{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:44:15Z","timestamp":1791474255648,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.jad.2020.06.068","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T22:02:26Z","timestamp":1594850546000},"page":"608-615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Relationship between hippocampal volume and inflammatory markers following six infusions of ketamine in major depressive disorder"],"prefix":"10.1016","volume":"276","author":[{"given":"Yan-Ling","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Chun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Feng","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Rong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ping","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2020.06.068_bib0001","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1038\/npp.2017.49","article-title":"The nucleus accumbens and ketamine treatment in major depressive disorder","volume":"42","author":"Abdallah","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2020.06.068_bib0002","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/0269881114544776","article-title":"Hippocampal volume and the rapid antidepressant effect of ketamine","volume":"29","author":"Abdallah","year":"2015","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2020.06.068_bib0003","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/bph.13714","article-title":"Rapid antidepressant effect of ketamine correlates with astroglial plasticity in the hippocampus","volume":"174","author":"Ardalan","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jad.2020.06.068_bib0004","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/hipo.22617","article-title":"Neurovascular plasticity of the hippocampus one week after a single dose of ketamine in genetic rat model of depression","volume":"26","author":"Ardalan","year":"2016","journal-title":"Hippocampus"},{"key":"10.1016\/j.jad.2020.06.068_bib0005","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses","volume":"475","author":"Autry","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jad.2020.06.068_bib0006","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.psychres.2018.08.078","article-title":"Rapid inflammation modulation and antidepressant efficacy of a low-dose ketamine infusion in treatment-resistant depression, A randomized, double-blind control study","volume":"269","author":"Chen","year":"2018","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2020.06.068_bib0007","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.psyneuen.2018.05.019","article-title":"Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes","volume":"95","author":"Doolin","year":"2018","journal-title":"Psychoneuroendocrinology"},{"issue":"12","key":"10.1016\/j.jad.2020.06.068_bib0008","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2020.06.068_bib0009","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pnpbp.2016.05.007","article-title":"Potential involvement of serotonergic signaling in ketamine's antidepressant actions, A critical review","volume":"71","author":"du Jardin","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2020.06.068_bib0010","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1038\/tp.2012.14","article-title":"Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1, high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder","volume":"2","author":"Frodl","year":"2012","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2020.06.068_bib0011","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1111\/j.1471-4159.1991.tb03460.x","article-title":"Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism","volume":"56","author":"Fukui","year":"1991","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jad.2020.06.068_bib0012","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/glia.20090","article-title":"Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons","volume":"49","author":"Guillemin","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.jad.2020.06.068_bib0013","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jat\/bkw071","article-title":"A Simple HPLC-MS\/MS method for determination of tryptophan, kynurenine and kynurenic acid in human serum and its potential for monitoring antidepressant therapy","volume":"41","author":"Hu","year":"2017","journal-title":"J Anal Toxicol"},{"key":"10.1016\/j.jad.2020.06.068_bib0014","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neurobiolaging.2019.03.015","article-title":"Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-\u03b2 and tau","volume":"80","author":"Jacobs","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jad.2020.06.068_bib0015","doi-asserted-by":"crossref","first-page":"10054","DOI":"10.1038\/s41598-018-28300-5","article-title":"Relationship between interleukin (IL)-6 and brain morphology in drug-na\u00efve, first-episode major depressive disorder using surface-based morphometry","volume":"8","author":"Kakeda","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2020.06.068_bib0016","doi-asserted-by":"crossref","first-page":"e1065","DOI":"10.1038\/tp.2017.31","article-title":"Altered peripheral immune profiles in treatment-resistant depression, response to ketamine and prediction of treatment outcome","volume":"7","author":"Kiraly","year":"2017","journal-title":"Transl. Psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2020.06.068_bib0017","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/acps.12698","article-title":"Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies","volume":"135","author":"Kohler","year":"2017","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.jad.2020.06.068_bib0018","first-page":"664","article-title":"Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression","volume":"10","author":"Koo","year":"2009","journal-title":"Curr. Op. Investigat. Drugs"},{"issue":"8","key":"10.1016\/j.jad.2020.06.068_bib0019","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/ijnp\/pyz030","article-title":"Hippocampal subfields in acute and remitted depression-an ultra-high field magnetic resonance imaging study","volume":"22","author":"Kraus","year":"2019","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2020.06.068_bib0020","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents, the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2020.06.068_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2018.12.015","article-title":"Plasma and cerebrospinal fluid inflammatory cytokines in perinatal depression","volume":"220","author":"Miller","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jad.2020.06.068_bib0022","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s40263-018-0519-3","article-title":"Antidepressant efficacy and tolerability of ketamine and esketamine, a critical review","volume":"32","author":"Molero","year":"2018","journal-title":"CNS Drugs"},{"key":"10.1016\/j.jad.2020.06.068_bib0023","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/mp.2009.116","article-title":"CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha, relationship to CNS immune responses and depression","volume":"15","author":"Raison","year":"2010","journal-title":"Mol. Psychiatry"},{"issue":"7","key":"10.1016\/j.jad.2020.06.068_bib0024","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrn3257","article-title":"Kynurenines in the mammalian brain: when physiology meets pathology","volume":"13","author":"Schwarcz","year":"2012","journal-title":"Nature Rev. Neurosci."},{"key":"10.1016\/j.jad.2020.06.068_bib0025","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/npp.2014.194","article-title":"Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder","volume":"40","author":"Savitz","year":"2015","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"10.1016\/j.jad.2020.06.068_bib0026","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.euroneuro.2015.06.007","article-title":"Inflammation and clinical response to treatment in depression: a meta-analysis","volume":"25","author":"Strawbridge","year":"2015","journal-title":"European Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.jad.2020.06.068_bib0027","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.biopsych.2017.10.025","article-title":"Stress, depression, and inflammation: molecular and microglial mechanisms","volume":"83","author":"Stein","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2020.06.068_bib0028","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1248\/bpb.b17-00131","article-title":"Ketamine alleviates depressive-like behaviors via down-regulating inflammatory cytokines induced by chronic restraint stress in mice","volume":"40","author":"Tan","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jad.2020.06.068_bib0029","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/4151030a","article-title":"Functional neurogenesis in the adult hippocampus","volume":"415","author":"van Praag","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jad.2020.06.068_bib0030","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1176\/appi.ajp.161.11.1957","article-title":"Hippocampal volume and depression, a meta-analysis of MRI studies","volume":"161","author":"Videbech","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2020.06.068_bib0031","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/npp.2013.71","article-title":"NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL\/6J mice","volume":"38","author":"Walker","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2020.06.068_bib0032","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3892\/etm.2013.930","article-title":"Ketamine exerts antidepressant effects and reduces IL-1\u03b2 and IL-6 levels in rat prefrontal cortex and hippocampus","volume":"5","author":"Yang","year":"2013","journal-title":"Eeperiment. Therapeutic Med."},{"key":"10.1016\/j.jad.2020.06.068_bib0033","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature25509","article-title":"Ketamine blocks bursting in the lateral habenula to rapidly relieve depression","volume":"554","author":"Yang","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jad.2020.06.068_bib0034","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1038\/mp.2017.239","article-title":"Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit","volume":"23","author":"Yao","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2020.06.068_bib0035","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbi.2018.09.007","article-title":"Antidepressant effect of repeated ketamine administration on kynurenine pathway metabolites in patients with unipolar and bipolar depression","volume":"74","author":"Zhou","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2020.06.068_bib0036","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/npp.2011.277","article-title":"Interleukin-1\u03b2, a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis","volume":"37","author":"Zunszain","year":"2012","journal-title":"Neuropsychopharmacology"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032720324654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032720324654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:47:33Z","timestamp":1759024053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032720324654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":36,"alternative-id":["S0165032720324654"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2020.06.068","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationship between hippocampal volume and inflammatory markers following six infusions of ketamine in major depressive disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2020.06.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}