{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:50:01Z","timestamp":1790787001969,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["2016YFC0906300"],"award-info":[{"award-number":["2016YFC0906300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801343"],"award-info":[{"award-number":["81801343"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801345"],"award-info":[{"award-number":["81801345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010843","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["201904010354"],"award-info":[{"award-number":["201904010354"]}],"id":[{"id":"10.13039\/501100010843","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Communication Foundation Science and Technology Commission of Shanghai Municipality","award":["16410722500"],"award-info":[{"award-number":["16410722500"]}]},{"name":"Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory","award":["201805010009"],"award-info":[{"award-number":["201805010009"]}]},{"name":"Science and Technology Program of Guangzhou"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jad.2019.08.012","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T19:51:33Z","timestamp":1565639493000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Repeated intravenous infusions of ketamine: Neurocognition in patients with anxious and nonanxious treatment-resistant depression"],"prefix":"10.1016","volume":"259","author":[{"given":"Weijian","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2019.08.012_bib0001","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1038\/npp.2017.49","article-title":"The nucleus accumbens and ketamine treatment in major depressive disorder","volume":"42","author":"Abdallah","year":"2017","journal-title":"Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2019.08.012_bib0002","series-title":"Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)","first-page":"4189","author":"Association","year":"2013"},{"key":"10.1016\/j.jad.2019.08.012_bib0003","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses","volume":"475","author":"Autry","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jad.2019.08.012_bib0004","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jagp.2017.06.002","article-title":"Anxious depression and neurocognition among middle-aged and older Hispanic\/Latino adults: Hispanic community health study\/study of Latinos (HCHS\/SOL) results","volume":"26","author":"Camacho","year":"2018","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0005","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.addbeh.2013.01.014","article-title":"Effects of chronic ketamine use on frontal and medial temporal cognition","volume":"38","author":"Chan","year":"2013","journal-title":"Addict. Behav."},{"key":"10.1016\/j.jad.2019.08.012_bib0006","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1176\/ajp.148.11.1512","article-title":"Follow-up and family study of anxious depression","volume":"148","author":"Clayton","year":"1991","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0007","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1080\/15622975.2016.1208840","article-title":"Smaller hippocampal volumes predict lower antidepressant response\/remission rates in depressed patients: a meta-analysis","volume":"19","author":"Colle","year":"2018","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0008","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1378\/chest.15-0171","article-title":"Effect of CPAP on cognition, brain function, and structure among elderly patients with OSA: a randomized pilot study","volume":"148","author":"Dalmases","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.jad.2019.08.012_bib0009","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/0269881114527361","article-title":"Ketamine infusions for treatment resistant depression: a series of 28 patients treated weekly or twice weekly in an ECT clinic","volume":"28","author":"Diamond","year":"2014","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2019.08.012_bib0011","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.4088\/JCP.09m05327blu","article-title":"Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder","volume":"71","author":"DiazGranados","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0012","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1017\/S0033291704002612","article-title":"Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*D","volume":"34","author":"Fava","year":"2004","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2019.08.012_bib0030","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1177\/070674370605101304","article-title":"What clinical and symptom features and comorbid disorders characterize outpatients with anxious major depressive disorder: a replication and extension","volume":"51","author":"Fava","year":"2006","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0013","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1176\/appi.ajp.2007.06111868","article-title":"Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report","volume":"165","author":"Fava","year":"2008","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0015","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1007\/s00213-013-3378-0","volume":"231","author":"Fukumoto","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2019.08.012_bib0016","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/s41398-017-0016-3","article-title":"The role of anxious distress in immune dysregulation in patients with major depressive disorder","volume":"7","author":"Gaspersz","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0017","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/YCO.0000000000000376","article-title":"Patients with anxious depression: overview of prevalence, pathophysiology and impact on course and treatment outcome","volume":"31","author":"Gaspersz","year":"2018","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0018","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1017\/S0033291713001827","article-title":"Anxious and non-anxious forms of major depression: familial, personality and symptom characteristics","volume":"44","author":"Goldberg","year":"2014","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2019.08.012_bib0019","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.biopsych.2004.06.023","article-title":"Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria","volume":"56","author":"Green","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0020","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/cercor\/bhj069","article-title":"Anatomical differences in the mirror neuron system and social cognition network in autism","volume":"16","author":"Hadjikhani","year":"2006","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.jad.2019.08.012_bib0021","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamiltom","year":"1959","journal-title":"Br. J. Med. Psychol."},{"key":"10.1016\/j.jad.2019.08.012_bib0022","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamiltom","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0023","doi-asserted-by":"crossref","first-page":"e932","DOI":"10.4088\/JCP.14m09049","article-title":"Effect of baseline anxious depression on initial and sustained antidepressant response to ketamine","volume":"75","author":"Ionescu","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0024","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1017\/S1092852913000114","article-title":"Defining anxious depression: a review of the literature","volume":"18","author":"Ionescu","year":"2013","journal-title":"CNS Spectr."},{"key":"10.1016\/j.jad.2019.08.012_bib0025","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3945\/ajcn.115.116970","article-title":"Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment","volume":"103","author":"K\u00f6be","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jad.2019.08.012_bib0026","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.biopsych.2013.03.026","article-title":"Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond","volume":"73","author":"Krystal","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0027","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.psychres.2014.08.048","article-title":"A comparison of inpatients with anxious depression to those with nonanxious depression","volume":"220","author":"Lin","year":"2014","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.jad.2019.08.012_bib0029","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s11682-012-9213-0","article-title":"Differences in verbal memory retrieval in breast cancer chemotherapy patients compared to healthy controls: a prospective fMRI study","volume":"7","author":"L\u00f3pez Zunini","year":"2013","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.jad.2019.08.012_bib0031","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/0006-3223(94)00132-M","article-title":"CRH challenge test in anxious depression","volume":"37","author":"Meller","year":"1995","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0032","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0033","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1360-0443.2008.02394.x","article-title":"Ketamine use, cognition and psychological wellbeing: a comparison of frequent, infrequent and ex-users with polydrug and non-using controls","volume":"104","author":"Morgan","year":"2009","journal-title":"Addiction"},{"key":"10.1016\/j.jad.2019.08.012_bib0034","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1360-0443.2009.02761.x","article-title":"Consequences of chronic ketamine self-administration upon neurocognitive function and psychological wellbeing: a 1-year longitudinal study","volume":"105","author":"Morgan","year":"2010","journal-title":"Addiction"},{"key":"10.1016\/j.jad.2019.08.012_bib0035","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.neuropharm.2014.08.009","article-title":"Evaluation of 5-HT2A and mGlu2\/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment","volume":"86","author":"Muguruza","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jad.2019.08.012_bib0036","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/npp.2014.298","article-title":"Neurocognitive effects of ketamine and association with antidepressant response in individuals with treatment-resistant depression: a randomized controlled trial","volume":"40","author":"Murrough","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2019.08.012_bib0037","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1176\/appi.ajp.2013.13030392","article-title":"Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial","volume":"170","author":"Murrough","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0038","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00213-013-3255-x","article-title":"Neurocognitive effects of ketamine in treatment-resistant major depression: association with antidepressant response","volume":"231","author":"Murrough","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jad.2019.08.012_bib0039","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1017\/S1041610215000836","article-title":"Gray matter characteristics associated with trait anxiety in older adults are moderated by depression","volume":"27","author":"Potvin","year":"2015","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.jad.2019.08.012_bib0040","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/da.22875","article-title":"Efficacy of intravenous ketamine treatment in anxious versus nonanxious unipolar treatment-resistant depression","volume":"36","author":"Salloum","year":"2019","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2019.08.012_bib0041","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.genhosppsych.2016.07.003","article-title":"Associations between immune activation and the current severity of the \"with anxious distress\" specifier in patients with depressive disorders","volume":"42","author":"Shim","year":"2016","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0042","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1017\/S1461145714001011","article-title":"Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression","volume":"17","author":"Shiroma","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2019.08.012_bib0044","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1192\/bjp.187.1.55","article-title":"Modafinil modulates anterior cingulate function in chronic schizophrenia","volume":"187","author":"Spence","year":"2005","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0045","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S1734-1140(11)70603-X","article-title":"Anxiolytic-like activity of MGS0039, a selective group II mGlu receptor antagonist, is serotonin- and GABA-dependent","volume":"63","author":"Stachowicz","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.jad.2019.08.012_bib0046","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.biopsych.2009.02.017","article-title":"Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?","volume":"66","author":"Vinogradov","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0047","doi-asserted-by":"crossref","first-page":"P246","DOI":"10.1093\/geronb\/57.3.P246","article-title":"Anxiety, cognitive performance, and cognitive decline in normal aging","volume":"57","author":"Wetherell","year":"2002","journal-title":"J. Gerontol. B"},{"key":"10.1016\/j.jad.2019.08.012_bib0048","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.pnpbp.2011.06.013","article-title":"Serum BDNF levels before treatment predict SSRI response in depression","volume":"35","author":"Wolkowitz","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0049","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jad.2013.03.012","article-title":"Difference in remission in a Chinese population with anxious versus nonanxious treatment-resistant depression: a report of operation study","volume":"150","author":"Wu","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.08.012_bib0051","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature17998","article-title":"NMDAR inhibition-independent antidepressant actions of ketamine metabolites","volume":"533","author":"Zanos","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jad.2019.08.012_bib0052","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/wps.20269","article-title":"Ketamine for depression: evidence, challenges and promise","volume":"14","author":"Zarate","year":"2015","journal-title":"World Psychiatry"},{"key":"10.1016\/j.jad.2019.08.012_bib0053","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jpsychires.2018.09.013","article-title":"Rapid and longerterm antidepressant effects of repeateddose intravenous ketamine for patients with unipolar and bipolar depression","volume":"106","author":"Zheng","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2019.08.012_bib0054","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jad.2018.12.005","article-title":"Neurocognitive performance and repeated-dose intravenous ketamine in major depressive disorder","volume":"246","author":"Zheng","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.08.012_bib0055","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1177\/0269881118798614","article-title":"Neurocognitive effects of six ketamine infusions and the association with antidepressant response in patients with unipolar and bipolar depression","volume":"32","author":"Zhou","year":"2018","journal-title":"J. Psychopharmacol."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719311553?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719311553?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:26:05Z","timestamp":1759022765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032719311553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":50,"alternative-id":["S0165032719311553"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2019.08.012","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repeated intravenous infusions of ketamine: Neurocognition in patients with anxious and nonanxious treatment-resistant depression","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2019.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}