{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:59:38Z","timestamp":1793937578190,"version":"4.8.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.jad.2018.02.082","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T13:36:54Z","timestamp":1519738614000},"page":"139-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder"],"prefix":"10.1016","volume":"234","author":[{"given":"Christina","family":"Boeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"B\u00fcrkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Vanhooren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Libert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Salinas-Manrique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef E.","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris-Tatjana","family":"Kolassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Karabatsiakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2018.02.082_bib1","unstructured":"American Psychiatric Association, 2000. Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.). Washington, DC."},{"issue":"3","key":"10.1016\/j.jad.2018.02.082_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/00949659908811936","article-title":"An empirical comparison of permutation methods for tests of partial regression coefficients in a linear model","volume":"62","author":"Anderson","year":"1999","journal-title":"J. Stat. Comput. Simul."},{"issue":"10","key":"10.1016\/j.jad.2018.02.082_bib3","doi-asserted-by":"crossref","first-page":"e46423","DOI":"10.1371\/journal.pone.0046423","article-title":"Novel statistical approaches for non-normal censored immunological data: analysis of cytokine and gene expression data","volume":"7","author":"Ballenberger","year":"2012","journal-title":"PLOS One"},{"issue":"3, 4","key":"10.1016\/j.jad.2018.02.082_bib4","first-page":"145","article-title":"Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma","volume":"10","author":"Bartling","year":"2011","journal-title":"Cancer Biomark."},{"issue":"1","key":"10.1016\/j.jad.2018.02.082_bib5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/1741-7015-11-200","article-title":"So depression is an inflammatory disease, but where does the inflammation come from?","volume":"11","author":"Berk","year":"2013","journal-title":"BMC Med."},{"issue":"2","key":"10.1016\/j.jad.2018.02.082_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/glycob\/cwj048","article-title":"A focused microarray approach to functional glycomics: transcriptional regulation of the glycome","volume":"16","author":"Comelli","year":"2006","journal-title":"Glycobiology"},{"key":"10.1016\/j.jad.2018.02.082_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-med-061212-171507","article-title":"Depression as a risk factor for cancer: from pathophysiological advances to treatment implications","volume":"65","author":"Currier","year":"2014","journal-title":"Annu. Rev. Med."},{"issue":"2","key":"10.1016\/j.jad.2018.02.082_bib8","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.arr.2012.02.002","article-title":"N-glycomic biomarkers of biological aging and longevity: a link with inflammaging","volume":"12","author":"Dall\u2019Olio","year":"2013","journal-title":"Ageing Res. Rev."},{"issue":"12","key":"10.1016\/j.jad.2018.02.082_bib9","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1001\/archpediatrics.2009.214","article-title":"Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers","volume":"163","author":"Danese","year":"2009","journal-title":"Arch. Pediatr. Adolesc. Med."},{"issue":"1","key":"10.1016\/j.jad.2018.02.082_bib10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/j.2051-5545.2011.tb00014.x","article-title":"Physical illness in patients with severe mental disordesr. I. Prevalence, impact of medications and disparities in health care","volume":"10","author":"De Hert","year":"2011","journal-title":"World Psychiatry"},{"key":"10.1016\/j.jad.2018.02.082_bib11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2458-9-14","article-title":"Depression and body mass index, a u-shaped association","volume":"9","author":"De Wit","year":"2009","journal-title":"BMC Public Health"},{"issue":"2","key":"10.1016\/j.jad.2018.02.082_bib12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.chc.2014.01.002","article-title":"The biological effects of childhood trauma","volume":"23","author":"DeBellis","year":"2014","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"issue":"5","key":"10.1016\/j.jad.2018.02.082_bib13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1373\/clinchem.2009.139295","article-title":"Diagnostic value of the hemopexin N-glycan profile in hepatocellular carcinoma patients","volume":"56","author":"Debruyne","year":"2010","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.jad.2018.02.082_bib14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/YCO.0b013e328315a561","article-title":"Inflammatory markers in depression","volume":"22","author":"Dinan","year":"2009","journal-title":"Curr. Opin. Psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2018.02.082_bib15","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/ageing\/afr084","article-title":"Human serum N-glycan profiles are age and sex dependent","volume":"40","author":"Ding","year":"2011","journal-title":"Age Ageing"},{"issue":"1","key":"10.1016\/j.jad.2018.02.082_bib16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/ijc.25030","article-title":"N-glycan based models improve diagnostic efficacies in hepatitis B virus-related hepatocellular carcinoma","volume":"127","author":"Fang","year":"2010","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.jad.2018.02.082_bib17","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1080\/07350015.1983.10509354","article-title":"A nonstochastic interpretation of reported significance levels","volume":"1","author":"Freedman","year":"1983","journal-title":"J. Bus. Econ. Stat."},{"key":"10.1016\/j.jad.2018.02.082_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.pnpbp.2017.03.016","article-title":"The anti-inflammatory mechanism of antidepressant \u2013 SSRIs, SNRIs","volume":"80","author":"Galecki","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"4\u20135","key":"10.1016\/j.jad.2018.02.082_bib19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1155\/2008\/493289","article-title":"Glycosylation of serum proteins in inflammatory diseases","volume":"25","author":"Gornik","year":"2008","journal-title":"Dis. Markers"},{"key":"10.1016\/j.jad.2018.02.082_bib20","series-title":"BDI-II. Beck Depressions Inventar Revision\u2014Manual","author":"Hautzinger","year":"2006"},{"key":"10.1016\/j.jad.2018.02.082_bib21","unstructured":"Henningsen A., 2017. censReg: Censored Regression (Tobit) Models. R package version 0.5. \u3008http:\/\/CRAN.R-Project.org\/package=censReg\u3009."},{"issue":"1","key":"10.1016\/j.jad.2018.02.082_bib22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bbagen.2005.03.012","article-title":"Glycosylation of site-specific glycans of alpha1-acid glycoprotein and alterations in acute and chronic inflammation","volume":"1725","author":"Higai","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jad.2018.02.082_bib23","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/glycob\/cwq051","article-title":"Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans","volume":"20","author":"Kne\u017eevi\u0107","year":"2010","journal-title":"Glycobiology"},{"key":"10.1016\/j.jad.2018.02.082_bib24","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1001\/jama.284.20.2606","article-title":"Smoking and mental illness. A population-based prevalence study","volume":"284","author":"Lasser","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2018.02.082_bib25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fgene.2014.00145","article-title":"Glycans \u2013 the third revolution in evolution","volume":"5","author":"Lauc","year":"2014","journal-title":"Front Genet."},{"issue":"5","key":"10.1016\/j.jad.2018.02.082_bib26","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/hep.21855","article-title":"N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus","volume":"46","author":"Liu","year":"2007","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.jad.2018.02.082_bib27","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2018.02.082_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1037\/0021-843X.110.1.40","article-title":"Misunderstanding analysis of covariance","volume":"110","author":"Miller","year":"2001","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.jad.2018.02.082_bib29","doi-asserted-by":"crossref","first-page":"e320","DOI":"10.1038\/tp.2013.93","article-title":"N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder","volume":"3","author":"Moreno-Villanueva","year":"2013","journal-title":"Transl. Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2018.02.082_bib30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1192\/bjp.bp.115.180752","article-title":"Childhood maltreatment and characteristics of adult depression: a meta-analysis","volume":"210","author":"Nelson","year":"2017","journal-title":"Br. J. Psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2018.02.082_bib31","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.neuron.2016.01.019","article-title":"Paradise lost: the neurobiological and clinical consequences of child abuse and neglect","volume":"89","author":"Nemeroff","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2018.02.082_bib32","unstructured":"R Development Core Team, 2016. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL \u3008https:\/\/www.R-project.org\/\u3009."},{"issue":"7","key":"10.1016\/j.jad.2018.02.082_bib33","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/pon.1292","article-title":"Cancer, mental disorders, suicidal ideation and attempts in a large community sample","volume":"17","author":"Rasic","year":"2008","journal-title":"Psycho\u2010Oncology"},{"issue":"10","key":"10.1016\/j.jad.2018.02.082_bib34","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S1470-2045(04)01597-9","article-title":"Stress, depression, the immune system, and cancer","volume":"5","author":"Reiche","year":"2004","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.jad.2018.02.082_bib35","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1601-183X.2007.00358.x","article-title":"Beta N-acetylglucosaminyltransferase V (Mgat5) deficiency reduces the depression-like phenotype in mice","volume":"7","author":"Soleimani","year":"2008","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.jad.2018.02.082_bib36","first-page":"75","article-title":"Das essener trauma-inventar (ETI) \u2013 ein screeninginstrument zur identifikation traumatischer ereignisse und posttraumatischer st\u00f6rungen","volume":"1","author":"Tagay","year":"2007","journal-title":"Psychother. Psychosom. Med. Psychol."},{"issue":"3","key":"10.1016\/j.jad.2018.02.082_bib37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.bbi.2011.12.011","article-title":"A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia","volume":"26","author":"Tynan","year":"2012","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.jad.2018.02.082_bib38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s10522-008-9140-z","article-title":"N-Glycan profiling in the study of human aging","volume":"9","author":"Vanhooren","year":"2008","journal-title":"Biogerontology"},{"issue":"10","key":"10.1016\/j.jad.2018.02.082_bib39","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.exger.2010.08.009","article-title":"Serum N-glycan profile shift during human ageing","volume":"45","author":"Vanhooren","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.jad.2018.02.082_bib40","series-title":"Essentials of Glycobiology","year":"2009"},{"issue":"4","key":"10.1016\/j.jad.2018.02.082_bib41","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/da.20686","article-title":"Depression gets old fast: do stress and depression accelerate cell aging?","volume":"27","author":"Wolkowitz","year":"2010","journal-title":"Depress. Anxiety."},{"key":"10.1016\/j.jad.2018.02.082_bib42","unstructured":"World Health Organization, 2017. Depression, Fact Sheet N\u00b0369. Available at: \u3008http:\/\/www.who.int\/mediacentre\/factsheets\/fs369\/en\/index.html\u3009."},{"key":"10.1016\/j.jad.2018.02.082_bib43","doi-asserted-by":"crossref","unstructured":"World Medical Association, 2013. Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. JAMA. 310(20), 2191\u20132194.","DOI":"10.1001\/jama.2013.281053"},{"issue":"3","key":"10.1016\/j.jad.2018.02.082_bib44","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/cncr.26342","article-title":"Identification and assessment of new biomarkers for colorectal cancer with serum N-glycan profiling","volume":"118","author":"Zhao","year":"2012","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.jad.2018.02.082_bib45","doi-asserted-by":"crossref","first-page":"e94536","DOI":"10.1371\/journal.pone.0094536","article-title":"Decreased core-fucosylation contributes to malignancy in gastric cancer","volume":"9","author":"Zhao","year":"2014","journal-title":"PloS One"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032717321730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032717321730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T12:31:03Z","timestamp":1719837063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032717321730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":45,"alternative-id":["S0165032717321730"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2018.02.082","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2018.02.082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}