{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:34:09Z","timestamp":1790159649357,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.jad.2017.11.077","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T02:02:16Z","timestamp":1511143336000},"page":"665-671","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Retinal changes in patients with major depressive disorder \u2013 A controlled optical coherence tomography study"],"prefix":"10.1016","volume":"227","author":[{"given":"Carlos","family":"Sch\u00f6nfeldt-Lecuona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kregel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kassubek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Dreyhaupt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland W.","family":"Freudenmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard J.","family":"Connemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar H.","family":"Pinkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Gahr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2017.11.077_bib1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/IJG.0b013e318255bb4a","article-title":"Analysis of normal retinal nerve fiber layer thickness by age, sex, and race using spectral domain optical coherence tomography","volume":"22","author":"Alasil","year":"2013","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.jad.2017.11.077_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.euroneuro.2011.05.003","article-title":"Magnetic resonance imaging studies in unipolar depression: systematic review and meta-regression analyses","volume":"22","author":"Arnone","year":"2012","journal-title":"Eur. Neuropsychopharmacol. J. Eur. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2017.11.077_bib3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4321\/S0213-61632010000400005","article-title":"Retinal nerve fiber layer thickness measured by optical coherence tomography in patients with schizophrenia: a short report","volume":"24","author":"Ascaso","year":"2010","journal-title":"Eur. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.psychres.2015.07.028","article-title":"Retinal nerve fiber layer and macular thickness in patients with schizophrenia: influence of recent illness episodes","volume":"229","author":"Ascaso","year":"2015","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2017.11.077_bib5","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1167\/iovs.12-11026","article-title":"Progressive loss of retinal ganglion cell function precedes structural loss by several years in glaucoma suspects","volume":"54","author":"Banitt","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jad.2017.11.077_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1001\/archpsyc.1989.01810030049007","article-title":"Reduction of prefrontal cortex glucose metabolism common to three types of depression","volume":"46","author":"Baxter","year":"1989","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib7","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1017\/S0033291700025368","article-title":"Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions","volume":"23","author":"Bench","year":"1993","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2017.11.077_bib8","first-page":"171","article-title":"Retinal nerve fibre layer imaging compared with histological measurements in a human eye","volume":"23","author":"Blumenthal","year":"2009","journal-title":"Eye Lond. Engl."},{"key":"10.1016\/j.jad.2017.11.077_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jad.2011.03.049","article-title":"Gray matter abnormalities in major depressive disorder: a meta-analysis of voxel based morphometry studies","volume":"138","author":"Bora","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.11.077_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1192\/bjp.bp.111.100560","article-title":"Effect of antidepressive therapy on retinal contrast processing in depressive disorder","volume":"201","author":"Bubl","year":"2012","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.biopsych.2010.02.009","article-title":"Seeing gray when feeling blue? Depression can be measured in the eye of the diseased","volume":"68","author":"Bubl","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00406-014-0573-x","article-title":"Retinal dysfunction of contrast processing in major depression also apparent in cortical activity","volume":"265","author":"Bubl","year":"2015","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2017.11.077_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1755-3768.2012.T123.x","article-title":"Optical coherence tomography: a window into the brain of schizophrenic patients","volume":"90","author":"Cabezon","year":"2012","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.jad.2017.11.077_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.eurpsy.2015.10.006","article-title":"Decreases in ganglion cell layer and inner plexiform layer volumes correlate better with disease severity in schizophrenia patients than retinal nerve fiber layer thickness: findings from spectral optic coherence tomography","volume":"32","author":"Celik","year":"2016","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pscychresns.2011.08.011","article-title":"A window into the brain: an in vivo study of the retina in schizophrenia using optical coherence tomography","volume":"203","author":"Chu","year":"2012","journal-title":"Psychiatry Res."},{"issue":"103","key":"10.1016\/j.jad.2017.11.077_bib16","first-page":"1796","article-title":"Photocoagulation for diabetic macular edema. early treatment diabetic retinopathy study report number 1","volume":"1960","author":"Early Treatment Diabetic Retinopathy Study Research Group","year":"1985","journal-title":"Arch. Ophthalmol. Chic. Ill."},{"key":"10.1016\/j.jad.2017.11.077_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrneurol.2009.215","article-title":"The clinical use of structural MRI in Alzheimer disease","volume":"6","author":"Frisoni","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jad.2017.11.077_bib18","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/00005053-199407000-00008","article-title":"A magnetic resonance imaging investigation into mood disorders in multiple sclerosis: a pilot study","volume":"182","author":"George","year":"1994","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.jad.2017.11.077_bib19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1176\/ajp.152.3.341","article-title":"Brain activity during transient sadness and happiness in healthy women","volume":"152","author":"George","year":"1995","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib20","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1212\/01.wnl.0000295995.46586.ae","article-title":"Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis","volume":"69","author":"Gordon-Lipkin","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2017.11.077_bib21","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1167\/iovs.15-19047","article-title":"Progressive loss of retinal ganglion cells and axons in nonoptic neuritis eyes in multiple sclerosis: aa longitudinal optical coherence tomography study","volume":"57","author":"Graham","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jad.2017.11.077_bib22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jns.2007.10.020","article-title":"Retinal nerve fiber layer thickness is associated with brain MRI outcomes in multiple sclerosis","volume":"268","author":"Grazioli","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jad.2017.11.077_bib23","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/schbul\/sbs118","article-title":"Brain volumes in Schizophrenia: a meta-analysis in over 18,000 subjects","volume":"39","author":"Haijma","year":"2013","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jad.2017.11.077_bib24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1212\/WNL.44.2.269","article-title":"Speech localization using repetitive transcranial magnetic stimulation","volume":"44","author":"Jennum","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2017.11.077_bib25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jad.2016.06.039","article-title":"Optic coherence tomography shows inflammation and degeneration in major depressive disorder patients correlated with disease severity","volume":"204","author":"Kalenderoglu","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2017.11.077_bib26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.comppsych.2016.02.005","article-title":"Can the retinal ganglion cell layer (GCL) volume be a new marker to detect neurodegeneration in bipolar disorder?","volume":"67","author":"Kalenderoglu","year":"2016","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib27","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1001\/archgenpsychiatry.2011.60","article-title":"Structural neuroimaging studies in major depressive disorder: meta-analysis and comparison with bipolar disorder","volume":"68","author":"Kempton","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib28","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1136\/bjo.2009.157875","article-title":"Retinal nerve fibre layer thickness measurement reproducibility improved with spectral domain optical coherence tomography","volume":"93","author":"Kim","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.jad.2017.11.077_bib29","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0006-3223(99)00195-X","article-title":"Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism","volume":"46","author":"Kimbrell","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib30","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1167\/iovs.13-12534","article-title":"Retinal nerve fiber layer structure abnormalities in Schizophrenia and its relationship to disease state: evidence from optical coherence tomography","volume":"54","author":"Lee","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jad.2017.11.077_bib31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","article-title":"The retina as a window to the brain\u2014from eye research to CNS disorders","volume":"9","author":"London","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jad.2017.11.077_bib32","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1176\/ajp.147.10.1313","article-title":"Left prefrontal glucose hypometabolism in the depressed state: a confirmation","volume":"147","author":"Martinot","year":"1990","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00417-015-2981-7","article-title":"Peripapillary retinal nerve fiber layer thickness in bipolar disorder","volume":"254","author":"Mehraban","year":"2016","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.jad.2017.11.077_bib34","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.biopsych.2006.10.006","article-title":"Long-term plasticity of visually evoked potentials in humans is altered in major depression","volume":"62","author":"Normann","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib35","doi-asserted-by":"crossref","first-page":"e0137316","DOI":"10.1371\/journal.pone.0137316","article-title":"Reliability of intra-retinal layer thickness estimates","volume":"10","author":"Oberwahrenbrock","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2017.11.077_bib36","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2014.10.010","article-title":"Retinal neurodegeneration on optical coherence tomography and cerebral atrophy","volume":"584","author":"Ong","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jad.2017.11.077_bib37","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archpsyc.63.5.530","article-title":"Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis","volume":"63","author":"Ownby","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib38","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1176\/ajp.150.5.713","article-title":"Neural correlates of self-induced dysphoria","volume":"150","author":"Pardo","year":"1993","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib39","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0161-6420(00)00644-8","article-title":"Correlation between optical coherence tomography, pattern electroretinogram, and visual evoked potentials in open-angle glaucoma patients","volume":"108","author":"Parisi","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jad.2017.11.077_bib40","first-page":"2520","article-title":"Correlation between morphological and functional retinal impairment in multiple sclerosis patients","volume":"40","author":"Parisi","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jad.2017.11.077_bib41","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1212\/WNL.41.5.697","article-title":"Induction of speech arrest and counting errors with rapid-rate transcranial magnetic stimulation","volume":"41","author":"Pascual-Leone","year":"1991","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2017.11.077_bib42","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S1474-4422(10)70168-X","article-title":"Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis","volume":"9","author":"Petzold","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jad.2017.11.077_bib43","doi-asserted-by":"crossref","first-page":"625","DOI":"10.4088\/JCP.11m06865","article-title":"Brain-volume increase with sustained remission in patients with treatment-resistant unipolar depression","volume":"73","author":"Phillips","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib44","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archpsyc.63.2.161","article-title":"Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression","volume":"63","author":"Rapp","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib45","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1176\/ajp.145.2.172","article-title":"Comparison of mania and depression after brain injury: causal factors","volume":"145","author":"Robinson","year":"1988","journal-title":"Am. J. Psychiatry"},{"issue":"Suppl. 51","key":"10.1016\/j.jad.2017.11.077_bib46","article-title":"Depression and cerebrovascular disease","author":"Robinson","year":"1990","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib47","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/ana.410090506","article-title":"Mood change following left hemispheric brain injury","volume":"9","author":"Robinson","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jad.2017.11.077_bib48","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1364\/BOE.7.001783","article-title":"Multi-modal adaptive optics system including fundus photography and optical coherence tomography for the clinical setting","volume":"7","author":"Salas","year":"2016","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.jad.2017.11.077_bib49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00702-013-1072-3","article-title":"Retinal single-layer analysis in Parkinsonian syndromes: an optical coherence tomography study","volume":"121","author":"Schneider","year":"2014","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.jad.2017.11.077_bib50","first-page":"9","article-title":"From Imaging the brain to imaging the retina: optical coherence tomography (OCT) in Schizophrenia","author":"Sch\u00f6nfeldt-Lecuona","year":"2015","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jad.2017.11.077_bib51","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0006-3223(91)90043-L","article-title":"Manic-depressive and pure manic states after brain lesions","volume":"29","author":"Starkstein","year":"1991","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2017.11.077_bib52","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1167\/iovs.06-0161","article-title":"The relationship between retinal ganglion cell function and retinal nerve fiber thickness in early glaucoma","volume":"47","author":"Ventura","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jad.2017.11.077_bib53","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.pneurobio.2010.04.005","article-title":"The putative neurodegenerative links between depression and Alzheimer's disease","volume":"91","author":"Wuwongse","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jad.2017.11.077_bib54","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pscychresns.2016.04.011","article-title":"Duration of the depressive episode is correlated with ganglion cell inner plexifrom layer and nasal retinal fiber layer thicknesses: optical coherence tomography findings in major depression","volume":"251","author":"Y\u0131ld\u0131z","year":"2016","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.jad.2017.11.077_bib55","doi-asserted-by":"crossref","first-page":"e85718","DOI":"10.1371\/journal.pone.0085718","article-title":"Retinal nerve fiber layer thickness changes in Parkinson disease: a meta-analysis","volume":"9","author":"Yu","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jad.2017.11.077_bib56","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1001\/jamaophthalmol.2013.2597","article-title":"Association between depression and functional vision loss in persons 20 years of age or older in the United States, NHANES 2005\u20132008","volume":"131","author":"Zhang","year":"2013","journal-title":"JAMA Ophthalmol."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032717306365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032717306365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:27:33Z","timestamp":1759022853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032717306365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":56,"alternative-id":["S0165032717306365"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2017.11.077","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinal changes in patients with major depressive disorder \u2013 A controlled optical coherence tomography study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2017.11.077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}