{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:23:13Z","timestamp":1777044193093,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Hospitalier de Recherche"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.jad.2019.01.004","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T18:24:34Z","timestamp":1546626274000},"page":"36-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Medial prefrontal disengagement during self-focus in formerly depressed patients prone to rumination"],"prefix":"10.1016","volume":"247","author":[{"given":"Ayna B.","family":"Nejad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Yves","family":"Rotg\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Valabregue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Gu\u00e9rin-Langlois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7890-1349","authenticated-orcid":false,"given":"Nicolas","family":"Hoertel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1845-3676","authenticated-orcid":false,"given":"Philip","family":"Gorwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Dubertret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Limosin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Fossati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-4721","authenticated-orcid":false,"given":"C\u00e9dric","family":"Lemogne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2019.01.004_bib0001","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1006\/nimg.2001.0746","article-title":"Modeling geometric deformations in EPI time series","volume":"13","author":"Andersson","year":"2001","journal-title":"NeuroImage"},{"key":"10.1016\/j.jad.2019.01.004_bib0002","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/scan\/nsq080","article-title":"Depression, rumination and the default network","volume":"6","author":"Berman","year":"2011","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0003","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3758\/s13415-016-0486-4","article-title":"Neural correlates of rumination in adolescents with remitted major depressive disorder and healthy controls","volume":"17","author":"Burkhouse","year":"2017","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0004","series-title":"On the Self-Regulation of Behavior","author":"Carver","year":"2001"},{"key":"10.1016\/j.jad.2019.01.004_bib0005","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3758\/CABN.10.4.470","article-title":"Neural correlates of rumination in depression","volume":"10","author":"Cooney","year":"2010","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0006","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1176\/appi.ajp.2017.16080883","article-title":"A brain model of disturbed self-appraisal in depression","volume":"174","author":"Davey","year":"2017","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.004_bib0007","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pscychresns.2015.11.007","article-title":"Antidepressant short-term and long-term brain effects during self-referential processing in major depression","volume":"247","author":"Delaveau","year":"2016","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.jad.2019.01.004_bib0100","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/mp.2011.16","article-title":"Short-term antidepressant administration reduces negative self-referential processing in the medial prefrontal cortex in subjects at risk for depression","volume":"17","author":"Di Simplicio","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.004_bib0008","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1214\/aoms\/1177705900","article-title":"Simplified estimation from censored normal samples","volume":"31","author":"Dixon","year":"1960","journal-title":"Ann. Math. Stat."},{"key":"10.1016\/j.jad.2019.01.004_bib0009","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.biopsych.2011.03.009","article-title":"Mood linked responses in medial prefrontal cortex predict relapse in patients with recurrent unipolar depression","volume":"70","author":"Farb","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.004_bib0010","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3758\/BRM.42.2.488","article-title":"The French Lexicon Project: lexical decision data for 38,840 French words and 38,840 pseudowords","volume":"42","author":"Ferrand","year":"2010","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.jad.2019.01.004_bib0011","doi-asserted-by":"crossref","first-page":"e1306","DOI":"10.4088\/JCP.14m09268","article-title":"Cognitive reactivity versus dysfunctional cognitions and the prediction of relapse in recurrent major depressive disorder","volume":"76","author":"Figueroa","year":"2015","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.004_bib0012","series-title":"Structured Clinical Interview For DSM-IV Axis II Personality Disorders, (SCID-II).","author":"First","year":"1997"},{"key":"10.1016\/j.jad.2019.01.004_bib0013","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neubiorev.2014.06.010","article-title":"Emotion regulation: quantitative meta-analysis of functional activation and deactivation","volume":"45","author":"Frank","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2019.01.004_bib0014","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1093\/scan\/nst178","article-title":"The dark side of self-focus: brain activity during self-focus in low and high brooders","volume":"9","author":"Freton","year":"2014","journal-title":"Soc. Cogn. Affect. Neurosci."},{"issue":"1","key":"10.1016\/j.jad.2019.01.004_bib0103","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-0447.2007.01119.x","article-title":"Definitions of recovery and outcomes of major depression: results from a 10-year follow-up","volume":"117","author":"Furukawa","year":"2008","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"10.1016\/j.jad.2019.01.004_bib0015","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1002\/hbm.20693","article-title":"Increased self-focus in major depressive disorder is related to neural abnormalities in subcortical-cortical midline structures","volume":"30","author":"Grimm","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jad.2019.01.004_bib0016","unstructured":"Guimpel, B., Douilliez, C., Philippot, P., French validation of brooding and reflection dimensions of the Ruminative Responses Scale (RRS). Annual meeting of the 41\u00e8mes Journ\u00e9es Scientifiques de Th\u00e9rapie Comportementale et Cognitive. Paris, France: 2012, December."},{"key":"10.1016\/j.jad.2019.01.004_bib0017","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/35094500","article-title":"Searching for a baseline: functional imaging and the resting human brain","volume":"2","author":"Gusnard","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0018","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.biopsych.2015.02.020","article-title":"Depressive rumination, the default-mode network, and the dark matter of clinical neuroscience","volume":"78","author":"Hamilton","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.004_bib0019","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/scan\/nsp022","article-title":"Medial cortex activity, self-reflection and depression","volume":"4","author":"Johnson","year":"2009","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/scan\/nsl004","article-title":"Dissociating medial frontal and posterior cingulate activity during self-reflection","volume":"1","author":"Johnson","year":"2006","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0021","doi-asserted-by":"crossref","first-page":"e15712","DOI":"10.1371\/journal.pone.0015712","article-title":"Individualized and clinically derived stimuli activate limbic structures in depression: an fMRI study","volume":"6","author":"Kessler","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.jad.2019.01.004_bib0022","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jad.2018.04.096","article-title":"Short-term escitalopram treatment normalizes aberrant self-referential processing in major depressive disorder","volume":"236","author":"Komulainen","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.01.004_bib0023","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jad.2010.11.034","article-title":"Medial prefrontal cortex and the self in major depression","volume":"136","author":"Lemogne","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.01.004_bib0024","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/scan\/nsq049","article-title":"Negative affectivity, self-referential processing and the cortical midline structures","volume":"6","author":"Lemogne","year":"2011","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0025","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/scan\/nsp008","article-title":"In search of the depressive self: extended medial prefrontal network during self-referential processing in major depression","volume":"4","author":"Lemogne","year":"2009","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0026","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jad.2009.11.003","article-title":"Self-referential processing and the prefrontal cortex over the course of depression: a pilot study","volume":"124","author":"Lemogne","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.01.004_bib0027","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1176\/appi.ajp.159.11.1830","article-title":"Unmasking disease-specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depression","volume":"159","author":"Liotti","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.004_bib0028","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/scan\/nsw085","article-title":"Differential association of default mode network connectivity and rumination in healthy individuals and remitted MDD patients","volume":"11","author":"Lois","year":"2016","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0029","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1093\/cercor\/bht099","article-title":"5-HTTLPR polymorphism modulates neural mechanisms of negative self-reflection","volume":"24","author":"Ma","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.jad.2019.01.004_bib0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrn2538","article-title":"Conflict-induced behavioural adjustment: a clue to the executive functions of the prefrontal cortex","volume":"10","author":"Mansouri","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0031","unstructured":"Maxwell, M., 1992. Manual for the FIGS."},{"key":"10.1016\/j.jad.2019.01.004_bib0101","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.neuroimage.2007.05.036","article-title":"Single dose antidepressant administration modulates the neural processing of self-referent personality trait words","volume":"37","author":"Miskowiak","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.jad.2019.01.004_bib0032","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-009510","article-title":"Vulnerability for new episodes in recurrent major depressive disorder: protocol for the longitudinal DELTA-neuroimaging cohort study","volume":"6","author":"Mocking","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.jad.2019.01.004_bib0033","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1037\/0033-2909.128.4.638","article-title":"Self-focused attention and negative affect: a meta-analysis","volume":"128","author":"Mor","year":"2002","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.jad.2019.01.004_bib0034","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3389\/fnhum.2013.00666","article-title":"Self-referential processing, rumination, and cortical midline structures in major depression","volume":"7","author":"Nejad","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0102","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/sj.mp.4002091","article-title":"The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study","volume":"13","author":"Norbury","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.004_bib0035","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1002\/hbm.24003","article-title":"Neural and behavioral correlates of negative self-focused thought associated with depression","volume":"39","author":"Philippi","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jad.2019.01.004_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2013.08.048","article-title":"Methods to detect, characterize, and remove motion artifact in resting state fMRI","volume":"84.","author":"Power","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.jad.2019.01.004_bib0037","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neulet.2016.09.049","article-title":"Personalized medicine: Prediction of disease vulnerability in mood disorders","volume":"669","author":"Prendes-Alvarez","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jad.2019.01.004_bib0038","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3758\/CABN.5.2.156","article-title":"Individual differences in trait rumination and the neural systems supporting cognitive reappraisal","volume":"5","author":"Ray","year":"2005","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0039","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jad.2015.07.008","article-title":"Neural correlates of self-referential processing and implicit self-associations in chronic depression","volume":"186","author":"Renner","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.01.004_bib0040","doi-asserted-by":"crossref","first-page":"e78844","DOI":"10.1371\/journal.pone.0078844","article-title":"The Queen and I: neural correlates of altered self-related cognitions in major depressive episode","volume":"8","author":"Sarsam","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jad.2019.01.004_bib0041","doi-asserted-by":"crossref","DOI":"10.3758\/s13415-018-0611-7","article-title":"Functional connectivity of reflective and brooding rumination in depressed and healthy women","author":"Satyshur","year":"2018","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"10.1016\/j.jad.2019.01.004_bib0042","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jad.2013.06.016","article-title":"Remitted major depression is characterized by reduced prefrontal cortex reactivity to reward loss","volume":"151","author":"Schiller","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.01.004_bib0043","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nrn2994","article-title":"The integration of negative affect, pain and cognitive control in the cingulate cortex","volume":"12","author":"Shackman","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"issue":"59 Suppl","key":"10.1016\/j.jad.2019.01.004_bib0044","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"20","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.004_bib0045","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1037\/0033-2909.121.3.371","article-title":"The self-reference effect in memory: a meta-analysis","volume":"121","author":"Symons","year":"1997","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.jad.2019.01.004_bib0046","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1017\/S0033291711000043","article-title":"Interaction between a history of depression and rumination on neural response to emotional faces","volume":"41","author":"Thomas","year":"2011","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2019.01.004_bib0047","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1023\/A:1023910315561","article-title":"Rumination reconsidered: a psychometric analysis","volume":"27","author":"Treynor","year":"2003","journal-title":"Cogn. Ther. Res."},{"key":"10.1016\/j.jad.2019.01.004_bib0048","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.neubiorev.2009.12.004","article-title":"Self-reflection and the brain: a theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia","volume":"34","author":"van der Meer","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2019.01.004_bib0049","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1037\/0033-2909.134.2.163","article-title":"Constructive and unconstructive repetitive thought","volume":"134","author":"Watkins","year":"2008","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.jad.2019.01.004_bib0050","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jad.2009.06.017","article-title":"Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity","volume":"122","author":"Yoshimura","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.01.004_bib0051","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1017\/S0033291714000464","article-title":"Neurophysiological correlates of autobiographical memory deficits in currently and formerly depressed subjects","volume":"44","author":"Young","year":"2014","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2019.01.004_bib0052","doi-asserted-by":"crossref","first-page":"43105","DOI":"10.1038\/srep43105","article-title":"Rumination and default mode network subsystems connectivity in first-episode, drug-naive young patients with major depressive disorder","volume":"7","author":"Zhu","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503271831824X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503271831824X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:20:28Z","timestamp":1759022428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503271831824X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":56,"alternative-id":["S016503271831824X"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2019.01.004","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Medial prefrontal disengagement during self-focus in formerly depressed patients prone to rumination","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2019.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}