{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:03:20Z","timestamp":1790694200351,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015756","name":"Cilag","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004756","name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jad.2021.09.034","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T10:56:44Z","timestamp":1631876204000},"page":"1474-1481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Switches and early discontinuations of antidepressant medication in young adults with depression"],"prefix":"10.1016","volume":"295","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5360-9723","authenticated-orcid":false,"given":"Pasi","family":"Lampela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3795-3126","authenticated-orcid":false,"given":"Antti","family":"Tanskanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7244-145X","authenticated-orcid":false,"given":"Markku","family":"L\u00e4hteenvuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0400-6798","authenticated-orcid":false,"given":"Jari","family":"Tiihonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3281-934X","authenticated-orcid":false,"given":"Heidi","family":"Taipale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2021.09.034_bib0001","unstructured":"ADHD: Current Care Guidelines. 2019. Working group set up by the Finnish Medical Society Duodecim, the Finnish Pediatric Neurology Association, the Finnish Adolescent Psychiatry Association and the Finnish Child Psychiatry Association. Helsinki: The Finnish Medical Society Duodecim. (referred February 20, 2021). Available online at: www.kaypahoito.fi."},{"key":"10.1016\/j.jad.2021.09.034_bib0002","unstructured":"American Psychiatric Association. 2010. Practice guideline for the treatment of patients with major depressive disorder. Third edition."},{"key":"10.1016\/j.jad.2021.09.034_bib0003","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/hup.1274","article-title":"Double-blind controlled trial of venlafaxine for treatment of adults with attention deficit\/hyperactivity disorder","volume":"27","author":"Amiri","year":"2012","journal-title":"Hum. Psychopharmacol. Clin. Exp."},{"key":"10.1016\/j.jad.2021.09.034_bib0004","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/ijcp.12263","article-title":"Factors associated with switching and combination use of antidepressant in young Swedish adults","volume":"67","author":"Andersson Sundell","year":"2013","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.jad.2021.09.034_bib0005","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/0269881116628440","article-title":"The safety and tolerability of vortioxetine: analysis of data from randomized placebo-controlled trials and open-label extension studies","volume":"30","author":"Baldwin","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2021.09.034_bib0006","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1744-859X-13-8","article-title":"What happens next?: A claims database study of second-line pharmacotherapy in patients with major depressive disorder (MDD) who initiate selective serotonin reuptake inhibitor (SSRI) treatment","volume":"13","author":"Ball","year":"2014","journal-title":"Ann. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2021.09.034_bib0007","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/1087054712443157","article-title":"Duloxetine in adults with ADHD: a randomized, placebo-controlled pilot study","volume":"18","author":"Bilodeau","year":"2012","journal-title":"J. Atten. Disord."},{"key":"10.1016\/j.jad.2021.09.034_bib0008","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12991-020-00306-2","article-title":"How to improve adherence to antidepressant treatments in patients with major depression: a psychoeducational consensus checklist","volume":"19","author":"Dell'Osso","year":"2020","journal-title":"Ann. Gen. Psych."},{"key":"10.1016\/j.jad.2021.09.034_bib0009","unstructured":"Depression: Current Care Guidelines. 2020. Working group set up by the Finnish Medical Society and the Finnish Psychiatric Association. Helsinki: The Finnish Medical Society Duodecim. (referred January 5, 2021). Available online at: www.kaypahoito.fi."},{"key":"10.1016\/j.jad.2021.09.034_bib0010","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40303-015-0011-7","article-title":"A systematic review of agomelatine-induced liver injury","volume":"3","author":"Freiesleben","year":"2015","journal-title":"J. Mol. Psychiatry."},{"key":"10.1016\/j.jad.2021.09.034_bib0011","doi-asserted-by":"crossref","unstructured":"FinHealth 2017: http:\/\/www.terveytemme.fi\/finterveys\/html\/m_ft17_l1_5_7_2lk.html.","DOI":"10.13188\/2330-0396.1000040"},{"key":"10.1016\/j.jad.2021.09.034_bib0012","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/pds.4426","article-title":"Comparison of dispensed medications and forensic-toxicological findings to assess pharmacotherapy in the Swedish population 2006 to 2013","volume":"27","author":"Forsman","year":"2018","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.jad.2021.09.034_bib0013","unstructured":"Insomnia: Current Care Guidelines. 2020. Working group set up by the Finnish Medical Society Duodecim and the Finnish sleep research society. Helsinki: the Finnish medical society Duodecim. (referred July 11, 2021). Available online at: www.kaypahoito.fi."},{"key":"10.1016\/j.jad.2021.09.034_bib0014","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4306\/pi.2016.13.4.440","article-title":"Times to discontinue antidepressants over 6 months in patients with major depressive disorder","volume":"13","author":"Jung","year":"2016","journal-title":"Psychiatry Invest"},{"key":"10.1016\/j.jad.2021.09.034_bib0015","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/JCP.0000000000000338","article-title":"Off-label prescriptions of low-dose quetiapine and mirtazapine for insomnia in the Netherlands","volume":"35","author":"Kamphuis","year":"2015","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2021.09.034_bib0016","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jad.2019.01.016","article-title":"Persistence with selective serotonin (norepinephrine) reuptake inhibitors in Germany \u2013 a retrospective database analysis","volume":"247","author":"Kap","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2021.09.034_bib0017","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41380-020-0843-0","article-title":"Discontinuation of antidepressants after remission with antidepressant medication in major depressive disorder: a systematic review and meta-analysis","volume":"26","author":"Kato","year":"2021","journal-title":"Mol. Psychiatry."},{"key":"10.1016\/j.jad.2021.09.034_bib0018","series-title":"Health, Functional Capacity and Welfare in Finland \u2013 FinHealth 2017 Study","year":"2018"},{"key":"10.1016\/j.jad.2021.09.034_bib0019","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s00787-018-01269-2","article-title":"Antidepressant prescription patterns and CNS polypharmacy with antidepressants among children, adolescents, and young adults: a population-based study in Sweden","volume":"28","author":"Lagerberg","year":"2019","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.jad.2021.09.034_bib0020","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1017\/S2045796017000099","article-title":"Mental health service use, depression, panic disorder and life events among Swedish young adults in 2000 and 2010: a repeated cross-sectional population study in Stockholm County, Sweden","volume":"27","author":"Lundin","year":"2018","journal-title":"Epidemiol. Psychiatr. Sci."},{"key":"10.1016\/j.jad.2021.09.034_bib0021","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.2147\/NDT.S241780","article-title":"Prevalence and determinants of long-term utilization of antidepressant drugs: a retrospective cohort study","volume":"16","author":"Lunghi","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.jad.2021.09.034_bib0022","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1176\/ps.2009.60.5.617","article-title":"Antidepressant switching among adherent patients treated for depression","volume":"60","author":"Marcus","year":"2009","journal-title":"Psychiatr. Serv."},{"key":"10.1016\/j.jad.2021.09.034_bib0023","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1177\/0269881117693748","article-title":"Prevalence and patterns of antidepressant switching amongst primary care patients in the UK","volume":"31","author":"Mars","year":"2017","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2021.09.034_bib0024","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/j.clinthera.2010.11.011","article-title":"Antidepressant monotherapy: a claims database analysis of treatment changes and treatment duration","volume":"32","author":"Milea","year":"2010","journal-title":"Clin. Ther."},{"key":"10.1016\/j.jad.2021.09.034_bib0025","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1017\/S1461145712001496","article-title":"On \u2018polypharmacy\u2019 and multi-target agents, complementary strategies for improving the treatment of depression: a comparative appraisal","volume":"17","author":"Millan","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2021.09.034_bib0026","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.3390\/jcm8101640","article-title":"Management strategies for antidepressant-related sexual dysfunction: a clinical approach","volume":"8","author":"Montejo","year":"2019","journal-title":"J. Clin. Med."},{"issue":"9","key":"10.1016\/j.jad.2021.09.034_bib0027","first-page":"421","article-title":"Antidepressant medication patterns in Asian patients with major depressive disorder","volume":"1","author":"Novick","year":"2015","journal-title":"Patient Prefer. Adherence."},{"key":"10.1016\/j.jad.2021.09.034_bib0028","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2147\/NDT.S199746","article-title":"Cognitive impairment in depression: recent advances and novel treatments","volume":"15","author":"Perini","year":"2019","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.jad.2021.09.034_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2045125319855206","article-title":"What combinations of agomelatine with other antidepressants could be successful during the treatment of major depressive disorder or anxiety in clinical practice?","volume":"9","author":"Potmesil","year":"2019","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"10.1016\/j.jad.2021.09.034_bib0030","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2165\/11315960-000000000-00000","article-title":"Validity of the Finnish Prescription Register for measuring psychotropic drug exposures among elderly Finns: a population-based intervention study","volume":"27","author":"Rikala","year":"2010","journal-title":"Drugs. Aging."},{"key":"10.1016\/j.jad.2021.09.034_bib0031","doi-asserted-by":"crossref","first-page":"329","DOI":"10.5694\/mja2.50522","article-title":"Antidepressant-induced sexual dysfunction","volume":"212","author":"Rothmore","year":"2020","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.jad.2021.09.034_bib0032","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/ph13060116","article-title":"Pharmacological treatments for patients with treatment-resistant depression","volume":"13","author":"Ruberto","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jad.2021.09.034_bib0033","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1742-1241.2012.03015.x","article-title":"Antidepressant switching patterns in the treatment of major depressive disorder: a General Practice Research Database (GPRD) Study","volume":"66","author":"Saragoussi","year":"2012","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.jad.2021.09.034_bib0034","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1176\/ps.2009.60.12.1604","article-title":"Costs associated with changes in antidepressant treatment in a managed population with major depressive disorder","volume":"60","author":"Schultz","year":"2009","journal-title":"Psychiatr. Serv."},{"key":"10.1016\/j.jad.2021.09.034_bib0035","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12911-015-0140-z","article-title":"From prescription drug purchases to drug use periods \u2013 a second generation method (PRE2DUP)","volume":"15","author":"Tanskanen","year":"2015","journal-title":"BMC Med. Inform. Decis. Mak."},{"key":"10.1016\/j.jad.2021.09.034_bib0036","doi-asserted-by":"crossref","first-page":"e852","DOI":"10.3399\/bjgp13X675430","article-title":"Prevalence of treatment-resistant depression in primary care: cross-sectional data","volume":"63","author":"Thomas","year":"2013","journal-title":"Br. J. Gen. Pract."},{"key":"10.1016\/j.jad.2021.09.034_bib0037","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5498\/wjp.v5.i3.330","article-title":"Pharmacologic approaches to treatment resistant depression: evidences and personal experience","volume":"5","author":"Tundo","year":"2015","journal-title":"World J. Psychiatr."},{"key":"10.1016\/j.jad.2021.09.034_bib0038","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1111\/j.1360-0443.2004.00884.x","article-title":"Adherence to pharmacotherapy in patients with alcohol and opioid dependence","volume":"99","author":"Weiss","year":"2004","journal-title":"Addiction"},{"key":"10.1016\/j.jad.2021.09.034_bib0039","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.genhosppsych.2012.12.003","article-title":"Persistence of antidepressant treatment for depressive disorder in Taiwan","volume":"35","author":"Wu","year":"2013","journal-title":"Gen. Hosp. Psychiatry."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721009939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721009939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:52:28Z","timestamp":1790693548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032721009939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":39,"alternative-id":["S0165032721009939"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2021.09.034","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Switches and early discontinuations of antidepressant medication in young adults with depression","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2021.09.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}