{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:21:41Z","timestamp":1791598901557,"version":"4.3.4"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"am","delay-in-days":253,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Faculty of Biology and Medicine of Lausanne"},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["3200B0-105993"],"award-info":[{"award-number":["3200B0-105993"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["3200B0-118308"],"award-info":[{"award-number":["3200B0-118308"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33CSCO-122661"],"award-info":[{"award-number":["33CSCO-122661"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33CS30-139468"],"award-info":[{"award-number":["33CS30-139468"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33CS30-148401"],"award-info":[{"award-number":["33CS30-148401"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.jad.2017.07.016","type":"journal-article","created":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T03:48:11Z","timestamp":1499485691000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Partially distinct combinations of psychological, metabolic and inflammatory risk factors are prospectively associated with the onset of the subtypes of Major Depressive Disorder in midlife"],"prefix":"10.1016","volume":"222","author":[{"given":"Dominique A.","family":"Rudaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline L.","family":"Vandeleur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirak Z.","family":"Gebreab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Gholam-Rezaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre F.","family":"Strippoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie M.","family":"Lasserre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Glaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Castelao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Pistis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"von K\u00e4nel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Marques-Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Waeber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vollenweider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Preisig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2017.07.016_bib1","series-title":"Task Force on DSM-IV. 2000. DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.jad.2017.07.016_bib2","first-page":"937","article-title":"Ev\u00e9nements existentiels et d\u00e9pression. une \u00e9tude comparative de plusieurs types de d\u00e9prim\u00e9s (Existential events and depression. A comparative study of several types of depressions)","volume":"142","author":"Amiel-Lebigre","year":"1984","journal-title":"Ann. M\u00e9d.-Psychol."},{"key":"10.1016\/j.jad.2017.07.016_bib3","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1001\/archpsyc.1977.01770220111013","article-title":"The family history method using diagnostic criteria: reliability and validity","volume":"34","author":"Andreasen","year":"1977","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib4","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0447.2007.00965.x","article-title":"Melancholia and atypical depression in the Zurich study: epidemiology, clinical characteristics, course, comorbidity and personality","author":"Angst","year":"2007","journal-title":"Acta Psychiatr. Scand. Suppl."},{"key":"10.1016\/j.jad.2017.07.016_bib5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jad.2008.09.023","article-title":"Long-term depression versus episodic major depression: results from the prospective Zurich study of a community sample","volume":"115","author":"Angst","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.07.016_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2005.04.004","article-title":"Depressive disorders \u2013 is it time to endorse different pathophysiologies?","volume":"31","author":"Antonijevic","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2017.07.016_bib7","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1038\/tp.2012.18","article-title":"The relationship between subtypes of depression and cardiovascular disease: a systematic review of biological models","volume":"2","author":"Baune","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/archgenpsychiatry.2009.177","article-title":"Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder","volume":"67","author":"Beesdo","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.4088\/JCP.10m06227","article-title":"Epidemiology of major depression with atypical features: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)","volume":"73","author":"Blanco","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/002075996401205","article-title":"Bien-\u00eatre et contraintes d'adolescents: une comparaison entre adolescents de familles monoparentales et de familles biparentales (Well-being and constraints of adolescents: a comparison of adolescents from single-parent and two-parent families)","volume":"31","author":"Bodmer","year":"1996","journal-title":"J. Int. Psychol."},{"key":"10.1016\/j.jad.2017.07.016_bib11","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1001\/archpsyc.59.11.1039","article-title":"Drug use and the risk of major depressive disorder, alcohol dependence, and substance use disorders","volume":"59","author":"Brook","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib12","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/da.22001","article-title":"Alcohol consumption and major depression in the general population: the critical importance of dependence","volume":"29","author":"Bulloch","year":"2012","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2017.07.016_bib13","doi-asserted-by":"crossref","first-page":"e28912","DOI":"10.1371\/journal.pone.0028912","article-title":"Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women: the power study","volume":"7","author":"Cizza","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2017.07.016_bib14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000087104","article-title":"Cytokine dysregulation, inflammation and well-being","volume":"12","author":"Elenkov","year":"2005","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.jad.2017.07.016_bib15","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archpsyc.1978.01770310043002","article-title":"A diagnostic interview: the schedule for affective disorders and schizophrenia","volume":"35","author":"Endicott","year":"1978","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jad.2010.05.016","article-title":"Gender differences in the developmental course of depression","volume":"127","author":"Essau","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.07.016_bib17","series-title":"Manual of the Eysenck Personality Questionnaire","author":"Eysenck","year":"1975"},{"key":"10.1016\/j.jad.2017.07.016_bib18","unstructured":"Eysenck, H.J., Eysenck, S.B.G., Gauquelin, M., Gauquelin, F., Pascal C., Pascal, D., 1980. The Structure of the Personality Among French Compared to that of an English: Cross-cultural Comparison, Vols. 1\u20132."},{"key":"10.1016\/j.jad.2017.07.016_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2261-8-6","article-title":"The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome","volume":"8","author":"Firmann","year":"2008","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.jad.2017.07.016_bib20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/da.20231","article-title":"A three-year follow-up of major depression, dysthymia, minor depression and subsyndromal depression: results from a population-based study","volume":"24","author":"Forsell","year":"2007","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2017.07.016_bib21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0924-9338(02)00682-X","article-title":"Life events and changes in the course of depression in young adults","volume":"17","author":"Friis","year":"2002","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1600-0447.2011.01746.x","article-title":"The heterogeneity of depression: an old debate renewed","volume":"124","author":"Ghaemi","year":"2011","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2017.07.016_bib23","first-page":"282","article-title":"Atypical depression and alcohol misuse are related to the cardiovascular risk in the general population","volume":"128","author":"Glaus","year":"2013","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2017.07.016_bib24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jpsychires.2014.07.012","article-title":"Associations between mood, anxiety or substance use disorders and inflammatory markers after adjustment for multiple covariates in a population-based study","volume":"58","author":"Glaus","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2017.07.016_bib25","series-title":"Living Conditions in Europe: The Case of Switzerland","author":"Grob","year":"1993"},{"key":"10.1016\/j.jad.2017.07.016_bib26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.clinpsy.1.102803.143938","article-title":"Stress and depression","volume":"1","author":"Hammen","year":"2005","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.jad.2017.07.016_bib27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jad.2011.07.015","article-title":"Meta-review of depressive subtyping models","volume":"139","author":"Harald","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.07.016_bib28","article-title":"C-reactive protein is elevated in atypical but not nonatypical depression: data from the National Health and Nutrition Examination Survey (NHANES) 1999\u20132004","author":"Hickman","year":"2013","journal-title":"J. Behav. Med."},{"key":"10.1016\/j.jad.2017.07.016_bib29","unstructured":"Hollingshead, A.B., 1975. (Four Factor Index of Social Status)."},{"key":"10.1016\/j.jad.2017.07.016_bib30","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1001\/archpsyc.1992.01820100061011","article-title":"Depressive symptoms as relative and attributable risk factors for first-onset major depression","volume":"49","author":"Horwath","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1192\/bjp.bp.113.130419","article-title":"Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study","volume":"205","author":"Hung","year":"2014","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib32","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1017\/S0033291716001653","volume":"46","author":"Jeronimus","year":"2016","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2017.07.016_bib33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jad.2005.03.012","article-title":"Different activation patterns of proinflammatory cytokines in melancholic and non-melancholic major depression are associated with HPA axis activity","volume":"87","author":"Kaestner","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.07.016_bib34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1001\/archpsyc.1996.01830050025004","article-title":"The identification and validation of distinct depressive syndromes in a population-based sample of female twins","volume":"53","author":"Kendler","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib35","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1176\/appi.ajp.159.7.1133","article-title":"Toward a comprehensive developmental model for major depression in women","volume":"159","author":"Kendler","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib36","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1176\/ajp.156.6.837","article-title":"Causal relationship between stressful life events and the onset of major depression","volume":"156","author":"Kendler","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib37","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1176\/appi.ajp.161.4.631","article-title":"The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression","volume":"161","author":"Kendler","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib38","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1017\/S003329170400265X","article-title":"Childhood sexual abuse, stressful life events and risk for major depression in women","volume":"34","author":"Kendler","year":"2004","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2017.07.016_bib39","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib40","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1001\/archpsyc.1994.03950010008002","article-title":"Lifetime and 12-month prevalence of Dsm-Iii-R psychiatric-disorders in the United-States \u2013 results from the National-Comorbidity-Survey","volume":"51","author":"Kessler","year":"1994","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib41","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/jamapsychiatry.2014.1332","article-title":"Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study","volume":"71","author":"Khandaker","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib42","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1001\/archpsyc.65.12.1368","article-title":"Development and validation of an international risk prediction algorithm for episodes of major depression in general practice attendees: the PredictD study","volume":"65","author":"King","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib43","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1192\/bjp.bp.114.153098","article-title":"Six-year longitudinal course and outcomes of subtypes of depression","volume":"208","author":"Lamers","year":"2016","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib44","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.4088\/JCP.09m05398blu","article-title":"Identifying depressive subtypes in a large cohort study: results from the Netherlands Study of Depression and Anxiety (NESDA)","volume":"71","author":"Lamers","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib45","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1017\/S0033291712000141","article-title":"Stability and transitions of depressive subtypes over a 2-year follow-up","volume":"42","author":"Lamers","year":"2012","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2017.07.016_bib46","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/mp.2012.144","article-title":"Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression","volume":"18","author":"Lamers","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib47","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1001\/jamapsychiatry.2014.411","article-title":"Depression with atypical features and increase in obesity, body mass index, waist circumference, and fat mass: a prospective, population-based study","volume":"71","author":"Lasserre","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib48","article-title":"Prospective associations of depression subtypes with cardio-metabolic risk factors in the general population","author":"Lasserre","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib49","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1017\/S0033291715002743","article-title":"Maltreatment in childhood substantially increases the risk of adult depression and anxiety in prospective cohort studies: systematic review, meta-analysis, and proportional attributable fractions","volume":"46","author":"Li","year":"2016","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2017.07.016_bib50","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1017\/S0033291714000749","article-title":"Subtypes of major depression: latent class analysis in depressed Han Chinese women","volume":"44","author":"Li","year":"2014","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2017.07.016_bib51","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1161\/HYPERTENSIONAHA.108.126698","article-title":"Depression is associated with decreased blood pressure, but antidepressant use increases the risk for hypertension","volume":"53","author":"Licht","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.jad.2017.07.016_bib52","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/aje\/kwf182","article-title":"Socioeconomic inequalities in depression: a meta-analysis","volume":"157","author":"Lorant","year":"2003","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.jad.2017.07.016_bib53","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.addbeh.2014.05.011","article-title":"How robust is the association between smoking and depression in adults? A meta-analysis using linear mixed-effects models","volume":"39","author":"Luger","year":"2014","journal-title":"Addict. Behav."},{"key":"10.1016\/j.jad.2017.07.016_bib54","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/archgenpsychiatry.2010.2","article-title":"Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies","volume":"67","author":"Luppino","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib55","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.amepre.2013.08.001","article-title":"Physical activity and the prevention of depression: a systematic review of prospective studies","volume":"45","author":"Mammen","year":"2013","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.jad.2017.07.016_bib56","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.eurpsy.2015.04.007","article-title":"The role of specific early trauma in adult depression: a meta-analysis of published literature. Childhood trauma and adult depression","volume":"30","author":"Mandelli","year":"2015","journal-title":"Depress. Eur. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib57","doi-asserted-by":"crossref","first-page":"e21002","DOI":"10.1371\/journal.pone.0021002","article-title":"Levels and determinants of inflammatory biomarkers in a Swiss population-based sample (CoLaus study)","volume":"6","author":"Marques-Vidal","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2017.07.016_bib58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jad.2005.04.002","article-title":"First incidence depression in the Lundby Study: a comparison of the two time periods 1947\u20131972 and 1972\u20131997","volume":"87","author":"Mattisson","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.07.016_bib59","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.2337\/dc08-0985","article-title":"Depression and type 2 diabetes over the lifespan: a meta-analysis","volume":"31","author":"Mezuk","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2017.07.016_bib60","article-title":"Polygenic dissection of major depression clinical heterogeneity","author":"Milaneschi","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib61","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0165-0327(00)00334-7","article-title":"Incidence of major depression: prediction from subthreshold categories in the Stirling County Study","volume":"68","author":"Murphy","year":"2002","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.07.016_bib62","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1007\/s00125-010-1874-x","article-title":"Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis","volume":"53","author":"Nouwen","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.jad.2017.07.016_bib63","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archpsyc.1994.03950110009002","article-title":"Diagnostic interview for genetic studies. rationale, unique features, and training. NIMH genetics initiative","volume":"51","author":"Nurnberger","year":"1994","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib64","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1001\/archpsyc.61.10.990","article-title":"Vulnerability before, during, and after a major depressive episode: a 3-wave population-based study","volume":"61","author":"Ormel","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib65","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1017\/S0033291701004524","article-title":"The incidence of first-onset depression in a population followed from the age of 70\u201385","volume":"31","author":"Palsson","year":"2001","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2017.07.016_bib66","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2337\/dc11-2055","article-title":"Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies","volume":"35","author":"Pan","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jad.2017.07.016_bib67","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1192\/bjp.bp.109.076430","article-title":"Association of high-sensitivity C-reactive protein with de novo major depression","volume":"197","author":"Pasco","year":"2010","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib68","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1741-7015-11-129","article-title":"Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile","volume":"11","author":"Penninx","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.jad.2017.07.016_bib69","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00127-013-0762-3","article-title":"Determinants of the development of post-traumatic stress disorder, in the general population","volume":"49","author":"Perrin","year":"2014","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"10.1016\/j.jad.2017.07.016_bib70","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1192\/bjp.177.6.486","article-title":"Gender differences in depression","volume":"177","author":"Piccinelli","year":"2000","journal-title":"Crit. Rev. Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib71","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s004060050084","article-title":"Diagnostic interview for genetic studies (DIGS): inter-rater and test-retest reliability of the French version","volume":"249","author":"Preisig","year":"1999","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2017.07.016_bib72","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-244X-9-9","article-title":"The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors","volume":"9","author":"Preisig","year":"2009","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib73","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/CIRCRESAHA.115.306656","article-title":"From C-reactive protein to interleukin-6 to Interleukin-1: moving upstream to identify novel targets for atheroprotection","volume":"118","author":"Ridker","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.jad.2017.07.016_bib74","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s004060170058","article-title":"Different immune patterns in melancholic and non-melancholic major depression","volume":"251","author":"Rothermundt","year":"2001","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2017.07.016_bib75","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/mp.2016.177","article-title":"Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci","volume":"21","author":"Smith","year":"2016","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.jad.2017.07.016_bib76","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nri1810","article-title":"Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens","volume":"6","author":"Sternberg","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jad.2017.07.016_bib77","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0165-0327(00)00364-5","article-title":"The subtypes of major depression in a twin registry","volume":"68","author":"Sullivan","year":"2002","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.07.016_bib78","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/pcn.12104","article-title":"Association of metabolic syndrome with atypical features of depression in Japanese people","volume":"67","author":"Takeuchi","year":"2013","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2017.07.016_bib79","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.biopsych.2012.10.028","article-title":"Vascular risk factors and depression in later life: a systematic review and meta-analysis","volume":"73","author":"Valkanova","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2017.07.016_bib80","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jad.2014.08.048","article-title":"Inter-informant agreement and prevalence estimates for mood syndromes: direct interview vs. family history method","volume":"171","author":"Vandeleur","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.07.016_bib81","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jpsychires.2013.01.013","article-title":"Risk markers for affective disorder, a seven-years follow up study of a twin cohort at low and high risk for affective disorder","volume":"47","author":"Vinberg","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2017.07.016_bib82","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbi.2014.05.004","article-title":"Late-life depression symptom profiles are differentially associated with immunometabolic functioning","volume":"41","author":"Vogelzangs","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2017.07.016_bib83","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jad.2009.07.016","article-title":"The incidence of major depression in Canada: the National Population Health Survey","volume":"123","author":"Wang","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.07.016_bib84","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1037\/0021-843X.108.4.674","article-title":"Marital dissatisfaction and incidence of major depressive episode in a community sample","volume":"108","author":"Whisman","year":"1999","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.jad.2017.07.016_bib85","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jad.2014.01.014","article-title":"A meta-analysis of the risk of major affective disorder in relatives of individuals affected by major depressive disorder or bipolar disorder","volume":"158","author":"Wilde","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.07.016_bib86","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.biopsych.2013.10.009","article-title":"Elevated C-reactive protein, depression, somatic diseases, and all-cause mortality: a Mendelian randomization study","volume":"76","author":"Wium-Andersen","year":"2014","journal-title":"Biol. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503271730993X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503271730993X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:17:45Z","timestamp":1759022265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503271730993X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":86,"alternative-id":["S016503271730993X"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2017.07.016","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Partially distinct combinations of psychological, metabolic and inflammatory risk factors are prospectively associated with the onset of the subtypes of Major Depressive Disorder in midlife","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2017.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}