{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:26:19Z","timestamp":1792092379909,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jad-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.jad.2016.04.021","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T16:27:10Z","timestamp":1462033630000},"page":"250-258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":180,"special_numbering":"C","title":["Peripheral whole blood microRNA alterations in major depression and bipolar disorder"],"prefix":"10.1016","volume":"200","author":[{"given":"Elisabetta","family":"Maffioletti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Cattaneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Rosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Maina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Maj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Gennarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Tardito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisella","family":"Bocchio-Chiavetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2016.04.021_bib1","series-title":"Handbook of psychiatric Measures","author":"American Psychiatric Association Task Force for the Handbook of Psychiatric Measures","year":"2000"},{"key":"10.1016\/j.jad.2016.04.021_bib2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fnbeh.2013.00185","article-title":"Life in groups: the roles of oxytocin in mammalian sociality","volume":"7","author":"Anacker","year":"2013","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.jad.2016.04.021_bib3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.psyneuen.2010.03.007","article-title":"The glucocorticoid receptor: pivot of depression and of antidepressant treatment?","volume":"36","author":"Anacker","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2016.04.021_bib4","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1126\/science.1193692","article-title":"miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants","volume":"329","author":"Baudry","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jad.2016.04.021_bib5","doi-asserted-by":"crossref","first-page":"e185","DOI":"10.1038\/tp.2012.112","article-title":"Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode","volume":"2","author":"Belzeaux","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2016.04.021_bib6","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/mp.2009.84","article-title":"Schizophrenia is associated with an increase in cortical microRNA biogenesis","volume":"15","author":"Beveridge","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2016.04.021_bib7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.euroneuro.2012.06.013","article-title":"Blood microRNA changes in depressed patients during antidepressant treatment","volume":"23","author":"Bocchio-Chiavetto","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2016.04.021_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jpsychires.2015.07.023","article-title":"Comparison of plasma MicroRNA levels in drug naive, first episode depressed patients and healthy controls","volume":"69","author":"Camkurt","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2016.04.021_bib9","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1017\/S1461145709000029","article-title":"MicroRNA expression changes in lymphoblastoid cell lines in response to lithium treatment","volume":"12","author":"Chen","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2016.04.021_bib10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.biopsych.2013.08.029","article-title":"Learning about oxytocin: pharmacologic and behavioral issues","volume":"76","author":"Chini","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2016.04.021_bib11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/jnc.12308","article-title":"MicroRNA profiling in the mouse hypothalamus reveals oxytocin-regulating microRNA","volume":"126","author":"Choi","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jad.2016.04.021_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways","volume":"14","author":"Cogswell","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jad.2016.04.021_bib13","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1098\/rstb.2013.0509","article-title":"Systematic identification of 3\u2032-UTR regulatory elements in activity-dependent mRNA stability in hippocampal neurons","volume":"369","author":"Cohen","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.jad.2016.04.021_bib14","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkt379","article-title":"ComiR: combinatorial microRNA target prediction tool","volume":"41","author":"Coronnello","year":"2013","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.jad.2016.04.021_bib15","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrclinonc.2011.76","article-title":"MicroRNAs in body fluids \u2013 the mix of hormones and biomarkers","volume":"8","author":"Cortez","year":"2011","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jad.2016.04.021_bib16","doi-asserted-by":"crossref","first-page":"e05","DOI":"10.4088\/JCP.13019tx1c","article-title":"Misdiagnosis of bipolar depression in primary care practices","volume":"75","author":"Culpepper","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2016.04.021_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpsychires.2014.08.007","article-title":"Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients","volume":"59","author":"Fan","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2016.04.021_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-94-007-5590-1_1","article-title":"MicroRNAs in human cancer","volume":"774","author":"Farazi","year":"2013","journal-title":"Adv. Exp. Med Biol."},{"key":"10.1016\/j.jad.2016.04.021_bib19","article-title":"Coordinated messenger RNA\/microRNA changes in fibroblasts of patients with major depression","author":"Garbett","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2016.04.021_bib20","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1176\/appi.ajp.2013.13050656","article-title":"The unrecognized side of bipolar disorder","volume":"170","author":"Hirschfeld","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2016.04.021_bib21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jad.2016.04.021_bib22","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.neuron.2014.05.042","article-title":"MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity","volume":"83","author":"Issler","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2016.04.021_bib23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/hup.1103","article-title":"A psychoneuroimmunological review on cytokines involved in antidepressant treatment response","volume":"25","author":"Janssen","year":"2010","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.jad.2016.04.021_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.schres.2010.07.002","article-title":"MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders","volume":"124","author":"Kim","year":"2010","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jad.2016.04.021_bib25","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1373\/clinchem.2009.131797","article-title":"Plasma microRNAs as sensitive and specific biomarkers of tissue injury","volume":"55","author":"Laterza","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jad.2016.04.021_bib26","doi-asserted-by":"crossref","first-page":"e63648","DOI":"10.1371\/journal.pone.0063648","article-title":"Alterations of serum levels of BDNF-related miRNAs in patients with depression","volume":"8","author":"Li","year":"2013","journal-title":"PLoS. ONE"},{"key":"10.1016\/j.jad.2016.04.021_bib27","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nm.3582","article-title":"miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment","volume":"20","author":"Lopez","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.jad.2016.04.021_bib28","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/sj.mp.4002006","article-title":"The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression","volume":"12","author":"M\u00fcller","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2016.04.021_bib29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fncel.2014.00075","article-title":"Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders","volume":"8","author":"Maffioletti","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jad.2016.04.021_bib30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4088\/JCP.13r08634","article-title":"Metabolic syndrome in bipolar disorder: a review with a focus on bipolar depression","volume":"75","author":"McElroy","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2016.04.021_bib31","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1073\/pnas.1113793109","article-title":"MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function","volume":"109","author":"Miller","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2016.04.021_bib32","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2016.04.021_bib33","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.biopsych.2010.09.039","article-title":"Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder","volume":"69","author":"Moreau","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2016.04.021_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/npp.2012.87","article-title":"General principals of miRNA biogenesis and regulation in the brain","volume":"38","author":"O\u2019Carrol","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2016.04.021_bib35","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1017\/S1461145713000448","article-title":"microRNAs as novel antidepressant targets: converging effects of ketamine and electroconvulsive shock therapy in the rat hippocampus","volume":"16","author":"O\u2019Connor","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2016.04.021_bib36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00018-011-0788-1","article-title":"MicroRNA networks direct neuronal development and plasticity","volume":"69","author":"Olde Loohuis","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jad.2016.04.021_bib37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2174\/1568026611313020009","article-title":"MicroRNAs and the heart: small things do matter","volume":"13","author":"Papoutsidakis","year":"2013","journal-title":"Curr. Top. Med Chem."},{"key":"10.1016\/j.jad.2016.04.021_bib38","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1158\/1078-0432.CCR-09-0736","article-title":"Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection","volume":"15","author":"Park","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jad.2016.04.021_bib39","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrg3162","article-title":"MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship","volume":"13","author":"Pasquinelli","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jad.2016.04.021_bib40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.npp.1301574","article-title":"Stress, depression, and neuroplasticity: a convergence of mechanisms","volume":"33","author":"Pittenger","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2016.04.021_bib41","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn3138","article-title":"The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission","volume":"13","author":"Popoli","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2016.04.021_bib42","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jpsychires.2010.04.028","article-title":"MicroRNA-134 plasma levels before and after treatment for bipolar mania","volume":"45","author":"Rong","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2016.04.021_bib43","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1186\/1471-2164-11-409","article-title":"Comprehensive survey of human brain microRNA by deep sequencing","volume":"11","author":"Shao","year":"2010","journal-title":"BMC Genom."},{"key":"10.1016\/j.jad.2016.04.021_bib44","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fncel.2013.00150","article-title":"Circulating cell-free microRNA as biomarkers for screening, diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologies","volume":"7","author":"Sheinerman","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jad.2016.04.021_bib45","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"Skog","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jad.2016.04.021_bib46","doi-asserted-by":"crossref","first-page":"e33201","DOI":"10.1371\/journal.pone.0033201","article-title":"MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects","volume":"7","author":"Smalheiser","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jad.2016.04.021_bib47","doi-asserted-by":"crossref","first-page":"e86469","DOI":"10.1371\/journal.pone.0086469","article-title":"Expression of microRNAs and other small RNAs in prefrontal cortex in schizophrenia, bipolar disorder and depressed subjects","volume":"9","author":"Smalheiser","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jad.2016.04.021_bib48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1517\/13543784.2013.749237","article-title":"Lost in translation. New unexplored avenues for neuropsychopharmacology: epigenetics and microRNAs","volume":"22","author":"Tardito","year":"2013","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.jad.2016.04.021_bib49","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/S0924-977X(15)30045-6","article-title":"Early and time dependent effects of antidepressant treatments on rat hippocampal miRNome","volume":"25","author":"Tardito","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2016.04.021_bib50","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/npp.2008.131","article-title":"Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers","volume":"34","author":"Zhou","year":"2009","journal-title":"Neuropsychopharmacology"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032716301458?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032716301458?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T01:56:00Z","timestamp":1567821360000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032716301458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":50,"alternative-id":["S0165032716301458"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2016.04.021","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peripheral whole blood microRNA alterations in major depression and bipolar disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2016.04.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}