{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:15:05Z","timestamp":1776410105929,"version":"3.51.2"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH082830"],"award-info":[{"award-number":["R01MH082830"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH090301"],"award-info":[{"award-number":["U01MH090301"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.jad.2021.05.042","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T11:40:22Z","timestamp":1622029222000},"page":"212-216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Maternal posttraumatic stress and FKBP5 Genotype interact to predict trauma-related symptoms in preschool-age offspring"],"prefix":"10.1016","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-4085","authenticated-orcid":false,"given":"Destiny M.B. Printz","family":"Pereira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9577-2764","authenticated-orcid":false,"given":"Damion J.","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin A.","family":"Hodgkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly J.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren S.","family":"Wakschlag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5826-5998","authenticated-orcid":false,"given":"Margaret J.","family":"Briggs-Gowan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2021.05.042_bib0001","series-title":"Diagnostic and Statistical Manual of Mental Disorders (4th ed.)","year":"2000"},{"issue":"8","key":"10.1016\/j.jad.2021.05.042_bib0002","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1176\/ajp.151.8.1132","article-title":"Initial reliability and validity of a new retrospective measure of child abuse and neglect","volume":"151","author":"Bernstein","year":"1994","journal-title":"Am. J. Psychiatry"},{"issue":"8","key":"10.1016\/j.jad.2021.05.042_bib0003","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1176\/appi.ajp.2019.19060618","article-title":"Intergenerational effects of maternal holocaust exposure on FKBP5 methylation","volume":"177","author":"Bierer","year":"2020","journal-title":"Am. J. Psychiatry"},{"issue":"8","key":"10.1016\/j.jad.2021.05.042_bib0004","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0145-2134(01)00253-8","article-title":"The trauma symptom checklist for young children (TSCYC): reliability and association with abuse exposure in a multi-site study","volume":"25","author":"Briere","year":"2001","journal-title":"Child Abuse Negl."},{"issue":"2","key":"10.1016\/j.jad.2021.05.042_bib0005","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2307\/1131407","article-title":"Socialization mediators of the relation between socioeconomic status and child conduct problems","volume":"65","author":"Dodge","year":"1994","journal-title":"Child Dev."},{"key":"10.1016\/j.jad.2021.05.042_bib0006","series-title":"Handbook of Infant, Toddler, and Preschool Mental Health Assessment","first-page":"223","article-title":"The preschool age psychiatric assessment (papa): a structured parent interview for diagnosing psychiatric disorders in preschool children","author":"Egger","year":"2004"},{"key":"10.1016\/j.jad.2021.05.042_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.104604","article-title":"Adverse childhood experiences, posttraumatic stress, and FKBP5 methylation patterns in postpartum women and their newborn infants","volume":"114","author":"Grasso","year":"2020","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"10.1016\/j.jad.2021.05.042_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15295192.2019.1707623","article-title":"Responsive parenting buffers the impact of maternal PTSD on young children","volume":"20","author":"Greene","year":"2020","journal-title":"Parenting"},{"key":"10.1016\/j.jad.2021.05.042_bib0009","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jad.2018.09.058","article-title":"GxE effects of FKBP5 and traumatic life events on PTSD: a meta-analysis","volume":"243","author":"Hawn","year":"2019","journal-title":"J. Affect Disord."},{"issue":"1","key":"10.1016\/j.jad.2021.05.042_bib0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nn.3275","article-title":"Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions","volume":"16","author":"Klengel","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jad.2021.05.042_bib0011","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/jts.21891","article-title":"Association between parents\u2019 PTSD severity and children's psychological distress: a meta-analysis","volume":"27","author":"Lambert","year":"2014","journal-title":"J. Trauma Stress"},{"issue":"2","key":"10.1016\/j.jad.2021.05.042_bib0012","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1017\/S095457941700013X","article-title":"Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation","volume":"29","author":"Mulder","year":"2017","journal-title":"Dev. Psychopathol."},{"issue":"6","key":"10.1016\/j.jad.2021.05.042_bib0013","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s10802-014-9950-1","article-title":"Punishment insensitivity in early childhood: a developmental, dimensional approach","volume":"43","author":"Nichols","year":"2015","journal-title":"J. Abnorm. Child Psychol."},{"key":"10.1016\/j.jad.2021.05.042_bib0014","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s11121-016-0707-7","article-title":"The family socialization interview\u2014revised (FSI-R): a comprehensive assessment of parental disciplinary behaviors","volume":"18","author":"O'Dor","year":"2017","journal-title":"Prevent. Sci."},{"key":"10.1016\/j.jad.2021.05.042_bib0015","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/jts.22484","article-title":"Meta-analysis of associations between hypothalamic-pituitary-adrenal axis genes and risk of posttraumatic stress disorder","volume":"33","author":"Sheerin","year":"2020","journal-title":"J. Trauma Stress"},{"key":"10.1016\/j.jad.2021.05.042_bib0016","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jad.2017.08.066","article-title":"Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: a systematic review and meta-analysis","volume":"225","author":"Wang","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2021.05.042_bib0017","first-page":"462","article-title":"The PTSD Checklist (PCL): reliability, validity, and diagnostic utility","author":"Weathers","year":"1993","journal-title":"Annu. Conven. Int. Soc. Traum. Stress Stud."},{"key":"10.1016\/j.jad.2021.05.042_bib0018","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/npp.2010.37","article-title":"Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder","volume":"35","author":"Xie","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"10.1016\/j.jad.2021.05.042_bib0019","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.biopsych.2015.08.005","article-title":"Holocaust exposure induced intergenerational effects on FKBP5 methylation","volume":"80","author":"Yehuda","year":"2016","journal-title":"Biol. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721004869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721004869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T02:02:48Z","timestamp":1759024968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032721004869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":19,"alternative-id":["S0165032721004869"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2021.05.042","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal posttraumatic stress and FKBP5 Genotype interact to predict trauma-related symptoms in preschool-age offspring","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2021.05.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}