{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:21:05Z","timestamp":1792153265223,"version":"4.4.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H04253"],"award-info":[{"award-number":["17H04253"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.jad.2018.11.011","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T11:45:04Z","timestamp":1541418304000},"page":"377-385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":140,"special_numbering":"C","title":["Effect of bifidobacterium breve A-1 on anxiety and depressive symptoms in schizophrenia: A proof-of-concept study"],"prefix":"10.1016","volume":"245","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1254-1926","authenticated-orcid":false,"given":"Ryo","family":"Okubo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minori","family":"Koga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Katsumata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Odamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiina","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8782-8331","authenticated-orcid":false,"given":"Matsuhiko","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0700-6600","authenticated-orcid":false,"given":"Hisashi","family":"Narita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-5070","authenticated-orcid":false,"given":"Ichiro","family":"Kusumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8690-8129","authenticated-orcid":false,"given":"Yutaka J.","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2018.11.011_bib0001","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jad.2016.05.038","article-title":"Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder","volume":"202","author":"Aizawa","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.11.011_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1875036201307010001","article-title":"Comparison of sequencing utility programs","volume":"7","author":"Aronesty","year":"2013","journal-title":"Open Bioinf."},{"key":"10.1016\/j.jad.2018.11.011_bib0003","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jad.2018.11.011_bib0004","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Benjamini","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2018.11.011_bib0005","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/schbul\/sbn135","article-title":"Psychiatric comorbidities and schizophrenia","volume":"35","author":"Buckley","year":"2009","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jad.2018.11.011_bib0006","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jad.2018.11.011_bib0007","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.schres.2011.05.018","article-title":"Efficacy of iloperidone in schizophrenia: a PANSS five-factor analysis","volume":"131","author":"Citrome","year":"2011","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jad.2018.11.011_bib0008","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00127-016-1333-1","article-title":"Consumption of low-fat dairy, but not whole-fat dairy, is inversely associated with depressive symptoms in Japanese adults","volume":"52","author":"Cui","year":"2017","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"10.1016\/j.jad.2018.11.011_bib0009","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbi.2016.12.010","article-title":"The microbiome, immunity, and schizophrenia and bipolar disorder","volume":"62","author":"Dickerson","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2018.11.011_bib0010","article-title":"Effect of probiotic supplementation on schizophrenia symptoms and association with gastrointestinal functioning: a randomized, placebo-controlled trial","volume":"16","author":"Dickerson","year":"2014","journal-title":"Prim. Care Companion CNS Disord."},{"key":"10.1016\/j.jad.2018.11.011_bib0011","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/mp.2014.93","article-title":"Genomics of schizophrenia: time to consider the gut microbiome?","volume":"19","author":"Dinan","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2018.11.011_bib0012","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","article-title":"UCHIME improves sensitivity and speed of chimera detection","volume":"27","author":"Edgar","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jad.2018.11.011_bib0013","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/phar.1890","article-title":"Interaction between atypical antipsychotics and the gut microbiome in a bipolar disease cohort","volume":"37","author":"Flowers","year":"2017","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jad.2018.11.011_bib0014","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/npp.2011.205","article-title":"Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior","volume":"37","author":"Haroon","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2018.11.011_bib0015","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.eurpsy.2018.05.011","article-title":"Gut microbiome and magnetic resonance spectroscopy study of subjects at ultra-high risk for psychosis may support the membrane hypothesis","volume":"53","author":"He","year":"2018","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2018.11.011_bib0016","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","article-title":"Altered fecal microbiota composition in patients with major depressive disorder","volume":"48","author":"Jiang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2018.11.011_bib0017","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF01064966","article-title":"Positive-negative symptom assessment in schizophrenia: psychometric issues and scale comparison","volume":"61","author":"Kay","year":"1990","journal-title":"Psychiatr. Q."},{"key":"10.1016\/j.jad.2018.11.011_bib0018","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/dnares\/dst006","article-title":"Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing","volume":"20","author":"Kim","year":"2013","journal-title":"DNA Res."},{"key":"10.1016\/j.jad.2018.11.011_bib0019","doi-asserted-by":"crossref","first-page":"13510","DOI":"10.1038\/s41598-017-13368-2","article-title":"Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer's disease","volume":"7","author":"Kobayashi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2018.11.011_bib0020","doi-asserted-by":"crossref","unstructured":"Kuczynski, J., Stombaugh, J., Walters, W.A., Gonzalez, A., Caporaso, J.G., Knight, R., 2012. Using QIIME to analyze 16S rRNA gene sequences from microbial communities. Current protocols in microbiology Chapter 1, Unit 1E 5.","DOI":"10.1002\/9780471729259.mc01e05s27"},{"key":"10.1016\/j.jad.2018.11.011_bib0021","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/jjco\/28.5.333","article-title":"Screening for psychological distress in Japanese cancer patients","volume":"28","author":"Kugaya","year":"1998","journal-title":"Jpn. J. Clin. Oncol."},{"key":"10.1016\/j.jad.2018.11.011_bib0022","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jad.2018.04.038","article-title":"The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study","volume":"235","author":"Kurokawa","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.11.011_bib0023","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jad.2017.05.029","article-title":"Antibiotics and mania: A systematic review","volume":"219","author":"Lambrichts","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.11.011_bib0024","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jad.2018.11.011_bib0025","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jad.2016.09.051","article-title":"Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder","volume":"207","author":"Lin","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.11.011_bib0026","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jad.2016.09.012","article-title":"Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness","volume":"208","author":"Macedo","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.11.011_bib0027","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jad.2012.02.023","article-title":"Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut","volume":"141","author":"Maes","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.11.011_bib0028","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn3071","article-title":"Gut feelings: the emerging biology of gut-brain communication","volume":"12","author":"Mayer","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2018.11.011_bib0029","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ismej.2011.139","article-title":"An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea","volume":"6","author":"McDonald","year":"2012","journal-title":"ISME J."},{"key":"10.1016\/j.jad.2018.11.011_bib0030","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1017\/S0007114510004319","article-title":"Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects","volume":"105","author":"Messaoudi","year":"2011","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.jad.2018.11.011_bib0031","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","article-title":"Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects","volume":"70","author":"Miller","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2018.11.011_bib0032","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/1471-0528.12972","article-title":"Intake of dairy products and calcium and prevalence of depressive symptoms during pregnancy in Japan: a cross-sectional study","volume":"122","author":"Miyake","year":"2015","journal-title":"BJOG"},{"key":"10.1016\/j.jad.2018.11.011_bib0033","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/00332747.1997.11024808","article-title":"Affect recognition in schizophrenia: a synthesis of findings across three studies","volume":"60","author":"Mueser","year":"1997","journal-title":"Psychiatry"},{"key":"10.1016\/j.jad.2018.11.011_bib0034","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pnpbp.2012.10.022","article-title":"The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia","volume":"48","author":"Na","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2018.11.011_bib0035","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/ni.3732","article-title":"Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota","volume":"18","author":"Nagashima","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jad.2018.11.011_bib0036","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jad.2017.11.063","article-title":"A meta-analysis of the use of probiotics to alleviate depressive symptoms","volume":"228","author":"Ng","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.11.011_bib0037","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jpsychires.2018.01.013","article-title":"Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder","volume":"99","author":"Nguyen","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2018.11.011_bib0038","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jtcme.2015.07.003","article-title":"Effects of yogurt containing Lactobacillus plantarum HOKKAIDO on immune function and stress markers","volume":"6","author":"Nishimura","year":"2016","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.jad.2018.11.011_bib0039","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12866-016-0708-5","article-title":"Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study","volume":"16","author":"Odamaki","year":"2016","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.jad.2018.11.011_bib0040","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.plefa.2018.03.006","article-title":"Mechanisms underlying the effects of n-3 polyunsaturated fatty acids on fear memory processing and their hypothetical effects on fear of cancer recurrence in cancer survivors","volume":"131","author":"Okubo","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.jad.2018.11.011_bib0041","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jad.2014.04.059","article-title":"Association between toll-like receptor 2 gene diversity and early-onset bipolar disorder","volume":"165","author":"Oliveira","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.11.011_bib0042","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/geronj\/39.2.187","article-title":"The Brief Psychiatric Rating-Scale (Bprs) in Geropsychiatric Research .1. Factor Structure Inpatient Unit","volume":"39","author":"Overall","year":"1984","journal-title":"J. Gerontol."},{"key":"10.1016\/j.jad.2018.11.011_bib0043","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.3945\/jn.116.233858","article-title":"Intake of high-fat yogurt, but not of low-fat yogurt or prebiotics, is related to lower risk of depression in women of the sun cohort study","volume":"146","author":"Perez-Cornago","year":"2016","journal-title":"J. Nutr."},{"key":"10.1016\/j.jad.2018.11.011_bib0044","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.nutres.2016.06.009","article-title":"Probiotic supplementation can positively affect anxiety and depressive symptoms: a systematic review of randomized controlled trials","volume":"36","author":"Pirbaglou","year":"2016","journal-title":"Nutr. Res."},{"key":"10.1016\/j.jad.2018.11.011_bib0045","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1017\/S0007114511005630","article-title":"Daily intake of Lactobacillus casei Shirota increases natural killer cell activity in smokers","volume":"108","author":"Reale","year":"2012","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.jad.2018.11.011_bib0046","doi-asserted-by":"crossref","first-page":"e545","DOI":"10.7717\/peerj.545","article-title":"Subsampled open-reference clustering creates consistent, comprehensive OTU definitions and scales to billions of sequences","volume":"2","author":"Rideout","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.jad.2018.11.011_bib0047","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/nutrit\/nuv025","article-title":"Systematic review of evidence to support the theory of psychobiotics","volume":"73","author":"Romijn","year":"2015","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.jad.2018.11.011_bib0048","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbi.2016.11.019","article-title":"Probiotic normalization of Candida albicans in schizophrenia: a randomized, placebo-controlled, longitudinal pilot study","volume":"62","author":"Severance","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2018.11.011_bib0049","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.schres.2014.06.027","article-title":"Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling","volume":"176","author":"Severance","year":"2016","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jad.2018.11.011_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.schres.2018.01.002","article-title":"Analysis of gut microbiota diversity and auxiliary diagnosis as a biomarker in patients with schizophrenia: A cross-sectional study","author":"Shen","year":"2018","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jad.2018.11.011_bib0051","first-page":"534","article-title":"IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis","volume":"118","author":"Sugimoto","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jad.2018.11.011_bib0052","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/nmo.12804","article-title":"Probiotic Lactobacillus casei strain Shirota relieves stress-associated symptoms by modulating the gut-brain interaction in human and animal models","volume":"28","author":"Takada","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.jad.2018.11.011_bib0053","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4137\/BMI.S22007","article-title":"Immunomodulatory effects of probiotic supplementation in schizophrenia patients: a randomized, placebo-controlled trial","volume":"10","author":"Tomasik","year":"2015","journal-title":"Biomarker Insights"},{"key":"10.1016\/j.jad.2018.11.011_bib0054","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2188\/jea.6.45","article-title":"A data-based approach for designing a semiquantitative food frequency questionnaire for a population-based prospective study in Japan","volume":"6","author":"Tsubono","year":"1996","journal-title":"J. Epidemiol."},{"key":"10.1016\/j.jad.2018.11.011_bib0055","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.2188\/jea.13.1sup_2","article-title":"Validity and reproducibility of the self-administered food frequency questionnaire in the JPHC Study Cohort I: study design, conduct and participant profiles","volume":"13","author":"Tsugane","year":"2003","journal-title":"J. Epidemiol."},{"key":"10.1016\/j.jad.2018.11.011_bib0056","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.nut.2013.09.007","article-title":"Probiotic supplementation improves inflammatory status in patients with rheumatoid arthritis","volume":"30","author":"Vaghef-Mehrabany","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.jad.2018.11.011_bib0057","doi-asserted-by":"crossref","first-page":"589","DOI":"10.5056\/jnm16018","article-title":"Effect of probiotics on central nervous system functions in animals and humans: a systematic review","volume":"22","author":"Wang","year":"2016","journal-title":"J. Neurogastroenterol. Motil."},{"key":"10.1016\/j.jad.2018.11.011_bib0058","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jtcme.2015.11.001","article-title":"Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain","volume":"6","author":"Yadav","year":"2016","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.jad.2018.11.011_bib0059","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2008.11.003","article-title":"Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease","volume":"29","author":"Zenewicz","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.jad.2018.11.011_bib0060","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.4049\/jimmunol.1300016","article-title":"IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic","volume":"190","author":"Zenewicz","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.jad.2018.11.011_bib0061","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr. Scand."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032718313600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032718313600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:21:14Z","timestamp":1759022474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032718313600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":61,"alternative-id":["S0165032718313600"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2018.11.011","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of bifidobacterium breve A-1 on anxiety and depressive symptoms in schizophrenia: A proof-of-concept study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2018.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}