{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:01:39Z","timestamp":1793296899379,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","award":["NPRP8-061\\u20133\\u2013011"],"award-info":[{"award-number":["NPRP8-061\\u20133\\u2013011"]}],"id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM008685"],"award-info":[{"award-number":["T32 GM008685"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH108348"],"award-info":[{"award-number":["R01MH108348"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG046171"],"award-info":[{"award-number":["R01AG046171"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["M2OVEAD"],"award-info":[{"award-number":["M2OVEAD"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1 AG051550"],"award-info":[{"award-number":["RF1 AG051550"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG057452"],"award-info":[{"award-number":["R01AG057452"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG061359"],"award-info":[{"award-number":["U01 AG061359"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007723","name":"Takeda Pharmaceuticals U.S.A.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002616","name":"Anxiety Disorders Association of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002616","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005277","name":"Presbyterian Historical Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["M01 RR0039"],"award-info":[{"award-number":["M01 RR0039"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 GM28157"],"award-info":[{"award-number":["RO1 GM28157"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 GM61388"],"award-info":[{"award-number":["U19 GM61388"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 MH086690"],"award-info":[{"award-number":["K23 MH086690"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jad.2019.11.122","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T20:06:03Z","timestamp":1575057963000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes"],"prefix":"10.1016","volume":"264","author":[{"given":"Ahmed T.","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"MahmoudianDehkordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeepa","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew","family":"Neavin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Arthur","family":"Moseley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Will","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa St John","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Louie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle K.","family":"Skime","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liewei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Riva-Posse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William V.","family":"Bobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Edward","family":"Craighead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranga","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Weinshilboum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boadie W.","family":"Dunlop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Millington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. John","family":"Rush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Frye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Kaddurah-Daouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2019.11.122_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2018.05.005","article-title":"Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders","volume":"238","author":"Ahmed","year":"2018","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.jad.2019.11.122_bib0003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208238","article-title":"Metabolomics approach in the investigation of depression biomarkers in pharmacologically induced immune-related depression","volume":"13","author":"Baranyi","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jad.2019.11.122_bib0004","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1002\/pmic.200500069","article-title":"Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: evidence for disease-associated changes","volume":"6","author":"Beasley","year":"2006","journal-title":"Proteomics"},{"key":"10.1016\/j.jad.2019.11.122_bib0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0014-4886(82)90047-4","article-title":"Carnitine, carnitine acyltransferases, and rat brain function","volume":"78","author":"Bresolin","year":"1982","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jad.2019.11.122_bib0006","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jnutbio.2005.03.027","article-title":"Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes","volume":"17","author":"Calabrese","year":"2006","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jad.2019.11.122_bib0007","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jad.2008.05.015","article-title":"Subtypes of depression in a nationally representative sample","volume":"113","author":"Carragher","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.11.122_bib0008","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jad.2008.09.006","article-title":"The factor structure of lifetime depressive spectrum in patients with unipolar depression","volume":"115","author":"Cassano","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2019.11.122_bib0009","series-title":"The Neurobiological Basis of Anxiety Disorders","author":"Charney","year":"2002"},{"key":"10.1016\/j.jad.2019.11.122_bib0010","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jpba.2013.10.045","article-title":"Effect of allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography\/mass spectrometry","volume":"89","author":"Chen","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jad.2019.11.122_bib0011","first-page":"115","article-title":"Factor analysis of the hamilton depression scale","volume":"1","author":"Cleary","year":"1977","journal-title":"Drugs. Exp. Clin. Res."},{"key":"10.1016\/j.jad.2019.11.122_bib0012","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1203\/00006450-199910000-00013","article-title":"Dynamic changes of plasma acylcarnitine levels induced by fasting and sunflower oil challenge test in children","volume":"46","author":"Costa","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jad.2019.11.122_bib0013","series-title":"Proceedings of the National Academy of Sciences of the United States of America","first-page":"10761","article-title":"Effect of sleep deprivation on the human metabolome","volume":"111","author":"Davies","year":"2014"},{"key":"10.1016\/j.jad.2019.11.122_bib0014","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1017\/S1092852900015303","article-title":"Psychiatric comorbidity in 36 adults with mitochondrial cytopathies","volume":"12","author":"Fattal","year":"2007","journal-title":"CNS Spectr."},{"key":"10.1016\/j.jad.2019.11.122_bib0015","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1126\/science.129.3345.334","article-title":"Effects of carnitine on fatty-acid oxidation by muscle","volume":"129","author":"FRITZ","year":"1959","journal-title":"Science"},{"key":"10.1016\/j.jad.2019.11.122_bib0016","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0026-0495(78)90022-7","article-title":"Effect of fasting on free and esterified carnitine levels in human serum and urine: correlation with serum levels of free fatty acids and beta-hydroxybutyrate","volume":"27","author":"Frohlich","year":"1978","journal-title":"Metabolism"},{"key":"10.1016\/j.jad.2019.11.122_bib0017","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3109\/13685538.2014.888053","article-title":"Carnitine deficiency is associated with late-onset hypogonadism and depression in uremic men with hemodialysis","volume":"17","author":"Fukami","year":"2014","journal-title":"Aging Male"},{"key":"10.1016\/j.jad.2019.11.122_bib0018","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0165-0327(02)00067-8","article-title":"Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients","volume":"76","author":"Gardner","year":"2003","journal-title":"J. Affect. Disord"},{"key":"10.1016\/j.jad.2019.11.122_bib0019","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1038\/mp.2016.6","article-title":"TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics","volume":"21","author":"Gupta","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2019.11.122_bib0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jad.2019.11.122_bib0021","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jad.2011.07.015","article-title":"Meta-review of depressive subtyping models","volume":"139","author":"Harald","year":"2012","journal-title":"J. Affect. Disord"},{"key":"10.1016\/j.jad.2019.11.122_bib0022","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/mp.2015.53","article-title":"Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major depression","volume":"21","author":"Hieronymus","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2019.11.122_bib0023","doi-asserted-by":"crossref","first-page":"E409","DOI":"10.1152\/ajpendo.1980.238.5.E409","article-title":"Carnitine metabolism in normal-weight and obese human subjects during fasting","volume":"238","author":"Hoppel","year":"1980","journal-title":"Am. J. Physiol. Endocrinol Metabol."},{"key":"10.1016\/j.jad.2019.11.122_bib0024","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1176\/appi.ajp.2010.09091379","article-title":"Research domain criteria (RDoC): toward a new classification framework for research on mental disorders","volume":"167","author":"Insel","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2019.11.122_bib0025","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/clpt.2010.250","article-title":"Glycine and a glycine dehydrogenase (GLDC) snp as citalopram\/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics","volume":"89","author":"Ji","year":"2011","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2019.11.122_bib0026","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/bcp.12348","article-title":"Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations","volume":"78","author":"Ji","year":"2014","journal-title":"Br. J. Clin Pharmacol."},{"key":"10.1016\/j.jad.2019.11.122_bib0027","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.plipres.2009.08.004","article-title":"Acylcarnitines: role in brain","volume":"49","author":"Jones","year":"2010","journal-title":"Prog. Lipid. Res."},{"key":"10.1016\/j.jad.2019.11.122_bib0028","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/sj.mp.4000926","article-title":"The other, forgotten genome: mitochondrial dna and mental disorders","volume":"6","author":"Kato","year":"2001","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2019.11.122_bib0029","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrn3229","article-title":"Impaired mitochondrial function in psychiatric disorders","volume":"13","author":"Manji","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jad.2019.11.122_bib0030","article-title":"Acylcarnitines, quantitative","year":"2017","journal-title":"Plasma"},{"key":"10.1016\/j.jad.2019.11.122_bib0031","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ymgme.2015.10.002","article-title":"Quantitative acylcarnitine determination by UHPLC-MS\/MS\u2013Going beyond tandem ms acylcarnitine \"profiles\"","volume":"116","author":"Minkler","year":"2015","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.jad.2019.11.122_bib0033","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1007\/s00213-018-4992-7","article-title":"Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects","volume":"235","author":"Moaddel","year":"2018","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.jad.2019.11.122_bib0034","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/JCP.0000000000000099","article-title":"Treatment outcomes of depression: the pharmacogenomic research network antidepressant medication pharmacogenomic study","volume":"34","author":"Mrazek","year":"2014","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2019.11.122_bib0035","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.mam.2004.06.001","article-title":"Carnitine: transport and physiological functions in the brain","volume":"25","author":"Na\u0142\u0119cz","year":"2004","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.jad.2019.11.122_bib0036","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.1073\/pnas.1801609115","article-title":"Acetyl-<span class=\"sc\">l<\/span>-carnitine deficiency in patients with major depressive disorder","volume":"115","author":"Nasca","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jad.2019.11.122_bib0037","doi-asserted-by":"crossref","DOI":"10.1007\/s11306-016-1066-x","article-title":"Pharmacometabolomics informs pharmacogenomics","volume":"12","author":"Neavin","year":"2016","journal-title":"Metabolomics"},{"key":"10.1016\/j.jad.2019.11.122_bib0038","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/sj.mp.4000805","article-title":"Acetyl-l-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in alzheimer's disease and geriatric depression","volume":"5","author":"Pettegrew","year":"2000","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2019.11.122_bib0039","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/NMD.0000000000000821","article-title":"Speculations on the future of psychiatric diagnosis","volume":"206","author":"Rush","year":"2018","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.jad.2019.11.122_bib0040","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pnpbp.2004.11.003","article-title":"Cytokines and major depression","volume":"29","author":"Schiepers","year":"2005","journal-title":"Progr. Neuro-Psychopharmacol. Biolog. Psych."},{"key":"10.1016\/j.jad.2019.11.122_bib0041","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/jclp.20213","article-title":"Meta-analysis of the factor structures of four depression questionnaires: beck, CES-D, hamilton, and zung","volume":"62","author":"Shafer","year":"2006","journal-title":"J. Clin. Psychol."},{"key":"10.1016\/j.jad.2019.11.122_bib0042","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/0024-3205(82)90677-4","article-title":"The distribution and role of carnitine in the mammalian brain","volume":"31","author":"Shug","year":"1982","journal-title":"Life Sci."},{"key":"10.1016\/j.jad.2019.11.122_bib0043","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1172\/JCI115856","article-title":"Multiple deletions of mitochondrial dna in several tissues of a patient with severe retarded depression and familial progressive external ophthalmoplegia","volume":"90","author":"Suomalainen","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jad.2019.11.122_bib0044","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2174\/1570180814666170216102632","article-title":"l-Carnitine supplementation improves self-rating depression scale scores in uremic male patients undergoing hemodialysis","volume":"14","author":"Tashiro","year":"2017","journal-title":"Lett. Drug. Des. Discov."},{"key":"10.1016\/j.jad.2019.11.122_bib0045","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.mam.2004.06.003","article-title":"Role of carnitine esters in brain neuropathology","volume":"25","author":"Virmani","year":"2004","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.jad.2019.11.122_bib0046","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7326\/0003-4819-147-8-200710160-00010","article-title":". the strengthening the reporting of observational studies in epidemiology (strobe) statement: guidelines for reporting observational studies","volume":"147","author":"von Elm","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jad.2019.11.122_bib0047","first-page":"153","article-title":"Mechanisms of ischemic neuroprotection by acetyl-l-carnitine","volume":"1053","author":"ZANELLI","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719312807?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719312807?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:18:52Z","timestamp":1777493932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032719312807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":45,"alternative-id":["S0165032719312807"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2019.11.122","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/632448","asserted-by":"object"}]},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2019.11.122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}