{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:57:04Z","timestamp":1791863824734,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jad-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.jad.2015.08.036","type":"journal-article","created":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T21:49:31Z","timestamp":1440107371000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["Peripheral inflammation during abnormal mood states in bipolar I disorder"],"prefix":"10.1016","volume":"187","author":[{"given":"Jess G.","family":"Fiedorowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Prossin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey P.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary E.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"Magnotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Wemmie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2015.08.036_bib1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1440-1819.2004.01294.x","article-title":"White matter hyperintensities in subjects with bipolar disorder","volume":"58","author":"Ahn","year":"2004","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2015.08.036_bib2","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2015.08.036_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jad.2014.05.009","article-title":"Comparison of inflammatory cytokine levels among type I\/type II and manic\/hypomanic\/euthymic\/depressive states of bipolar disorder","volume":"166","author":"Bai","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.08.036_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jad.2013.12.042","article-title":"A preliminary report of increased plasma levels of IL-33 in bipolar disorder: further evidence of pro-inflammatory status","volume":"157","author":"Barbosa","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.08.036_bib5","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.jpsychires.2013.08.019","article-title":"Altered intracellular signaling cascades in peripheral blood mononuclear cells from BD patients","volume":"47","author":"Barbosa","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2015.08.036_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00406-012-0327-6","article-title":"Chemokines in bipolar disorder: trait or state?","volume":"263","author":"Barbosa","year":"2013","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2015.08.036_bib7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jad.2008.12.001","article-title":"Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder","volume":"116","author":"Brietzke","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.08.036_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: software for analysis and visualization of functional magnetic resonance neuroimages","volume":"29","author":"Cox","year":"1996","journal-title":"Comput. Biomed. Res."},{"key":"10.1016\/j.jad.2015.08.036_bib9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s00406-007-0797-0","article-title":"Investigation of serum high-sensitive C-reactive protein levels across all mood states in bipolar disorder","volume":"258","author":"Cunha","year":"2008","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2015.08.036_bib10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/01.PSY.0000041542.29808.01","article-title":"Association between depression and elevated C-reactive protein","volume":"65","author":"Danner","year":"2003","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2015.08.036_bib11","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2015.08.036_bib12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1177\/039463200802100208","article-title":"Evaluation of C-reactive protein and total serum cholesterol in adult patients with bipolar disorder","volume":"21","author":"De Berardis","year":"2008","journal-title":"Int.J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.jad.2015.08.036_bib13","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.pnpbp.2007.02.018","article-title":"Elevated serum levels of C-reactive protein are associated with mania symptoms in outpatients with bipolar disorder","volume":"31","author":"Dickerson","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.036_bib14","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.psyneuen.2012.08.005","article-title":"Reduced regulatory T cells are associated with higher levels of Th1\/TH17 cytokines and activated MAPK in type 1 bipolar disorder","volume":"38","author":"do Prado","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2015.08.036_bib15","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s11920-014-0492-6","article-title":"Depression and cardiovascular disease: an update on how course of illness may influence risk","volume":"16","author":"Fiedorowicz","year":"2014","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.jad.2015.08.036_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000334779","article-title":"Vasculopathy related to manic\/hypomanic symptom burden and first-generation antipsychotics in a sub-sample from the collaborative depression study","volume":"81","author":"Fiedorowicz","year":"2012","journal-title":"Psychother. Psychosom."},{"key":"10.1016\/j.jad.2015.08.036_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.psym.2014.02.001","article-title":"Vascular Mortality in Participants of a Bipolar Genomics Study","author":"Fiedorowicz","year":"2014","journal-title":"Psychosomatics"},{"key":"10.1016\/j.jad.2015.08.036_bib18","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/PSY.0b013e3181acee26","article-title":"Manic\/hypomanic symptom burden and cardiovascular mortality in bipolar disorder","volume":"71","author":"Fiedorowicz","year":"2009","journal-title":"Psychosom Med"},{"key":"10.1016\/j.jad.2015.08.036_bib19","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/PSY.0b013e3182689460","article-title":"Defective nitric oxide-cyclic guanosine monophosphate signaling in patients with bipolar disorder: a potential role for platelet dysfunction","volume":"74","author":"Fontoura","year":"2012","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.jad.2015.08.036_bib20","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jad.2010.04.027","article-title":"Cytokine levels in euthymic bipolar patients","volume":"126","author":"Guloksuz","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.08.036_bib21","series-title":"Multi-Modality MRI Based Atlas of the Brain","author":"Halle","year":"2013"},{"key":"10.1016\/j.jad.2015.08.036_bib22","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.jpsychires.2011.08.003","article-title":"Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia","volume":"45","author":"Hope","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2015.08.036_bib23","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nri3042","article-title":"Reciprocal regulation of the neural and innate immune systems","volume":"11","author":"Irwin","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jad.2015.08.036_bib24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/mp.2014.157","article-title":"Brain abnormalities in bipolar disorder detected by quantitative T1rho mapping","volume":"20","author":"Johnson","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.036_bib25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/mp.2015.10","article-title":"Quantiative T1rho mapping links the cerebellum and lithium use in bipolar disorder","volume":"20","author":"Johnson","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.036_bib26","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jneuroim.2004.01.006","article-title":"Immunologic variables in acute mania of bipolar disorder","volume":"150","author":"Liu","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jad.2015.08.036_bib27","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.neubiorev.2009.10.012","article-title":"A role for white matter abnormalities in the pathophysiology of bipolar disorder","volume":"34","author":"Mahon","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2015.08.036_bib28","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1177\/1352458513515084","article-title":"Magnetization transfer and adiabatic T1rho MRI reveal abnormalities in normal-appearing white matter of subjects with multiple sclerosis","volume":"20","author":"Mangia","year":"2013","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jad.2015.08.036_bib29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/bdi.12135","article-title":"White matter alterations in bipolar disorder: potential for drug discovery and development","volume":"16","author":"Marlinge","year":"2014","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2015.08.036_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biopsych.2013.01.007","article-title":"Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies","volume":"74","author":"Modabbernia","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.036_bib31","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jpsychires.2013.05.018","article-title":"Cytokines in bipolar disorder vs. healthy control subjects: a systematic review and meta-analysis","volume":"47","author":"Munkholm","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2015.08.036_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbi.2014.09.021","article-title":"Elevated levels of IL-6 and IL-18 in manic and hypomanic states in rapid cycling bipolar disorder patients","volume":"43","author":"Munkholm","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2015.08.036_bib33","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1192\/bjp.bp.105.011015","article-title":"Antidepressant therapy and C-reactive protein levels","volume":"188","author":"O\u2019Brien","year":"2006","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.036_bib34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jad.2005.11.015","article-title":"Cytokine profiles in bipolar affective disorder: focus on acutely ill patients","volume":"90","author":"O\u2019Brien","year":"2006","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.08.036_bib35","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1399-5618.2007.00493.x","article-title":"Immune variations in bipolar disorder: phasic differences","volume":"9","author":"Ortiz-Dominguez","year":"2007","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2015.08.036_bib36","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neuroimage.2010.06.047","article-title":"Fully automated analysis using BRAINS: AutoWorkup","volume":"54","author":"Pierson","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2015.08.036_bib37","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.biopsych.2010.10.014","article-title":"Association of plasma interleukin-18 levels with emotion regulation and mu-opioid neurotransmitter function in major depression and healthy volunteers","volume":"69","author":"Prossin","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.036_bib38","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/npp.2014.202","article-title":"Dynamic interactions between plasma IL-1 family cytokines and central endogenous opioid neurotransmitter function in humans","volume":"40","author":"Prossin","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2015.08.036_bib39","first-page":"268","article-title":"Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes","volume":"72","author":"Setiawan","year":"2015","journal-title":"J. Am. Med. Assoc. Psychiatry"},{"key":"10.1016\/j.jad.2015.08.036_bib40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jpsychores.2012.06.004","article-title":"Evidence for accelerated vascular aging in bipolar disorder","volume":"73","author":"Sodhi","year":"2012","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.jad.2015.08.036_bib41","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jad.2011.08.022","article-title":"Inflammatory markers and their relationships with leptin and insulin from acute mania to full remission in bipolar disorder","volume":"136","author":"Tsai","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.08.036_bib42","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0165-0327(00)00252-4","article-title":"Effects of symptomatic severity on elevation of plasma soluble interleukin-2 receptor in bipolar mania","volume":"64","author":"Tsai","year":"2001","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.08.036_bib43","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1046\/j.1471-4159.2000.740457.x","article-title":"\u201cInflammatory\u201d cytokines: neuromodulators in normal brain?","volume":"74","author":"Vitkovic","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jad.2015.08.036_bib44","first-page":"40","article-title":"Cardiovascular morbidity and mortality in bipolar disorder","volume":"23","author":"Weiner","year":"2011","journal-title":"Ann. Clin. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032715304365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032715304365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T23:53:40Z","timestamp":1537401220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032715304365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":44,"alternative-id":["S0165032715304365"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2015.08.036","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peripheral inflammation during abnormal mood states in bipolar I disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2015.08.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}