{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:03:38Z","timestamp":1792404218918,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004109"],"award-info":[{"award-number":["82004109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7204250"],"award-info":[{"award-number":["7204250"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jad.2021.09.064","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T03:06:50Z","timestamp":1632712010000},"page":"150-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["T cell responses in depressed mice induced by chronic unpredictable mild stress"],"prefix":"10.1016","volume":"296","author":[{"given":"Wei","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2021.09.064_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11030220","article-title":"Expansion of CD4 T lymphocytes expressing interleukin 17 and tumor necrosis factor in patients with major depressive disorder","volume":"11","author":"Alvarez-Mon","year":"2021","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.jad.2021.09.064_bib0002","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S0140-6736(77)92780-5","article-title":"Depressed lymphocyte function after bereavement","volume":"1","author":"Bartrop","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2021.09.064_bib0003","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0304-3940(99)00545-5","article-title":"Evidence for activation of microglia in patients with psychiatric illnesses","volume":"271","author":"Bayer","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jad.2021.09.064_bib0004","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.biopsych.2012.09.021","article-title":"Inflammatory T helper 17 cells promote depression-like behavior in mice","volume":"73","author":"Beurel","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2021.09.064_bib0005","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neuron.2020.06.002","article-title":"The Bidirectional Relationship of Depression and Inflammation: double Trouble","volume":"107","author":"Beurel","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.jad.2021.09.064_bib0006","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1523\/JNEUROSCI.2278-14.2015","article-title":"Lymphocytes from chronically stressed mice confer antidepressant-like effects to naive mice","volume":"35","author":"Brachman","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2021.09.064_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106182","article-title":"Antidepressant-like effects of penta-acetyl geniposide in chronic unpredictable mild stress-induced depression rat model: involvement of inhibiting neuroinflammation in prefrontal cortex and regulating hypothalamic-pituitaryadrenal axis","volume":"80","author":"Cai","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jad.2021.09.064_bib0008","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3389\/fimmu.2020.00348","article-title":"Transcriptional regulators of T helper 17 cell differentiation in health and autoimmune diseases","volume":"11","author":"Capone","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jad.2021.09.064_bib0009","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.psychres.2010.10.029","article-title":"Emerging tendency towards autoimmune process in major depressive patients: a novel insight from Th17 cells","volume":"188","author":"Chen","year":"2011","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2021.09.064_bib0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/10253890.2016.1191466","article-title":"CD4(+) T cells confer anxiolytic and antidepressant-like effects, but enhance fear memory processes in Rag2(-\/-) mice","volume":"19","author":"Clark","year":"2016","journal-title":"Stress"},{"key":"10.1016\/j.jad.2021.09.064_bib0011","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbi.2021.02.009","article-title":"M1\/M2 polarization in major depressive disorder: disentangling state from trait effects in an individualized cell-culture-based approach","volume":"94","author":"Cosma","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2021.09.064_bib0012","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.psyneuen.2014.03.019","article-title":"The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery","volume":"45","author":"Dahl","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2021.09.064_bib0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-1781(88)90152-7","article-title":"Cellular immunity and the hypothalamic-pituitary axis in major affective disorder: a preliminary study","volume":"25","author":"Darko","year":"1988","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2021.09.064_bib0014","first-page":"137","article-title":"Elevated IL-17 and TGF-\u03b2 Serum Levels: a Positive Correlation between T-helper 17 Cell-Related Pro-Inflammatory Responses with Major Depressive Disorder","volume":"7","author":"Davami","year":"2016","journal-title":"Basic Clin. Neurosci."},{"key":"10.1016\/j.jad.2021.09.064_bib0015","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1084\/jem.20091419","article-title":"Regulation of learning and memory by meningeal immunity: a key role for IL-4","volume":"207","author":"Derecki","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jad.2021.09.064_bib0016","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.it.2015.12.008","article-title":"Understanding the role of T cells in CNS homeostasis","volume":"37","author":"Ellwardt","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jad.2021.09.064_bib0017","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.cell.2019.10.001","article-title":"Stress-induced metabolic disorder in peripheral CD4(+) T cells leads to anxiety-like behavior","volume":"179","author":"Fan","year":"2019","journal-title":"Cell."},{"key":"10.1016\/j.jad.2021.09.064_bib0018","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature18626","article-title":"Unexpected role of interferon-\u03b3 in regulating neuronal connectivity and social behaviour","volume":"535","author":"Filiano","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jad.2021.09.064_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112811","article-title":"Circulating T helper 17 and IFN-\u03b3 positive Th17 cells in major depressive disorder","volume":"394","author":"Ghosh","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2021.09.064_bib0020","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbi.2015.12.003","article-title":"Deficiencies of the T and natural killer cell system in major depressive disorder: t regulatory cell defects are associated with inflammatory monocyte activation","volume":"54","author":"Grosse","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2021.09.064_bib0021","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.biopha.2018.11.046","article-title":"Protective effect of Convolvulus pluricaulis against neuroinflammation associated depressive behavior induced by chronic unpredictable mild stress in rat","volume":"109","author":"Gupta","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jad.2021.09.064_bib0022","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000343100","article-title":"Imbalance between Th17 and Treg cells may play an important role in the development of chronic unpredictable mild stress-induced depression in mice","volume":"20","author":"Hong","year":"2013","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.jad.2021.09.064_bib0023","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jad.2021.09.064_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2019.104487","article-title":"Dysfunctional adaptive immune response in adolescents and young adults with suicide behavior","volume":"111","author":"Jha","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2021.09.064_bib0025","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0149-7634(81)90005-1","article-title":"Acute and chronic stress effects on open field activity in the rat: implications for a model of depression","volume":"5","author":"Katz","year":"1981","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2021.09.064_bib0026","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-publhealth-031912-114409","article-title":"The epidemiology of depression across cultures","volume":"34","author":"Kessler","year":"2013","journal-title":"Annu. Rev. Public Health"},{"key":"10.1016\/j.jad.2021.09.064_bib0027","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4306\/pi.2013.10.3.294","article-title":"Plasma levels of IL-23 and IL-17 before and after antidepressant treatment in patients with major depressive disorder","volume":"10","author":"Kim","year":"2013","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.jad.2021.09.064_bib0028","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.pnpbp.2007.03.004","article-title":"Cytokine imbalance in the pathophysiology of major depressive disorder","volume":"31","author":"Kim","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2021.09.064_bib0029","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0024-3205(83)90382-X","article-title":"Impaired lymphocyte function in depressive illness","volume":"33","author":"Kronfol","year":"1983","journal-title":"Life Sci."},{"key":"10.1016\/j.jad.2021.09.064_bib0030","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.intimp.2017.02.007","article-title":"Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress","volume":"45","author":"Liu","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jad.2021.09.064_bib0031","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jad.2005.07.008","article-title":"Th1, Th2, and Th3 cytokine alterations in major depression","volume":"88","author":"Myint","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2021.09.064_bib0032","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1111\/ejn.15205","article-title":"Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression","volume":"53","author":"Obermanns","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jad.2021.09.064_bib0033","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jneuroim.2005.08.014","article-title":"Th2 cytokine response in major depressive disorder patients before treatment","volume":"172","author":"Pav\u00f3n","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jad.2021.09.064_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpr.2021.102048","article-title":"Risk factors for self-harm repetition in adolescents: a systematic review","volume":"88","author":"Rahman","year":"2021","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.jad.2021.09.064_bib0035","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41398-020-00979-z","article-title":"Childhood trauma, suicide risk and inflammatory phenotypes of depression: insights from monocyte gene expression","volume":"10","author":"Schiweck","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2021.09.064_bib0036","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.bbi.2020.02.005","article-title":"Depression and suicidality: a link to premature T helper cell aging and increased Th17 cells","volume":"87","author":"Schiweck","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jad.2021.09.064_bib0037","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/515180a","article-title":"Mental health: a world of depression","volume":"515","author":"Smith","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jad.2021.09.064_bib0038","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.2147\/NDT.S66504","article-title":"Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure","volume":"10","author":"Spanemberg","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.jad.2021.09.064_bib0039","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jpsychires.2006.10.013","article-title":"Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide","volume":"42","author":"Steiner","year":"2008","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2021.09.064_bib0040","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s10517-011-1453-2","article-title":"Effect of ladasten on the content of cytokine markers of inflammation and behavior of mice with experimental depression-like syndrome","volume":"152","author":"Tallerova","year":"2011","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.jad.2021.09.064_bib0041","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bbr.2018.07.001","article-title":"Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat","volume":"356","author":"Zhang","year":"2019","journal-title":"Behav. Brain Res."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721010235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721010235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T02:06:30Z","timestamp":1759025190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032721010235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":41,"alternative-id":["S0165032721010235"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2021.09.064","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T cell responses in depressed mice induced by chronic unpredictable mild stress","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2021.09.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}