{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:55:27Z","timestamp":1791960927890,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["17\/07089-8"],"award-info":[{"award-number":["17\/07089-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/11963-8"],"award-info":[{"award-number":["2018\/11963-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/05087-0"],"award-info":[{"award-number":["2020\/05087-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jad.2021.08.127","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T11:05:35Z","timestamp":1630580735000},"page":"681-687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Exploring machine learning to predict depressive relapses of bipolar disorder patients"],"prefix":"10.1016","volume":"295","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9175-7567","authenticated-orcid":false,"given":"Luisa de Siqueira","family":"Rotenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Gomes","family":"Borges-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beny","family":"Lafer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogerio","family":"Salvini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo da Silva","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jad.2021.08.127_bib0001","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.1192\/j.eurpsy.2019.18","article-title":"Initial and relapse prodromes in adult patients with episodes of bipolar disorder: a systematic review","volume":"63","author":"Andrade-Gonz\u00e1lez","year":"2020","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2021.08.127_bib0002","series-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM-5\u00ae)","year":"2013"},{"key":"10.1016\/j.jad.2021.08.127_bib0004","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests","volume":"45","author":"Breiman","year":"2001","journal-title":"Mach. Learn."},{"key":"10.1016\/j.jad.2021.08.127_bib0006","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1613\/jair.953","article-title":"SMOTE: synthetic minority over-sampling technique","volume":"16","author":"Chawla","year":"2002","journal-title":"J. Artif. Intell. Res."},{"key":"10.1016\/j.jad.2021.08.127_bib0007","series-title":"Proceedings of the Fifteenth Conference on Uncertainty in Artificial Intelligence","first-page":"101","article-title":"Comparing Bayesian network classifiers","author":"Cheng","year":"1999"},{"issue":"3","key":"10.1016\/j.jad.2021.08.127_bib0009","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1023\/A:1022627411411","article-title":"Support-vector networks","volume":"20","author":"Cortes","year":"1995","journal-title":"Mach. Learn."},{"issue":"8","key":"10.1016\/j.jad.2021.08.127_bib0010","doi-asserted-by":"crossref","first-page":"e18818","DOI":"10.2196\/18818","article-title":"Toi M\u00eame, a mobile health platform for measuring bipolar illness activity: protocol for a feasibility study","volume":"9","author":"Darg\u00e9l","year":"2020","journal-title":"JMIR Res. Protoc."},{"key":"10.1016\/j.jad.2021.08.127_bib0012","first-page":"1","article-title":"Statistical comparisons of classifiers over multiple data sets","volume":"7","author":"Dem\u0161ar","year":"2006","journal-title":"J. Mach. Learn. Res."},{"key":"10.1016\/j.jad.2021.08.127_bib0015","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1146\/annurev-clinpsy-032816-045037","article-title":"Machine learning approaches for clinical psychology and psychiatry","volume":"14","author":"Dwyer","year":"2018","journal-title":"Annu. Rev. Clin. Psychol"},{"issue":"1","key":"10.1016\/j.jad.2021.08.127_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13063-017-2015-3","article-title":"Reducing the rate and duration of Re-ADMISsions among patients with unipolar disorder and bipolar disorder using smartphone-based monitoring and treatment\u2013the RADMIS trials: study protocol for two randomized controlled trials","volume":"18","author":"Faurholt-Jepsen","year":"2017","journal-title":"Trials"},{"key":"10.1016\/j.jad.2021.08.127_bib0019","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/bdi.12423","article-title":"The prevalence and burden of bipolar disorder: findings from the global burden of disease study 2013","volume":"18","author":"Ferrari","year":"2016","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2021.08.127_bib0022","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/jamia\/ocw042","article-title":"Opportunities and challenges in developing risk prediction models with electronic health records data: a systematic review","volume":"24","author":"Goldstein","year":"2017","journal-title":"J. Am. Med. Inform. Assoc."},{"key":"10.1016\/j.jad.2021.08.127_bib0023","series-title":"Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression","author":"Goodwin","year":"2007"},{"key":"10.1016\/j.jad.2021.08.127_bib0025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1145\/1656274.1656278","article-title":"The WEKA data mining software: an update","volume":"11","author":"Hall","year":"2009","journal-title":"ACM SIGKDD Explor. Newslett."},{"key":"10.1016\/j.jad.2021.08.127_bib0026","series-title":"Neural Networks and Learning Machines\/Simon Haykin","author":"Haykin","year":"2009"},{"key":"10.1016\/j.jad.2021.08.127_bib0027","series-title":"Applied Logistic Regression","author":"Hosmer","year":"2013"},{"key":"10.1016\/j.jad.2021.08.127_bib0063","doi-asserted-by":"crossref","unstructured":"Kishi, T., Matsuda, Y., Sakuma, K., Okuya, M., Mishima, K., & Iwata, N. (2020). Recurrence rates in stable bipolar disorder patients after drug discontinuation v. drug maintenance: A systematic review and meta-analysis. Psychol. Med., 1\u20139.","DOI":"10.1017\/S0033291720003505"},{"key":"10.1016\/j.jad.2021.08.127_bib0028","series-title":"Proceedings of the IJCAI International Joint Conferences on Artificial Intelligence Organization","first-page":"1137","article-title":"A study of cross-validation and bootstrap for accuracy estimation and model selection","author":"Kohavi","year":"1995"},{"key":"10.1016\/j.jad.2021.08.127_bib0031","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1590\/1516-4446-2020-0018","article-title":"Negative early life experiences as risk factors for suicidal behavior in bipolar disorders","volume":"42","author":"Lafer","year":"2020","journal-title":"Braz. J. Psychiatry"},{"key":"10.1016\/j.jad.2021.08.127_bib0032","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jad.2018.08.073","article-title":"Applications of machine learning algorithms to predict therapeutic outcomes in depression: a meta-analysis and systematic review","volume":"241","author":"Lee","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2021.08.127_bib0034","first-page":"127","article-title":"Challenges and future prospects of precision medicine in psychiatry","volume":"13","author":"Manchia","year":"2020","journal-title":"Pharmgenomics Pers. Med."},{"issue":"7","key":"10.1016\/j.jad.2021.08.127_bib0043","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/bdi.12828","article-title":"Machine learning and big data analytics in bipolar disorder: a position paper from the international society for bipolar disorders big data task force","volume":"21","author":"Passos","year":"2019","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2021.08.127_bib0048","doi-asserted-by":"crossref","unstructured":"Pohlert, T. (2014). The pairwise multiple comparison of mean ranks package (PMCMR). R package, 27 (2019), 9.","DOI":"10.32614\/CRAN.package.PMCMR"},{"key":"10.1016\/j.jad.2021.08.127_bib0049","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1017\/S1092852916000547","article-title":"Treatment of mixed features in bipolar disorder","volume":"22","author":"Rosenblat","year":"2017","journal-title":"CNS Spectr."},{"key":"10.1016\/j.jad.2021.08.127_bib0050","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0006-3223(03)00165-3","article-title":"Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)","volume":"53","author":"Sachs","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2021.08.127_bib0051","unstructured":"Salvini, R., da Silva Dias, R., Lafer, B., & Dutra, I. (2015). A multi-relational model for depression relapse in patients with bipolar disorder. In MEDINFO 2015: eHealth-enabled Health (pp. 741\u2013745). IOS Press."},{"key":"10.1016\/j.jad.2021.08.127_bib0052","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jad.2014.10.061","article-title":"Prevalence rates and clinical implications of bipolar disorder \u201cwith mixed features\u201d as defined by DSM-5","volume":"173","author":"Shim","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2021.08.127_bib0056","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1371\/journal.pcbi.0030116","article-title":"Machine learning and its applications to biology","volume":"3","author":"Tarca","year":"2007","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jad.2021.08.127_bib0057","unstructured":"Team, R. C. (2013). R: A language and environment for statistical computing."},{"key":"10.1016\/j.jad.2021.08.127_bib0058","series-title":"Deep Medicine: How Artificial Intelligence can Make Healthcare Human Again","author":"Topol","year":"2019"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721009320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721009320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:36:24Z","timestamp":1790692584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032721009320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":30,"alternative-id":["S0165032721009320"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2021.08.127","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring machine learning to predict depressive relapses of bipolar disorder patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2021.08.127","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}