{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:24:19Z","timestamp":1777609459493,"version":"3.51.4"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012652","name":"ETH Z\u00fcrich Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012652","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.jad.2019.04.015","type":"journal-article","created":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T09:27:48Z","timestamp":1554629268000},"page":"404-412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Abdominal vagal deafferentation alters affective behaviors in rats"],"prefix":"10.1016","volume":"252","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-5212","authenticated-orcid":false,"given":"Melanie","family":"Klarer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Weber-Stadlbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrtha","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Langhans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2019.04.015_bib0001","doi-asserted-by":"crossref","DOI":"10.1176\/appi.ajp.2017.16010034","article-title":"A 5-year observational study of patients with treatment-resistant depression treated with vagus nerve stimulation or treatment as usual: comparison of response, remission, and suicidality","author":"Aaronson","year":"2017","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.04.015_bib0002","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1113\/jphysiol.1957.sp005703","article-title":"Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat","volume":"135","author":"Agostoni","year":"1957","journal-title":"J. Physiol."},{"key":"10.1016\/j.jad.2019.04.015_bib0003","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.yfrne.2014.05.004","article-title":"Sex differences in anxiety and depression clinical perspectives","volume":"35","author":"Altemus","year":"2014","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.jad.2019.04.015_bib0004","doi-asserted-by":"crossref","first-page":"11052","DOI":"10.1523\/JNEUROSCI.2606-06.2006","article-title":"Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat","volume":"26","author":"Arnold","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0005","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0079-6123(08)63830-3","article-title":"Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance","volume":"88","author":"Aston-Jones","year":"1991","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.jad.2019.04.015_bib0006","doi-asserted-by":"crossref","first-page":"R167","DOI":"10.1152\/ajpregu.00067.2014","article-title":"Vagal afferents are not necessary for the satiety effect of the gut lipid messenger oleoylethanolamide","volume":"307","author":"Azari","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jad.2019.04.015_bib0007","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbi.2013.12.003","article-title":"Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring","volume":"37","author":"Babri","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2019.04.015_bib0008","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1037\/0735-7044.121.5.1113","article-title":"Previous experience affects subsequent anxiety-like responses in rats bred for novelty seeking","volume":"121","author":"Ballaz","year":"2007","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0009","series-title":"Conflict, Arousal, and Curiosity","author":"Berlyne","year":"1960"},{"key":"10.1016\/j.jad.2019.04.015_bib0010","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00213-006-0578-x","article-title":"The debate over dopamine's role in reward: the case for incentive salience","volume":"191","author":"Berridge","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2019.04.015_bib0011","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0166-2236(03)00233-9","article-title":"Parsing reward","volume":"26","author":"Berridge","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1566-0702(00)00215-0","article-title":"Functional and chemical anatomy of the afferent vagal system","volume":"85","author":"Berthoud","year":"2000","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0013","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrn1846","article-title":"New approaches to antidepressant drug discovery: beyond monoamines","volume":"7","author":"Berton","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0014","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/BF00181937","article-title":"The effects of chronic antidepressant treatment in an animal model of anxiety","volume":"95","author":"Bodnoff","year":"1988","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2019.04.015_bib0015","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nrn1909","article-title":"Why sex matters for neuroscience","volume":"7","author":"Cahill","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0016","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.biopsych.2004.06.025","article-title":"Effect of vagus nerve stimulation on cerebrospinal fluid monoamine metabolites, norepinephrine, and gamma-aminobutyric acid concentrations in depressed patients","volume":"56","author":"Carpenter","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.04.015_bib0017","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/s13311-017-0537-8","article-title":"Vagal nerve stimulation for treatment-resistant depression","volume":"14","author":"Carreno","year":"2017","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jad.2019.04.015_bib0019","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0006-8993(88)91225-5","article-title":"Lesions of the dorsal noradrenergic bundle simultaneously enhance and reduce responsivity to novelty in a food preference test","volume":"472","author":"Cole","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.jad.2019.04.015_bib0020","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.brs.2012.11.006","article-title":"Association of cerebral metabolic activity changes with vagus nerve stimulation antidepressant response in treatment-resistant depression","volume":"6","author":"Conway","year":"2013","journal-title":"Brain Stimul."},{"key":"10.1016\/j.jad.2019.04.015_bib0021","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1037\/a0037128","article-title":"Dopamine modulates novelty seeking behavior during decision making","volume":"128","author":"Costa","year":"2014","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0022","series-title":"Emotional Behaviors: Animal Models of Psychiatric Disease., What's Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice","first-page":"227","author":"Crawley","year":"2007"},{"key":"10.1016\/j.jad.2019.04.015_bib0023","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.neuron.2013.02.008","article-title":"Visceral influences on brain and behavior","volume":"77","author":"Critchley","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2019.04.015_bib0024","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0025","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrd1825","article-title":"The ascent of mouse: advances in modelling human depression and anxiety","volume":"4","author":"Cryan","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jad.2019.04.015_bib0026","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0165-6147(02)02017-5","article-title":"Assessing antidepressant activity in rodents: recent developments and future needs","volume":"23","author":"Cryan","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jad.2019.04.015_bib0027","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/sj.mp.4001457","article-title":"In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice","volume":"9","author":"Cryan","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2019.04.015_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/YCO.0b013e3280117733","article-title":"Animal models of mood disorders: recent developments","volume":"20","author":"Cryan","year":"2007","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.jad.2019.04.015_bib0029","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1098\/rstb.1996.0125","article-title":"The somatic marker hypothesis and the possible functions of the prefrontal cortex","volume":"351","author":"Damasio","year":"1996","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.jad.2019.04.015_bib0030","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1124\/jpet.106.104166","article-title":"Effect of vagus nerve stimulation on serotonergic and noradrenergic transmission","volume":"318","author":"Dorr","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jad.2019.04.015_bib0031","doi-asserted-by":"crossref","first-page":"9550","DOI":"10.1523\/JNEUROSCI.19-21-09550.1999","article-title":"Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli","volume":"19","author":"Dulawa","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0032","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neubiorev.2005.03.017","article-title":"Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test","volume":"29","author":"Dulawa","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2019.04.015_bib0033","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/cne.900670104","article-title":"Quantitative studies of the vagus nerve in the cat - I. The ratio of sensory to motor fibers","volume":"67","author":"Foley","year":"1937","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.jad.2019.04.015_bib0034","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.brainres.2007.08.045","article-title":"Vagus nerve stimulation increases norepinephrine concentration and the gene expression of BDNF and bFGF in the rat brain","volume":"1179","author":"Follesa","year":"2007","journal-title":"Brain Res."},{"issue":"Suppl 1","key":"10.1016\/j.jad.2019.04.015_bib0035","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1097\/00004714-199704001-00002","article-title":"Pharmacology of antidepressants","volume":"17","author":"Frazer","year":"1997","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2019.04.015_bib0036","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.biopsych.2011.07.020","article-title":"Serotonergic and noradrenergic pathways are required for the anxiolytic-like and antidepressant-like behavioral effects of repeated vagal nerve stimulation in rats","volume":"70","author":"Furmaga","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2019.04.015_bib0037","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/cne.20738","article-title":"Prefrontal cortex in the rat: projections to subcortical autonomic, motor, and limbic centers","volume":"492","author":"Gabbott","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.jad.2019.04.015_bib0038","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0193-953X(05)70196-9","article-title":"Vagus nerve stimulation. A potential therapy for resistant depression?","volume":"23","author":"George","year":"2000","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.jad.2019.04.015_bib0039","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(00)26003-2","article-title":"The prefrontal cortex and the integration of sensory, limbic and autonomic information","volume":"126","author":"Groenewegen","year":"2000","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.jad.2019.04.015_bib0040","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neubiorev.2015.06.019","article-title":"The antidepressant mechanism of action of vagus nerve stimulation: evidence from preclinical studies","volume":"56","author":"Grimonprez","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2019.04.015_bib0041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2015.05.002","article-title":"The antidepressant-like effect of vagus nerve stimulation is mediated through the locus coeruleus","volume":"68","author":"Grimonprez","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2019.04.015_bib0042","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.neubiorev.2005.01.004","article-title":"Vagal nerve stimulation: a review of its applications and potential mechanisms that mediate its clinical effects","volume":"29","author":"Groves","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2019.04.015_bib0043","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neubiorev.2015.10.006","article-title":"Defeat stress in rodents: from behavior to molecules","volume":"59","author":"Hammels","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2019.04.015_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/S2215-0366(17)30015-9","article-title":"How do antidepressants work? New perspectives for refining future treatment approaches","author":"Harmer","year":"2017","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.jad.2019.04.015_bib0045","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0165-0173(01)00082-0","article-title":"Depression as a spreading adjustment disorder of monoaminergic neurons: a case for primary implication of the locus coeruleus","volume":"38","author":"Harro","year":"2001","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.jad.2019.04.015_bib0046","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.pbb.2006.10.015","article-title":"Differential involvement of endogenous opioids in sucrose consumption and food reinforcement","volume":"85","author":"Hayward","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jad.2019.04.015_bib0047","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1212\/WNL.59.6_suppl_4.S3","article-title":"Therapeutic mechanisms of vagus nerve stimulation","volume":"59","author":"Henry","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.jad.2019.04.015_bib0048","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1038\/tp.2013.132","article-title":"Long-term effects of maternal immune activation on depression-like behavior in the mouse","volume":"4","author":"Khan","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2019.04.015_bib0049","doi-asserted-by":"crossref","first-page":"7067","DOI":"10.1523\/JNEUROSCI.0252-14.2014","article-title":"Gut vagal afferents differentially modulate innate anxiety and learned fear","volume":"34","author":"Klarer","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0050","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nlm.2017.05.006","article-title":"Cognitive effects of subdiaphragmatic vagal deafferentation in rats","volume":"142","author":"Klarer","year":"2017","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.jad.2019.04.015_bib0051","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1523\/JNEUROSCI.0813-17.2017","article-title":"Abdominal vagal afferents modulate the brain transcriptome and behaviors relevant to schizophrenia","volume":"38","author":"Klarer","year":"2018","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.jad.2019.04.015_bib0052","doi-asserted-by":"crossref","first-page":"e12525","DOI":"10.1111\/gbb.12525","article-title":"Ecological validity of social interaction tests in rats and mice","volume":"18","author":"Kondrakiewicz","year":"2019","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.jad.2019.04.015_bib0053","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fpsyt.2018.00020","article-title":"Treating depression with transcutaneous auricular vagus nerve stimulation: state of the art and future perspectives","volume":"9","author":"Kong","year":"2018","journal-title":"Front. Psychiatry"},{"issue":"Suppl 8","key":"10.1016\/j.jad.2019.04.015_bib0054","first-page":"35","article-title":"Revisiting monoamine oxidase inhibitors","volume":"68","author":"Krishnan","year":"2007","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2019.04.015_bib0055","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jad.2019.04.015_bib0056","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.bbr.2011.10.020","article-title":"Behavioral phenotyping of glutathione-deficient mice: relevance to schizophrenia and bipolar disorder","volume":"226","author":"Kulak","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2019.04.015_bib0057","first-page":"64","article-title":"Revisiting the effectiveness of standard antidepressants in bipolar disorder: are monoamine oxidase inhibitors superior?","volume":"42","author":"Mallinger","year":"2009","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.jad.2019.04.015_bib0058","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1139\/jpn.0936","article-title":"Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation","volume":"34","author":"Manta","year":"2009","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0059","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1017\/S1461145712000387","article-title":"Electrophysiological and neurochemical effects of long-term vagus nerve stimulation on the rat monoaminergic systems","volume":"16","author":"Manta","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2019.04.015_bib0060","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0006-3223(01)01343-9","article-title":"Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes","volume":"51","author":"Marangell","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.04.015_bib0061","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0010-9452(08)70156-4","article-title":"The effects of vagus nerve stimulation on decision-making","volume":"40","author":"Martin","year":"2004","journal-title":"Cortex"},{"key":"10.1016\/j.jad.2019.04.015_bib0062","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn3071","article-title":"Gut feelings: the emerging biology of gut-brain communication","volume":"12","author":"Mayer","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0063","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1523\/JNEUROSCI.5372-11.2012","article-title":"Sex differences in the brain: the not so inconvenient truth","volume":"32","author":"McCarthy","year":"2012","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.jad.2019.04.015_bib0064","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/jne.12272","article-title":"The medial prefrontal cortex: coordinator of autonomic, neuroendocrine and behavioural responses to stress","volume":"27","author":"McKlveen","year":"2015","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.jad.2019.04.015_bib0065","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.nlm.2012.12.002","article-title":"The nucleus of the solitary tract \u2013>nucleus paragigantocellularis \u2013>locus coeruleus \u2013>CA1 region of dorsal hippocampus pathway is important for consolidation of object recognition memory","volume":"100","author":"Mello-Carpes","year":"2013","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.jad.2019.04.015_bib0067","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1037\/h0048596","article-title":"The relation between fear and exploratory behavior","volume":"48","author":"Montgomery","year":"1955","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.jad.2019.04.015_bib0068","article-title":"Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis","author":"Naoi","year":"2017","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.jad.2019.04.015_bib0069","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/sj.npp.1301082","article-title":"VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanisms","volume":"31","author":"Nemeroff","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2019.04.015_bib0070","first-page":"R1136","article-title":"A method for selective section of vagal afferent or efferent axons in the rat","volume":"267","author":"Norgren","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jad.2019.04.015_bib0071","article-title":"Social brain, social dysfunction and social withdrawal","author":"Porcelli","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2019.04.015_bib0072","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0810as14","article-title":"Rodent models of depression: forced swimming and tail suspension behavioral despair tests in rats and mice","author":"Porsolt","year":"2001","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0073","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.jad.2019.04.015_bib0074","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.bbr.2003.10.020","article-title":"The balance between approach and avoidance behaviors in a novel object exploration paradigm in mice","volume":"152","author":"Powell","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2019.04.015_bib0075","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0028-3908(02)00412-4","article-title":"RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice","volume":"44","author":"Powell","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jad.2019.04.015_bib0076","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/9780470942390.mo110176","article-title":"Depression-related behavioral tests","volume":"2","author":"Powell","year":"2012","journal-title":"Curr. Protoc. Mouse Biol."},{"key":"10.1016\/j.jad.2019.04.015_bib0077","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.psyneuen.2010.05.003","article-title":"A translational research framework for enhanced validity of mouse models of psychopathological states in depression","volume":"36","author":"Pryce","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2019.04.015_bib0078","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jchemneu.2010.12.002","article-title":"The chemical neuroanatomy of vagus nerve stimulation","volume":"42","author":"Ruffoli","year":"2011","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.jad.2019.04.015_bib0079","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0006-3223(99)00304-2","article-title":"Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study","volume":"47","author":"Rush","year":"2000","journal-title":"Biol. Psychiatry"},{"issue":"9","key":"10.1016\/j.jad.2019.04.015_bib0080","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrn3381","article-title":"The brain reward circuitry in mood disorders","volume":"14","author":"Russo","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0081","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nrn2851","article-title":"Behavioural phenotyping assays for mouse models of autism","volume":"11","author":"Silverman","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0082","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nprot.2012.044","article-title":"Using the rat forced swim test to assess antidepressant-like activity in rodents","volume":"7","author":"Slattery","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jad.2019.04.015_bib0084","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00213-006-0630-x","article-title":"Evaluation of reward processes in an animal model of depression","volume":"190","author":"Slattery","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2019.04.015_bib0085","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1749-6632.1985.tb29936.x","article-title":"The satiety effect of cholecystokinin. Recent progress and current problems","volume":"448","author":"Smith","year":"1985","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.jad.2019.04.015_bib0086","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tins.2018.09.008","article-title":"From stress to anhedonia: molecular processes through functional circuits","volume":"42","author":"Stanton","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jad.2019.04.015_bib0087","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0031-9384(89)90335-1","article-title":"Forebrain norepinephrine involvement in selective attention and neophobia","volume":"46","author":"Steketee","year":"1989","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jad.2019.04.015_bib0088","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0079-6123(00)26006-8","article-title":"Functional neuroanatomy of the prefrontal cortex: autonomic interactions","volume":"126","author":"Van Eden","year":"2000","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.jad.2019.04.015_bib0089","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1601-183X.2011.00698.x","article-title":"Schizophrenia-relevant behaviors in a genetic mouse model of constitutive Nurr1 deficiency","volume":"10","author":"Vuillermot","year":"2011","journal-title":"Genes Brain Behav."},{"issue":"3","key":"10.1016\/j.jad.2019.04.015_bib0090","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.pscychresns.2014.09.005","article-title":"Distinct structural neural patterns of trait physical and social anhedonia: evidence from cortical thickness, subcortical volumes and inter-regional correlations","volume":"224","author":"Wang","year":"2014","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2019.04.015_bib0091","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/104012371302500308","article-title":"Advances in brain stimulation for depression","volume":"25","author":"Wani","year":"2013","journal-title":"Ann. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2019.04.015_bib0092","first-page":"95","article-title":"Free versus forced exploration of a novel situation by rats","volume":"3","author":"Welker","year":"1957","journal-title":"Psychol. Rep."},{"key":"10.1016\/j.jad.2019.04.015_bib0093","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology"},{"issue":"12","key":"10.1016\/j.jad.2019.04.015_bib0094","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.biopsych.2011.12.029","article-title":"Optogenetic insights into social behavior function","volume":"71","author":"Yizhar","year":"2012","journal-title":"Biol. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032718319761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032718319761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:30:44Z","timestamp":1759023044000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032718319761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":91,"alternative-id":["S0165032718319761"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2019.04.015","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abdominal vagal deafferentation alters affective behaviors in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2019.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}