{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:12:56Z","timestamp":1787800376776,"version":"build-2784847793"},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.jad.2020.03.123","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T10:32:25Z","timestamp":1585909945000},"page":"114-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Generalized Anxiety Disorder is Prospectively Associated With Decreased Levels of Interleukin-6 and Adiponectin Among Individuals from the Community"],"prefix":"10.1016","volume":"270","author":[{"given":"En-Young N.","family":"Wagner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre F.","family":"Strippoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladeta","family":"Ajdacic-Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Gholam-Rezaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Glaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Vandeleur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vollenweider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Preisig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"von K\u00e4nel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2020.03.123_bib0001","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-027925","article-title":"Systematic review and meta-analysis of the association between peripheral inflammatory cytokines and generalised anxiety disorder","volume":"9","author":"Costello","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.jad.2020.03.123_bib0002","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.1523\/JNEUROSCI.4287-13.2014","article-title":"Impaired contextual modulation of memories in PTSD: an fMRI and psychophysiological study of extinction retention and fear renewal","volume":"34","author":"Garfinkel","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2020.03.123_bib0003","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jpsychires.2014.07.012","article-title":"Associations between mood, anxiety or substance use disorders and inflammatory markers after adjustment for multiple covariates in a population-based study","volume":"58","author":"Glaus","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2020.03.123_bib0004","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/da.22710","article-title":"The bidirectional relationship between anxiety disorders and circulating levels of inflammatory markers: Results from a large longitudinal population-based study","volume":"35","author":"Glaus","year":"2018","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2020.03.123_bib0005","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/eurheartj\/eht367","article-title":"Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis","volume":"35","author":"Kaptoge","year":"2014","journal-title":"Eur. Heart. J."},{"key":"10.1016\/j.jad.2020.03.123_bib0006","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.biopsych.2018.12.020","article-title":"Longitudinal Association Between Depression and Inflammatory Markers: Results From the Netherlands Study of Depression and Anxiety","volume":"85","author":"Lamers","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.123_bib0007","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/B978-0-12-398313-8.00014-2","article-title":"Adiponectin and interleukin-6 in inflammation-associated disease","volume":"90","author":"Li","year":"2012","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.jad.2020.03.123_bib0008","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.neuropharm.2011.03.009","article-title":"Gene x environment vulnerability factors for PTSD: the HPA-axis","volume":"62","author":"Mehta","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jad.2020.03.123_bib0009","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-94-024-0921-5_4","article-title":"Narazaki, M., Masuda, K., Kishimoto, T. Regulation of IL-6 in Immunity and Diseases","volume":"941","author":"Tanaka","year":"2016","journal-title":"Adv. Exp. Med. Biol"},{"key":"10.1016\/j.jad.2020.03.123_bib0010","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jad.2019.09.050","article-title":"Peripheral adiponectin levels in anxiety, mood, trauma- and stressor-related disorders: A systematic review and meta-analysis","volume":"260","author":"Vuong","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.123_bib0011","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/da.10065","article-title":"Generalized anxiety disorder: prevalence, burden, and cost to society","volume":"16","author":"Wittchen","year":"2002","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.jad.2020.03.123_bib0012","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/mp.2016.58","article-title":"Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors","volume":"22","author":"Zhang","year":"2017","journal-title":"Mol. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719334202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719334202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:39:15Z","timestamp":1759023555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032719334202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":12,"alternative-id":["S0165032719334202"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2020.03.123","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generalized Anxiety Disorder is Prospectively Associated With Decreased Levels of Interleukin-6 and Adiponectin Among Individuals from the Community","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2020.03.123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}