{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:26:08Z","timestamp":1778808368453,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jad-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jad.2016.09.034","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T04:48:36Z","timestamp":1475210916000},"page":"136-140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder"],"prefix":"10.1016","volume":"207","author":[{"given":"Leena","family":"Kovanen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kati","family":"Donner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Kaunisto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Partonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2016.09.034_bib1","doi-asserted-by":"crossref","first-page":"15548","DOI":"10.1523\/JNEUROSCI.3338-14.2014","article-title":"Differentially methylated plasticity genes in the amygdala of young primates are linked to anxious temperament, an at risk phenotype for anxiety and depressive disorders","volume":"34","author":"Alisch","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2016.09.034_bib2","doi-asserted-by":"crossref","first-page":"7145","DOI":"10.1523\/JNEUROSCI.4950-12.2013","article-title":"Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3Afh mutation","volume":"33","author":"Anand","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2016.09.034_bib3","unstructured":"AromaaA.KoskinenS., 2004. Health and functional capacity in Finland. Baseline Results of the Health 2000 Health Examination Survey. Kansanterveyslaitoksen julkaisuja B: 12\/2004."},{"key":"10.1016\/j.jad.2016.09.034_bib4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jad.2016.09.034_bib5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.molcel.2009.10.012","article-title":"Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism","volume":"36","author":"Chen","year":"2009","journal-title":"Mol. Cell."},{"key":"10.1016\/j.jad.2016.09.034_bib6","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/BJ20060827","article-title":"Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression","volume":"402","author":"Dardente","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.jad.2016.09.034_bib7","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1073\/pnas.1519044113","article-title":"Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling","volume":"113","author":"Edwards","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jad.2016.09.034_bib8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/YPG.0b013e3283539594","article-title":"Chryptochrome 2 variants, chronicity, and seasonality of mood disorders","volume":"22","author":"Fiedorowicz","year":"2012","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.jad.2016.09.034_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0165-0327(92)90037-7","article-title":"The effects of cortisol infusion upon hormone secretion from the anterior pituitary and subjective mood in depressive illness and in controls","volume":"26","author":"Goodwin","year":"1992","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2016.09.034_bib10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jad.2013.11.019","article-title":"Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population","volume":"157","author":"Hua","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2016.09.034_bib11","first-page":"179","article-title":"Automated genotyping using the DNA MassArray technology","volume":"187","author":"Jurinke","year":"2002","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.jad.2016.09.034_bib12","doi-asserted-by":"crossref","first-page":"R271","DOI":"10.1093\/hmg\/ddl207","article-title":"Molecular components of the mammalian circadian clock","volume":"15","author":"Ko","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jad.2016.09.034_bib13","doi-asserted-by":"crossref","first-page":"e71450","DOI":"10.1371\/journal.pone.0071450","article-title":"CRY2 genetic variants associate with dysthymia","volume":"8","author":"Kovanen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2016.09.034_bib14","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/humu.20346","article-title":"A quality assessment survey of SNP genotyping laboratories","volume":"27","author":"Lahermo","year":"2006","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.jad.2016.09.034_bib15","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nature10700","article-title":"Cryptochromes mediate rhythmic repression of the glucocorticoid receptor","volume":"480","author":"Lamia","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jad.2016.09.034_bib16","doi-asserted-by":"crossref","first-page":"e9407","DOI":"10.1371\/journal.pone.0009407","article-title":"CRY2 is associated with depression","volume":"5","author":"Lavebratt","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2016.09.034_bib17","doi-asserted-by":"crossref","first-page":"12036","DOI":"10.1073\/pnas.1108125108","article-title":"Regulation of apoptosis by the circadian clock through NF-kappaB signaling","volume":"108","author":"Lee","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jad.2016.09.034_bib18","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.bbrc.2016.03.010","article-title":"The ratio of intracellular CRY proteins determines the clock period length","volume":"472","author":"Li","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jad.2016.09.034_bib19","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1046\/j.1365-2826.2003.00990.x","article-title":"Clock genes and the long-term regulation of prolactin secretion: evidence for a photoperiod\/circannual timer in the pars tuberalis","volume":"15","author":"Lincoln","year":"2003","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.jad.2016.09.034_bib20","doi-asserted-by":"crossref","first-page":"e821","DOI":"10.1038\/tp.2016.79","article-title":"Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment","volume":"6","author":"Mellon","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2016.09.034_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.psychres.2016.04.120","article-title":"Inflammatory cytokines and nuclear factor-kappa B activation in adolescents with bipolar and major depressive disorders","volume":"241","author":"Miklowitz","year":"2016","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2016.09.034_bib22","doi-asserted-by":"crossref","first-page":"12662","DOI":"10.1073\/pnas.1209965109","article-title":"Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines","volume":"109","author":"Narasimamurthy","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2016.09.034_bib23","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1152506","article-title":"cAMP-dependent signaling as a core component of the mammalian circadian pacemaker","volume":"320","author":"O\u2019Neill","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.jad.2016.09.034_bib24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2005.05.031","article-title":"Par-4 links dopamine signaling and depression","volume":"122","author":"Park","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jad.2016.09.034_bib25","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jad.2016.09.034_bib26","unstructured":"R Core Team, 2015. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL \u3008https:\/\/www.R-project.org\/\u3009."},{"key":"10.1016\/j.jad.2016.09.034_bib27","unstructured":"Rosenthal, N., Bradt, G., Wehr, T., 1984. Seasonal Pattern Assessment Questionnaire (SPAQ). National Institute of Mental Health,\u00a0Bethesda, Maryland."},{"key":"10.1016\/j.jad.2016.09.034_bib28","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/embor.2012.158","article-title":"CAVIN-3 regulates circadian period length and PER: cry protein abundance and interactions","volume":"13","author":"Schneider","year":"2012","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jad.2016.09.034_bib29","doi-asserted-by":"crossref","first-page":"e12632","DOI":"10.1371\/journal.pone.0012632","article-title":"CRY2 is associated with rapid cycling in bipolar disorder patients","volume":"5","author":"Sjoholm","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2016.09.034_bib30","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/npp.2009.230","article-title":"Differential association of circadian genes with mood disorders: cry1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder","volume":"35","author":"Soria","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2016.09.034_bib31","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1214\/aos\/1074290335","article-title":"The positive false discovery rate: a Bayesian Interpretation and the q-Value","volume":"31","author":"Storey","year":"2003","journal-title":"Ann. Stat."},{"key":"10.1016\/j.jad.2016.09.034_bib32","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1210\/en.2008-1683","article-title":"Cryptochrome 2 expression level is critical for adrenocorticotropin stimulation of cortisol production in the capuchin monkey adrenal","volume":"150","author":"Torres-Farfan","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.jad.2016.09.034_bib33","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/ncb1775","article-title":"Proof-by-synthesis of the transcriptional logic of mammalian circadian clocks","volume":"10","author":"Ukai-Tadenuma","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jad.2016.09.034_bib34","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.cell.2010.12.019","article-title":"Delay in feedback repression by cryptochrome 1 is required for circadian clock function","volume":"144","author":"Ukai-Tadenuma","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jad.2016.09.034_bib35","doi-asserted-by":"crossref","first-page":"e9259","DOI":"10.1371\/journal.pone.0009259","article-title":"Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance","volume":"5","author":"Utge","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2016.09.034_bib36","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s001270050095","article-title":"Test-retest reliability of the computerized DSM-IV version of the Munich-Composite International Diagnostic Interview (m-CIDI)","volume":"33","author":"Wittchen","year":"1998","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"10.1016\/j.jad.2016.09.034_bib37","doi-asserted-by":"crossref","first-page":"25891","DOI":"10.1074\/jbc.M111.254680","article-title":"Biochemical analysis of the canonical model for the mammalian circadian clock","volume":"286","author":"Ye","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jad.2016.09.034_bib38","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1101\/gad.249417.114","article-title":"Dual modes of CLOCK: bmal1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock","volume":"28","author":"Ye","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.jad.2016.09.034_bib39","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/nm.2214","article-title":"Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis","volume":"16","author":"Zhang","year":"2010","journal-title":"Nat. Med."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032716309624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032716309624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T00:32:29Z","timestamp":1568421149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032716309624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":39,"alternative-id":["S0165032716309624"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2016.09.034","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2016.09.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}