{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:55:28Z","timestamp":1793393728064,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.jad.2018.12.030","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T22:03:00Z","timestamp":1545084180000},"page":"659-666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Hypersomnia and Bipolar Disorder: A systematic review and meta-analysis of proportion"],"prefix":"10.1016","volume":"246","author":[{"given":"Ruth B.","family":"Grigolon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisson P.","family":"Trevizol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9219-2534","authenticated-orcid":false,"given":"Raphael O.","family":"Cerqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0629-9456","authenticated-orcid":false,"given":"Yena","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo B.","family":"Mansur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Brietzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2018.12.030_bib0001","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jad.2004.05.004","article-title":"Atypical depression: a variant of bipolar II or a bridge between unipolar and bipolar II?","volume":"84","author":"Akiskal","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.12.030_bib0002","year":"2013"},{"key":"10.1016\/j.jad.2018.12.030_bib0003","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12931-015-0166-x","article-title":"Sleepiness, inflammation and oxidative stress markers in middle-aged males with obstructive sleep apnea without metabolic syndrome: a cross-sectional study","volume":"16","author":"Andaku","year":"2015","journal-title":"Respir. Res."},{"key":"10.1016\/j.jad.2018.12.030_bib0004","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.5665\/sleep.3216","article-title":"The complex associations among sleep quality, anxiety-depression, and quality of life in patients with extreme obesity","volume":"36","author":"Araghi","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.jad.2018.12.030_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11920-017-0763-0","article-title":"Hypersomnolence, hypersomnia, and mood disorders","volume":"19","author":"Barateau","year":"2017","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.jad.2018.12.030_bib0006","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.pnpbp.2005.11.016","article-title":"Symptoms of depression as possible markers of bipolar II disorder","volume":"30","author":"Benazzi","year":"2006","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2018.12.030_bib0007","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0165-1781(00)00121-9","article-title":"Sensitivity and specificity of DSM-IV atypical features for bipolar II disorder diagnosis","volume":"93","author":"Benazzi","year":"2000","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2018.12.030_bib0008","doi-asserted-by":"crossref","first-page":"827","DOI":"10.12740\/PP\/44680","article-title":"Depression with atypical features in various kinds of depression","volume":"50","author":"Buzuk","year":"2016","journal-title":"Psychiatr. Pol."},{"key":"10.1016\/j.jad.2018.12.030_bib0009","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1001\/archpsyc.1985.01790340082012","article-title":"Somatic symptoms in primary affective disorder. Presence and relationship to the classification of depression","volume":"42","author":"Casper","year":"1985","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2018.12.030_bib0010","article-title":"High rates of osteoarthritis develop after anterior cruciate ligament surgery: an analysis of 4108 patients","author":"Cinque","year":"2017","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.jad.2018.12.030_bib0011","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1080\/07420520600920759","article-title":"Hypersomnolence and accidents in truck drivers: a cross-sectional study","volume":"23","author":"de Pinho","year":"2006","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.jad.2018.12.030_bib0012","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1017\/S1461145712000326","article-title":"Use of adjunctive stimulants in adult bipolar depression","volume":"16","author":"Dell'Osso","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2018.12.030_bib0013","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control. Clin. Trials"},{"key":"10.1016\/j.jad.2018.12.030_bib0014","doi-asserted-by":"crossref","unstructured":"Detre, B.Y.T., Kupfer, J., 1972. By t. detre, 1303\u20131305.","DOI":"10.1176\/ajp.128.10.1303"},{"key":"10.1016\/j.jad.2018.12.030_bib0015","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"Br. Med. J."},{"key":"10.1016\/j.jad.2018.12.030_bib0016","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1192\/bjp.bp.107.045294","article-title":"Clinical differences between bipolar and unipolar depression","volume":"192","author":"Forty","year":"2008","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2018.12.030_bib0017","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jad.2011.05.054","article-title":"A predictive model for diagnosing bipolar disorder based on the clinical characteristics of major depressive episodes in Chinese population","volume":"134","author":"Gan","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.12.030_bib0018","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1176\/ps.2006.57.5.660","article-title":"Pharmacological treatment patterns at study entry for the first 500 STEP-BD participants","volume":"57","author":"Ghaemi","year":"2006","journal-title":"Psychiatr. Serv."},{"key":"10.1016\/j.jad.2018.12.030_bib0019","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/0006-3223(86)90319-7","article-title":"Sleep parameters in bipolar I, bipolar II, and unipolar depressions","volume":"21","author":"Giles","year":"1986","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2018.12.030_bib0020","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2147\/NSS.S85754","article-title":"The role of sleep in bipolar disorder","volume":"8","author":"Gold","year":"2016","journal-title":"Nat. Sci. Sleep"},{"key":"10.1016\/j.jad.2018.12.030_bib0021","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1176\/appi.ajp.162.1.50","article-title":"Sleep-related functioning in euthymic patients with bipolar disorder, patients with insomnia, and subjects without sleep problems","volume":"162","author":"Harvey","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2018.12.030_bib0022","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ Br. Med. J."},{"key":"10.1016\/j.jad.2018.12.030_bib0023","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/crj.12276","article-title":"The relationship between excessive daytime sleepiness and metabolic syndrome in severe obstructive sleep apnea syndrome","volume":"10","author":"Huang","year":"2016","journal-title":"Clin. Respir. J."},{"key":"10.1016\/j.jad.2018.12.030_bib0024","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jad.2011.03.013","article-title":"Hypersomnia in inter-episode bipolar disorder: does it have prognostic significance?","volume":"132","author":"Kaplan","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.12.030_bib0025","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.smrv.2008.09.001","article-title":"Hypersomnia across mood disorders: a review and synthesis","volume":"13","author":"Kaplan","year":"2009","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.jad.2018.12.030_bib0026","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1017\/S0033291714002918","article-title":"Hypersomnia types, sleep and relapse in bipolar disorder","volume":"45","author":"Kaplan","year":"2015","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2018.12.030_bib0027","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1136\/eb-2016-102433","article-title":"Hypersomnia: an overlooked, but not overestimated, sleep disturbance in bipolar disorder","volume":"20","author":"Kaplan","year":"2017","journal-title":"Evid. Based. Ment. Health"},{"key":"10.1016\/j.jad.2018.12.030_bib0028","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1017\/S0950268814002829","article-title":"Systematic review and meta-analysis of the proportion of non-typhoidal Salmonella cases that develop chronic sequelae","volume":"143","author":"Keithlin","year":"2015","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.jad.2018.12.030_bib0029","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0165-0327(94)00077-M","article-title":"The reproducibility of depressive and hypomanic symptoms across repeated episodes in patients with rapid-cycling bipolar disorder","volume":"33","author":"Leibenluft","year":"1995","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.12.030_bib0030","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1590\/S1415-790X2013000400007","article-title":"Excessive daytime sleepiness in the elderly: association with cardiovascular risk, obesity and depression","volume":"16","author":"Lopes","year":"2013","journal-title":"Rev. Bras. Epidemiol."},{"key":"10.1016\/j.jad.2018.12.030_bib0031","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/0004867416634208","article-title":"Stimulants for depression: On the up and up?","volume":"50","author":"Malhi","year":"2016","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.jad.2018.12.030_bib0032","first-page":"S31","article-title":"Association of inflammatory markers with cardiovascular risk and sleepiness","volume":"7","author":"Miller","year":"2011","journal-title":"J. Clin. sleep Med. JCSM Off. Publ. Am. Acad. Sleep Med."},{"key":"10.1016\/j.jad.2018.12.030_bib0033","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4088\/JCP.v62n0314a","article-title":"The clinical features of bipolar depression: a comparison with matched major depressive disorder patients","volume":"62","author":"Mitchell","year":"2001","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2018.12.030_bib0034","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3736\/jcim20090918","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement (Chinese edition)","volume":"7","author":"Moher","year":"2009","journal-title":"J. Chinese Integr. Med."},{"key":"10.1016\/j.jad.2018.12.030_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0162306","article-title":"The proportion of regulatory T cells in patients with rheumatoid arthritis: a meta-analysis","volume":"11","author":"Morita","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2018.12.030_bib0036","first-page":"34","article-title":"PSYCHopathological characteristics of bipolar and unipolar depression-potential indicators of bipolarity","volume":"25","author":"Motovsky","year":"2013","journal-title":"Psychiatr. Danub."},{"key":"10.1016\/j.jad.2018.12.030_bib0037","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jsmc.2017.03.007","article-title":"Subjective and objective assessment of hypersomnolence","volume":"12","author":"Murray","year":"2017","journal-title":"Sleep Med. Clin."},{"key":"10.1016\/j.jad.2018.12.030_bib0038","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.smrv.2014.06.006","article-title":"Sleep-wake disturbance in interepisode bipolar disorder and high-risk individuals: A systematic review and meta-analysis","volume":"20","author":"Ng","year":"2015","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.jad.2018.12.030_bib0039","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/2049-3258-72-39","article-title":"Metaprop: a stata command to perform meta-analysis of binomial data","volume":"72","author":"Nyaga","year":"2014","journal-title":"Arch. Public Heal."},{"key":"10.1016\/j.jad.2018.12.030_bib0040","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.sleep.2013.03.002","article-title":"Narcolepsy is complicated by high medical and psychiatric comorbidities: a comparison with the general population","volume":"14","author":"Ohayon","year":"2013","journal-title":"Sleep Med."},{"issue":"June","key":"10.1016\/j.jad.2018.12.030_bib0041","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s40675-015-0017-9","article-title":"Hypersomnia in mood disorders: a rapidly changing landscape","volume":"1","author":"Plante","year":"2015","journal-title":"Curr. Sleep Med. Rep."},{"key":"10.1016\/j.jad.2018.12.030_bib0042","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.jad.2013.05.003","article-title":"Differences between unipolar depression and bipolar II depression in women","volume":"150","author":"Rastelli","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.12.030_bib0043","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/15389588.2012.692493","article-title":"Excessive sleepiness prevalence in public transportation drivers of a developing country","volume":"14","author":"Risco","year":"2013","journal-title":"Traffic Inj. Prev."},{"key":"10.1016\/j.jad.2018.12.030_bib0044","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jad.2004.01.005","article-title":"Bipolar mood disorders among Polish psychiatric outpatients treated for major depression","volume":"84","author":"Rybakowski","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2018.12.030_bib0045","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.jad.2018.12.030_bib0046","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/acps.12523","article-title":"Sleep problems in bipolar disorders: more than just insomnia","volume":"133","author":"Steinan","year":"2016","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2018.12.030_bib0047","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jad.2018.12.030_bib0048","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ccm.2010.02.007","article-title":"Excessive sleepiness","volume":"31","author":"Tsai","year":"2010","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.jad.2018.12.030_bib0049","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s11325-012-0796-x","article-title":"Correlation between sleep parameters, physical activity and quality of life in somnolent moderate to severe obstructive sleep apnea adult patients","volume":"17","author":"Verwimp","year":"2013","journal-title":"Sleep Breath."},{"issue":"Suppl 1","key":"10.1016\/j.jad.2018.12.030_bib0050","first-page":"207","article-title":"Narcolepsy, metabolic syndrome and obstructive sleep apnea syndrome as the causes of hypersomnia in children. report of three cases.","volume":"52","author":"Wasilewska","year":"2007","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.jad.2018.12.030_bib0051","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.wnp.0000190416.62482.42","article-title":"Objective measures of sleepiness and wakefulness: application to the real world?","volume":"23","author":"Wise","year":"2006","journal-title":"J. Clin. Neurophysiol."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032718301745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032718301745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:31:01Z","timestamp":1759023061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032718301745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":51,"alternative-id":["S0165032718301745"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2018.12.030","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypersomnia and Bipolar Disorder: A systematic review and meta-analysis of proportion","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2018.12.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}