{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:13:28Z","timestamp":1774426408196,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jad-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jad.2015.10.005","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T17:47:15Z","timestamp":1445708835000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["The specificity of the familial aggregation of early-onset bipolar disorder : A controlled 10-year follow-up study of offspring of parents with mood disorders"],"prefix":"10.1016","volume":"190","author":[{"given":"Martin","family":"Preisig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Pierre F.","family":"Strippoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Castelao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen Ries","family":"Merikangas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Gholam-Rezaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Marquet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Michel","family":"Aubry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline L.","family":"Vandeleur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2015.10.005_bib1","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1001\/archpsyc.1977.01770220111013","article-title":"The family history method using diagnostic criteria. Reliability and validity","volume":"34","author":"Andreasen","year":"1977","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1176\/appi.ajp.2014.14010035","article-title":"Diagnostic Precursors to Bipolar Disorder in Offspring of Parents With Bipolar Disorder: a Longitudinal Study","volume":"172","author":"Axelson","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib3","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1176\/appi.ajp.160.5.999","article-title":"Age at onset in bipolar I affective disorder: further evidence for three subgroups","volume":"160","author":"Bellivier","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0376-8716(01)00156-9","article-title":"Diagnostic interview for genetic studies (DIGS): inter-rater and test-retest reliability of alcohol and drug diagnoses","volume":"65","author":"Berney","year":"2002","journal-title":"Drug. Alcohol Depend."},{"key":"10.1016\/j.jad.2015.10.005_bib5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1001\/archgenpsychiatry.2008.546","article-title":"Lifetime psychiatric disorders in school-aged offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring study","volume":"66","author":"Birmaher","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000096364","article-title":"Childhood separation anxiety and the risk of subsequent psychopathology: results from a community study","volume":"76","author":"Bruckl","year":"2007","journal-title":"Psychother. Psychosom."},{"key":"10.1016\/j.jad.2015.10.005_bib7","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archpsyc.1985.01790300064008","article-title":"The assessment of affective disorders in children and adolescents by semistructured interview. Test-retest reliability of the schedule for affective disorders and schizophrenia for school-age children, present episode version","volume":"42","author":"Chambers","year":"1985","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cpr.2004.12.002","article-title":"Distinctions between bipolar and unipolar depression","volume":"25","author":"Cuellar","year":"2005","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.jad.2015.10.005_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pscychresns.2013.06.013","article-title":"Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: a pilot fMRI study","volume":"214","author":"Diler","year":"2013","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2015.10.005_bib10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jad.2009.05.022","article-title":"Early stages in the development of bipolar disorder","volume":"121","author":"Duffy","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.10.005_bib11","doi-asserted-by":"crossref","first-page":"e561","DOI":"10.4088\/JCP.10m06504","article-title":"Clinical expression of bipolar disorder type I as a function of age and polarity at onset: convergent findings in samples from France and the United States","volume":"73","author":"Etain","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib12","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.patrec.2005.10.010","article-title":"An introduction to ROC analysis","volume":"27","author":"Fawcett","year":"2006","journal-title":"Pattern Recognit. Lett."},{"key":"10.1016\/j.jad.2015.10.005_bib13","first-page":"1","article-title":"Familiality and SNP heritability of age at onset and episodicity in major depressive disorder","author":"Ferentinos","year":"2015","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2015.10.005_bib14","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1176\/ajp.140.5.543","article-title":"Use of a structured diagnostic interview to identify bipolar disorder in adolescent inpatients: frequency and manifestations of the disorder","volume":"140","author":"Gammon","year":"1983","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib15","first-page":"278","article-title":"Reconsideration of bipolar disorder as a developmental disorder: importance of the time of onset","volume":"107","author":"Geoffroy","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.jad.2015.10.005_bib16","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1177\/1352458514564590","article-title":"Analysis of genes, pathways and networks involved in disease severity and age at onset in primary-progressive multiple sclerosis","volume":"21","author":"Giacalone","year":"2015","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jad.2015.10.005_bib17","first-page":"388","article-title":"Clinical, demographic, and familial correlates of bipolar spectrum disorders among offspring of parents with bipolar disorder","volume":"49","author":"Goldstein","year":"2010","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib18","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ajmg.10047","article-title":"Different familial transmission patterns in bipolar I disorder with onset before and after age 25","volume":"105","author":"Grigoroiu-Serbanescu","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.jad.2015.10.005_bib19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jad.2014.06.054","article-title":"Commingling analysis of age-of-onset in bipolar I disorder and the morbid risk for major psychoses in first degree relatives of bipolar I probands","volume":"168","author":"Grigoroiu-Serbanescu","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.10.005_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0165-0327(96)00091-2","article-title":"Psychiatric disorders in the relatives of depressed probands. I. Comparison of prepubertal, adolescent and early adult onset cases","volume":"42","author":"Harrington","year":"1997","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.10.005_bib21","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.biopsych.2005.06.010","article-title":"Psychopathology in the offspring of parents with bipolar disorder: a controlled study","volume":"58","author":"Henin","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/mp.2013.173","article-title":"Evidence for separate inheritance of mania and depression challenges current concepts of bipolar mood disorder","volume":"19","author":"Hickie","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib23","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1176\/appi.ajp.2012.11101514","article-title":"Psychopathology in adolescent offspring of parents with panic disorder, major depression, or both: a 10-year follow-up","volume":"169","author":"Hirshfeld-Becker","year":"2012","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib24","series-title":"Four Factor Index of Social Status","author":"Hollingshead","year":"1975"},{"key":"10.1016\/j.jad.2015.10.005_bib25","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0197-2456(00)00104-5","article-title":"Sample-size calculations for the Cox proportional hazards regression model with nonbinary covariates","volume":"21","author":"Hsieh","year":"2000","journal-title":"Control. Clin. Trials"},{"key":"10.1016\/j.jad.2015.10.005_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2015.05.017","article-title":"The genetics of early-onset bipolar disorder: a systematic review","volume":"184","author":"Kennedy","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.10.005_bib27","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.1088759","article-title":"Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2","volume":"302","author":"King","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jad.2015.10.005_bib28","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/mp.2012.144","article-title":"Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression","volume":"18","author":"Lamers","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib29","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/bdi.12175","article-title":"Cortical thickness differences between bipolar depression and major depressive disorder","volume":"16","author":"Lan","year":"2014","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2015.10.005_bib30","series-title":"Interview Diagnostique pour les Etudes G\u00e9n\u00e9tiques","author":"Leboyer","year":"1995"},{"key":"10.1016\/j.jad.2015.10.005_bib31","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1001\/archpsyc.1982.04290080001001","article-title":"Best estimate of lifetime psychiatric diagnosis: a methodological study","volume":"39","author":"Leckman","year":"1982","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib32","doi-asserted-by":"crossref","first-page":"e79999","DOI":"10.1371\/journal.pone.0079999","article-title":"Identify changes of brain regional homogeneity in bipolar disorder and unipolar depression using resting-state FMRI","volume":"8","author":"Liang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2015.10.005_bib33","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1176\/appi.ajp.163.2.240","article-title":"Clinical correlates and familial aggregation of age at onset in bipolar disorder","volume":"163","author":"Lin","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib34","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/mp.2012.21","article-title":"A mega-analysis of genome-wide association studies for major depressive disorder","volume":"18","author":"Major Depressive Disorder Working Group of the Psychiatric","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib35","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1001\/archpsyc.60.5.497","article-title":"The heritability of bipolar affective disorder and the genetic relationship to unipolar depression","volume":"60","author":"McGuffin","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib36","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/mp.2013.116","article-title":"Independence of familial transmission of mania and depression: results of the NIMH family study of affective spectrum disorders","volume":"19","author":"Merikangas","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/archgenpsychiatry.2007.18","article-title":"Specificity of bipolar spectrum conditions in the comorbidity of mood and substance use disorders: results from the Zurich cohort study","volume":"65","author":"Merikangas","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib38","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archpsyc.1994.03950110009002","article-title":"Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative","volume":"51","author":"Nurnberger","year":"1994","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib39","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1001\/archgenpsychiatry.2011.126","article-title":"A high-risk study of bipolar disorder: childhood clinical phenotypes as precursors of major mood disorders","volume":"68","author":"Nurnberger","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib40","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/bdi.12107","article-title":"Familial transmission of parental mood disorders: unipolar and bipolar disorders in offspring","volume":"15","author":"Oquendo","year":"2013","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2015.10.005_bib41","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0002-7138(09)60944-4","article-title":"Retrospective assessment of prepubertal major depression with the Kiddie-SADS-E","volume":"21","author":"Orvaschel","year":"1982","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib42","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0140-6736(13)60989-7","article-title":"Bipolar disorder diagnosis: challenges and future directions","volume":"381","author":"Phillips","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2015.10.005_bib43","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s004060050084","article-title":"Diagnostic interview for genetic studies (DIGS): inter-rater and test-retest reliability of the French version","volume":"249","author":"Preisig","year":"1999","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2015.10.005_bib44","first-page":"1222","article-title":"Brain morphometric biomarkers distinguishing unipolar and bipolar depression. A voxel-based morphometry-pattern classification approach. JAMA","volume":"71","author":"Redlich","year":"2014","journal-title":"Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v047.i04","article-title":"Frailtypack: an R package for the analysis of correlated survival data with frailty models using penalized likelihood estimation or parametric estimation","volume":"47","author":"Rondeau","year":"2012","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.jad.2015.10.005_bib46","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/mpr.281","article-title":"Parent-child agreement and prevalence estimates of diagnoses in childhood: direct interview versus family history method","volume":"18","author":"Rothen","year":"2009","journal-title":"Int. J. Methods Psychiatr. Res."},{"key":"10.1016\/j.jad.2015.10.005_bib47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.psychres.2006.04.022","article-title":"Inter-informant agreement on diagnoses and prevalence estimates of anxiety disorders: direct interview versus family history method","volume":"157","author":"Rougemont-Buecking","year":"2008","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2015.10.005_bib48","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1001\/archpsyc.63.12.1368","article-title":"What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics","volume":"63","author":"Schulze","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib49","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0165-0327(99)00111-1","article-title":"Early and late onset bipolar disorders: two different forms of manic-depressive illness?","volume":"58","author":"Schurhoff","year":"2000","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.10.005_bib50","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0165-0327(00)00372-4","article-title":"A family study of early-onset bipolar I disorder","volume":"70","author":"Somanath","year":"2002","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.10.005_bib51","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/bioinformatics\/btr597","article-title":"MissForest \u2013 non-parametric missing value imputation for mixed-type data","volume":"28","author":"Stekhoven","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jad.2015.10.005_bib52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cancergen.2014.12.004","article-title":"Systematic search for rare variants in Finnish early-onset colorectal cancer patients","volume":"208","author":"Tanskanen","year":"2015","journal-title":"Cancer Genet."},{"key":"10.1016\/j.jad.2015.10.005_bib53","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1399-5618.2012.01048.x","article-title":"Mental disorders in offspring of parents with bipolar and major depressive disorders","volume":"14","author":"Vandeleur","year":"2012","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2015.10.005_bib54","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/mp.2013.132","article-title":"Specificity of psychosis, mania and major depression in a contemporary family study","volume":"19","author":"Vandeleur","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2015.10.005_bib55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.drugalcdep.2007.05.023","article-title":"Inter-informant agreement and prevalence estimates for substance use disorders: direct interview versus family history method","volume":"92","author":"Vandeleur","year":"2008","journal-title":"Drug. Alcohol. Depend."},{"key":"10.1016\/j.jad.2015.10.005_bib56","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jad.2014.08.048","article-title":"Inter-informant agreement and prevalence estimates for mood syndromes: direct interview vs. family history method","volume":"171","author":"Vandeleur","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2015.10.005_bib57","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00041444-200109000-00004","article-title":"Genetic survival analysis of age-at-onset of bipolar disorder: evidence for anticipation or cohort effect in families","volume":"11","author":"Visscher","year":"2001","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.jad.2015.10.005_bib58","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/archpsyc.1984.01790230022003","article-title":"Onset of major depression in early adulthood. Increased familial loading and specificity","volume":"41","author":"Weissman","year":"1984","journal-title":"Arch. Gen. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032715304766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032715304766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T06:53:27Z","timestamp":1537253607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032715304766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":58,"alternative-id":["S0165032715304766"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2015.10.005","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The specificity of the familial aggregation of early-onset bipolar disorder: A controlled 10-year follow-up study of offspring of parents with mood disorders","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2015.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}