{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:51:03Z","timestamp":1780480263719,"version":"3.54.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jad.2019.06.015","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T11:48:54Z","timestamp":1559821734000},"page":"433-440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Updates in treating comorbid bipolar disorder and obsessive-compulsive disorder: A systematic review"],"prefix":"10.1016","volume":"256","author":[{"given":"A.","family":"Amerio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Maina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.N.","family":"Ghaemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2019.06.015_bib0001","article-title":"Comorbid bipolar disorder and obsessive-compulsive disorder: efficacy of aripiprazole augmentation","author":"Amerio","year":"2018","journal-title":"Aust. N. Z. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2019.06.015_bib0002","article-title":"Aripiprazole augmentation in treating comorbid bipolar disorder and obsessive-compulsive disorder","volume":"31","author":"Amerio","year":"2018","journal-title":"Gen. Psychiatry"},{"key":"10.1016\/j.jad.2019.06.015_bib0003","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jad.2014.05.026","article-title":"Treatment of comorbid bipolar disorder and obsessive-compulsive disorder: a systematic review","volume":"166","author":"Amerio","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.06.015_bib0004","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1177\/0004867417721653","article-title":"The Osler's view: treating comorbid bipolar disorder and obsessive-compulsive disorder","volume":"51","author":"Amerio","year":"2017","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.06.015_bib0005","first-page":"307","article-title":"Heredity in comorbid bipolar disorder and obsessive-compulsive disorder patients","volume":"27","author":"Amerio","year":"2015","journal-title":"Shanghai Arch. Psychiatry"},{"key":"10.1016\/j.jad.2019.06.015_bib0006","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ajp.2016.01.009","article-title":"Course of illness in comorbid bipolar disorder and obsessive-compulsive disorder patients","volume":"20","author":"Amerio","year":"2016","journal-title":"Asian J. Psychiatr."},{"key":"10.1016\/j.jad.2019.06.015_bib0007","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1177\/0004867415617839","article-title":"Treatment of comorbid bipolar disorder and anxiety disorders: a great challenge to modern psychiatry","volume":"50","author":"Amerio","year":"2016","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.06.015_bib0008","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00131746-200507000-00004","article-title":"Aripiprazole: initial clinical experience with 142 hospitalized psychiatric patients","volume":"11","author":"Centorrino","year":"2005","journal-title":"J. Psychiatr. Pract."},{"key":"10.1016\/j.jad.2019.06.015_bib0009","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/jech.52.6.377","article-title":"The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions","volume":"52","author":"Downs","year":"1998","journal-title":"J. Epidemiol. Commun. Health"},{"key":"10.1016\/j.jad.2019.06.015_bib0010","series-title":"Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0","author":"Higgins","year":"2011"},{"key":"10.1016\/j.jad.2019.06.015_bib0011","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jad.2017.08.012","article-title":"Exploration of comorbid obsessive-compulsive disorder in patients with bipolar disorder: the clinic-based prevalence rate, symptoms nature and clinical correlates","volume":"225","author":"Jeon","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.06.015_bib0012","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jad.2014.05.017","article-title":"Impact of comorbid anxiety disorders and obsessive-compulsive disorder on 24-month clinical outcomes of bipolar I disorder","volume":"166","author":"Kim","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.06.015_bib0013","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2147\/NDT.S122316","article-title":"Aripiprazole augmentation in managing comorbid obsessive-compulsive disorder and bipolar disorder: a case with suicidal attempts","volume":"13","author":"Lai","year":"2017","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.jad.2019.06.015_bib0014","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.jad.2019.06.015_bib0015","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jad.2018.01.020","article-title":"A naturalistic exploratory study of obsessive-compulsive bipolar comorbidity in youth","volume":"231","author":"Masi","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.06.015_bib0016","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1177\/0004867416656262","article-title":"Treat the disease not the symptoms: successful management of obsessive compulsive disorder in bipolar disorder with aripiprazole augmentation","volume":"50","author":"Patra","year":"2016","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.06.015_bib0017","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s13256-017-1508-8","article-title":"Electroconvulsive therapy for manic state with mixed and psychotic features in a teenager with bipolar disorder and comorbid episodic obsessive-compulsive disorder: a case report","volume":"11","author":"Rask","year":"2017","journal-title":"J. Med. Case Rep."},{"key":"10.1016\/j.jad.2019.06.015_bib0018","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jad.2014.05.015","article-title":"Topiramate as an adjuvant treatment for obsessive compulsive symptoms in patients with bipolar disorder: a randomized double blind placebo controlled clinical trial","volume":"166","author":"Sahraian","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.06.015_bib0019","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.pnpbp.2018.03.014","article-title":"Aripiprazole as an adjuvant treatment for obsessive and compulsive symptoms in manic phase of bipolar disorder: a randomized, double-blind, placebo-controlled clinical trial","volume":"84","author":"Sahraian","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.06.015_bib0020","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/JCP.0000000000000651","article-title":"Memantine as an adjuvant treatment for obsessive compulsive symptoms in manic phase of bipolar disorder: a randomized, double-blind, placebo-controlled clinical trial","volume":"37","author":"Sahraian","year":"2017","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2019.06.015_bib0021","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/13651501.2016.1233344","article-title":"Bipolar disorder comorbidity in patients with a primary diagnosis of OCD","volume":"21","author":"Saraf","year":"2017","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"10.1016\/j.jad.2019.06.015_bib0022","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jad.2014.12.019","article-title":"Comorbid obsessive compulsive disorder in patients with bipolar-I disorder","volume":"174","author":"Shashidhara","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.06.015_bib0023","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1177\/0004867415621395","article-title":"Comorbid bipolar disorder and obsessive-compulsive disorder: which came first","volume":"50","author":"Tonna","year":"2016","journal-title":"Aust. N. Z. J. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719304227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719304227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:31:47Z","timestamp":1759023107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032719304227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":23,"alternative-id":["S0165032719304227"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2019.06.015","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Updates in treating comorbid bipolar disorder and obsessive-compulsive disorder: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2019.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}