{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:23:11Z","timestamp":1782742991556,"version":"3.54.5"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.jad.2020.03.140","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T21:08:52Z","timestamp":1588194532000},"page":"249-258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Predictive factors of functional outcome in patients with bipolar I disorder: a five-year follow-up"],"prefix":"10.1016","volume":"272","author":[{"given":"Ana","family":"L\u00f3pez-Villarreal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Mar\u00eda","family":"S\u00e1nchez-Morla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Jim\u00e9nez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Mart\u00ednez-Vizca\u00edno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Isabel","family":"Aparicio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mateo-Sotos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Rodriguez-Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2020.03.140_bib0001","series-title":"Practical multivariate analysis","author":"Afifi","year":"2020"},{"key":"10.1016\/j.jad.2020.03.140_bib0002","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1176\/ps.2007.58.11.1441","article-title":"Executive function and employment status among veterans with bipolar disorder","volume":"58","author":"Altshuler","year":"2007","journal-title":"Psychiatr. Serv."},{"key":"10.1016\/j.jad.2020.03.140_bib0003","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/acps.12535","article-title":"Cognitive reserve in bipolar disorder: relation to cognition, psychosocial functioning and quality of life","volume":"133","author":"Anaya","year":"2016","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2020.03.140_bib0004","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/YCO.0b013e32835a2acf","article-title":"The predictive significance of neurocognitive factors for functional outcome in bipolar disorder","volume":"26","author":"Andreou","year":"2013","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0005","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/acps.12706","article-title":"Emotion processing and psychosocial functioning in euthymic bipolar disorder","volume":"135","author":"Aparicio","year":"2017","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2020.03.140_bib0006","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1600-0447.2010.01601.x","article-title":"A 2-year naturalistic study on cognitive functioning in bipolar disorder","volume":"123","author":"Arts","year":"2011","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2020.03.140_bib0007","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1017\/S0033291707001675","article-title":"Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives","volume":"38","author":"Arts","year":"2008","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2020.03.140_bib0008","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/bdi.12349","article-title":"Predictors of long-term work disability among patients with type I and II bipolar disorder: a prospective 18-month follow-up study","volume":"17","author":"Arvilommi","year":"2015","journal-title":"Bipolar Disord"},{"issue":"2","key":"10.1016\/j.jad.2020.03.140_bib0009","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/bdi.12341","article-title":"A review on the impact of cognitive dysfunction on social, occupational, and general functional outcomes in bipolar disorder","volume":"17","author":"Baune","year":"2015","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0010","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1399-5618.2011.00928.x","article-title":"The impact of neurocognitive impairment on occupational recovery of clinically stable patients with bipolar disorder: a prospective study","volume":"13","author":"Bearden","year":"2011","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0011","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jad.2016.09.063","article-title":"Neurocognition and psychosocial functioning in adolescents with bipolar disorder","volume":"207","author":"Best","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0012","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jad.2014.02.034","article-title":"Verbal memory as a mediator in the relationship between subthreshold depressive symptoms and functional outcome in bipolar disorder","volume":"160","author":"Bonn\u00edn","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0013","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3390\/jcm8071046","article-title":"Lifetime Psychotic Symptoms, Subthreshold Depression and Cognitive Impairment as Barriers to Functional Recovery in Patients with Bipolar Disorder","volume":"8","author":"Bonn\u00edn","year":"2019","journal-title":"J. Clin. Med"},{"key":"10.1016\/j.jad.2020.03.140_bib0014","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jad.2009.05.014","article-title":"Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study","volume":"121","author":"Bonn\u00edn","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jad.2015.04.043","article-title":"Predictors of functional outcome after a manic episode","volume":"182","author":"Bonn\u00edn","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0016","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1192\/bjp.bp.114.162123","article-title":"Functional remediation in bipolar disorder: 1-year follow-up of neurocognitive and functional outcome","volume":"208","author":"Bonnin","year":"2016","journal-title":"Br. J. psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0017","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1017\/S0033291717001490","article-title":"Meta-analysis of longitudinal studies of cognition in bipolar disorder: comparison with healthy controls and schizophrenia","volume":"47","author":"Bora","year":"2017","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2020.03.140_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2008.06.009","article-title":"Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives","volume":"113","author":"Bora","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0019","doi-asserted-by":"crossref","unstructured":"Borgelt, L., Strakowski, S.M., DelBello, M.P., Weber, W., Eliassen, J.C., Komoroski, R.A., Chu, W.J., Welge, J.A., Blom, T.J., Rummelhoff, E., Tallman, M., Lee, J.H., Adler, C.M., 2019. Neurophysiological effects of multiple mood episodes in bipolar disorder. Bipolar Disord. 10.1111\/bdi.12782.","DOI":"10.1111\/bdi.12782"},{"key":"10.1016\/j.jad.2020.03.140_bib0020","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.eurpsy.2019.09.001","article-title":"Correlates of current rapid-cycling bipolar disorder: Results from the Italian multicentric RENDiBi study","volume":"62","author":"Buoli","year":"2019","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0021","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1600-0447.2010.01590.x","article-title":"Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15-year follow-up","volume":"122","author":"Burdick","year":"2010","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2020.03.140_bib0022","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/bdi.12775","article-title":"Functional outcome assessment in bipolar disorder: A systematic literature review","volume":"21","author":"Chen","year":"2019","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0023","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1192\/bjp.180.4.313","article-title":"Sustained attention deficit in bipolar disorder","volume":"180","author":"Clark","year":"2002","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0024","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0025-7753(02)73419-2","article-title":"[Spanish version of a scale for the assessment of mania: validity and reliability of the Young Mania Rating Scale]","volume":"119","author":"Colom","year":"2002","journal-title":"Med. Clin. (Barc)."},{"key":"10.1016\/j.jad.2020.03.140_bib0025","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/NMD.0000000000000683","article-title":"Functional Impairment in Older Adults With Bipolar Disorder","volume":"205","author":"Comes","year":"2017","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.jad.2020.03.140_bib0026","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jad.2016.06.063","article-title":"Prevalence and correlates of cognitive impairment in euthymic adults with bipolar disorder: A systematic review","volume":"205","author":"Cullen","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0027","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.psychres.2016.12.048","article-title":"Course of neurocognitive function in first treatment bipolar I disorder: One-year follow-up study","volume":"249","author":"Demmo","year":"2017","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.jad.2020.03.140_bib0028","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/bdi.12569","article-title":"Neurocognitive functioning, clinical course and functional outcome in first-treatment bipolar I disorder patients with and without clinical relapse: A 1-year follow-up study","volume":"20","author":"Demmo","year":"2018","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0030","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1399-5618.2009.00784.x","article-title":"Occupational status and social adjustment six months after hospitalization early in the course of bipolar disorder: A prospective study","volume":"12","author":"Dickerson","year":"2010","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0031","doi-asserted-by":"crossref","unstructured":"Dickinson, T., Becerra, R., Coombes, J., 2017. Executive functioning deficits among adults with Bipolar Disorder (types I and II): A systematic review and meta-analysis. J. Affect. Disord. 10.1016\/j.jad.2017.04.010.","DOI":"10.1016\/j.jad.2017.04.010"},{"key":"10.1016\/j.jad.2020.03.140_bib0032","doi-asserted-by":"crossref","first-page":"659","DOI":"10.5964\/ejop.v12i4.909","article-title":"The Relationship Between Neurocognitive Functioning and Occupational Functioning in Bipolar Disorder: A Literature Review","volume":"12","author":"Duarte","year":"2016","journal-title":"Eur. J. Psychol."},{"key":"10.1016\/j.jad.2020.03.140_bib0033","article-title":"Longitudinal relationships between cognition and functioning over 2 years in euthymic patients with bipolar disorder: a cross-lagged panel model approach with the FACE-BD cohort","volume":"1\u20138","author":"Ehrminger","year":"2019","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0034","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jad.2016.11.021","article-title":"The difficult lives of individuals with bipolar disorder: A review of functional outcomes and their implications for treatment","volume":"209","author":"Gitlin","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0035","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1176\/ajp.152.3.379","article-title":"Course and outcome in bipolar affective disorder: a longitudinal follow- up study","volume":"152","author":"Goldberg","year":"1995","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0036","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/acps.12003","article-title":"Occupational disability in bipolar disorder: analysis of predictors of being on severe disablement benefit (PREBIS study data)","volume":"127","author":"Grande","year":"2013","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2020.03.140_bib0038","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.psychres.2014.05.047","article-title":"The role of social relationships in bipolar disorder: a review","volume":"219","author":"Greenberg","year":"2014","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.jad.2020.03.140_bib0039","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/mp.2017.73","article-title":"Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group","volume":"23","author":"Hibar","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1399-5618.2007.00427.x","article-title":"Neurocognitive test performance predicts functional recovery from acute exacerbation leading to hospitalization in bipolar disorder","volume":"9","author":"Jaeger","year":"2007","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0041","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jad.2017.07.014","article-title":"Neurocognition in patients with psychotic and non-psychotic bipolar I disorder. A comparative study with individuals with schizophrenia","volume":"222","author":"Jim\u00e9nez-L\u00f3pez","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0042","first-page":"177","article-title":"Psychosocial functioning in patients with psychotic and non-psychotic bipolar I disorder","volume":"229","author":"Jim\u00e9nez-L\u00f3pez","year":"2018","journal-title":"A comparative study with individuals with schizophrenia. J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0043","first-page":"60","article-title":"Neurocognition and functional outcome in patients with psychotic, non-psychotic bipolar I disorder, and schizophrenia","volume":"56","author":"Jim\u00e9nez-L\u00f3pez","year":"2019","journal-title":"A five-year follow-up. Eur. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0044","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/acps.12305","article-title":"Staging systems in bipolar disorder: an International Society for Bipolar Disorders Task Force Report","volume":"130","author":"Kapczinski","year":"2014","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2020.03.140_bib0045","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/14737175.2017.1240615","article-title":"Neuroprogression and illness trajectories in bipolar disorder","volume":"17","author":"Kapczinski","year":"2017","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.jad.2020.03.140_bib0046","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4088\/JCP.v63n0206","article-title":"Demographic and clinical characteristics of individuals in a bipolar disorder case registry","volume":"63","author":"Kupfer","year":"2002","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0047","doi-asserted-by":"crossref","first-page":"e1242","DOI":"10.4088\/JCP.17m11476","article-title":"Treatment to Enhance Cognition in Bipolar Disorder (TREC-BD): Efficacy of a Randomized Controlled Trial of Cognitive Remediation Versus Active Control","volume":"78","author":"Lewandowski","year":"2017","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0048","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jad.2018.12.044","article-title":"Identifying cognitive subgroups in bipolar disorder: A cluster analysis","volume":"246","author":"Lima","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0049","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1399-5618.2010.00835.x","article-title":"Effects of recurrence on the cognitive performance of patients with bipolar I disorder: implications for relapse prevention and treatment adherence","volume":"12","author":"L\u00f3pez-Jaramillo","year":"2010","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0050","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Villarreal, A., S\u00e1nchez-Morla, E.M., Jim\u00e9nez-L\u00f3pez, E., Mart\u00ednez-Vizca\u00edno, V., Aparicio, A.I., Mateo-Sotos, J., Rodriguez-Jimenez, R., Vieta, E., Santos, J.L., 2019. Progression of the functional deficit in a group of patients with bipolar disorder: a cluster analysis based on longitudinal data. Eur. Arch. Psychiatry Clin. Neurosci. 10.1007\/s00406-019-01050-9.","DOI":"10.1007\/s00406-019-01050-9"},{"key":"10.1016\/j.jad.2020.03.140_bib0051","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1034\/j.1600-0447.2001.00059.x","article-title":"A review of psychosocial outcome in patients with bipolar disorder","volume":"103","author":"MacQueen","year":"2001","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2020.03.140_bib0052","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1034\/j.1600-0447.2000.101005374.x","article-title":"Effect of number of episodes on wellbeing and functioning of patients with bipolar disorder","volume":"101","author":"MacQueen","year":"2000","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2020.03.140_bib0053","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1177\/0004867412460593","article-title":"Cumulative morbidity and prognostic staging of illness in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)","volume":"46","author":"Magalh\u00e3es","year":"2012","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0054","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4088\/JCP.v69n0209","article-title":"Neurocognitive impairment in bipolar patients with and without history of psychosis","volume":"69","author":"Mart\u00ednez-Ar\u00e1n","year":"2008","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0055","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1399-5618.2004.00111.x","article-title":"Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcome","volume":"6","author":"Mart\u00ednez-Ar\u00e1n","year":"2004","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0056","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1176\/appi.ajp.161.2.262","article-title":"Cognitive Function Across Manic or Hypomanic, Depressed, and Euthymic States in Bipolar Disorder","volume":"161","author":"Mart\u00ednez-Ar\u00e1n","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0057","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1399-5618.2007.00327.x","article-title":"Functional outcome in bipolar disorder: the role of clinical and cognitive factors","volume":"9","author":"Mart\u00ednez-Ar\u00e1n","year":"2007","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0058","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jad.2017.08.011","article-title":"Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder","volume":"225","author":"Martino","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0059","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jad.2008.10.023","article-title":"Neurocognitive and symptomatic predictors of functional outcome in bipolar disorders: a prospective 1 year follow-up study","volume":"116","author":"Martino","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.comppsych.2016.07.008","article-title":"A preliminary longitudinal study on the cognitive and functional outcome of bipolar excellent lithium responders","volume":"71","author":"Mora","year":"2016","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0061","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1017\/S0033291712001948","article-title":"Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study","volume":"43","author":"Mora","year":"2013","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2020.03.140_bib0062","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000207456","article-title":"Influence of clinical and neuropsychological variables on the psychosocial and occupational outcome of remitted bipolar patients","volume":"42","author":"Mur","year":"2009","journal-title":"Psychopathology"},{"key":"10.1016\/j.jad.2020.03.140_bib0063","doi-asserted-by":"crossref","first-page":"712","DOI":"10.4088\/JCP.v69n0504","article-title":"Long-term stability of cognitive impairment in bipolar disorder: a 2-year follow-up study of lithium-treated euthymic bipolar patients","volume":"69","author":"Mur","year":"2008","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0064","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00406-017-0811-0","article-title":"Modifiable and non-modifiable factors associated with functional impairment during the inter-episodic periods of bipolar disorder","volume":"268","author":"Murru","year":"2018","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jad.2020.03.140_bib0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.schres.2004.09.007","article-title":"Identification of separable cognitive factors in schizophrenia","volume":"72","author":"Nuechterlein","year":"2004","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jad.2020.03.140_bib0066","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jad.2017.03.015","article-title":"Depression and executive functioning deficits predict poor occupational functioning in a large longitudinal sample with bipolar disorder","volume":"215","author":"O'Donnell","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0067","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jad.2009.12.012","article-title":"Ecologically valid cognitive tests and everyday functioning in euthymic bipolar disorder patients","volume":"125","author":"O\u00b4Shea","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0068","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/acps.12581","article-title":"Areas of controversy in neuroprogression in bipolar disorder","volume":"134","author":"Passos","year":"2016","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2020.03.140_bib0069","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4088\/JCP.09m05514yel","article-title":"Clinical features associated with poor pharmacologic adherence in bipolar disorder: Results from the STEP-BD study","volume":"71","author":"Perlis","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0070","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jpsychires.2012.02.004","article-title":"Neurobiological correlates of illness progression in the recurrent affective disorders","volume":"46","author":"Post","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2020.03.140_bib0071","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0022-3956(88)90024-6","article-title":"A new validation of the Hamilton Rating Scale for Depression","volume":"22","author":"Ramos-Brieva","year":"1988","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2020.03.140_bib0072","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jad.2012.06.005","article-title":"Towards a clinical staging for bipolar disorder: defining patient subtypes based on functional outcome","volume":"144","author":"Reinares","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0073","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jad.2013.12.017","article-title":"Psychosocial interventions in bipolar disorder: what, for whom, and when","volume":"156","author":"Reinares","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0074","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1399-5618.2006.00277.x","article-title":"Evolution of cognitive impairment in bipolar disorder: a systematic review of cross-sectional evidence","volume":"8","author":"Robinson","year":"2006","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0075","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1600-0447.2011.01830.x","article-title":"One-year psychosocial functioning in patients in the early vs. late stage of bipolar disorder","volume":"125","author":"Rosa","year":"2012","journal-title":"Acta Psychiatr. Scand"},{"key":"10.1016\/j.jad.2020.03.140_bib0076","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1399-5618.2009.00698.x","article-title":"Clinical predictors of functional outcome of bipolar patients in remission","volume":"11","author":"Rosa","year":"2009","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0077","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1745-0179-3-5","article-title":"Validity and reliability of the Functioning Assessment Short Test (FAST) in bipolar disorder","volume":"3","author":"Rosa","year":"2007","journal-title":"Clin. Pract. Epidemiol. Ment. Heal."},{"key":"10.1016\/j.jad.2020.03.140_bib0078","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/bdi.12485","article-title":"Cognitive profiles in euthymic patients with bipolar disorders: results from the FACE-BD cohort","volume":"19","author":"Roux","year":"2017","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0079","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rpsm.2018.10.001","article-title":"CIBERSAM: Ten years of collaborative translational research in mental disorders","volume":"12","author":"Salagre","year":"2019","journal-title":"Rev. Psiquiatr. Salud Ment."},{"key":"10.1016\/j.jad.2020.03.140_bib0080","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1034\/j.1399-5618.2000.20308.x","article-title":"Impact of substance abuse on the course and treatment of bipolar disorder","volume":"2","author":"Salloum","year":"2000","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0081","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jad.2016.12.054","article-title":"Residual depressive symptoms, sleep disturbance and perceived cognitive impairment as determinants of functioning in patients with bipolar disorder","volume":"210","author":"Samalin","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0082","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/acps.12894","article-title":"Factors associated with poor functional outcome in bipolar disorder: sociodemographic, clinical, and neurocognitive variables","volume":"138","author":"Sanchez-Moreno","year":"2018","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2020.03.140_bib0083","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.psychres.2008.06.032","article-title":"Comparative study of neurocognitive function in euthymic bipolar patients and stabilized schizophrenic patients","volume":"169","author":"S\u00e1nchez-Morla","year":"2009","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.jad.2020.03.140_bib0084","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1600-0447.2007.01141.x","article-title":"P50 sensory gating deficit is a common marker of vulnerability to bipolar disorder and schizophrenia","volume":"117","author":"S\u00e1nchez-Morla","year":"2008","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2020.03.140_bib0085","article-title":"Impact of number of episodes on neurocognitive trajectory in bipolar disorder patients: a 5-year follow-up study","volume":"1\u20139","author":"S\u00e1nchez-Morla","year":"2018","journal-title":"Psychol. Med"},{"key":"10.1016\/j.jad.2020.03.140_bib0086","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/bdi.12215","article-title":"A five-year follow-up study of neurocognitive functioning in bipolar disorder","volume":"16","author":"Santos","year":"2014","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0087","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/NMD.0b013e31829db5ed","article-title":"Attention\/processing speed prospectively predicts social impairment 18 years later in mood disorders","volume":"201","author":"Sarapas","year":"2013","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.jad.2020.03.140_bib0088","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/bdi.12056","article-title":"Occupational outcome in bipolar disorder is not predicted by premorbid functioning and intelligence","volume":"15","author":"Schoeyen","year":"2013","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0089","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/bdi.12374","article-title":"Five-year follow-up of cognitive impairment in older adults with bipolar disorder","volume":"18","author":"Schouws","year":"2016","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2020.03.140_bib0090","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jad.2019.02.053","article-title":"Predominant polarity in bipolar disorder patients: The COPE bipolar sample","volume":"250","author":"Sentissi","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0091","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11920-018-0897-8","article-title":"Medical Comorbidities in Bipolar Disorder","volume":"20","author":"Sinha","year":"2018","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.jad.2020.03.140_bib0092","doi-asserted-by":"crossref","unstructured":"Sol\u00e9, B., Bonnin, C.M., Jim\u00e9nez, E., Torrent, C., Torres, I., Varo, C., Valls, E., Montejo, L., G\u00f3mez-Oca\u00f1a, C., Tomioka, Y., Vieta, E., Martinez-Aran, A., Reinares, M., 2018. Heterogeneity of functional outcomes in patients with bipolar disorder: a cluster-analytic approach. Acta Psychiatr. Scand. 10.1111\/acps.12871.","DOI":"10.1111\/acps.12871"},{"key":"10.1016\/j.jad.2020.03.140_bib0093","first-page":"26","article-title":"Impact of Cognition and Clinical Factors on Functional Outcome in Patients with Bipolar Disorder","volume":"27","author":"Soni","year":"2017","journal-title":"East Asian Arch. psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0094","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5498\/wjp.v9.i1.7","article-title":"Comorbidity of bipolar and anxiety disorders: An overview of trends in research","volume":"9","author":"Spoorthy","year":"2019","journal-title":"World J. psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0095","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jad.2007.12.234","article-title":"Neurocognitive and clinical predictors of functional outcome in patients with schizophrenia and bipolar I disorder at one-year follow-up","volume":"109","author":"Tabar\u00e9s-Seisdedos","year":"2008","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2020.03.140_bib0096","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2018.00709","article-title":"Staging, Neurocognition and Social Functioning in Bipolar Disorder","volume":"9","author":"Tatay-Manteiga","year":"2018","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0097","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1176\/appi.ajp.157.2.220","article-title":"Two-Year Syndromal and Functional Recovery in 219 Cases of First-Episode Major Affective Disorder With Psychotic Features","volume":"157","author":"Tohen","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0098","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1176\/appi.ajp.160.12.2099","article-title":"The McLean-Harvard First-Episode Mania Study: prediction of recovery and first recurrence","volume":"160","author":"Tohen","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0099","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/archpsyc.55.1.41","article-title":"Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence","volume":"55","author":"van Gorp","year":"1998","journal-title":"A preliminary study. Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0100","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.eurpsy.2018.05.002","article-title":"Functional outcome and social cognition in bipolar disorder: Is there a connection?","volume":"52","author":"Vlad","year":"2018","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0101","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/jamapsychiatry.2013.19","article-title":"Recovery in Remitted First-Episode Psychosis at 7 Years of Follow-up of an Early Dose Reduction\/Discontinuation or Maintenance Treatment Strategy","volume":"70","author":"Wunderink","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2020.03.140_bib0102","doi-asserted-by":"crossref","unstructured":"Xiaoling, L., Dali, L., Yinghua, Z., Xia, L., Zhixin, H., Wen, C., 2019. The effects of cognitive reserve on predicting and moderating the cognitive and psychosocial functioning of patients with bipolar disorder. J. Affect. Disord. 10.1016\/j.jad.2019.09.019.","DOI":"10.1016\/j.jad.2019.09.019"},{"key":"10.1016\/j.jad.2020.03.140_bib0103","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jad.2016.01.029","article-title":"A pilot study of a combined group and individual functional remediation program for patients with bipolar i disorder","volume":"194","author":"Zyto","year":"2016","journal-title":"J. Affect. Disord."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719330290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032719330290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:42:49Z","timestamp":1759023769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032719330290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":101,"alternative-id":["S0165032719330290"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2020.03.140","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictive factors of functional outcome in patients with bipolar I disorder: a five-year follow-up","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2020.03.140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}