{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:16:49Z","timestamp":1791919009198,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371196"],"award-info":[{"award-number":["81371196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771151"],"award-info":[{"award-number":["81771151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.jad.2019.01.031","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T09:40:18Z","timestamp":1548668418000},"page":"81-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"special_numbering":"C","title":["The enriched environment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive impairment by activating the SIRT1\/miR-134 signaling pathway in hippocampus"],"prefix":"10.1016","volume":"248","author":[{"given":"Jun","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chujie","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2019.01.031_bib0001","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/hipo.22555","article-title":"The requirement of BDNF for hippocampal synaptic plasticity is experience-dependent","volume":"26","author":"Aarse","year":"2016","journal-title":"Hippocampus"},{"key":"10.1016\/j.jad.2019.01.031_bib0002","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.biopsych.2016.01.009","article-title":"Hippocampal sirtuin 1 signaling mediates depression-like behavior","volume":"80","author":"Abe-Higuchi","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.031_bib0003","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.2174\/1871527313666141130203823","article-title":"Cognitive dysfunction in major depressive disorder: a state-of-the-art clinical review","volume":"13","author":"Bortolato","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.jad.2019.01.031_bib0004","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrneurol.2011.60","article-title":"Depression and risk of developing dementia","volume":"7","author":"Byers","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jad.2019.01.031_bib0005","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jep.2016.06.012","article-title":"Chronic administration tetrahydroxystilbene glucoside promotes hippocampal memory and synaptic plasticity and activates ERKs, CaMKII and SIRT1\/miR-134 in vivo","volume":"190","author":"Chen","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jad.2019.01.031_bib0006","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nature14659","article-title":"Sparse whole-genome sequencing identifies two loci for major depressive disorder","volume":"523","author":"consortium","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jad.2019.01.031_bib0007","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1007\/s12035-016-0087-9","article-title":"SIRT1 overexpression in mouse hippocampus induces cognitive enhancement through proteostatic and neurotrophic mechanisms","volume":"54","author":"Corpas","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jad.2019.01.031_bib0008","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1177\/0269881107083798","article-title":"Review: bupropion and SSRI-induced side effects","volume":"22","author":"Demyttenaere","year":"2008","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2019.01.031_bib0009","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.neuropharm.2018.01.009","article-title":"MiR-134 modulates chronic stress-induced structural plasticity and depression-like behaviors via downregulation of Limk1\/cofilin signaling in rats","volume":"131","author":"Fan","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jad.2019.01.031_bib0010","doi-asserted-by":"crossref","first-page":"11368","DOI":"10.1523\/JNEUROSCI.3795-04.2004","article-title":"Different presynaptic roles of synapsins at excitatory and inhibitory synapses","volume":"24","author":"Gitler","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2019.01.031_bib0011","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neuron.2014.01.028","article-title":"SIRT1 in neurodevelopment and brain senescence","volume":"81","author":"Herskovits","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2019.01.031_bib0012","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1038\/tp.2011.33","article-title":"Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV","volume":"1","author":"Jha","year":"2011","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.031_bib0013","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jad.2010.04.003","article-title":"SIRT1 gene is associated with major depressive disorder in the Japanese population","volume":"126","author":"Kishi","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.01.031_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141001","article-title":"SIRT1 polymorphisms associate with seasonal weight variation, depressive disorders, and diastolic blood pressure in the general population","volume":"10","author":"Kovanen","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.jad.2019.01.031_bib0015","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.bbrc.2016.09.123","article-title":"G-CSF improves CUMS-induced depressive behaviors through downregulating Ras\/ERK\/MAPK signaling pathway","volume":"479","author":"Li","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jad.2019.01.031_bib0016","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.physbeh.2016.12.003","article-title":"Elevation of synaptic protein is associated with the antidepressant-like effects of ferulic acid in a chronic model of depression","volume":"169","author":"Liu","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jad.2019.01.031_bib0017","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brainresbull.2017.09.009","article-title":"Enriched environment combined with fluoxetine ameliorates depression-like behaviors and hippocampal SYP expression in a rat CUS model","volume":"135","author":"Liu","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jad.2019.01.031_bib0018","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8596903","article-title":"Role and possible mechanisms of Sirt1 in depression","volume":"2018","author":"Lu","year":"2018","journal-title":"Oxid. Med. Cell. Longev.."},{"key":"10.1016\/j.jad.2019.01.031_bib0019","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.nlm.2016.08.017","article-title":"Enriched environment ameliorates depression-induced cognitive deficits and restores abnormal hippocampal synaptic plasticity","volume":"134 Pt B","author":"Mahati","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.jad.2019.01.031_bib0020","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s40263-015-0263-x","article-title":"The prevalence, measurement, and treatment of the cognitive dimension\/domain in major depressive disorder","volume":"29","author":"McIntyre","year":"2015","journal-title":"CNS Drugs"},{"key":"10.1016\/j.jad.2019.01.031_bib0021","doi-asserted-by":"crossref","first-page":"9695","DOI":"10.1523\/JNEUROSCI.0027-10.2010","article-title":"SIRT1 is essential for normal cognitive function and synaptic plasticity","volume":"30","author":"Michan","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2019.01.031_bib0022","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1177\/0269881114553646","article-title":"The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition","volume":"28","author":"Morais","year":"2014","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2019.01.031_bib0023","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbr.2017.09.022","article-title":"The effects of aerobic exercise on depression-like, anxiety-like, and cognition-like behaviors over the healthy adult lifespan of C57BL\/6 mice","volume":"337","author":"Morgan","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2019.01.031_bib0024","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.neuropharm.2013.04.011","article-title":"Synaptic regulation of affective behaviors; role of BDNF","volume":"76 Pt C","author":"Ninan","year":"2014","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.jad.2019.01.031_bib0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainres.2017.02.020","article-title":"Role of proBDNF and BDNF in dendritic spine plasticity and depressive-like behaviors induced by an animal model of depression","volume":"1663","author":"Qiao","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.jad.2019.01.031_bib0026","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nature04367","article-title":"A brain-specific microRNA regulates dendritic spine development","volume":"439","author":"Schratt","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jad.2019.01.031_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2018.04.050","article-title":"Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: Sirt1\/miR-134 signaling pathway regulates CREB\/BDNF expression in hippocampus in vivo and in vitro","volume":"349","author":"Shen","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2019.01.031_bib0028","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7434692","article-title":"The antidepressant effect of angelica sinensis extracts on chronic unpredictable mild stress-induced depression is mediated via the upregulation of the BDNF signaling pathway in rats","volume":"2016","author":"Shen","year":"2016","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jad.2019.01.031_bib0029","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.biopsych.2004.08.022","article-title":"Cellular changes in the postmortem hippocampus in major depression","volume":"56","author":"Stockmeier","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.031_bib0030","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2174\/156720210793180819","article-title":"Environmental enrichment influences BDNF and NR1 levels in the hippocampus and restores cognitive impairment in chronic cerebral hypoperfused rats","volume":"7","author":"Sun","year":"2010","journal-title":"Curr. Neurovas. Res."},{"key":"10.1016\/j.jad.2019.01.031_bib0031","doi-asserted-by":"crossref","DOI":"10.1007\/s12264-018-0235-5","article-title":"SIRT1 rs3758391 and major depressive disorder: new data and meta-analysis","author":"Tang","year":"2018","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.jad.2019.01.031_bib0032","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1123\/pes.2017-0016","article-title":"Exercise and cognition-2016","volume":"29","author":"Tomporowski","year":"2017","journal-title":"Pediat. Exer. Sci."},{"key":"10.1016\/j.jad.2019.01.031_bib0033","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/jnr.21907","article-title":"Enriched environment restores hippocampal cell proliferation and ameliorates cognitive deficits in chronically stressed rats","volume":"87","author":"Veena","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jad.2019.01.031_bib0034","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1017\/S1461145713001661","article-title":"Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats","volume":"17","author":"Zhang","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2019.01.031_bib0035","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.bbrc.2013.05.025","article-title":"Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway","volume":"435","author":"Zhao","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jad.2019.01.031_bib0036","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jep.2016.09.037","article-title":"Kai-Xin-San, a standardized traditional Chinese medicine formula, up-regulates the expressions of synaptic proteins on hippocampus of chronic mild stress induced depressive rats and primary cultured rat hippocampal neuron","volume":"193","author":"Zhu","year":"2016","journal-title":"J. Ethnopharmacol."}],"updated-by":[{"DOI":"10.1016\/j.jad.2022.05.068","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000}},{"DOI":"10.1016\/j.jad.2022.05.042","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000}}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032718318688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032718318688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T12:34:45Z","timestamp":1588854885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032718318688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":36,"alternative-id":["S0165032718318688"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2019.01.031","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jad.2022.05.042","asserted-by":"object"},{"id-type":"doi","id":"10.1016\/j.jad.2022.05.068","asserted-by":"object"}]},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The enriched environment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive impairment by activating the SIRT1\/miR-134 signaling pathway in hippocampus","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2019.01.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}