{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:00:28Z","timestamp":1793307628577,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006426","name":"Eva and Henry Fr\u00e6nkel Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011958","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.jad.2021.05.103","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T11:22:54Z","timestamp":1623064974000},"page":"204-211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["An analysis of the relative and absolute incidence of somatic morbidity in patients with affective disorders\u2014A nationwide cohort study"],"prefix":"10.1016","volume":"292","author":[{"given":"Marie Kim","family":"Wium-Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Kim","family":"Wium-Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terese Sara H\u00f8j","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Balslev","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete","family":"Osler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2021.05.103_bib0001","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/sim.4780080803","article-title":"A linear regression model for the analysis of life times","volume":"8","author":"Aalen","year":"1989","journal-title":"Stat. Med."},{"key":"10.1016\/j.jad.2021.05.103_bib0002","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/pon.4084","article-title":"Risk of cancer among patients with depressive disorder: a meta-analysis and implications","volume":"25","author":"Ahn","year":"2016","journal-title":"Psychooncology"},{"key":"10.1016\/j.jad.2021.05.103_bib0003","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1474-4422(11)70072-2","article-title":"The Projected Impact of Risk Factor Reduction on Alzheimer\u2019s Disease Prevalence","volume":"10","author":"Barnes","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jad.2021.05.103_bib0004","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.maturitas.2014.05.009","article-title":"Depression and dementia: cause, consequence or coincidence?","volume":"79","author":"Bennett","year":"2014","journal-title":"Maturitas"},{"key":"10.1016\/j.jad.2021.05.103_bib0005","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/1741-7015-11-200","article-title":"So depression is an inflammatory disease, but where does the inflammation come from?","volume":"11","author":"Berk","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.jad.2021.05.103_bib0006","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrneurol.2011.60","article-title":"Depression and risk of developing dementia","volume":"7","author":"Byers","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jad.2021.05.103_bib0007","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/1074248418817344","article-title":"Prospects for the Primary Prevention of Myocardial Infarction and Stroke","volume":"24","author":"Caldwell","year":"2019","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.jad.2021.05.103_bib0008","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.genhosppsych.2016.09.007","article-title":"Examining the relationship between physical illness and depression: Is there a difference between inflammatory and non inflammatory diseases? A cohort study","volume":"43","author":"Caneo","year":"2016","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jad.2021.05.103_bib0009","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/jamadermatol.2015.3605","article-title":"Psoriasis and the Risk of Depression in the US Population: National Health and Nutrition Examination Survey 2009-2012","volume":"152","author":"Cohen","year":"2016","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.jad.2021.05.103_bib0010","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1001\/archinte.160.14.2101","article-title":"Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence","volume":"160","author":"DiMatteo","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.jad.2021.05.103_bib0011","series-title":"Statens Institut for Folkesundhed","author":"Flachs","year":"2015"},{"key":"10.1016\/j.jad.2021.05.103_bib0012","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","year":"2017","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.jad.2021.05.103_bib0013","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/7854_2016_28","article-title":"Inflammation-Associated Co-morbidity Between Depression and Cardiovascular Disease","volume":"31","author":"Halaris","year":"2017","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.jad.2021.05.103_bib0014","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/ggi.13516","article-title":"Community-dwelling older men with dementia are at high risk of hip fracture, but not any other fracture: The Concord Health and Aging in Men Project","volume":"18","author":"Hsu","year":"2018","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.jad.2021.05.103_bib0015","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/1403494810394715","article-title":"Danish Education Registers","volume":"39","author":"Jensen","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"10.1016\/j.jad.2021.05.103_bib0016","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/YIC.0000000000000197","article-title":"No apparent association between bipolar disorder and cancer in a large epidemiological study of outpatients in a managed care population","volume":"33","author":"Kahan","year":"2018","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2021.05.103_bib0017","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1403494810394717","article-title":"The Danish National Prescription Registry","volume":"39","author":"Kildemoes","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"10.1016\/j.jad.2021.05.103_bib0018","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1001\/archgenpsychiatry.2009.61","article-title":"Somatic hospital contacts, invasive cardiac procedures, and mortality from heart disease in patients with severe mental disorder","volume":"66","author":"Laursen","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2021.05.103_bib0019","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.genhosppsych.2010.04.004","article-title":"Receipt of preventive medical care and medical screening for patients with mental illness: a comparative analysis","volume":"32","author":"Lord","year":"2010","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jad.2021.05.103_bib0020","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1403494811401482","article-title":"The Danish National Patient Register","volume":"39","author":"Lynge","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"10.1016\/j.jad.2021.05.103_bib0021","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41380-018-0017-5","article-title":"Depression and obesity: evidence of shared biological mechanisms","volume":"24","author":"Milaneschi","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2021.05.103_bib0022","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1056\/NEJMoa1915784","article-title":"Association between Mental Disorders and Subsequent Medical Conditions","volume":"382","author":"Momen","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jad.2021.05.103_bib0023","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/1403494810395825","article-title":"The Danish Psychiatric Central Research Register","volume":"39","author":"Mors","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"10.1016\/j.jad.2021.05.103_bib0024","doi-asserted-by":"crossref","first-page":"e55176","DOI":"10.1371\/journal.pone.0055176","article-title":"Excess mortality, causes of death and life expectancy in 270,770 patients with recent onset of mental disorders in Denmark, Finland and Sweden","volume":"8","author":"Nordentoft","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jad.2021.05.103_bib0025","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1532-5415.2010.03288.x","article-title":"Greater risk of Alzheimer's disease in older adults with insomnia","volume":"59","author":"Osorio","year":"2011","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.jad.2021.05.103_bib0026","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neubiorev.2018.08.007","article-title":"Low on energy? An energy supply-demand perspective on stress and depression","volume":"94","author":"\u00d8stergaard","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2021.05.103_bib0027","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish Civil Registration System","volume":"39","author":"Pedersen","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"10.1016\/j.jad.2021.05.103_bib0028","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1741-7015-11-129","article-title":"Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile","volume":"11","author":"Penninx","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.jad.2021.05.103_bib0029","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1098-3597(03)90031-7","article-title":"Insomnia: epidemiology, characteristics, and consequences","volume":"5","author":"Roth","year":"2003","journal-title":"Clin. Cornerstone"},{"key":"10.1016\/j.jad.2021.05.103_bib0030","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jad.2016.12.059","article-title":"Medical comorbidity in bipolar disorder: the link with metabolic-inflammatory systems","volume":"211","author":"SayuriYamagata","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2021.05.103_bib0031","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/2047487312460020","article-title":"Insomnia and risk of cardiovascular disease: a meta-analysis","volume":"21","author":"Sofi","year":"2014","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.jad.2021.05.103_bib0032","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3109\/00952990.2016.1171327","article-title":"Depression and cigarette smoking behavior: a critical review of population-based studies","volume":"43","author":"Weinberger","year":"2017","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"10.1016\/j.jad.2021.05.103_bib0033","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/ijcp.12522","article-title":"COPD: early diagnosis and treatment to slow disease progression","volume":"69","author":"Welte","year":"2015","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.jad.2021.05.103_bib0034","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/joim.12363","article-title":"Berkson's paradox in medical care","volume":"278","author":"Woodfine","year":"2015","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.jad.2021.05.103_bib0035","series-title":"Depression and Other Common Mental Disorders: Global Health Estimates","year":"2017"},{"key":"10.1016\/j.jad.2021.05.103_bib0036","unstructured":"World Health Organizaion, 2008. World Health Organization: The global burden of disease: 2004 update."},{"key":"10.1016\/j.jad.2021.05.103_bib0037","article-title":"Additive hazard regression models: an application to the natural history of human papillomavirus","volume":"796270","author":"Xie","year":"2013","journal-title":"Comput. Math. Methods Med."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721005486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721005486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T02:02:20Z","timestamp":1759024940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032721005486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":37,"alternative-id":["S0165032721005486"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2021.05.103","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An analysis of the relative and absolute incidence of somatic morbidity in patients with affective disorders\u2014A nationwide cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2021.05.103","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}