{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T02:40:07Z","timestamp":1759027207084,"version":"3.44.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007112","name":"University of Cape Town","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007112","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jad.2020.12.062","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T13:22:25Z","timestamp":1610544145000},"page":"740-756","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Overlap in genetic risk for cross-disorder vulnerability to mental disorders and genetic risk for altered subcortical brain volumes"],"prefix":"10.1016","volume":"282","author":[{"given":"Megan","family":"Campbell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Jahanshad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Mufford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karmel W.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Ramesar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan W.","family":"Smoller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan J.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shareefa","family":"Dalvie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2020.12.062_bib0001","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.schres.2012.01.035","article-title":"Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?","volume":"137","author":"Aas","year":"2012","journal-title":"Schizophrenia research"},{"key":"10.1016\/j.jad.2020.12.062_bib0002","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/nn.4398","article-title":"Novel genetic loci underlying human intracranial volume identified through genome-wide association","volume":"19","author":"Adams","year":"2016","journal-title":"Nature neuroscience"},{"key":"10.1016\/j.jad.2020.12.062_bib0003","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ajhg.2013.01.001","article-title":"Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors","volume":"92","author":"Andreassen","year":"2013","journal-title":"The American Journal of Human Genetics"},{"key":"10.1016\/j.jad.2020.12.062_bib0004","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"Journal of the Royal statistical society: series B (Methodological)"},{"key":"10.1016\/j.jad.2020.12.062_bib0005","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/bioinformatics\/btv546","article-title":"Approximately independent linkage disequilibrium blocks in human populations","volume":"32","author":"Berisa","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jad.2020.12.062_bib0006","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1017\/thg.2012.11","article-title":"Genetic and environmental influences on neuroimaging phenotypes: a meta-analytical perspective on twin imaging studies","volume":"15","author":"Blokland","year":"2012","journal-title":"Twin Research and Human Genetics"},{"key":"10.1016\/j.jad.2020.12.062_bib0007","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1176\/appi.ajp.2018.17121383","article-title":"All for one and one for all: Mental disorders in one dimension","volume":"175","author":"Caspi","year":"2018","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2020.12.062_bib0008","doi-asserted-by":"crossref","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"Gigascience"},{"key":"10.1016\/j.jad.2020.12.062_bib0009","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"Consortium","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jad.2020.12.062_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: generalized gene-set analysis of GWAS data","volume":"11","author":"De Leeuw","year":"2015","journal-title":"PLoS computational biology"},{"key":"10.1016\/j.jad.2020.12.062_bib0011","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nn.4228","article-title":"Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept","volume":"19","author":"Franke","year":"2016","journal-title":"Nature neuroscience"},{"key":"10.1016\/j.jad.2020.12.062_bib0012","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.biopsych.2010.05.037","article-title":"Genetic variation in CACNA1C, a gene associated with bipolar disorder, influences brainstem rather than gray matter volume in healthy individuals","volume":"68","author":"Franke","year":"2010","journal-title":"Biological psychiatry"},{"key":"10.1016\/j.jad.2020.12.062_bib0013","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.schres.2019.05.041","article-title":"Differential contributions of brainstem structures to neurological soft signs in first-and multiple-episode schizophrenia spectrum disorders","volume":"210","author":"Fritze","year":"2019","journal-title":"Schizophrenia research"},{"key":"10.1016\/j.jad.2020.12.062_bib0014","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ajmg.b.32349","article-title":"Genome-wide association study of schizophrenia in Ashkenazi Jews","volume":"168","author":"Goes","year":"2015","journal-title":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"},{"key":"10.1016\/j.jad.2020.12.062_bib0015","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/ajmg.b.32592","article-title":"The role of cadherin genes in five major psychiatric disorders: A literature update","volume":"177","author":"Hawi","year":"2018","journal-title":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"},{"key":"10.1016\/j.jad.2020.12.062_bib0016","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1176\/appi.ajp.158.10.1568","article-title":"A review and meta-analysis of the genetic epidemiology of anxiety disorders","volume":"158","author":"Hettema","year":"2001","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2020.12.062_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms13624","article-title":"Novel genetic loci associated with hippocampal volume","volume":"8","author":"Hibar","year":"2017","journal-title":"Nature communications"},{"key":"10.1016\/j.jad.2020.12.062_bib0018","doi-asserted-by":"crossref","unstructured":"Hibar, D. P., Cheung, J. W., Medland, S. E., Mufford, M. S., Jahanshad, N., Dalvie, S., Ramesar, R., Stewart, E., Van Den Heuvel, O. A. & Pauls, D. L. J. T. B. J. O. P. 2018. Significant concordance of genetic variation that increases both the risk for obsessive\u2013compulsive disorder and the volumes of the nucleus accumbens and putamen. 213,430-436.","DOI":"10.1192\/bjp.2018.62"},{"key":"10.1016\/j.jad.2020.12.062_bib0019","doi-asserted-by":"crossref","DOI":"10.1176\/jnp.2010.22.1.iv","article-title":"The brainstem: anatomy, assessment, and clinical syndromes","volume":"22","author":"Hurley","year":"2010","journal-title":"The Journal of neuropsychiatry and clinical neurosciences"},{"key":"10.1016\/j.jad.2020.12.062_bib0020","doi-asserted-by":"crossref","first-page":"e656","DOI":"10.1038\/tp.2015.151","article-title":"Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case\u2013control sample of schizophrenia","volume":"5","author":"Ingason","year":"2015","journal-title":"Translational psychiatry"},{"key":"10.1016\/j.jad.2020.12.062_bib0021","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/bdi.12516","article-title":"Amygdala and hippocampus volumes are differently affected by childhood trauma in patients with bipolar disorders and healthy controls","volume":"19","author":"Janiri","year":"2017","journal-title":"Bipolar disorders"},{"key":"10.1016\/j.jad.2020.12.062_bib0022","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1176\/appi.ajp.2018.18020149","article-title":"Genetic markers of ADHD-related variations in intracranial volume","volume":"176","author":"Klein","year":"2019","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jad.2020.12.062_bib0023","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2019.11.020","article-title":"Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders","volume":"179","author":"Lee","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jad.2020.12.062_bib0024","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/ng.3973","article-title":"Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia","volume":"49","author":"Li","year":"2017","journal-title":"Nature genetics"},{"key":"10.1016\/j.jad.2020.12.062_bib0025","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0140-6736(09)60072-6","article-title":"Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study","volume":"373","author":"Lichtenstein","year":"2009","journal-title":"The Lancet"},{"key":"10.1016\/j.jad.2020.12.062_bib0026","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1001\/archpsyc.1993.01820230041004","article-title":"Continuity and discontinuity of affective disorders and schizophrenia: results of a controlled family study","volume":"50","author":"Maier","year":"1993","journal-title":"Archives of general psychiatry"},{"key":"10.1016\/j.jad.2020.12.062_bib0027","article-title":"Not just one p: Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities","author":"Mallard","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.jad.2020.12.062_bib0028","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1001\/archpsyc.60.5.497","article-title":"The heritability of bipolar affective disorder and the genetic relationship to unipolar depression","volume":"60","author":"Mcguffin","year":"2003","journal-title":"Archives of general psychiatry"},{"key":"10.1016\/j.jad.2020.12.062_bib0029","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41398-019-0452-3","article-title":"Concordance of genetic variation that increases risk for tourette syndrome and that influences its underlying neurocircuitry","volume":"9","author":"Mufford","year":"2019","journal-title":"Translational psychiatry"},{"key":"10.1016\/j.jad.2020.12.062_bib0030","first-page":"2086","article-title":"SECA: SNP effect concordance analysis using genome-wide association summary results","volume":"30","author":"Nyholt","year":"2014","journal-title":"Journal of Bionformatics"},{"key":"10.1016\/j.jad.2020.12.062_bib0031","doi-asserted-by":"crossref","unstructured":"Pfefferbaum, A., Sullivan, E. V., Swan, G. E. & Carmelli, D. J. N. O. A. 2000. Brain structure in men remains highly heritable in the seventh and eighth decades of life\u2606. 21,63-74.","DOI":"10.1016\/S0197-4580(00)00086-5"},{"key":"10.1016\/j.jad.2020.12.062_bib0032","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pscychresns.2015.06.004","article-title":"Alterations in hippocampal connectivity across the psychosis dimension","volume":"233","author":"Samudra","year":"2015","journal-title":"Psychiatry Research: Neuroimaging"},{"key":"10.1016\/j.jad.2020.12.062_bib0033","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1038\/s41588-019-0511-y","article-title":"Genetic architecture of subcortical brain structures in 38,851 individuals","volume":"51","author":"Satizabal","year":"2019","journal-title":"Nature genetics"},{"key":"10.1016\/j.jad.2020.12.062_bib0034","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ajhg.2017.09.022","article-title":"Local genetic correlation gives insights into the shared genetic architecture of complex traits","volume":"101","author":"Shi","year":"2017","journal-title":"The American Journal of Human Genetics"},{"key":"10.1016\/j.jad.2020.12.062_bib0035","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/schbul\/sbx148","article-title":"Genetic overlap between schizophrenia and volumes of hippocampus, putamen, and intracranial volume indicates shared molecular genetic mechanisms","volume":"44","author":"Smeland","year":"2017","journal-title":"Schizophrenia bulletin"},{"key":"10.1016\/j.jad.2020.12.062_bib0036","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0140-6736(12)62129-1","article-title":"Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis","volume":"381","author":"Smoller","year":"2013","journal-title":"The Lancet"},{"key":"10.1016\/j.jad.2020.12.062_bib0037","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ajmg.c.20013","article-title":"Family, twin, and adoption studies of bipolar disorder","author":"Smoller","year":"2003","journal-title":"American Journal of Medical Genetics Part C: Seminars in Medical Genetics"},{"key":"10.1016\/j.jad.2020.12.062_bib0038","article-title":"Better estimation of SNP heritability from summary statistics provides a new understanding of the genetic architecture of complex traits","author":"Speed","year":"2018","journal-title":"bioRxiv"},{"key":"10.1016\/j.jad.2020.12.062_bib0039","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jad.2013.06.008","article-title":"No evidence for association between bipolar disorder risk gene variants and brain structural phenotypes","volume":"151","author":"Tesli","year":"2013","journal-title":"J Affect Disord"},{"key":"10.1016\/j.jad.2020.12.062_bib0040","doi-asserted-by":"crossref","unstructured":"Tramo, M. J., Loftus, W., Stukel, T., Green, R., Weaver, J. & Gazzaniga, M. J. N. 1998. Brain size, head size, and intelligence quotient in monozygotic twins. 50,1246-1252.","DOI":"10.1212\/WNL.50.5.1246"},{"key":"10.1016\/j.jad.2020.12.062_bib0041","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/mp.2016.244","article-title":"GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium","volume":"22","author":"Trampush","year":"2017","journal-title":"Molecular psychiatry"},{"key":"10.1016\/j.jad.2020.12.062_bib0042","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jad.2018.11.082","article-title":"Concordance of genetic variation that increases risk for anxiety disorders and posttraumatic stress disorders and that influences their underlying neurocircuitry","volume":"245","author":"Van Der Merwe","year":"2019","journal-title":"J Affect Disord"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032720331529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032720331529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T01:59:11Z","timestamp":1759024751000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032720331529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":42,"alternative-id":["S0165032720331529"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2020.12.062","relation":{},"ISSN":["0165-0327"],"issn-type":[{"type":"print","value":"0165-0327"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overlap in genetic risk for cross-disorder vulnerability to mental disorders and genetic risk for altered subcortical brain volumes","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2020.12.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}