{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:25:03Z","timestamp":1790846703607,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000276","name":"Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jad-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jad.2016.05.010","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T18:16:40Z","timestamp":1462904200000},"page":"131-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Effect of valproic acid on dementia onset in patients with bipolar disorder"],"prefix":"10.1016","volume":"201","author":[{"given":"Pei-Shan","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Huan","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Jen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Yeh","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2016.05.010_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jagp.2012.08.013","article-title":"Cognitive impairment in euthymic older adults with bipolar disorder: a controlled study using cognitive screening tests","volume":"22","author":"Aprahamian","year":"2014","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2016.05.010_bib2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12640-010-9155-5","article-title":"Persistence of long-term memory storage: new insights into its molecular signatures in the hippocampus and related structures","volume":"18","author":"Bekinschtein","year":"2010","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.jad.2016.05.010_bib3","doi-asserted-by":"crossref","first-page":"e342","DOI":"10.4088\/JCP.14cs09399","article-title":"Assessing cognitive function in bipolar disorder: challenges and recommendations for clinical trial design","volume":"76","author":"Burdick","year":"2015","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2016.05.010_bib4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jamda.2015.01.084","article-title":"Risk of subsequent dementia among patients with bipolar disorder or major depression: a nationwide longitudinal study in Taiwan","volume":"16","author":"Chen","year":"2015","journal-title":"J. Am. Med Dir. Assoc."},{"key":"10.1016\/j.jad.2016.05.010_bib5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/pds.2087","article-title":"Validation of the National Health Insurance Research Database with ischemic stroke cases in Taiwan","volume":"20","author":"Cheng","year":"2011","journal-title":"Pharmacoepidemiol. Drug. Saf."},{"key":"10.1016\/j.jad.2016.05.010_bib6","first-page":"10","article-title":"Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder","volume":"t17","author":"Cipriani","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jad.2016.05.010_bib7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.seizure.2011.02.009","article-title":"Reversible dementia and gait disturbance after prolonged use of valproic acid","volume":"20","author":"Evans","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.jad.2016.05.010_bib8","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1017\/S1041610209991694","article-title":"Manic episode precedes development of early dementia: a case report","volume":"22","author":"Hu","year":"2010","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.jad.2016.05.010_bib9","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1399-5618.2008.00628.x","article-title":"A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression","volume":"10","author":"Holmes","year":"2008","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2016.05.010_bib10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1440-169X.2009.01094.x","article-title":"Continuous neurogenesis in the adult brain","volume":"51","author":"Imayoshi","year":"2009","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.jad.2016.05.010_bib11","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1136\/jnnp.2003.031773","article-title":"Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder?","volume":"75","author":"Kessing","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2016.05.010_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1399-5618.2009.00788.x","article-title":"Does lithium protect against dementia?","volume":"12","author":"Kessing","year":"2010","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2016.05.010_bib13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1017\/S1041610207006540","article-title":"Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review","volume":"20","author":"Konovalov","year":"2007","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.jad.2016.05.010_bib14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cnr.2004.09.013","article-title":"Valproic acid: how it works. Or not","volume":"4","author":"Lagace","year":"2004","journal-title":"Clin. Neurosci. Res."},{"key":"10.1016\/j.jad.2016.05.010_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5507\/bp.155.2011.003","article-title":"Cognitive impairment in bipolar disorder","volume":"155","author":"Latalova","year":"2011","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc Czech Repub."},{"key":"10.1016\/j.jad.2016.05.010_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-2006-931471","article-title":"Parkinsonism and\/or cognitive impairment with valproic acid therapy: a report of ten cases","volume":"39","author":"Masmoudi","year":"2006","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.jad.2016.05.010_bib17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.euroneuro.2014.09.005","article-title":"Are cognitive deficits similar in remitted early bipolar I disorder patients treated with lithium or valproate? Data from the STOP-EM study","volume":"25","author":"Muralidharan","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2016.05.010_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jad.2006.04.030","article-title":"Carbamazepine and valproate for the treatment of bipolar disorder: a review of the literature","volume":"95","author":"Nasrallah","year":"2006","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.jad.2016.05.010_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.brainres.2009.09.051","article-title":"Valproate reversibly reduces neurite outgrowth by human SY5Y neuroblastoma cells","volume":"1302","author":"Qian","year":"2009","journal-title":"Brain Res."},{"issue":"Suppl. 1","key":"10.1016\/j.jad.2016.05.010_bib20","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1399-5618.2007.00481.x","article-title":"Impaired verbal memory and otherwise spared cognition in remitted bipolar patients on monotherapy with lithium or valproate","volume":"9","author":"Senturk","year":"2007","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2016.05.010_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuroscience.2009.11.073","article-title":"Valproic acid reduces spatial working memory and cell proliferation in the hippocampus","volume":"166","author":"Umka","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.jad.2016.05.010_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/bdi.12116","article-title":"Increased risk of developing dementia in patients with bipolar disorder: a nested matched case-control study","volume":"15","author":"Wu","year":"2013","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2016.05.010_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.kjms.2011.10.025","article-title":"Mood stabilizers for the treatment of behavioral and psychological symptoms of dementia: an update review","volume":"28","author":"Yeh","year":"2011","journal-title":"Kaohsiung J. Med Sci."},{"key":"10.1016\/j.jad.2016.05.010_bib24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.brainresbull.2009.09.003","article-title":"Valproic acid as a promising agent to combat Alzheimer's disease","volume":"81","author":"Zhang","year":"2011","journal-title":"Brain Res. Bull."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032716302506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032716302506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T02:49:23Z","timestamp":1748918963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032716302506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":24,"alternative-id":["S0165032716302506"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2016.05.010","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of valproic acid on dementia onset in patients with bipolar disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2016.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}