{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:21:27Z","timestamp":1778311287701,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jad.2018.02.047","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T17:17:17Z","timestamp":1519060637000},"page":"103-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Long-term use of valproic acid and the prevalence of cancers in bipolar disorder patients in a Taiwanese population: An association analysis using the National Health Insurance Research Database (NHIRD)"],"prefix":"10.1016","volume":"232","author":[{"given":"Cheng Chia","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Cheng","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence Shih-Hsin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2018.02.047_bib1","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.urology.2007.12.060","article-title":"Effect of DNA methylation on identification of aggressive prostate cancer","volume":"72","author":"Alumkal","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.jad.2018.02.047_bib2","first-page":"2370","article-title":"Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers","volume":"62","author":"Belinsky","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.jad.2018.02.047_bib3","first-page":"7089","article-title":"Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer","volume":"63","author":"Belinsky","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.jad.2018.02.047_bib4","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1158\/0008-5472.CAN-05-3408","article-title":"Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort","volume":"66","author":"Belinsky","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.jad.2018.02.047_bib5","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/carcin\/bgi058","article-title":"CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype","volume":"26","author":"Brandes","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jad.2018.02.047_bib6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1158\/1940-6207.CAPR-13-0254","article-title":"Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer","volume":"7","author":"Brodie","year":"2014","journal-title":"Cancer Prev. Res"},{"key":"10.1016\/j.jad.2018.02.047_bib7","doi-asserted-by":"crossref","first-page":"ra80","DOI":"10.1126\/scisignal.2001462","article-title":"DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination","volume":"3","author":"Du","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jad.2018.02.047_bib8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ctrv.2007.11.003","article-title":"Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors","volume":"34","author":"Duenas-Gonzalez","year":"2008","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.jad.2018.02.047_bib9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1470-2045(09)70003-8","article-title":"Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study","volume":"10","author":"Fenaux","year":"2009","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.jad.2018.02.047_bib10","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"Gottlicher","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.jad.2018.02.047_bib11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1470-2045(05)70540-4","article-title":"Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma","volume":"7","author":"Ha","year":"2006","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.jad.2018.02.047_bib12","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1158\/1055-9965.EPI-08-0646","article-title":"Cancer risk in long-term users of valproate: a population-based case-control study","volume":"18","author":"Hallas","year":"2009","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.jad.2018.02.047_bib13","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMra023075","article-title":"Gene silencing in cancer in association with promoter hypermethylation","volume":"349","author":"Herman","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jad.2018.02.047_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2217\/epi.10.64","article-title":"Epigenetics of kidney cancer and bladder cancer","volume":"3","author":"Hoffman","year":"2011","journal-title":"Epigenomics"},{"key":"10.1016\/j.jad.2018.02.047_bib15","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1158\/0008-5472.CAN-07-5913","article-title":"Genome-wide promoter analysis uncovers portions of the cancer methylome","volume":"68","author":"Hoque","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.jad.2018.02.047_bib16","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1192\/bjp.bp.116.181362","article-title":"Use of lithium and cancer risk in patients with bipolar disorder: population-based cohort study","volume":"209","author":"Huang","year":"2016","journal-title":"Br. J. Psych."},{"key":"10.1016\/j.jad.2018.02.047_bib17","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1158\/2159-8290.CD-11-0214","article-title":"Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer","volume":"1","author":"Juergens","year":"2011","journal-title":"Cancer Discov."},{"key":"10.1016\/j.jad.2018.02.047_bib18","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/cncr.28479","article-title":"Long-term use of valproic acid in US veterans is associated with a reduced risk of smoking-related cases of head and neck cancer","volume":"120","author":"Kang","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.jad.2018.02.047_bib19","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/cncr.21792","article-title":"Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study","volume":"106","author":"Kantarjian","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.jad.2018.02.047_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1442-2042.2008.02143.x","article-title":"Epigenetic markers as promising prognosticators for bladder cancer","volume":"16","author":"Kim","year":"2009","journal-title":"Int. J. Urol."},{"key":"10.1016\/j.jad.2018.02.047_bib21","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/schbul\/sbr162","article-title":"Cancer incidence in patients with schizophrenia or bipolar disorder: a nationwide population-based study in Taiwan, 1997\u20132009","volume":"39","author":"Lin","year":"2013","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jad.2018.02.047_bib22","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1200\/JCO.2010.30.9245","volume":"29","author":"Lubbert","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jad.2018.02.047_bib23","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1158\/0008-5472.CAN-05-2020","article-title":"Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer","volume":"66","author":"McCabe","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.jad.2018.02.047_bib24","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1158\/1078-0432.CCR-08-2784","article-title":"Cancer DNA methylation: molecular mechanisms and clinical implications","volume":"15","author":"McCabe","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jad.2018.02.047_bib25","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.2741\/2385","article-title":"Abnormal DNA methylation, epigenetics, and prostate cancer","volume":"12","author":"Nelson","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jad.2018.02.047_bib26","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1200\/JCO.2006.10.2434","article-title":"Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma","volume":"25","author":"Olsen","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jad.2018.02.047_bib27","first-page":"5954","article-title":"Predicting lung cancer by detecting aberrant promoter methylation in sputum","volume":"60","author":"Palmisano","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.jad.2018.02.047_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/biomet\/70.1.41","article-title":"The central role of the propensity score in observational studies for causal effects","volume":"70","author":"Rosenbaum","year":"1983","journal-title":"Biometrika"},{"key":"10.1016\/j.jad.2018.02.047_bib29","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1371\/journal.pgen.0030157","article-title":"Comparing the DNA hypermethylome with gene mutations in human colorectal cancer","volume":"3","author":"Schuebel","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jad.2018.02.047_bib30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/carcin\/bgp220","article-title":"Epigenetics in cancer","volume":"31","author":"Sharma","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jad.2018.02.047_bib31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1600-0404.2011.01607.x","article-title":"Cancer risk in people with epilepsy using valproate sodium","volume":"125","author":"Singh","year":"2012","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.jad.2018.02.047_bib32","doi-asserted-by":"crossref","first-page":"739461","DOI":"10.1155\/2012\/739461","article-title":"Epigenetic dysregulation in laryngeal squamous cell carcinoma","volume":"2012","author":"Wong","year":"2012","journal-title":"J. Oncol."},{"key":"10.1016\/j.jad.2018.02.047_bib33","series-title":"International Statistical Classification of Diseases and Related Health Problem (ICD-9)","author":"World Health Organization","year":"1978"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032717322061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032717322061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T05:05:05Z","timestamp":1547701505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032717322061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":33,"alternative-id":["S0165032717322061"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2018.02.047","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term use of valproic acid and the prevalence of cancers in bipolar disorder patients in a Taiwanese population: An association analysis using the National Health Insurance Research Database (NHIRD)","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2018.02.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}