{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:33:04Z","timestamp":1791221584010,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Chinese Academy of Sciences","award":["Y229461211"],"award-info":[{"award-number":["Y229461211"]}]},{"name":"Applied Basic Research Programs of Qinghai Province"},{"name":"Science and Technology Plan Projects in Xinjiang Science","award":["2014AB043"],"award-info":[{"award-number":["2014AB043"]}]},{"name":"Technology Plan Projects in Qinghai Province","award":["2015-ZJ-733"],"award-info":[{"award-number":["2015-ZJ-733"]}]},{"name":"Jiangsu Province","award":["BY2016078-02"],"award-info":[{"award-number":["BY2016078-02"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603216"],"award-info":[{"award-number":["81603216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The National Natural Science Foundation of China","award":["81603216"],"award-info":[{"award-number":["81603216"]}]},{"name":"One Hundred Person Project of The Chinese Academy of Sciences, Applied Basic Research Programs of Qinghai Province","award":["Y229461211"],"award-info":[{"award-number":["Y229461211"]}]},{"name":"Science and Technology Plan Projects in Xinjiang Science","award":["2014AB043"],"award-info":[{"award-number":["2014AB043"]}]},{"name":"Technology Plan Projects in Qinghai Province","award":["2015-ZJ-733"],"award-info":[{"award-number":["2015-ZJ-733"]}]},{"name":"Prospective joint research project of Jiangsu Province","award":["BY2016078-02"],"award-info":[{"award-number":["BY2016078-02"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jad.2018.09.022","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T22:26:45Z","timestamp":1536618405000},"page":"83-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Simvastatin therapy in adolescent mice attenuates HFD-induced depression-like behavior by reducing hippocampal neuroinflammation"],"prefix":"10.1016","volume":"243","author":[{"given":"Huali","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-8069","authenticated-orcid":false,"given":"Praveen Kumar","family":"Kalavagunta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongzhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxuan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjiang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2018.09.022_bib0001","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.psyneuen.2010.09.004","article-title":"A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression","volume":"36","author":"Abildgaard","year":"2011","journal-title":"Psychoneuroendocrinol."},{"key":"10.1016\/j.jad.2018.09.022_bib0002","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1177\/0748233710397418","article-title":"Hippocampal neuron number loss in rats exposed to ingested sulfite","volume":"27","author":"Akdogan","year":"2011","journal-title":"Toxicol. Industr. Health"},{"key":"10.1016\/j.jad.2018.09.022_bib0003","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbi.2014.03.012","article-title":"Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: Focus on brain indoleamine 2,3-dioxygenase activation","volume":"41","author":"Andre","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jad.2018.09.022_bib0004","doi-asserted-by":"crossref","first-page":"448","DOI":"10.4088\/JCP.v62n0608","article-title":"Patients with severe depression may benefit from buspirone augmentation of selective serotonin reuptake inhibitors: Results from a placebo-controlled, randomized, double-blind, placebo wash-in study","volume":"62","author":"Appelberg","year":"2001","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2018.09.022_bib0005","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1002\/hipo.22032","article-title":"Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice","volume":"22","author":"Boitard","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.jad.2018.09.022_bib0006","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0306-4522(98)00401-1","article-title":"Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: Electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy","volume":"89","author":"Bouilleret","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.jad.2018.09.022_bib0007","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/FBP.0b013e328356c3f2","article-title":"The effect of simvastatin treatment on behavioral parameters, cognitive performance, and hippocampal morphology in rats fed a standard or a high-fat diet","volume":"23","author":"Can","year":"2012","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.jad.2018.09.022_bib0008","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.neuropharm.2016.03.028","article-title":"Simvastatin enhances NMDA receptor GluN2B expression and phosphorylation of GluN2B and GluN2A through increased histone acetylation and Src signaling in hippocampal CA1 neurons","volume":"107","author":"Chen","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jad.2018.09.022_bib0009","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1096\/fj.04-2204com","article-title":"Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects","volume":"18","author":"Clement","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.jad.2018.09.022_bib0010","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1381\/096089204323093345","article-title":"The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: Implications and effects of weight loss","volume":"14","author":"Cottam","year":"2004","journal-title":"Obesity Surgery"},{"key":"10.1016\/j.jad.2018.09.022_bib0011","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0165-6147(02)02017-5","article-title":"Assessing antidepressant activity in rodents: Recent developments and future needs","volume":"23","author":"Cryan","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jad.2018.09.022_bib0012","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainresbull.2013.01.005","article-title":"Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice","volume":"95","author":"Cunha","year":"2013","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jad.2018.09.022_bib0013","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1017\/S0007114511006738","article-title":"Effects of a high-fat diet and bamboo extract supplement on anxiety- and depression-like neurobehaviours in mice","volume":"108","author":"Del Rosario","year":"2012","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.jad.2018.09.022_bib0014","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1139\/cjpp-2014-0560","article-title":"Antidepressant-like effect of simvastatin in diabetic rats","volume":"93","author":"ElBatsh","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.jad.2018.09.022_bib0015","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fneur.2018.00167","article-title":"Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder","volume":"9","author":"Ellul","year":"2018","journal-title":"Front Neurol."},{"key":"10.1016\/j.jad.2018.09.022_bib0016","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3389\/fnhum.2016.00370","article-title":"Brain-derived Neurotrophic Factor (Val66Met) and Serotonin Transporter (5-HTTLPR) Polymorphisms modulate plasticity in inhibitory control performance over time but independent of inhibitory control training","volume":"10","author":"Enge","year":"2016","journal-title":"Front. Hum Neurosci."},{"key":"10.1016\/j.jad.2018.09.022_bib0017","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1523\/JNEUROSCI.4200-13.2014","article-title":"Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity","volume":"34","author":"Erion","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2018.09.022_bib0018","first-page":"1","article-title":"Trends in intake of energy and macronutrients in children and adolescents from 1999-2000 through 2009-2010","volume":"113","author":"Ervin","year":"2013","journal-title":"NCHS Data Brief"},{"key":"10.1016\/j.jad.2018.09.022_bib0019","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bpg.2013.03.007","article-title":"Diabetes, obesity and gut microbiota","volume":"27","author":"Everard","year":"2013","journal-title":"Best Practice Res."},{"key":"10.1016\/j.jad.2018.09.022_bib0020","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.neuroscience.2011.06.072","article-title":"High-fat diet selectively protects against the effects of chronic social stress in the mouse","volume":"192","author":"Finger","year":"2011","journal-title":"Neurosci."},{"key":"10.1016\/j.jad.2018.09.022_bib0021","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jneuroim.2015.08.011","article-title":"Behavioral and systemic consequences of long-term inflammatory challenge","volume":"288","author":"Fischer","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jad.2018.09.022_bib0022","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.appet.2012.12.018","article-title":"The longer-term impacts of Western diet on human cognition and the brain","volume":"63","author":"Francis","year":"2013","journal-title":"Appetite"},{"key":"10.1016\/j.jad.2018.09.022_bib0023","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.yfrne.2008.10.001","article-title":"Interleukin-1 (IL-1): A central regulator of stress responses","volume":"30","author":"Goshen","year":"2009","journal-title":"Front Neuroendocrinol."},{"key":"10.1016\/j.jad.2018.09.022_bib0024","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neulet.2010.09.007","article-title":"Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF","volume":"487","author":"Han","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jad.2018.09.022_bib0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/ana.20875","article-title":"Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: Relevance to multiple sclerosis","volume":"60","author":"Ifergan","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jad.2018.09.022_bib0026","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1096\/fj.201700984RR","article-title":"Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity","volume":"32","author":"Jena","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.jad.2018.09.022_bib0027","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1161\/STROKEAHA.108.544395","article-title":"Simvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhage","volume":"40","author":"Karki","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jad.2018.09.022_bib0028","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/386493a0","article-title":"More hippocampal neurons in adult mice living in an enriched environment","volume":"386","author":"Kempermann","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jad.2018.09.022_bib0029","first-page":"39","article-title":"Acute antidepressant and anxiolytic effects of simvastatin and its mechanisms in rats","volume":"17","author":"Kilic","year":"2012","journal-title":"Neurosciences (Riyadh)"},{"key":"10.1016\/j.jad.2018.09.022_bib0030","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0166-2236(00)02088-9","article-title":"Cytokine-induced sickness behaviour: Mechanisms and implications","volume":"25","author":"Konsman","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jad.2018.09.022_bib0031","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.physbeh.2016.02.007","article-title":"Time-dependent behavioral, neurochemical, and metabolic dysregulation in female C57BL\/6 mice caused by chronic high-fat diet intake","volume":"157","author":"Krishna","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jad.2018.09.022_bib0032","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1038\/oby.2011.73","article-title":"Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents","volume":"19","author":"Lavin","year":"2011","journal-title":"Obesity"},{"key":"10.1016\/j.jad.2018.09.022_bib0033","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1212\/01.wnl.0000277657.95487.1c","article-title":"Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease","volume":"69","author":"Li","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2018.09.022_bib0034","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s12028-016-0290-6","article-title":"Simvastatin therapy in the acute stage of traumatic brain injury attenuates brain trauma-induced depression-like behavior in rats by reducing Neuroinflammation in the hippocampus","volume":"26","author":"Lim","year":"2017","journal-title":"Neurocrit. Care"},{"key":"10.1016\/j.jad.2018.09.022_bib0035","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.pbb.2014.06.006","article-title":"Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress","volume":"124","author":"Lin","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jad.2018.09.022_bib0036","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nrn1867","article-title":"Adult neurogenesis and functional plasticity in neuronal circuits","volume":"7","author":"Lledo","year":"2006","journal-title":"Nature Rev. Neurosci."},{"key":"10.1016\/j.jad.2018.09.022_bib0037","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1089\/neu.2007.0288","article-title":"Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury","volume":"24","author":"Lu","year":"2007","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.jad.2018.09.022_bib0038","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/archgenpsychiatry.2010.2","article-title":"Overweight, obesity, and depression: A systematic review and meta-analysis of longitudinal studies","volume":"67","author":"Luppino","year":"2010","journal-title":"Arch. General Psychiatry"},{"key":"10.1016\/j.jad.2018.09.022_bib0039","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbi.2013.09.011","article-title":"The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats","volume":"36","author":"Maric","year":"2014","journal-title":"Brain, Behav. Immun."},{"key":"10.1016\/j.jad.2018.09.022_bib0040","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1523\/JNEUROSCI.2760-08.2009","article-title":"Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity","volume":"29","author":"Milanski","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2018.09.022_bib0041","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neuroscience.2003.09.020","article-title":"Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor","volume":"123","author":"Molteni","year":"2004","journal-title":"Neurosci."},{"key":"10.1016\/j.jad.2018.09.022_bib0042","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(06)69472-5","article-title":"Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): A prospective randomised controlled trial","volume":"368","author":"Nakamura","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2018.09.022_bib0043","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1248\/yakushi.127.1125","article-title":"Reversal of memory deficits by Atorvastatin and Simvastatin in rats","volume":"127","author":"Parle","year":"2007","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.jad.2018.09.022_bib0044","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0304-3940(02)00369-5","article-title":"Ethanol-induced neurotoxicity is counterbalanced by increased cell proliferation in mouse dentate gyrus","volume":"327","author":"Pawlak","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jad.2018.09.022_bib0045","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3171\/jns.2005.103.4.0695","article-title":"Effect of atorvastatin on spatial memory, neuronal survival, and vascular density in female rats after traumatic brain injury","volume":"103","author":"Qu","year":"2005","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.jad.2018.09.022_bib0046","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0149-7634(00)00048-8","article-title":"The immune system and memory consolidation: A role for the cytokine IL-1beta","volume":"25","author":"Rachal Pugh","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2018.09.022_bib0047","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2174\/157015912800604533","article-title":"Somatic drugs for psychiatric diseases: Aspirin or simvastatin for depression?","volume":"10","author":"Rahola","year":"2012","journal-title":"Current Neuropharmacol."},{"key":"10.1016\/j.jad.2018.09.022_bib0048","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/mp.2009.116","article-title":"CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: Relationship to CNS immune responses and depression","volume":"15","author":"Raison","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2018.09.022_bib0049","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nature06471","article-title":"Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease","volume":"451","author":"Romani","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jad.2018.09.022_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399406000068","article-title":"Tryptophan metabolism in the central nervous system: Medical implications","volume":"8","author":"Ruddick","year":"2006","journal-title":"Expert Mol.Med."},{"key":"10.1016\/j.jad.2018.09.022_bib0051","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.tibs.2006.04.003","article-title":"Ribosomal protein S6 phosphorylation: From protein synthesis to cell size","volume":"31","author":"Ruvinsky","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jad.2018.09.022_bib0052","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/ijo.2012.48","article-title":"Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry","volume":"37","author":"Sharma","year":"2013","journal-title":"Int. J. Obesity"},{"key":"10.1016\/j.jad.2018.09.022_bib0053","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1523\/JNEUROSCI.22-08-03251.2002","article-title":"Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression","volume":"22","author":"Shirayama","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2018.09.022_bib0054","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"Spear","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2018.09.022_bib0055","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1111\/j.1742-4658.2012.08487.x","article-title":"Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection","volume":"279","author":"Stone","year":"2012","journal-title":"Febs. J."},{"key":"10.1016\/j.jad.2018.09.022_bib0056","first-page":"65","article-title":"Comparison of lipid profiles in relation to APOB EcoRI polymorphism in obese children with hyperlipidemia","volume":"24","author":"Timirci","year":"2010","journal-title":"In Vivo"},{"key":"10.1016\/j.jad.2018.09.022_bib0057","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nlm.2010.11.007","article-title":"High-fat diets impair spatial learning in the radial-arm maze in mice","volume":"95","author":"Valladolid-Acebes","year":"2011","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.jad.2018.09.022_bib0058","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1001\/archneur.60.4.510","article-title":"Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease","volume":"60","author":"Vega","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jad.2018.09.022_bib0059","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/sj.mp.4000813","article-title":"Cytokine signals propagate through the brain","volume":"5","author":"Vitkovic","year":"2000","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2018.09.022_bib0060","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.expneurol.2007.03.031","article-title":"Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury","volume":"206","author":"Wang","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jad.2018.09.022_bib0061","first-page":"017","article-title":"Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL\/6 mice","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2018.09.022_bib0062","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.expneurol.2008.11.016","article-title":"High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: The association with the up-regulation of NMDA receptor binding in the rat brain","volume":"216","author":"Wang","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jad.2018.09.022_bib0063","first-page":"017","article-title":"Normal diet Vs High fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice","volume":"3","author":"Wu","year":"2017","journal-title":"Metab. Brain. Dis."},{"key":"10.1016\/j.jad.2018.09.022_bib0064","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11011-017-0140-z","article-title":"Normal diet Vs High fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice","volume":"33","author":"Wu","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jad.2018.09.022_bib0065","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1089\/neu.2007.0369","article-title":"Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K\/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury","volume":"25","author":"Wu","year":"2008","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.jad.2018.09.022_bib0066","first-page":"528","article-title":"[Effect of Manual Acupuncture Intervention on Levels of 5-HTT, 5-HT1AR, NEalpha2R of Brain Tissues in Rats with Post-stroke Depression]","volume":"41","author":"Xiao","year":"2016","journal-title":"Zhen Ci Yan Jiu"},{"key":"10.1016\/j.jad.2018.09.022_bib0067","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1046\/j.1440-1819.2003.01099.x","article-title":"Clinical efficacy of tandospirone augmentation in patients with major depressive disorder: A randomized controlled trial","volume":"57","author":"Yamada","year":"2003","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2018.09.022_bib0068","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1210\/en.2011-0004","article-title":"Impaired CNS leptin action is implicated in depression associated with obesity","volume":"152","author":"Yamada","year":"2011","journal-title":"Endocrinol."},{"key":"10.1016\/j.jad.2018.09.022_bib0069","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0735-1097(03)00785-X","article-title":"Long-term statin use and psychological well-being","volume":"42","author":"Young-Xu","year":"2003","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503271830288X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503271830288X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T06:46:22Z","timestamp":1569221182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503271830288X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":69,"alternative-id":["S016503271830288X"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2018.09.022","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simvastatin therapy in adolescent mice attenuates HFD-induced depression-like behavior by reducing hippocampal neuroinflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2018.09.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}