{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T20:02:18Z","timestamp":1760385738820,"version":"3.44.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jad.2019.10.015","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T11:13:25Z","timestamp":1570792405000},"page":"181-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Association between CANCA1C gene rs1034936 polymorphism and alcohol dependence in bipolar disorder"],"prefix":"10.1016","volume":"261","author":[{"given":"Mariela","family":"Mosheva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Serretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelena","family":"Stukalin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Fabbri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Hagin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagi","family":"Horev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilma","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Bin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Mattiaccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Nivoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Popovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2000","series-title":"Diagnostic and Statistical Manual of Mental Disorders","key":"10.1016\/j.jad.2019.10.015_bib0001"},{"key":"10.1016\/j.jad.2019.10.015_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2012.06.001","article-title":"CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease","author":"Bhat","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jad.2019.10.015_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2012.02.003","article-title":"Euthymia, depression, and mania: what do we know about the switch?","author":"Blumberg","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0004","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000468543","article-title":"Genes involved in neurodevelopment, neuroplasticity, and bipolar disorder: CACNA1C, CHRNA1, and MAPK1","volume":"74","author":"Calabr\u00f2","year":"2016","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.jad.2019.10.015_bib0005","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10519-011-9505-y","article-title":"Affect-related behaviors in mice selectively bred for high and low voluntary alcohol consumption","volume":"42","author":"Can","year":"2012","journal-title":"Behav. Genet."},{"key":"10.1016\/j.jad.2019.10.015_bib0006","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.242","article-title":"Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder","author":"Charney","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0007","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/mp.2016.86","article-title":"A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development","volume":"21","author":"Cipriani","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2010.06.019","article-title":"Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans","author":"Dao","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0009","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.eurpsy.2013.07.004","article-title":"Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates","volume":"29","author":"Di Florio","year":"2014","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2007.07.001","article-title":"Heritability of bipolar spectrum disorders. Unity or heterogeneity?","author":"Edvardsen","year":"2008","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.10.015_bib0011","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1111\/ejn.13707","article-title":"Altered CAV1.2 function in the Timothy syndrome mouse model produces ascending serotonergic abnormalities","volume":"46","author":"Ehlinger","year":"2017","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jad.2019.10.015_bib0012","doi-asserted-by":"crossref","DOI":"10.1007\/s11920-012-0320-9","article-title":"Bipolar disorder and alcohol use disorder: a review","author":"Farren","year":"2012","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.jad.2019.10.015_bib0013","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/ajmg.b.30132","article-title":"Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence","volume":"133B","author":"Feinn","year":"2005","journal-title":"Am. J. Med. Genet. \u2013 Neuropsychiatr. Genet."},{"key":"10.1016\/j.jad.2019.10.015_bib0014","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/bdi.12423","article-title":"The prevalence and burden of bipolar disorder: findings from the global burden of disease study 2013","volume":"18","author":"Ferrari","year":"2016","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2019.10.015_bib0015","doi-asserted-by":"crossref","unstructured":"First, M.B.et, Spitzer, R.L., Gibbon, M., Williams, J.B.W., 1996. Structured clinical interview for DSM-IV for Axis I disorders (SCID-I) clinician version, for DSMIV.","DOI":"10.1037\/t07827-000"},{"key":"10.1016\/j.jad.2019.10.015_bib0016","doi-asserted-by":"crossref","DOI":"10.1038\/mp.2009.49","article-title":"The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia","volume":"15","author":"Green","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0017","article-title":"What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review","author":"Gurung","year":"2017","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2019.10.015_bib0018","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0022-3565(25)32107-5","article-title":"Inhibition of synaptosomal calcium uptake by ethanol","volume":"213","author":"Harris","year":"1980","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jad.2019.10.015_bib0019","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1083\/jcb.123.4.949","article-title":"Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel\u202f??1 subunits","volume":"123","author":"Hell","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jad.2019.10.015_bib0020","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.biopsych.2011.10.038","article-title":"Neural activation during facial emotion processing in unmedicated bipolar depression, euthymia, and mania","volume":"71","author":"Hulvershorn","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0021","article-title":"Comorbidity of bipolar and substance use disorders in national surveys of general populations, 1990\u20132015: systematic review and meta-analysis","author":"Hunt","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.10.015_bib0022","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.3","article-title":"Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder","author":"Lescai","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0023","first-page":"1","article-title":"CACNA1C polymorphisms impact cognitive recovery in patients with bipolar disorder in a six-week open-label trial","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2019.10.015_bib0024","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1177\/014107688307600713","article-title":"Tolerance and physical dependence on alcohol at the level of synaptic membranes\u202f: a review1","volume":"76","author":"Littleton","year":"1983","journal-title":"J. R. Soc. Med."},{"key":"10.1016\/j.jad.2019.10.015_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2006.02.022","article-title":"Toward a unitary perspective on the bipolar spectrum and substance abuse: opiate addiction as a paradigm","author":"Maremmani","year":"2006","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.10.015_bib0026","doi-asserted-by":"crossref","first-page":"203","DOI":"10.31887\/DCNS.2008.10.2\/rsmcintyre","article-title":"Medical and substance-related comorbidity in bipolar disorder: translational research and treatment opportunities","volume":"10","author":"McIntyre","year":"2008","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.jad.2019.10.015_bib0027","doi-asserted-by":"crossref","DOI":"10.1001\/archpsyc.64.5.543","article-title":"Lifetime and 12-month prevalence of bipolar spectrum disorder in the national comorbidity survey replication","author":"Merikangas","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0028","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.16r11165","article-title":"Review and meta-analysis of epidemiologic studies of adult bipolar disorder","author":"Moreira","year":"2017","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0029","doi-asserted-by":"crossref","DOI":"10.1080\/15622970802688929","article-title":"Lower rates of comorbidities in euthymic bipolar patients","author":"Nery-Fernandes","year":"2009","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0030","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jad.2011.04.055","article-title":"Gender differences in a cohort study of 604 bipolar patients: the role of predominant polarity","volume":"133","author":"Nivoli","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.10.015_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(96)91561-5","article-title":"Addiction: brain mechanisms and their treatment implications","author":"Nutt","year":"1996","journal-title":"Lancet."},{"key":"10.1016\/j.jad.2019.10.015_bib0032","doi-asserted-by":"crossref","first-page":"902","DOI":"10.4088\/JCP.09m05198gry","article-title":"Increased risk for suicidal behavior in comorbid bipolar disorder and alcohol use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)","volume":"71","author":"Oquendo","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0033","doi-asserted-by":"crossref","DOI":"10.1080\/15622970701558488","article-title":"Bipolar disorder preceded by substance abuse: a different phenotype with not so poor outcome?","author":"Pacchiarotti","year":"2009","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0034","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/acps.12179","article-title":"Clinical implications of predominant polarity and the polarity index in bipolar disorder: a naturalistic study","volume":"129","author":"Popovic","year":"2014","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2019.10.015_bib0035","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/bdi.12338","article-title":"Suicide attempts in major depressive episode: evidence from the BRIDGE-II-Mix study","volume":"17","author":"Popovic","year":"2015","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2019.10.015_bib0036","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/ajmg.b.32466","article-title":"Common variants in CACNA1C and MDD susceptibility: a comprehensive meta-analysis","volume":"171","author":"Rao","year":"2016","journal-title":"Am. J. Med. Genet. Part B Neuropsychiatr. Genet."},{"key":"10.1016\/j.jad.2019.10.015_bib0037","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1749-6632.2012.06794.x","article-title":"The genetics of alcohol dependence","volume":"1282","author":"Rietschel","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jad.2019.10.015_bib0038","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature13595","article-title":"Biological insights from 108 schizophrenia-associated genetic loci","volume":"511","author":"Ripke","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jad.2019.10.015_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.pcl.2011.06.010","article-title":"Psychiatric features in children with genetic syndromes: toward functional phenotypes","author":"Siegel","year":"2011","journal-title":"Pediatr. Clin. N. Am."},{"key":"10.1016\/j.jad.2019.10.015_bib0040","first-page":"95S","article-title":"Collaborative genome-wide analysis supports a role for ank3 and cacna1c in bipolar disorder","volume":"65","author":"Sklar","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0041","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/sj.mp.4002151","article-title":"Whole-genome association study of bipolar disorder","volume":"13","author":"Sklar","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0042","doi-asserted-by":"crossref","DOI":"10.1038\/s41588-019-0397-8","article-title":"Genome-wide association study identifies 30 loci associated with bipolar disorder","author":"Stahl","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2019.10.015_bib0043","doi-asserted-by":"crossref","DOI":"10.1111\/j.1399-5618.2004.00110.x","article-title":"Impulsivity: a link between bipolar disorder and substance abuse","author":"Swann","year":"2004","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2019.10.015_bib0044","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-018-0116-7","article-title":"Harmony and heresy of an L-type calcium channel inhibitor: suppression of cocaine seeking via increased dopamine transmission in the nucleus accumbens","author":"Swinford-Jackson","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2019.10.015_bib0045","doi-asserted-by":"crossref","DOI":"10.1001\/archgenpsychiatry.2008.541","article-title":"Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder","author":"Van Der Schot","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2019.10.015_bib0046","doi-asserted-by":"crossref","DOI":"10.1038\/bjp.2008.30","article-title":"Neuropharmacology of alcohol addiction","author":"Vengeliene","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jad.2019.10.015_bib0047","doi-asserted-by":"crossref","DOI":"10.1017\/S0033291714002165","article-title":"The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies","author":"Verhulst","year":"2015","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2019.10.015_bib0048","doi-asserted-by":"crossref","DOI":"10.1034\/j.1399-5618.2001.30504.x","article-title":"Clinical correlates of psychiatric comorbidity in bipolar I patients","author":"Vieta","year":"2001","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2019.10.015_bib0049","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.eurpsy.2011.11.007","article-title":"The clinical implications of cognitive impairment and allostatic load in bipolar disorder","volume":"28","author":"Vieta","year":"2013","journal-title":"Eur. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719315381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719315381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:29:53Z","timestamp":1759022993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032719315381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":49,"alternative-id":["S0165032719315381"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2019.10.015","relation":{},"ISSN":["0165-0327"],"issn-type":[{"type":"print","value":"0165-0327"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between CANCA1C gene rs1034936 polymorphism and alcohol dependence in bipolar disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2019.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}