"226-231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Late onset mania as an organic syndrome: A review of case reports in the literature"],"prefix":"10.1016","volume":"188","author":[{"given":"Musa","family":"Sami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Nilforooshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2015.08.027_bib1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jcgg.2013.10.001","article-title":"Geriatric mania complicated by hyponatremia and psychogenic adipsic hypernatremia","volume":"5","author":"Achalia","year":"2014","journal-title":"J. Clin. Gerontol. Geriatics"},{"key":"10.1016\/j.jad.2015.08.027_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/S0193-953X(05)70093-9","article-title":"The evolving bipolar spectrum: Prototypes I, II, III, and IV","author":"Akiskal","year":"1999","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.jad.2015.08.027_bib3","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/gps.2408","article-title":"Late onset mania in the elderly","volume":"25","author":"Amaladoss","year":"2010","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib4","article-title":"Late onset bipolar disorder due to a lacunar state","author":"Antelmi","year":"2013","journal-title":"Behav. Neurol"},{"key":"10.1016\/j.jad.2015.08.027_bib300","doi-asserted-by":"crossref","first-page":"780742","DOI":"10.1155\/2014\/780742","article-title":"A late onset bipolar disorder due to a lacunar state","volume":"2014","author":"Antelmi","year":"2014","journal-title":"Behav. Neurol"},{"key":"10.1016\/j.jad.2015.08.027_bib5","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1176\/jnp.2007.19.2.194","article-title":"Mania as a possible prodrome to dementia","volume":"19","author":"Appleby","year":"2007","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2015.08.027_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/j.1755-5949.2011.00255.x","article-title":"Late-onset Bipolar Illness: The Geriatric Bipolar Type VI","author":"Azorin","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jad.2015.08.027_bib7","first-page":"53","article-title":"Early- versus late-onset bipolar II disorder","volume":"25","author":"Benazzi","year":"2000","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.jad.2015.08.027_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1745-0179-4-22","article-title":"Bipolar disorder in late life: clinical characteristics in a sample of older adults admitted for manic episode","volume":"4","author":"Benedetti","year":"2008","journal-title":"Clin Pr. Epidemiol Ment Heal."},{"key":"10.1016\/j.jad.2015.08.027_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.maturitas.2011.07.005","article-title":"The role of white matter damage in late onset bipolar disorder","author":"Besga","year":"2011","journal-title":"Maturitas"},{"key":"10.1016\/j.jad.2015.08.027_bib10","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/gps.2466","article-title":"Does age at onset have clinical significance in older adults with bipolar disorder?","volume":"25","author":"Chu","year":"2010","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2788.1994.tb00350.x","article-title":"Late onset mania in Down\u2019s syndrome","author":"Cooper","year":"1994","journal-title":"J. Intellectual Disab. Res."},{"key":"10.1016\/j.jad.2015.08.027_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/10673229609030520","article-title":"Treatment of bipolar illness in an older, skeptical patient","volume":"4","author":"Davidoff","year":"1996","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3928\/00485713-20110425-04","article-title":"A 68-year-old woman with lung cancer and late-onset bipolar disorder","volume":"41","author":"DeKay","year":"2011","journal-title":"Psychiatr. Ann"},{"key":"10.1016\/j.jad.2015.08.027_bib14","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1097\/01.nmd.0000145055.45944.d6","article-title":"Bipolar disorder in middle-aged and elderly adults: is age of onset important?","volume":"192","author":"Depp","year":"2004","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.jad.2015.08.027_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/j.1399-5618.2004.00139.x","article-title":"Bipolar disorder in older adults: A critical review","author":"Depp","year":"2004","journal-title":"Bipol. Disord."},{"key":"10.1016\/j.jad.2015.08.027_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/bdi.12104","article-title":"The prevalence of late-life mania: a review","author":"Dols","year":"2014","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2015.08.027_bib17","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4088\/JCP.v68n0522a","article-title":"Resolution of late-onset hypomania after repair of carotid artery stenosis: a case of vascular hypomania","volume":"68","author":"Donovan","year":"2007","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib18","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1176\/jnp.2.3.322","article-title":"Secondary mania after ventral pontine infarction","volume":"2","author":"Drake","year":"1990","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2015.08.027_bib19","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s11920-000-0069-4","article-title":"Prevalence and description of psychotic features in bipolar mania","volume":"2","author":"Dunayevich","year":"2000","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.jad.2015.08.027_bib20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1017\/S0790966700014269","article-title":"Bipolar affective disorder and thrombocytopaenia","author":"Evans","year":"1995","journal-title":"Ir. J. Psychol. Med"},{"key":"10.1016\/j.jad.2015.08.027_bib21","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1080\/j.1440-1614.1999.00539.x","article-title":"Post-stroke mania late in life involving the left hemisphere","volume":"33","author":"Fenn","year":"1999","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib22","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1176\/ajp.137.11.1453","article-title":"Thiazide-Induced hypercalcaemia in a Manic-Depressive Patient","volume":"137","author":"Gammon","year":"1980","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib23","article-title":"Late onset mania","author":"Habib","year":"1998","journal-title":"Clin. Gerontol. J. Aging Ment. Heal"},{"key":"10.1016\/j.jad.2015.08.027_bib24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/(SICI)1520-6394(1998)7:2<76::AID-DA5>3.0.CO;2-3","article-title":"Age of first onset of bipolar disorder: Demographic, family history, and psychosocial correlates","volume":"7","author":"Hays","year":"1998","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2015.08.027_bib25","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/070674379103600812","article-title":"A first episode of mania after age 80","volume":"36","author":"Kellner","year":"1991","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib26","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1001\/archpsyc.1978.01770350059005","article-title":"Secondary mania: manic syndromes associated with antecedent physical illness or drugs","volume":"35","author":"Krauthammer","year":"1978","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1177\/070674379103600524","article-title":"Late Onset (Hypo)mania","volume":"36","author":"Kubacki","year":"1991","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib28","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/gps.1607","article-title":"Factors related to hospitalization in elderly manic patients with early and late-onset bipolar disorder","volume":"21","author":"Lehmann","year":"2006","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.genhosppsych.2010.11.002","article-title":"Secondary mania associated with enterococcal meningitis in an elderly patient","volume":"33","author":"Liang","year":"2011","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib30","first-page":"233","article-title":"Late-onset bipolar disorder following right thalamic injury","volume":"37","author":"L\u00f3pez","year":"2009","journal-title":"Actas Esp. Psiquiatr."},{"key":"10.1016\/j.jad.2015.08.027_bib31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/gps.930060412","article-title":"A case of late-onset rapid cycling affective disorder","volume":"6","author":"Lovestone","year":"1991","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib32","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/gps.3801","article-title":"Neurocognitive functioning in early-onset and late-onset older patients with euthymic bipolar disorder","volume":"28","author":"Martino","year":"2013","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0925-4927(91)90013-G","article-title":"Occurrence of subcortical hyperintensities in elderly subjects with mania","volume":"40","author":"McDonald","year":"1991","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2015.08.027_bib34","first-page":"33","article-title":"Hyponatremia-induced change in mood mimicking late-onset bipolar disorder","author":"McKnight","year":"2011","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/bdi.12001","article-title":"Course, outcomes, and psychosocial interventions for first-episode mania","author":"McMurrich","year":"2012","journal-title":"Bipol. Disord."},{"key":"10.1016\/j.jad.2015.08.027_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/S0924-977X(11)70718-0","article-title":"P.2.g.007 Fentanyl induced organic mania","author":"Medjugorac","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2015.08.027_bib37","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/NMD.0b013e31829c508d","article-title":"Understanding bipolar disorder in late life","volume":"201","author":"Montes","year":"2013","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.jad.2015.08.027_bib38","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4088\/JCP.08l04577","article-title":"Late-onset manic episode in a 91-year-old man without previous psychiatric history as a unique clinical manifestation of a pancreatic neoplasm","volume":"70","author":"Murru","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib39","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1034\/j.1600-0447.2001.00303.x","article-title":"Late-onset bipolar disorder due to hyperthyroidism","volume":"104","author":"Nath","year":"2001","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2015.08.027_bib40","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jad.2007.08.018","article-title":"A case series on the hypothesized connection between dementia and bipolar spectrum disorders: Bipolar type VI?","volume":"107","author":"Ng","year":"2008","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.08.027_bib41","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jad.2008.11.012","article-title":"Bipolar disorder in the elderly; different effects of age and of age of onset","volume":"116","author":"Oostervink","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.08.027_bib42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/1471-244X-14-175","article-title":"Case report: bipolar disorder as the first manifestation of CADASIL","volume":"14","author":"Park","year":"2014","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib43","first-page":"34","article-title":"Late-onset bipolar disorder: a case for careful appraisal","volume":"7","author":"Prabhakar","year":"2010","journal-title":"Psychiatry (Edgmont)"},{"key":"10.1016\/j.jad.2015.08.027_bib44","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1177\/070674370805301208","article-title":"The epidemiology of psychiatric disorders in Quebec\u2019s older adult population","volume":"53","author":"Pr\u00e9ville","year":"2008","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib45","unstructured":"Ramirez-Bermudez, J., 2011. The differential diagnosis of late-onset manic episode. In: Proceedings of the 9th International Conference on Bipolar Disorders, Pittsburgh, USA. p. 80."},{"key":"10.1016\/j.jad.2015.08.027_bib46","doi-asserted-by":"crossref","first-page":"E39","DOI":"10.1176\/jnp.23.3.jnpe39","article-title":"Geriatric Manic Delirium With No Previous History of Mania","volume":"23","author":"Rosenzweig","year":"2011","journal-title":"J. Neuropsychiatr."},{"key":"10.1016\/j.jad.2015.08.027_bib47","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/pnp.318","article-title":"Post-stroke mania: A rare but treatable presentation","volume":"18","author":"Routh","year":"2014","journal-title":"Prog. Neurol. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s004060170064","article-title":"Sleep and sleep-wake cycle in an 81-year-old patient with de novo ultra-rapid cycling bipolar disorder","volume":"251","author":"Schreiner","year":"2001","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2015.08.027_bib49","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.4088\/JCP.v67n0821d","article-title":"A Case of Probable Bipolar VI Disorder?","volume":"67","author":"Senturk","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib50","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/gps.1730","article-title":"The role of vascular risk factors in late onset bipolar disorder","volume":"22","author":"Subramaniam","year":"2007","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib51","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1399-5618.2008.00621.x","article-title":"Increased rates of white matter hyperintensities in late-onset bipolar disorder","volume":"10","author":"Tamashiro","year":"2008","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2015.08.027_bib52","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1176\/ajp.151.1.130","article-title":"First-episode mania in late life","volume":"151","author":"Tohen","year":"1994","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib53","first-page":"354","article-title":"Late-onset mania with psychosis associated with hypothyroidism in an elderly Chinese lady","volume":"48","author":"Tor","year":"2007","journal-title":"Singapore Med. J."},{"key":"10.1016\/j.jad.2015.08.027_bib54","doi-asserted-by":"crossref","DOI":"10.1017\/S1041610212000701","article-title":"A rivastigmine-precipitated manic episode in a patient with Alzheimer-type dementia","author":"Tseng","year":"2012","journal-title":"Int. Psychogeriatrics"},{"key":"10.1016\/j.jad.2015.08.027_bib55","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/00019442-199908000-00002","article-title":"Mania in the geriatric patient population: a review of the literature","volume":"7","author":"Van Gerpen","year":"1999","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.maturitas.2010.02.013","article-title":"\u201cBipolar disorder\u201d in the elderly: What\u2019s in a name?","author":"Vasudev","year":"2010","journal-title":"Maturitas"},{"key":"10.1016\/j.jad.2015.08.027_bib57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/00048678809158948","article-title":"Pseudodementia in schizophrenia and mania","volume":"22","author":"Wright","year":"1988","journal-title":"Aust. New Zeal. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib58","first-page":"77","article-title":"Age at onset in geriatric bipolar disorder. Effects on clinical presentation and treatment outcomes in an inpatient sample","volume":"7","author":"Wylie","year":"1999","journal-title":"Am. J. Geriatr. Psychiatry."},{"key":"10.1016\/j.jad.2015.08.027_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.genhosppsych.2010.12.007","article-title":"Post-stroke mania precipitated by withdrawal of antidepressant in an elderly patient with chronic major depression","volume":"33","author":"Yeh","year":"2011","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib60","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/gps.855","article-title":"Antidepressant-associated mania in late life","volume":"18","author":"Young","year":"2003","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.027_bib61","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.pnpbp.2006.10.004","article-title":"Late onset bipolar disorder associated with white matter hyperintensities: a pathophysiological hypothesis","volume":"31","author":"Zanetti","year":"2007","journal-title":"Prog. Neuro-psychopharmacol. Biol. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032715301762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032715301762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T20:16:03Z","timestamp":1718050563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032715301762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":62,"alternative-id":["S0165032715301762"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2015.08.027","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Late onset mania as an organic syndrome: A review of case reports in the literature","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2015.08.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}