{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:46:20Z","timestamp":1791909980105,"version":"4.3.4"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.jad.2017.05.013","type":"journal-article","created":{"date-parts":[[2017,5,7]],"date-time":"2017-05-07T17:45:19Z","timestamp":1494179119000},"page":"398-406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Prefrontal and amygdala engagement during emotional reactivity and regulation in generalized anxiety disorder"],"prefix":"10.1016","volume":"218","author":[{"given":"Jacklynn M.","family":"Fitzgerald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Luan","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart A.","family":"Shankman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Langenecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heide","family":"Klumpp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2017.05.013_bib1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.brat.2011.12.004","article-title":"Paradoxical cardiovascular effects of implementing adaptive emotion regulation strategies in generalized anxiety disorder","volume":"50","author":"Aldao","year":"2012","journal-title":"Behav. Res. Ther."},{"key":"10.1016\/j.jad.2017.05.013_bib2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/02699931.2012.739998","article-title":"One versus many: capturing the use of multiple emotion regulation strategies in response to an emotion-eliciting stimulus","volume":"27","author":"Aldao","year":"2013","journal-title":"Cogn. Emot."},{"key":"10.1016\/j.jad.2017.05.013_bib3","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association, 2013. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Arlington, VA.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"10.1016\/j.jad.2017.05.013_bib4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.janxdis.2007.02.004","article-title":"Emotion regulation and anxiety disorders","volume":"22","author":"Amstadter","year":"2008","journal-title":"J. Anxiety Disord."},{"key":"10.1016\/j.jad.2017.05.013_bib5","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nn1001","article-title":"Dissociated neural representations of intensity and valence in human olfaction","volume":"6","author":"Anderson","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jad.2017.05.013_bib6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/da.20799","article-title":"Altered cerebral blood flow patterns associated with pathologic worry in the elderly","volume":"28","author":"Andreescu","year":"2011","journal-title":"Depression Anxiety"},{"key":"10.1016\/j.jad.2017.05.013_bib7","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1017\/S0033291712002383","article-title":"Prefrontal dysfunction during emotion regulation in generalized anxiety and panic disorders","volume":"43","author":"Ball","year":"2013","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2017.05.013_bib8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/scan\/nsm029","article-title":"Amygdala\u2013frontal connectivity during emotion regulation","volume":"2","author":"Banks","year":"2007","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.jad.2017.05.013_bib9","series-title":"Anxiety and Its Disorders: The Nature and Treatment of Anxiety and Panic","author":"Barlow","year":"2004"},{"key":"10.1016\/j.jad.2017.05.013_bib10","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1176\/appi.ajp.2008.07071060","article-title":"Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders","volume":"165","author":"Blair","year":"2008","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib11","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.biopsych.2012.04.013","article-title":"Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia\/generalized anxiety disorder","volume":"72","author":"Blair","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib12","unstructured":"Brett, M., Anton, J.-.L., Valabregue, R., Poline, J.-.B., 2002. Region of Interest Analysis Using an SPM Toolbox [Abstract], In: NeuroImage."},{"key":"10.1016\/j.jad.2017.05.013_bib13","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1093\/cercor\/bht154","article-title":"Cognitive reappraisal of emotion: a meta-analysis of human neuroimaging studies","volume":"24","author":"Buhle","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.jad.2017.05.013_bib14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/02699931.2015.1087973","article-title":"Heightened sensitivity to emotional expressions in generalised anxiety disorder, compared to social anxiety disorder, and controls","volume":"31","author":"Bui","year":"2017","journal-title":"Cogn. Emot."},{"key":"10.1016\/j.jad.2017.05.013_bib15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1517\/14656566.2013.759559","article-title":"New approaches to the pharmacological management of generalized anxiety disorder","volume":"14","author":"Buoli","year":"2013","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.jad.2017.05.013_bib16","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/scan\/nst061","article-title":"Linear association between social anxiety symptoms and neural activations to angry faces: from subclinical to clinical levels","volume":"9","author":"Carr\u00e9","year":"2014","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.jad.2017.05.013_bib17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s10862-009-9161-1","article-title":"Emotion regulation and the anxiety disorders: an integrative review","volume":"32","author":"Cisler","year":"2010","journal-title":"J. Psychopathol. Behav. Assess."},{"key":"10.1016\/j.jad.2017.05.013_bib18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: software for analysis and visualization of functional magnetic resonance neuroimages","volume":"29","author":"Cox","year":"1996","journal-title":"Comput. Biomed. Res."},{"key":"10.1016\/j.jad.2017.05.013_bib19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/0963721411430832","article-title":"Motivational Salience: amygdala Tuning From Traits, Needs, Values, and Goals","volume":"21","author":"Cunningham","year":"2012","journal-title":"Curr. Dir. Psychol. Sci."},{"key":"10.1016\/j.jad.2017.05.013_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2014.00175","article-title":"Cognitive reappraisal and expressive suppression strategies role in the emotion regulation: an overview on their modulatory effects and neural correlates","volume":"8","author":"Cutuli","year":"2014","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.jad.2017.05.013_bib21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.janxdis.2007.04.002","article-title":"Emotion regulation among individuals classified with and without generalized anxiety disorder","volume":"22","author":"Decker","year":"2008","journal-title":"J. Anxiety Disord."},{"key":"10.1016\/j.jad.2017.05.013_bib22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/hbm.20291","article-title":"Regulation of emotional responses elicited by threat-related stimuli","volume":"28","author":"Eippert","year":"2007","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jad.2017.05.013_bib23","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1602413113","article-title":"Cluster failure: why fMRI inferences for spatial extent have inflated false-positive rates","volume":"113","author":"Eklund","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jad.2017.05.013_bib24","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1001\/archgenpsychiatry.2009.104","article-title":"Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder","volume":"66","author":"Etkin","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib25","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1176\/appi.ajp.2007.07030504","article-title":"Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia","volume":"164","author":"Etkin","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib26","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1002\/hbm.23320","article-title":"Brain responses to disorder-related visual threat in panic disorder: disorder-related scene processing in PD","volume":"37","author":"Feldker","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jad.2017.05.013_bib27","unstructured":"First, M., Spitzer, R., Gibbon, M., Williams, J., 2002. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I\/P). New York."},{"key":"10.1016\/j.jad.2017.05.013_bib28","series-title":"Worry and Its Psychological Disorders: Theory, Assessment and Treatment","article-title":"The efficacy of psychological treatments for generalised anxiety disorder?","author":"Fisher","year":"2006"},{"key":"10.1016\/j.jad.2017.05.013_bib29","article-title":"Individual differences in cognitive reappraisal use and emotion regulatory brain function in combat-exposed veterans with and without PTSD","author":"Fitzgerald","year":"2016","journal-title":"Depression Anxiety"},{"key":"10.1016\/j.jad.2017.05.013_bib30","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1192\/bjp.bp.114.149880","article-title":"Common and disorder-specific neural responses to emotional faces in generalised anxiety, social anxiety and panic disorders","volume":"206","author":"Fonzo","year":"2015","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neubiorev.2014.06.010","article-title":"Emotion regulation: quantitative meta-analysis of functional activation and deactivation","volume":"45","author":"Frank","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2017.05.013_bib32","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1093\/brain\/awr232","article-title":"The neural correlates of inner speech defined by voxel-based lesion-symptom mapping","volume":"134","author":"Geva","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.jad.2017.05.013_bib33","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.biopsych.2007.05.031","article-title":"The neural bases of emotion regulation: reappraisal and suppression of negative emotion","volume":"63","author":"Goldin","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib34","series-title":"Generalized Anxiety Disorders: Advances in Research and Practice","first-page":"248","article-title":"A meta-analytic review of cognitive-behavioral treatments","author":"Gould","year":"2004"},{"key":"10.1016\/j.jad.2017.05.013_bib35","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1037\/a0032135","article-title":"Emotion regulation: taking stock and moving forward","volume":"13","author":"Gross","year":"2013","journal-title":"Emotion"},{"key":"10.1016\/j.jad.2017.05.013_bib36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib37","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br. J. Med. Psychol."},{"key":"10.1016\/j.jad.2017.05.013_bib38","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/nimg.2002.1179","article-title":"The amygdala response to emotional stimuli: a Comparison of faces and scenes","volume":"17","author":"Hariri","year":"2002","journal-title":"NeuroImage"},{"key":"10.1016\/j.jad.2017.05.013_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1586\/ern.12.161","article-title":"Metacognitions in generalized anxiety disorder: theoretical and practical perspectives","volume":"13","author":"Heiden","year":"2013","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.jad.2017.05.013_bib40","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4088\/JCP.v69n0415","article-title":"Cognitive-behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials","volume":"69","author":"Hofmann","year":"2008","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib41","series-title":"Cochrane Database of Systematic Reviews","article-title":"Psychological therapies for generalised anxiety disorder","author":"Hunot","year":"2007"},{"key":"10.1016\/j.jad.2017.05.013_bib42","series-title":"Cochrane Database of Systematic Reviews","article-title":"Cognitive behavioural therapy for anxiety disorders in children and adolescents","author":"James","year":"2013"},{"key":"10.1016\/j.jad.2017.05.013_bib43","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cpr.2006.10.001","article-title":"Neural correlates of inner speech and auditory verbal hallucinations: a critical review and theoretical integration","volume":"27","author":"Jones","year":"2007","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.jad.2017.05.013_bib44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jbtep.2015.06.001","article-title":"Psychophsyiological reactivity during uncertainty and ambiguity processing in high and low worriers","volume":"50","author":"Kirschner","year":"2016","journal-title":"J. Behav. Ther. Exp. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib45","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuroimage.2013.11.001","article-title":"Neural network of cognitive emotion regulation \u2014 an ALE meta-analysis and MACM analysis","volume":"87","author":"Kohn","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.jad.2017.05.013_bib46","unstructured":"Lang, P., Bradley, M., Cuthbert B.N., 2008. International Affective Picture System (IAPS): Affective Ratings of Pictures and Instruction Manual Technical Report A-8. Gainesville, FL."},{"key":"10.1016\/j.jad.2017.05.013_bib47","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1196\/annals.1280.016","article-title":"Blood, sweat, and fears: the autonomic architecture of emotion","volume":"1000","author":"Levenson","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jad.2017.05.013_bib48","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10862-009-9170-0","article-title":"Advances, problems, and challenges in the study of emotion regulation: a commentary","volume":"32","author":"Lewis","year":"2010","journal-title":"J. Psychopathol. Behav. Assess."},{"key":"10.1016\/j.jad.2017.05.013_bib49","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1080\/16506073.2014.964303","article-title":"An examination of distress intolerance in undergraduate students high in symptoms of generalized anxiety disorder","volume":"44","author":"MacDonald","year":"2015","journal-title":"Cogn. Behav. Ther."},{"key":"10.1016\/j.jad.2017.05.013_bib50","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/npp.2015.190","article-title":"Emotion regulatory brain function and SSRI treatment in PTSD: neural Correlates and predictors of change","volume":"41","author":"MacNamara","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2017.05.013_bib51","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/archpsyc.64.1.97","article-title":"Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder","volume":"64","author":"McClure","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib52","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/scan\/nsq103","article-title":"Bottom-up and top-down emotion generation: implications for emotion regulation","volume":"7","author":"McRae","year":"2012","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.jad.2017.05.013_bib53","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/da.22377","article-title":"An open trial of emotion regulation therapy for generalized anxiety disorder and cooccuring depression","volume":"32","author":"Mennin","year":"2015","journal-title":"Depression Anxiety"},{"key":"10.1016\/j.jad.2017.05.013_bib54","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.brat.2004.08.008","article-title":"Preliminary evidence for an emotion dysregulation model of generalized anxiety disorder","volume":"43","author":"Mennin","year":"2005","journal-title":"Behav. Res. Ther."},{"key":"10.1016\/j.jad.2017.05.013_bib55","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.beth.2006.09.001","article-title":"Delineating components of emotion and its dysregulation in anxiety and mood psychopathology","volume":"38","author":"Mennin","year":"2007","journal-title":"Behav. Ther."},{"key":"10.1016\/j.jad.2017.05.013_bib56","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.janxdis.2009.04.006","article-title":"Emotion regulation deficits in generalized anxiety disorder, social anxiety disorder, and their co-occurrence","volume":"23","author":"Mennin","year":"2009","journal-title":"J. Anxiety Disord."},{"key":"10.1016\/j.jad.2017.05.013_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2015.00956","article-title":"Executive and semantic processes in reappraisal of negative stimuli: insights from a meta-analysis of neuroimaging studies","volume":"6","author":"Messina","year":"2015","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2017.05.013_bib58","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0005-7967(90)90135-6","article-title":"Development and validation of the Penn state worry questionnaire","volume":"28","author":"Meyer","year":"1990","journal-title":"Behav. Res. Ther."},{"key":"10.1016\/j.jad.2017.05.013_bib59","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jad.2014.06.041","article-title":"A systematic review of fMRI studies in generalized anxiety disorder: evaluating its neural and cognitive basis","volume":"167","author":"Mochcovitch","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.05.013_bib60","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1001\/archpsyc.65.5.568","article-title":"Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder","volume":"65","author":"Monk","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib61","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/cercor\/bhv005","article-title":"Changes in effective connectivity between dorsal and ventral prefrontal regions moderate emotion regulation","volume":"26","author":"Morawetz","year":"2016","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.jad.2017.05.013_bib62","doi-asserted-by":"crossref","DOI":"10.2174\/1874440001206010078","article-title":"Self-reflection and the inner voice: activation of the left inferior frontal gyrus during perceptual and conceptual self-referential thinking","volume":"6","author":"Morin","year":"2012","journal-title":"Open Neuroimaging J."},{"key":"10.1016\/j.jad.2017.05.013_bib63","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bbr.2014.11.034","article-title":"Prefrontal engagement by cognitive reappraisal of negative faces","volume":"279","author":"Nelson","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2017.05.013_bib64","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1176\/appi.ajp.2008.07101682","article-title":"Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response","volume":"166","author":"Nitschke","year":"2009","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib65","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0193-953X(05)70205-7","article-title":"Comorbidity in generalized anxiety disorder","volume":"24","author":"Noyes","year":"2001","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.jad.2017.05.013_bib66","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1162\/089892902760807212","article-title":"Rethinking feelings: an fMRI study of the cognitive regulation of emotion","volume":"15","author":"Ochsner","year":"2002","journal-title":"J. Cogn. Neurosci."},{"key":"10.1016\/j.jad.2017.05.013_bib67","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1467-9280.2009.02459.x","article-title":"Bottom-Up and top-down processes in emotion generation: common and distinct neural mechanisms","volume":"20","author":"Ochsner","year":"2009","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.jad.2017.05.013_bib68","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1749-6632.2012.06751.x","article-title":"Functional imaging studies of emotion regulation: a synthetic review and evolving model of the cognitive control of emotion: functional imaging studies of emotion regulation","volume":"1251","author":"Ochsner","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jad.2017.05.013_bib69","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.biopsych.2004.10.030","article-title":"Neural substrates for voluntary suppression of negative affect: a functional magnetic resonance imaging study","volume":"57","author":"Phan","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib70","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuron.2005.09.025","article-title":"Contributions of the amygdala to emotion processing: from animal models to human behavior","volume":"48","author":"Phelps","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2017.05.013_bib71","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/da.22243","article-title":"Focal and aberrant prefrontal engagement during emotion regulation in veterans with posttraumatic stress disorder","volume":"31","author":"Rabinak","year":"2014","journal-title":"Depression Anxiety"},{"key":"10.1016\/j.jad.2017.05.013_bib72","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1469-8986.1991.tb01991.x","article-title":"Neuroanatomical correlates of skin conductance orienting in normal humans: a magnetic resonance imaging study","volume":"28","author":"Raine","year":"1991","journal-title":"Psychophysiology"},{"key":"10.1016\/j.jad.2017.05.013_bib73","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1749-6632.2003.tb07096.x","article-title":"Neuroimaging studies of amygdala function in anxiety disorders","volume":"985","author":"Rauch","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jad.2017.05.013_bib74","doi-asserted-by":"crossref","first-page":"e673","DOI":"10.1038\/tp.2015.160","article-title":"Effective emotion regulation strategies improve fMRI and ECG markers of psychopathology in panic disorder: implications for psychological treatment action","volume":"5","author":"Reinecke","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib75","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1097\/CHI.0b013e3181825ace","article-title":"Attention bias toward threat in pediatric anxiety disorders","volume":"47","author":"Roy","year":"2008","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib76","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10608-006-9055-4","article-title":"Evidence of broad deficits in emotion regulation associated with chronic worry and generalized anxiety disorder","volume":"30","author":"Salters-Pedneault","year":"2006","journal-title":"Cogn. Ther. Res."},{"key":"10.1016\/j.jad.2017.05.013_bib77","doi-asserted-by":"crossref","first-page":"e93432","DOI":"10.1371\/journal.pone.0093432","article-title":"The common traits of the ACC and PFC in anxiety disorders in the DSM-5: meta-analysis of voxel-based morphometry studies","volume":"9","author":"Shang","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jad.2017.05.013_bib78","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1176\/ajp.2007.164.2.318","article-title":"Increased amygdala and insula activation during emotion processing in anxiety-prone subjects","volume":"164","author":"Stein","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib79","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.janxdis.2015.03.004","article-title":"Neurostructural abnormalities in pediatric anxiety disorders","volume":"32","author":"Strawn","year":"2015","journal-title":"J. Anxiety Disord."},{"key":"10.1016\/j.jad.2017.05.013_bib80","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10608-005-1651-1","article-title":"Emotion Dysregulation in generalized anxiety disorder: a comparison with social anxiety disorder","volume":"29","author":"Turk","year":"2005","journal-title":"Cogn. Ther. Res."},{"key":"10.1016\/j.jad.2017.05.013_bib81","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1001\/archpsyc.62.8.922","article-title":"Disorder-specific neuroanatomical correlates of attentional bias in obsessive-compulsive disorder, panic disorder, and hypochondriasis","volume":"62","author":"van den Heuvel","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib82","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.brat.2011.12.005","article-title":"Randomized controlled trial on the effectiveness of metacognitive therapy and intolerance-of-uncertainty therapy for generalized anxiety disorder","volume":"50","author":"van der Heiden","year":"2012","journal-title":"Behav. Res. Ther."},{"key":"10.1016\/j.jad.2017.05.013_bib83","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1469-8986.2010.01149.x","article-title":"Electrocortical evidence for vigilance-avoidance in Generalized Anxiety Disorder: vigilance-avoidance in GAD","volume":"48","author":"Weinberg","year":"2011","journal-title":"Psychophysiology"},{"key":"10.1016\/j.jad.2017.05.013_bib84","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.biopsych.2007.08.019","article-title":"A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder","volume":"63","author":"Whalen","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2017.05.013_bib85","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.cogbrainres.2004.06.005","article-title":"The dynamics of cortico-amygdala and autonomic activity over the experimental time course of fear perception","volume":"21","author":"Williams","year":"2004","journal-title":"Cogn. Brain Res."},{"key":"10.1016\/j.jad.2017.05.013_bib86","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1006\/nimg.2001.0904","article-title":"Arousal dissociates amygdala and hippocampal fear responses: evidence from simultaneous fMRI and skin conductance recording","volume":"14","author":"Williams","year":"2001","journal-title":"NeuroImage"},{"key":"10.1016\/j.jad.2017.05.013_bib87","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1177\/0956797612464242","article-title":"Neural evidence that human emotions share core affective properties","volume":"24","author":"Wilson-Mendenhall","year":"2013","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.jad.2017.05.013_bib88","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.neuroimage.2013.12.058","article-title":"Cluster-extent based thresholding in fMRI analyses: pitfalls and recommendations","volume":"91","author":"Woo","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.jad.2017.05.013_bib89","article-title":"Neuroimaging cognitive reappraisal in clinical populations to define neural targets for enhancing emotion regulation. A systematic review","author":"Zilverstand","year":"2016","journal-title":"NeuroImage"},{"key":"10.1016\/j.jad.2017.05.013_bib90","article-title":"Emotion regulation in social anxiety disorder: behavioral and neural responses to three socio-emotional tasks","volume":"3","author":"Ziv","year":"2013","journal-title":"Biol. Mood Anxiety Disord."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032717301064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032717301064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:22:14Z","timestamp":1759022534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032717301064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":90,"alternative-id":["S0165032717301064"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2017.05.013","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prefrontal and amygdala engagement during emotional reactivity and regulation in generalized anxiety disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2017.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}