{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:01:17Z","timestamp":1785189677802,"version":"3.55.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Aret\u00e6us Foundation of Rome"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.jad.2020.03.066","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T19:29:13Z","timestamp":1585769353000},"page":"9-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Clinical response and metabolic effects of lithium in 323 mood disorder patients"],"prefix":"10.1016","volume":"270","author":[{"given":"Marco","family":"Pinna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Manchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Visioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Tondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2020.03.066_bib0001","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1177\/0269881115573808","article-title":"Effects of 10 to 30 years of lithium treatment on kidney function","volume":"29","author":"Aiff","year":"2015","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2020.03.066_bib0002","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/wps.20462","article-title":"Who are excellent lithium responders and why do they matter?","volume":"16","author":"Alda","year":"2017","journal-title":"World Psychiatry"},{"key":"10.1016\/j.jad.2020.03.066_bib0003","series-title":"Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA","year":"2013"},{"key":"10.1016\/j.jad.2020.03.066_bib0004","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1089\/cap.2013.0046","article-title":"Short-term effects of lithium on white blood cell counts and on levels of serum thyroid-stimulating hormone and creatinine in adolescent inpatients: a retrospective naturalistic study","volume":"24","author":"Amitai","year":"2014","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"10.1016\/j.jad.2020.03.066_bib0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40345-015-0028-y","article-title":"Lithium nephrotoxicity","volume":"3","author":"Azab","year":"2015","journal-title":"Int. J. Bipolar Disord."},{"key":"10.1016\/j.jad.2020.03.066_bib0006","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1001\/archpsyc.57.2.187","article-title":"Does lithium treatment still work? Evidence of stable responses over three decades","volume":"57","author":"Baldessarini","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.066_bib0007","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1749-6632.2001.tb05796.x","article-title":"Treating the suicidal patient with bipolar disorder. Reducing suicide risk with lithium","volume":"932","author":"Baldessarini","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jad.2020.03.066_bib0008","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.metabol.2009.02.002","article-title":"A link between hyperlipidemia and lithium? Confirmation of a recent previous observation","volume":"58","author":"Bardini","year":"2009","journal-title":"Metabolism"},{"key":"10.1016\/j.jad.2020.03.066_bib0009","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2165\/00002018-199921060-00002","article-title":"Drug-induced diabetes insipidus: incidence, prevention and management","volume":"21","author":"Bendz","year":"1999","journal-title":"Drug Saf."},{"key":"10.1016\/j.jad.2020.03.066_bib0010","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/oxfordjournals.ndt.a027311","article-title":"Renal function on and off lithium in patients treated with lithium for 15 years or more. A controlled, prospective lithium-withdrawal study","volume":"11","author":"Bendz","year":"1996","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.jad.2020.03.066_bib0011","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1046\/j.1365-2796.1996.28864000.x","article-title":"Hyperparathyroidism and long-term lithium therapy\u2013a cross-sectional study and the effect of lithium withdrawal","volume":"240","author":"Bendz","year":"1996","journal-title":"J. Int. Med."},{"key":"10.1016\/j.jad.2020.03.066_bib0012","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.metabol.2006.11.001","article-title":"Lithium\u2013a role in hyperlipidemia?","volume":"56","author":"Bergmann","year":"2007","journal-title":"Metabolism"},{"key":"10.1016\/j.jad.2020.03.066_bib0013","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0272-6386(87)80098-7","article-title":"Prevalence, pathogenesis, and treatment of renal dysfunction associated with chronic lithium therapy","volume":"10","author":"Boton","year":"1987","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.jad.2020.03.066_bib0014","doi-asserted-by":"crossref","first-page":"349","DOI":"10.5694\/j.1326-5377.1949.tb36912.x","article-title":"Lithium salts in the treatment of psychotic excitement","volume":"2","author":"Cade","year":"1949","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.jad.2020.03.066_bib0015","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpsychires.2018.03.006","article-title":"Course of bipolar illness worsens after onset of insulin resistance","volume":"102","author":"Cairns","year":"2018","journal-title":"J. Psychiatr. Res."},{"issue":"1","key":"10.1016\/j.jad.2020.03.066_bib0016","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1192\/bjp.bp.114.152850","article-title":"Insulin resistance and outcome in bipolar disorder","volume":"206","author":"Calkin","year":"2015","journal-title":"Br. J. Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2020.03.066_bib0017","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1399-5618.2009.00730.x","article-title":"Can body mass index help predict outcome in patients with bipolar disorder?","volume":"11","author":"Calkin","year":"2009","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2020.03.066_bib0018","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1176\/ajp.156.9.1417","article-title":"Elevated frequency of diabetes mellitus in hospitalized manic-depressive patients","volume":"156","author":"Cassidy","year":"1999","journal-title":"Am. J. Psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2020.03.066_bib0019","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/hup.700","article-title":"Antipsychotic drug use: mcLean hospital","volume":"20","author":"Centorrino","year":"2005","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.jad.2020.03.066_bib0020","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1586\/14737175.2014.947965","article-title":"Lithium for bipolar disorder: a review of the recent literature","volume":"14","author":"Curran","year":"2014","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.jad.2020.03.066_bib0021","first-page":"205","article-title":"The thyroid axis and mood disorders: overview and future prospects","volume":"33","author":"Esposito","year":"1997","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.jad.2020.03.066_bib0022","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/oxfordjournals.aje.a117545","article-title":"Relation of body fat distribution to ischemic heart disease. The National Health and Nutrition Examination Survey I (NHANES I) Epidemiologic Follow-up Study","volume":"142","author":"Freedman","year":"1995","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.jad.2020.03.066_bib0023","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/1097-0142(19800101)45:1<91::AID-CNCR2820450116>3.0.CO;2-#","article-title":"The effect of lithium carbonate on lymphocyte, granulocyte, and platelet function","volume":"45","author":"Friedenberg","year":"1980","journal-title":"Cancer"},{"key":"10.1016\/j.jad.2020.03.066_bib0024","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1176\/ajp.156.12.1909","article-title":"Association between lower serum free T4 and greater mood instability and depression in lithium-maintained bipolar patients","volume":"156","author":"Frye","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.066_bib0025","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1365-2141.1982.tb02799.x","article-title":"Lithium enhances growth of human leukaemia cells in vitro","volume":"51","author":"Gauwerky","year":"1982","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jad.2020.03.066_bib0026","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1176\/appi.ajp.161.2.217","article-title":"Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials","volume":"161","author":"Geddes","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.066_bib0027","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0140-6736(09)61828-6","article-title":"Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial","volume":"375","author":"Geddes","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2020.03.066_bib0028","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40345-016-0068-y","article-title":"Lithium side effects and toxicity: prevalence and management strategies","volume":"4","author":"Gitlin","year":"2016","journal-title":"Int. J. Bipolar Disord."},{"key":"10.1016\/j.jad.2020.03.066_bib0029","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2165\/00023210-200923030-00004","article-title":"Lithium: updated human knowledge using an evidence-based approach: part I: clinical efficacy in bipolar disorder","volume":"23","author":"Grandjean","year":"2009","journal-title":"CNS Drugs"},{"key":"10.1016\/j.jad.2020.03.066_bib0030","doi-asserted-by":"crossref","first-page":"942","DOI":"10.4088\/JCP.v63n1013","article-title":"Is response to prophylactic lithium a familial trait?","volume":"63","author":"Grof","year":"2002","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.066_bib0031","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","article-title":"Development of a rating scale for primary depressive illness","volume":"6","author":"Hamilton","year":"1967","journal-title":"Br. J. Soc. Clin. Psychol."},{"key":"10.1016\/j.jad.2020.03.066_bib0032","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJM198001243020402","article-title":"Primary hyperparathyroidism. Incidence, morbidity, and potential economic impact in a community","volume":"302","author":"Heath","year":"1980","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jad.2020.03.066_bib0033","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1139\/jpn.0213","article-title":"Lithium side-effects and predictors of hypothyroidism in patients with bipolar disorder: sex differences","volume":"27","author":"Henry","year":"2002","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.jad.2020.03.066_bib0034","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/jcu.22336","article-title":"Renal sonography in bipolar patients on long-term lithium treatment","volume":"44","author":"Jonczyk-Potoczna","year":"2016","journal-title":"J. Clin. Ultrasound"},{"key":"10.1016\/j.jad.2020.03.066_bib0035","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/YIC.0b013e32834a5cd0","article-title":"Predictors of excellent response to lithium: results from a nationwide register-based study","volume":"26","author":"Kessing","year":"2011","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2020.03.066_bib0036","first-page":"227","article-title":"Effect of lithium maintenance therapy on thyroid and parathyroid function","volume":"24","author":"Kusalic","year":"1999","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.jad.2020.03.066_bib0037","first-page":"1525","article-title":"Lithium carbonate and leukocytosis","volume":"37","author":"Lapierre","year":"1980","journal-title":"Am. J. Hosp. Pharm."},{"key":"10.1016\/j.jad.2020.03.066_bib0038","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/0010-440X(80)90030-9","article-title":"Prevalence of diabetes in a manic-depressive population","volume":"21","author":"Lilliker","year":"1980","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.066_bib0039","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1177\/0269881105057515","article-title":"Lithium: a review of its metabolic adverse effects","volume":"20","author":"Livingstone","year":"2006","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2020.03.066_bib0040","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1056\/NEJM198001313020503","article-title":"The use of lithium carbonate to reduce infection and leukopenia during systemic chemotherapy","volume":"302","author":"Lyman","year":"1980","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.jad.2020.03.066_bib0041","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065636","article-title":"Assessment of response to lithium maintenance treatment in bipolar disorder: a consortium on lithium genetics (ConLiGen) report","volume":"8","author":"Manchia","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jad.2020.03.066_bib0042","first-page":"161","article-title":"Lithium: a molecular transducer of mood-stabilization in the treatment of bipolar disorder","volume":"19","author":"Manji","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2020.03.066_bib0043","first-page":"115","article-title":"The prevalence, mechanism and clinical significance of lithium-induced hypercalcaemia","volume":"44","author":"McIntosh","year":"1987","journal-title":"Med. Lab. Sci."},{"key":"10.1016\/j.jad.2020.03.066_bib0044","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(11)61516-X","article-title":"Lithium toxicity profile: a systematic review and meta-analysis","volume":"379","author":"McKnight","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2020.03.066_bib0045","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.psychres.2018.01.022","article-title":"Leukocytes in peripheral blood in patients with bipolar disorder - Trait and state alterations and association with levels of cytokines and C-reactive protein","volume":"261","author":"Munkholm","year":"2018","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2020.03.066_bib0046","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/0026-0495(94)90017-5","article-title":"Biochemical hyperparathyroidism and bone mineral status in patients treated long-term with lithium","volume":"43","author":"Nordenstrom","year":"1994","journal-title":"Metabolism"},{"key":"10.1016\/j.jad.2020.03.066_bib0047","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12888-018-1622-1","article-title":"Reasons for lithium discontinuation in men and women with bipolar disorder: a retrospective cohort study","volume":"18","author":"Ohlund","year":"2018","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jad.2020.03.066_bib0048","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0006-3223(94)91155-X","article-title":"Lithium-induced hematologic changes in patients with bipolar affective disorder","volume":"35","author":"Ozdemir","year":"1994","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.066_bib0049","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0165-0327(80)90031-2","article-title":"Lithium carbonate and weight gain","volume":"2","author":"Peselow","year":"1980","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.066_bib0050","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1056\/NEJM199409013310907","article-title":"Lithium in the treatment of mood disorders","volume":"331","author":"Price","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jad.2020.03.066_bib0051","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/0026-0495(86)90170-8","article-title":"Symptomatic reactive hypoglycemia during glucose tolerance test in lithium-treated patients","volume":"35","author":"Shah","year":"1986","journal-title":"Metabolism"},{"key":"10.1016\/j.jad.2020.03.066_bib0052","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1399-5618.2007.00490.x","article-title":"Effectiveness of mood stabilizers and antipsychotics in the maintenance phase of bipolar disorder: a systematic review of randomized controlled trials","volume":"9","author":"Smith","year":"2007","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2020.03.066_bib0053","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40345-017-0096-2","article-title":"Long-term lithium treatment in bipolar disorder: effects on glomerular filtration rate and other metabolic parameters","volume":"5","author":"Tondo","year":"2017","journal-title":"Int. J. Bipolar Disord."},{"key":"10.1016\/j.jad.2020.03.066_bib0054","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ygeno.2008.07.011","article-title":"Pathway analysis of seven common diseases assessed by genome-wide association","volume":"92","author":"Torkamani","year":"2008","journal-title":"Genomics"},{"key":"10.1016\/j.jad.2020.03.066_bib0055","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.4088\/JCP.14r09635","article-title":"Prevalence and predictors of type 2 diabetes mellitus in people with bipolar disorder: a systematic review and meta-analysis","volume":"76","author":"Vancampfort","year":"2015","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.066_bib0056","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-0447.1976.tb00067.x","article-title":"Lithium treatment and weight gain","volume":"53","author":"Vendsborg","year":"1976","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2020.03.066_bib0057","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1600-0447.1988.tb06363.x","article-title":"Prospective studies on a lithium cohort. 3. Tremor, weight gain, diarrhea, psychological complaints","volume":"78","author":"Vestergaard","year":"1988","journal-title":"Acta Psychiatr. Scand"},{"key":"10.1016\/j.jad.2020.03.066_bib0058","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1017\/S1461145711000885","article-title":"Effectiveness of psychotropic medications in the maintenance phase of bipolar disorder: a meta-analysis of randomized controlled trials","volume":"14","author":"Vieta","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2020.03.066_bib0059","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0895-7061(00)01228-0","article-title":"Relation between sodium-lithium countertransport and hypertriglyceridemia in type V hyperlipidemia","volume":"14","author":"Wierzbicki","year":"2001","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.jad.2020.03.066_bib0060","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719327387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719327387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:37:40Z","timestamp":1759023460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032719327387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":60,"alternative-id":["S0165032719327387"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2020.03.066","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical response and metabolic effects of lithium in 323 mood disorder patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2020.03.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}