{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:50:07Z","timestamp":1778287807648,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571327"],"award-info":[{"award-number":["81571327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["201640003"],"award-info":[{"award-number":["201640003"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Committee","doi-asserted-by":"publisher","award":["16411965300"],"award-info":[{"award-number":["16411965300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program","award":["2016YFC0906400"],"award-info":[{"award-number":["2016YFC0906400"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jad.2019.01.048","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T12:05:59Z","timestamp":1552910759000},"page":"78-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Intrinsic gray-matter connectivity of the brain in major depressive disorder"],"prefix":"10.1016","volume":"251","author":[{"given":"Huifeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihui","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mellor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daihui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jad.2019.01.048_bib0001","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/acps.12724","article-title":"Insula and amygdala resting-state functional connectivity differentiate bipolar from unipolar depression","volume":"136","author":"Ambrosi","year":"2017","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.jad.2019.01.048_bib0002","series-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM-5\u00ae)","year":"2013"},{"issue":"1","key":"10.1016\/j.jad.2019.01.048_bib0003","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nrn.2017.149","article-title":"Communication dynamics in complex brain networks","volume":"19","author":"Avena-Koenigsberger","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2019.01.048_bib0004","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.brainres.2017.06.013","article-title":"Statistical differences in the white matter tracts in subjects with depression by using different skeletonized voxel-wise analysis approaches and DTI fitting procedures","volume":"1669","author":"Bergamino","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.jad.2019.01.048_bib0005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnana.2012.00042","article-title":"Communication and wiring in the cortical connectome","volume":"6","author":"Budd","year":"2012","journal-title":"Front Neuroanat."},{"issue":"5","key":"10.1016\/j.jad.2019.01.048_bib0006","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nrn3214","article-title":"The economy of brain network organization","volume":"13","author":"Bullmore","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"Pt 5","key":"10.1016\/j.jad.2019.01.048_bib0007","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/brain\/awf110","article-title":"The minicolumn hypothesis in neuroscience","volume":"125","author":"Buxhoeveden","year":"2002","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.jad.2019.01.048_bib0008","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/ajmg.b.32130","article-title":"Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume","volume":"162B","author":"Carballedo","year":"2013","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"3","key":"10.1016\/j.jad.2019.01.048_bib0009","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/da.22025","article-title":"Val66met Bdnf genotypes in melancholic depression: effects on brain structure and treatment outcome","volume":"30","author":"Cardoner","year":"2013","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2019.01.048_bib0010","series-title":"Exact Solution For the Optimal Neuronal Layout Problem","author":"Chklovskii","year":"2004"},{"issue":"2","key":"10.1016\/j.jad.2019.01.048_bib0011","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"Neuroimage"},{"issue":"8","key":"10.1016\/j.jad.2019.01.048_bib0012","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1002\/hbm.23215","article-title":"Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder","volume":"37","author":"Demirta\u015f","year":"2016","journal-title":"Hum. Brain Mapp."},{"issue":"1","key":"10.1016\/j.jad.2019.01.048_bib0013","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nm.4246","article-title":"Resting-state connectivity biomarkers define neurophysiological subtypes of depression","volume":"23","author":"Drysdale","year":"2017","journal-title":"Nat. Med."},{"issue":"32","key":"10.1016\/j.jad.2019.01.048_bib0014","doi-asserted-by":"crossref","first-page":"13222","DOI":"10.1073\/pnas.1221880110","article-title":"Intrinsic gray-matter connectivity of the brain in adults with autism spectrum disorder","volume":"110","author":"Ecker","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"2","key":"10.1016\/j.jad.2019.01.048_bib0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/nimg.1998.0396","article-title":"Cortical surface-based analysis. II. Inflation, flattening, and a surface-based coordinate system","volume":"9","author":"Fischl","year":"1999","journal-title":"Neuroimage"},{"issue":"15","key":"10.1016\/j.jad.2019.01.048_bib0016","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuroscience.2012.04.044","article-title":"Dendritic spine pathology in schizophrenia","volume":"251","author":"Glausier","year":"2013","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.jad.2019.01.048_bib0017","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.biopsych.2014.08.009","article-title":"Depression, neuroimaging and connectomics: a selective overview","volume":"77","author":"Gong","year":"2015","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2019.01.048_bib0018","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3109\/15622975.2010.507786","article-title":"Association of the brain-derived neurotrophic factor Val66Met polymorphism with hippocampus volumes in drug-free depressed patients","volume":"12","author":"Gonul","year":"2010","journal-title":"World J. Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2019.01.048_bib0019","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/jtbi.1994.1024","article-title":"The intrinsic geometry of the cerebral cortex","volume":"166","author":"Griffin","year":"1994","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.jad.2019.01.048_bib0020","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jad.2017.08.089","article-title":"Increased anterior default-mode network homogeneity in first-episode, drug-naive major depressive disorder: a replication study","volume":"225","author":"Guo","year":"2018","journal-title":"J. Affect. Disord."},{"issue":"4","key":"10.1016\/j.jad.2019.01.048_bib0021","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","article-title":"Development of a rating scale for primary depressive illness","volume":"6","author":"Hamilton","year":"1967","journal-title":"Br. J. Soc. Clin. Psychol."},{"key":"10.1016\/j.jad.2019.01.048_bib0022","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br. J. Med. Psychol."},{"issue":"11","key":"10.1016\/j.jad.2019.01.048_bib0023","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/nn927","article-title":"BDNF release from single cells elicits local dendritic growth in nearby neurons","volume":"5","author":"Horch","year":"2002","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.jad.2019.01.048_bib0025","doi-asserted-by":"crossref","DOI":"10.1186\/s12888-016-0777-x","article-title":"The influence of 5-HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study","volume":"16","author":"Jaworska","year":"2016","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jad.2019.01.048_bib0026","article-title":"Wiring Principles of Cerebral Cortex","author":"Julian","year":"2015","journal-title":"Front. Neuroanat."},{"issue":"15","key":"10.1016\/j.jad.2019.01.048_bib0027","doi-asserted-by":"crossref","first-page":"8431","DOI":"10.1073\/pnas.95.15.8431","article-title":"Computing geodesic paths on manifolds","volume":"95","author":"Kimmel","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"7599","key":"10.1016\/j.jad.2019.01.048_bib0028","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nature17192","article-title":"Anatomy and function of an excitatory network in the visual cortex","volume":"532","author":"Lee","year":"2016","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.jad.2019.01.048_bib0029","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1192\/bjp.bp.113.143529","article-title":"Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder","volume":"206","author":"Legge","year":"2015","journal-title":"Br. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2019.01.048_bib0030","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1503\/jpn.110180","article-title":"Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD","volume":"38","author":"Liao","year":"2013","journal-title":"J. Psychiatry Neurosci. JPN"},{"issue":"2","key":"10.1016\/j.jad.2019.01.048_bib0031","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/1096-9861(20010205)430:2<209::AID-CNE1026>3.0.CO;2-#","article-title":"Synaptic targets of the intrinsic axon collaterals of supragranular pyramidal neurons in monkey pre-frontal cortex","volume":"430","author":"Melchitzky","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.jad.2019.01.048_bib0032","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fnsys.2013.00080","article-title":"Inter-laminar microcircuits across neocortex: repair and augmentation","volume":"7","author":"Opris","year":"2013","journal-title":"Front. Syst. Neurosci."},{"issue":"Pt 7","key":"10.1016\/j.jad.2019.01.048_bib0033","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/brain\/awt359","article-title":"Prefrontal cortical minicolumn: from executive control to disrupted cognitive processing","volume":"137","author":"Opris","year":"2014","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.jad.2019.01.048_bib0034","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3379","article-title":"Neurotrophin regulation of neural circuit development and function","volume":"14","author":"Park","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"issue":"6158","key":"10.1016\/j.jad.2019.01.048_bib0035","doi-asserted-by":"crossref","DOI":"10.1126\/science.1238411","article-title":"Structural and functional brain networks: from connections to cognition","volume":"342","author":"Park","year":"2013","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.jad.2019.01.048_bib0036","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.pscychresns.2015.03.003","article-title":"Dissociated large-scale functional connectivity networks of the precuneus in medication-naive first-episode depression","volume":"232","author":"Peng","year":"2015","journal-title":"Psychiatry Res."},{"issue":"06","key":"10.1016\/j.jad.2019.01.048_bib0038","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1017\/neu.2015.25","article-title":"Impact of monoamine-related gene polymorphisms on hippocampal volume in treatment-resistant depression","volume":"27","author":"Phillips","year":"2015","journal-title":"Acta Neuropsychiatrica"},{"issue":"32","key":"10.1016\/j.jad.2019.01.048_bib0039","doi-asserted-by":"crossref","first-page":"10032","DOI":"10.1073\/pnas.1420315112","article-title":"Wiring cost and topological participation of the mouse brain connectome","volume":"112","author":"Rubinov","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"1","key":"10.1016\/j.jad.2019.01.048_bib0040","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.euroneuro.2015.08.022","article-title":"GWAS-identified risk variants for major depressive disorder: preliminary support for an association with late-life depressive symptoms and brain structural alterations","volume":"26","author":"Ryan","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2019.01.048_bib0041","article-title":"Anterior cingulate volume predicts response to psychotherapy and functional connectivity with the inferior parietal cortex in major depressive disorder","author":"Sambataro","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"7","key":"10.1016\/j.jad.2019.01.048_bib0042","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jaac.2017.05.008","article-title":"Brain structural signatures of adolescent depressive symptom trajectories: a longitudinal magnetic resonance imaging study","volume":"56","author":"Schmaal","year":"2017","journal-title":"J. Am. Acad. Child .Adolesc. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.048_bib0043","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jad.2017.10.030","article-title":"Correlations between working memory impairment and neurometabolites of prefrontal cortex and lenticular nucleus in patients with major depressive disorder","volume":"227","author":"Shan","year":"2017","journal-title":"J. Affect. Disord."},{"issue":"2","key":"10.1016\/j.jad.2019.01.048_bib0044","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4306\/pi.2015.12.2.227","article-title":"Increased cognition connectivity network in major depression disorder: a FMRI study","volume":"12","author":"Shen","year":"2015","journal-title":"Psychiatry Investig."},{"issue":"46","key":"10.1016\/j.jad.2019.01.048_bib0045","doi-asserted-by":"crossref","first-page":"16580","DOI":"10.1073\/pnas.1414153111","article-title":"Spatial embedding of structural similarity in the cerebral cortex","volume":"111","author":"Song","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.jad.2019.01.048_bib0046","series-title":"Networks of the Brain","author":"Sporns","year":"2011"},{"key":"10.1016\/j.jad.2019.01.048_bib0047","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1146\/annurev-psych-122414-033634","article-title":"Modular brain networks","volume":"67","author":"Sporns","year":"2016","journal-title":"Annu. Rev. Psychol.,"},{"issue":"4","key":"10.1016\/j.jad.2019.01.048_bib0048","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s00429-014-0769-x","article-title":"Childhood adversity, depression, age and gender effects on white matter microstructure: a DTI study","volume":"220","author":"Ugwu","year":"2014","journal-title":"Brain Struct. Function"},{"issue":"9904","key":"10.1016\/j.jad.2019.01.048_bib0049","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0140-6736(13)61611-6","article-title":"Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010","volume":"382","author":"Whiteford","year":"2013","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.jad.2019.01.048_bib0050","doi-asserted-by":"crossref","first-page":"e866","DOI":"10.1038\/tp.2016.137","article-title":"Association between reduced white matter integrity in the corpus callosum and serotonin transporter gene DNA methylation in medication-naive patients with major depressive disorder","volume":"6","author":"Won","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.048_bib0051","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.pnpbp.2015.03.014","article-title":"Imaging genetics studies on monoaminergic genes in major depressive disorder","volume":"64","author":"Won","year":"2016","journal-title":"Prog. Neuro-psychopharmacol. Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.jad.2019.01.048_bib0052","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.biopsych.2011.05.018","article-title":"Disrupted brain connectivity networks in drug-naive, first-episode major depressive disorder","volume":"70","author":"Zhang","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.01.048_bib0053","series-title":"Rating Scales Manual for Mental Health","author":"Zhang","year":"1998"},{"issue":"3","key":"10.1016\/j.jad.2019.01.048_bib0054","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12264-016-0030-0","article-title":"Molecular, functional, and structural imaging of major depressive disorder","volume":"32","author":"Zhang","year":"2016","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.jad.2019.01.048_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2016.09.009","article-title":"Effects of cigarette smoking on cortical thickness in major depressive disorder","volume":"84","author":"Zorlu","year":"2016","journal-title":"J. Psychiatr. Res."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032718309790?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032718309790?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T06:43:55Z","timestamp":1565160235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032718309790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":53,"alternative-id":["S0165032718309790"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2019.01.048","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intrinsic gray-matter connectivity of the brain in major depressive disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2019.01.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}