{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:16:10Z","timestamp":1778688970295,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jad.2020.11.037","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T04:16:02Z","timestamp":1605240962000},"page":"899-907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Impaired cortico-striatal functional connectivity is related to trait impulsivity in unmedicated patients with obsessive-compulsive disorder"],"prefix":"10.1016","volume":"281","author":[{"given":"Tingting","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiumeng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9134-0160","authenticated-orcid":false,"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2020.11.037_bib0001","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.ne.09.030186.002041","article-title":"Parallel organization of functionally segregated circuits linking basal ganglia and cortex","volume":"9","author":"Alexander","year":"1986","journal-title":"Annual Review of Neuroscience"},{"issue":"6","key":"10.1016\/j.jad.2020.11.037_bib0002","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/scan\/nsx031","article-title":"Associating resting-state connectivity with trait impulsivity","volume":"12","author":"Angelides","year":"2017","journal-title":"Social Cognitive and Affective Neuroscience"},{"issue":"11","key":"10.1016\/j.jad.2020.11.037_bib0003","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1038\/nn.2933","article-title":"Dorsolateral and ventromedial prefrontal cortex orchestrate normative choice","volume":"14","author":"Baumgartner","year":"2011","journal-title":"Nature Neuroscience"},{"issue":"3","key":"10.1016\/j.jad.2020.11.037_bib0004","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3109\/13651501.2013.855792","article-title":"Characterizing impulsivity profile in patients with Obsessive-Compulsive Disorder","volume":"18","author":"Benatti","year":"2014","journal-title":"International Journal of Psychiatry in Clinical Practice"},{"issue":"10","key":"10.1016\/j.jad.2020.11.037_bib0005","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1073\/pnas.0911855107","article-title":"Toward discovery science of human brain function","volume":"107","author":"Biswal","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2-3","key":"10.1016\/j.jad.2020.11.037_bib0006","doi-asserted-by":"crossref","first-page":"1062\u20101066","DOI":"10.1016\/j.psychres.2012.06.010","article-title":"Behavioral and cognitive impulsivity in obsessive-compulsive disorder and eating disorders","volume":"200","author":"Boisseau","year":"2012","journal-title":"Psychiatry Research"},{"issue":"3","key":"10.1016\/j.jad.2020.11.037_bib0007","doi-asserted-by":"crossref","first-page":"413\u2010421","DOI":"10.1016\/j.neuroimage.2007.07.039","article-title":"Brain structural correlates of depressive comorbidity in obsessive-compulsive disorder","volume":"38","author":"Cardoner","year":"2007","journal-title":"Neuroimage"},{"issue":"12","key":"10.1016\/j.jad.2020.11.037_bib0008","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.biopsych.2010.02.012","article-title":"Executive dysfunctions in obsessive-compulsive patients and unaffected relatives: searching for a new intermediate phenotype","volume":"67","author":"Cavedini","year":"2010","journal-title":"Biological Psychiatry"},{"issue":"7","key":"10.1016\/j.jad.2020.11.037_bib0009","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1176\/ajp.2006.163.7.1282","article-title":"Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania","volume":"163","author":"Chamberlain","year":"2006","journal-title":"American Journal of Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2020.11.037_bib0010","doi-asserted-by":"crossref","first-page":"335\u2010338","DOI":"10.1176\/ajp.2007.164.2.335","article-title":"Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder","volume":"164","author":"Chamberlain","year":"2007","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2020.11.037_bib0011","doi-asserted-by":"crossref","first-page":"111\u2010118","DOI":"10.1016\/j.comppsych.2016.04.010","article-title":"Are obsessive-compulsive symptoms impulsive, compulsive or both?","volume":"68","author":"Chamberlain","year":"2016","journal-title":"Comprehensive Psychiatry"},{"issue":"5887","key":"10.1016\/j.jad.2020.11.037_bib0012","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1126\/science.1154433","article-title":"Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives","volume":"321","author":"Chamberlain","year":"2008","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.jad.2020.11.037_bib0013","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s10548-012-0270-x","article-title":"Morphometric correlation of impulsivity in medial prefrontal cortex","volume":"26","author":"Cho","year":"2013","journal-title":"Brain Topography"},{"issue":"4","key":"10.1016\/j.jad.2020.11.037_bib0014","doi-asserted-by":"crossref","first-page":"680\u2010694","DOI":"10.1016\/j.neuron.2011.01.020","article-title":"Impulsivity, compulsivity, and top-down cognitive control","volume":"69","author":"Dalley","year":"2011","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.jad.2020.11.037_bib0015","doi-asserted-by":"crossref","first-page":"1\u201010","DOI":"10.1177\/1051228405001474","article-title":"Functional imaging of mood and anxiety disorders","volume":"16","author":"Deckersbach","year":"2006","journal-title":"Journal of Neuroimaging"},{"issue":"12","key":"10.1016\/j.jad.2020.11.037_bib0016","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1093\/cercor\/bhn041","article-title":"Functional connectivity of human striatum: a resting state FMRI study","volume":"18","author":"Martino","year":"2008","journal-title":"Cerebral Cortex"},{"issue":"3","key":"10.1016\/j.jad.2020.11.037_bib0018","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4088\/JCP.12m07657","article-title":"Five-year course of obsessive-compulsive disorder: predictors of remission and relapse","volume":"74","author":"Eisen","year":"2013","journal-title":"The Journal of Clinical Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2020.11.037_bib0019","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0447.2006.00835.x","article-title":"Impulsiveness in obsessive-compulsive disorder: Results from a family study","volume":"115","author":"Ettelt","year":"2007","journal-title":"Acta Psychiatrica Scandinavica"},{"issue":"1","key":"10.1016\/j.jad.2020.11.037_bib0021","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1017\/S1092852913000801","article-title":"New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity","volume":"19","author":"Fineberg","year":"2014","journal-title":"CNS Spectrums"},{"issue":"3","key":"10.1016\/j.jad.2020.11.037_bib0022","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/npp.2009.185","article-title":"Probing compulsive and impulsive behaviors, from animal models to endophenotypes: A narrative review","volume":"35","author":"Fineberg","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"11","key":"10.1016\/j.jad.2020.11.037_bib0025","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","article-title":"The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability","volume":"46","author":"Goodman","year":"1989","journal-title":"Archives of General Psychiatry"},{"issue":"4","key":"10.1016\/j.jad.2020.11.037_bib0027","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1556\/2006.4.2015.039","article-title":"Think twice: impulsivity and decision making in obsessive-compulsive disorder","volume":"4","author":"Grassi","year":"2015","journal-title":"Journal of Behavioral Addictions"},{"issue":"51","key":"10.1016\/j.jad.2020.11.037_bib0028","doi-asserted-by":"crossref","first-page":"13213","DOI":"10.1523\/JNEUROSCI.3446-06.2006","article-title":"Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity","volume":"26","author":"Hariri","year":"2006","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"11","key":"10.1016\/j.jad.2020.11.037_bib0029","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1001\/archgenpsychiatry.2009.152","article-title":"Altered corticostriatal functional connectivity in obsessive-compulsive disorder","volume":"66","author":"Harrison","year":"2009","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2020.11.037_bib0035","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1001\/jamapsychiatry.2015.1","article-title":"Impaired functional connectivity within and between frontostriatal circuits and its association with compulsive drug use and trait impulsivity in cocaine addiction","volume":"72","author":"Hu","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"9","key":"10.1016\/j.jad.2020.11.037_bib0036","first-page":"1146\u20101152","article-title":"'Impulsive compulsivity' in obsessive-compulsive disorder: a phenotypic marker of patients with poor clinical outcome","volume":"46","author":"Kashyap","year":"2012","journal-title":"Journal of Psychiatry Research"},{"issue":"1","key":"10.1016\/j.jad.2020.11.037_bib0038","doi-asserted-by":"crossref","first-page":"43\u201051","DOI":"10.1016\/j.tics.2011.11.003","article-title":"Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways","volume":"16","author":"Milad","year":"2012","journal-title":"Trends in Cognitive Science"},{"issue":"3","key":"10.1016\/j.jad.2020.11.037_bib0039","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.pscychresns.2007.11.001","article-title":"Functional MRI study of brain activation alterations in patients with obsessive-compulsive disorder after symptom improvement","volume":"163","author":"Nabeyama","year":"2008","journal-title":"Psychiatry Research"},{"issue":"8","key":"10.1016\/j.jad.2020.11.037_bib0040","doi-asserted-by":"crossref","first-page":"815\u2010825","DOI":"10.1001\/jamapsychiatry.2016.0700","article-title":"Structural and Functional Brain Abnormalities in Attention-Deficit\/Hyperactivity Disorder and Obsessive-Compulsive Disorder: A Comparative Meta-analysis","volume":"73","author":"Norman","year":"2016","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"10.1016\/j.jad.2020.11.037_bib0041","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.conb.2004.10.016","article-title":"Reward representations and reward-related learning in the human brain: insights from neuroimaging","volume":"14","author":"O'Doherty","year":"2004","journal-title":"Current Opinion in Neurobiology"},{"issue":"6","key":"10.1016\/j.jad.2020.11.037_bib0042","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1","article-title":"Factor structure of the Barratt impulsiveness scale","volume":"51","author":"Patton","year":"1995","journal-title":"Journal of Clinical Psychology"},{"issue":"26","key":"10.1016\/j.jad.2020.11.037_bib0043","doi-asserted-by":"crossref","first-page":"8888","DOI":"10.1523\/JNEUROSCI.6028-09.2010","article-title":"Dopamine, time and impulsivity in humans","volume":"30","author":"Pine","year":"2010","journal-title":"Journal of Neuroscience"},{"issue":"3","key":"10.1016\/j.jad.2020.11.037_bib0044","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion","volume":"59","author":"Power","year":"2012","journal-title":"Neuroimage"},{"issue":"5","key":"10.1016\/j.jad.2020.11.037_bib0046","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0893-133X(02)00351-2","article-title":"Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation study","volume":"27","author":"Rauch","year":"2002","journal-title":"Neuropsychopharmacology."},{"issue":"4","key":"10.1016\/j.jad.2020.11.037_bib0047","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/13651501.2016.1220580","article-title":"Relationship between impulsivity and obsession types in obsessive-compulsive disorder","volume":"20","author":"Onur","year":"2016","journal-title":"International Journal of Psychiatry in Clinical Practice"},{"issue":"Suppl 20","key":"10.1016\/j.jad.2020.11.037_bib0048","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"Journal of Clinical Psychiatry"},{"issue":"9","key":"10.1016\/j.jad.2020.11.037_bib62","doi-asserted-by":"crossref","first-page":"e25031","DOI":"10.1371\/journal.pone.0025031","article-title":"REST: a toolkit for resting-state functional magnetic resonance imaging data processing","volume":"6","author":"Song","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jad.2020.11.037_bib0049","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2466\/pr0.1997.80.2.443","article-title":"Further evidence for the construct validity of the Beck Depression Inventory-II with psychiatric outpatients","volume":"80","author":"Steer","year":"1997","journal-title":"Psychological Reports"},{"issue":"3","key":"10.1016\/j.jad.2020.11.037_bib0050","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1207\/s15327752jpa6003_10","article-title":"Structure of the computer-assisted Beck Anxiety Inventory with psychiatric inpatients","volume":"60","author":"Steer","year":"1993","journal-title":"Journal of Personality Assessment"},{"key":"10.1016\/j.jad.2020.11.037_bib0051","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3389\/fnhum.2015.00384","article-title":"Impulsivity relates to striatal gray matter volumes in humans: evidence from a delay discounting paradigm","volume":"9","author":"Tschernegg","year":"2015","journal-title":"Frontiers in Human Neuroscience"},{"key":"10.1016\/j.jad.2020.11.037_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116715","article-title":"The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression","volume":"214","author":"Tozzi","year":"2020","journal-title":"Neuroimage"},{"issue":"29","key":"10.1016\/j.jad.2020.11.037_bib0053","doi-asserted-by":"crossref","first-page":"E3765","DOI":"10.1073\/pnas.1423095112","article-title":"Adolescent impatience decreases with increased frontostriatal connectivity","volume":"112","author":"van den Bos","year":"2015","journal-title":"PNAS"},{"issue":"5","key":"10.1016\/j.jad.2020.11.037_bib0054","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.euroneuro.2015.12.005","article-title":"Brain circuitry of compulsivity","volume":"26","author":"van den Heuvel","year":"2016","journal-title":"European Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2020.11.037_bib0059","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuroimage.2013.03.004","article-title":"A comprehensive assessment of regional variation in the impact of head micromovements on functional connectomics","volume":"76","author":"Yan","year":"2013","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.jad.2020.11.037_bib0060","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","article-title":"DPABI: Data Processing & Analysis for (Resting-State) Brain Imaging","volume":"14","author":"Yan","year":"2016","journal-title":"Neuroinformatics"},{"issue":"4","key":"10.1016\/j.jad.2020.11.037_bib0061","first-page":"343","article-title":"Reliability and validity of Chinese version of Barratt impulsiveness scale-11","volume":"14","author":"Zhou","year":"2006","journal-title":"China Journal of Clinical Psychology"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032720329670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032720329670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:57:07Z","timestamp":1759024627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032720329670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":46,"alternative-id":["S0165032720329670"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2020.11.037","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired cortico-striatal functional connectivity is related to trait impulsivity in unmedicated patients with obsessive-compulsive disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2020.11.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}