{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:05:07Z","timestamp":1790831107047,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.jad.2017.04.024","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:32:01Z","timestamp":1492561921000},"page":"49-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Microtubule associated protein 2 in bipolar depression: Impact of pregnenolone"],"prefix":"10.1016","volume":"218","author":[{"given":"Shivani","family":"Daftary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Min","family":"Yon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehn-Kyoung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Bae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collette","family":"Bice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Kulikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sherwood Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2017.04.024_bib1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0960-0760(90)90490-C","article-title":"Neurosteroids: a new brain function?","volume":"37","author":"Baulieu","year":"1990","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jad.2017.04.024_bib2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/0039-128X(92)90096-R","article-title":"Administration of pregnenolone and dehydroepiandrosterone to guinea pigs and rats causes the accumulation of fatty acid esters of pregnenolone and dehydroepiandrosterone in plasma lipoproteins","volume":"57","author":"B\u00e9langer","year":"1992","journal-title":"Steroids"},{"key":"10.1016\/j.jad.2017.04.024_bib3","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1073\/pnas.1121485109","article-title":"3beta-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders","volume":"109","author":"Bianchi","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2017.04.024_bib4","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1038\/npp.2014.138","article-title":"A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression","volume":"39","author":"Brown","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2017.04.024_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1744-9081-8-61","article-title":"GABAergic neuroactive steroids: a new frontier in bipolar disorders?","volume":"8","author":"Carta","year":"2012","journal-title":"Behav. Brain Funct."},{"key":"10.1016\/j.jad.2017.04.024_bib6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/cm.21290","article-title":"The emerging role of the tubulin code: from the tubulin molecule to neuronal function and disease","volume":"73","author":"Chakraborti","year":"2016","journal-title":"Cytoskelet. (Hoboken)"},{"key":"10.1016\/j.jad.2017.04.024_bib7","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.jad.2017.04.024_bib8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.jad.2017.04.024_bib9","first-page":"5004","article-title":"Effects of tau and MAP2 on the interaction of maytansine with tubulin: inhibitory effect of maytansine on vinblastine-induced aggregation of tubulin","volume":"45","author":"Fellous","year":"1985","journal-title":"Cancer Res."},{"key":"10.1016\/j.jad.2017.04.024_bib10","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/sj.npp.1300104","article-title":"Flattening the glucocorticoid rhythm causes changes in hippocampal expression of messenger RNAs coding structural and functional proteins: implications for aging and depression","volume":"28","author":"Gartside","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2017.04.024_bib11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.brs.2012.05.002","article-title":"Transcranial ultrasound (TUS) effects on mental states: a pilot study","volume":"6","author":"Hameroff","year":"2013","journal-title":"Brain Stimul."},{"key":"10.1016\/j.jad.2017.04.024_bib12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br. J. Med. Psychol."},{"key":"10.1016\/j.jad.2017.04.024_bib13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2017.04.024_bib14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/01.jcp.0000229483.52955.ec","article-title":"Increased neuroactive steroid concentrations in women with bipolar disorder or major depressive disorder","volume":"26","author":"Hardoy","year":"2006","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2017.04.024_bib15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.expneurol.2010.08.023","article-title":"Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases","volume":"226","author":"Ishrat","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jad.2017.04.024_bib16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jnr.490330402","article-title":"The role of microtubule-associated protein 2 (MAP-2) in neuronal growth, plasticity, and degeneration","volume":"33","author":"Johnson","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jad.2017.04.024_bib17","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1194\/jlr.M400244-JLR200","article-title":"Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain","volume":"45","author":"Liere","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jad.2017.04.024_bib18","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.1995.75.4.835","article-title":"Role of microtubule-associated proteins in the control of microtubule assembly","volume":"75","author":"Maccioni","year":"1995","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jad.2017.04.024_bib19","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/cm.21300","article-title":"Microtubule and microtubule associated protein anomalies in psychiatric disease","volume":"73","author":"Marchisella","year":"2016","journal-title":"Cytoskelet. (Hoboken)"},{"key":"10.1016\/j.jad.2017.04.024_bib20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/iub.1384","article-title":"Microtubule-associated proteins as direct crosslinkers of actin filaments and microtubules","volume":"67","author":"Mohan","year":"2015","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jad.2017.04.024_bib21","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/2171053a0","article-title":"Amino-acid composition of \"Tubulin\" constituting microtubules of sperm flagella","volume":"217","author":"Mohri","year":"1968","journal-title":"Nature"},{"key":"10.1016\/j.jad.2017.04.024_bib22","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3109\/02699052.2012.700083","article-title":"Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury","volume":"26","author":"Mondello","year":"2012","journal-title":"Brain Inj."},{"key":"10.1016\/j.jad.2017.04.024_bib23","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1073\/pnas.97.7.3579","article-title":"Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assembly","volume":"97","author":"Murakami","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2017.04.024_bib24","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.psychres.2009.09.006","article-title":"Pregnenolone for cognition and mood in dual diagnosis patients","volume":"178","author":"Osuji","year":"2010","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2017.04.024_bib25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/jnr.22769","article-title":"Microtubule-associated protein 2, an early blood marker of ischemic brain injury","volume":"90","author":"Park","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jad.2017.04.024_bib26","doi-asserted-by":"crossref","first-page":"708306","DOI":"10.1155\/2015\/708306","article-title":"Disruption in the blood-brain barrier: the missing link between brain and body inflammation in bipolar disorder?","volume":"2015","author":"Patel","year":"2015","journal-title":"Neural Plast."},{"key":"10.1016\/j.jad.2017.04.024_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0014-5793(96)01524-4","article-title":"Estramustine phosphate but not estramustine inhibits the interaction of microtubule associated protein 2 (MAP2) with actin filaments","volume":"403","author":"Pedrotti","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jad.2017.04.024_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0924-977X(95)00024-J","article-title":"Effects of fluvoxamine on the protein phosphorylation system associated with rat neuronal microtubules","volume":"5","author":"Perez","year":"1995","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2017.04.024_bib29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/mpr.79","article-title":"The Inventory of depressive symptomatology (IDS): Clinician (IDS-C) and self-report (IDS-SR) ratings of depressive symptoms","volume":"9","author":"Rush","year":"2000","journal-title":"Int. J. Methods Psychiatry"},{"key":"10.1016\/j.jad.2017.04.024_bib30","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1021\/bi00192a009","article-title":"The difference in the binding of phosphatidylinositol distinguishes MAP2 from MAP2C and Tau","volume":"33","author":"Surridge","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.jad.2017.04.024_bib31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0165-0173(90)90013-E","article-title":"The roles of microtubule-associated proteins in brain morphogenesis: a review","volume":"15","author":"Tucker","year":"1990","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.jad.2017.04.024_bib32","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/ajmg.b.32058","article-title":"Different gene sets contribute to different symptom dimensions of depression and anxiety","volume":"159B","author":"van Veen","year":"2012","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.jad.2017.04.024_bib33","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032716318626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032716318626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:16:45Z","timestamp":1759022205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032716318626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":33,"alternative-id":["S0165032716318626"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2017.04.024","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microtubule associated protein 2 in bipolar depression: Impact of pregnenolone","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2017.04.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}