{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:00:28Z","timestamp":1792652428145,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jad.2021.10.083","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T02:29:18Z","timestamp":1635647358000},"page":"381-387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"PA","title":["Comorbid anxiety and depression, depression, and anxiety in comparison in multi-ethnic community of west China: prevalence, metabolic profile, and related factors"],"prefix":"10.1016","volume":"298","author":[{"given":"Xiaolei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiukui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongchang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirong","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2021.10.083_bib0036","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1192\/bjp.bp.111.106666","article-title":"Vitamin D deficiency and depression in adults: systematic review and meta-analysis","volume":"202","author":"Anglin","year":"2013","journal-title":"The British journal of psychiatry: the journal of mental science"},{"issue":"3","key":"10.1016\/j.jad.2021.10.083_bib0004","doi-asserted-by":"crossref","first-page":"327","DOI":"10.31887\/DCNS.2015.17.3\/bbandelow","article-title":"Epidemiology of anxiety disorders in the 21st century","volume":"17","author":"Bandelow","year":"2015","journal-title":"Dialogues in clinical neuroscience"},{"issue":"1","key":"10.1016\/j.jad.2021.10.083_bib0015","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1176\/ajp.157.1.89","article-title":"Anxiety and depression in later life: Co-occurrence and communality of risk factors","volume":"157","author":"Beekman","year":"2000","journal-title":"The American journal of psychiatry"},{"key":"10.1016\/j.jad.2021.10.083_bib0022","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1741-7015-9-90","article-title":"Cross-national epidemiology of DSM-IV major depressive episode","volume":"9","author":"Bromet","year":"2011","journal-title":"BMC medicine"},{"issue":"10063","key":"10.1016\/j.jad.2021.10.083_bib0005","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1016\/S0140-6736(16)30381-6","article-title":"Anxiety","volume":"388","author":"Craske","year":"2016","journal-title":"Lancet (London, England)"},{"issue":"16","key":"10.1016\/j.jad.2021.10.083_bib0030","first-page":"1","article-title":"Patient experiences of depression and anxiety with chronic disease: a systematic review and qualitative meta-synthesis","volume":"13","author":"DeJean","year":"2013","journal-title":"Ontario health technology assessment series"},{"issue":"21","key":"10.1016\/j.jad.2021.10.083_bib0037","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.2174\/1381612826666200406090051","article-title":"Vitamin D and N-Acetyl cysteine supplementation in treatment resistant depressive disorder patients: a general review","volume":"26","author":"di Michele","year":"2020","journal-title":"Current pharmaceutical design"},{"key":"10.1016\/j.jad.2021.10.083_bib0026","doi-asserted-by":"crossref","unstructured":"Feng, L., Li, P., Lu, C., et\u00a0al. Burden and correlates of geriatric depression in the Uyghur elderly population, observation from Xinjiang, China. PloS one, Dec 2014; 9(12), e114139. https:\/\/doi.org\/10.1371\/journal.pone.0114139.","DOI":"10.1371\/journal.pone.0114139"},{"key":"10.1016\/j.jad.2021.10.083_bib0007","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jad.2020.03.086","article-title":"Comorbid anxiety and depression (CAD) at early stages of the pregnancy. A multicultural cross-sectional study","volume":"270","author":"Gonzalez-Mesa","year":"2020","journal-title":"Journal of affective disorders"},{"issue":"10","key":"10.1016\/j.jad.2021.10.083_bib0032","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jagp.2016.05.015","article-title":"Anxiety as a Predictor for Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis. The American journal of geriatric psychiatry","volume":"24","author":"Gulpers","year":"2016","journal-title":"official journal of the American Association for Geriatric Psychiatry"},{"key":"10.1016\/j.jad.2021.10.083_bib0033","doi-asserted-by":"crossref","DOI":"10.1001\/jamapsychiatry.2020.0158","article-title":"The Age of Depression and Its Treatments","author":"Hofmann","year":"2020","journal-title":"JAMA Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2021.10.083_bib0003","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S2215-0366(18)30511-X","article-title":"Prevalence of mental disorders in China: a cross-sectional epidemiological study","volume":"6","author":"Huang","year":"2019","journal-title":"The lancet. Psychiatry"},{"issue":"13","key":"10.1016\/j.jad.2021.10.083_bib0011","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.3390\/ijms21134784","article-title":"Metabolomic biomarkers in anxiety disorders","volume":"21","author":"Humer","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jad.2021.10.083_bib0023","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1037\/0033-295X.115.2.291","article-title":"The ABCs of depression: integrating affective, biological, and cognitive models to explain the emergence of the gender difference in depression","volume":"115","author":"Hyde","year":"2008","journal-title":"Psychological review"},{"issue":"16","key":"10.1016\/j.jad.2021.10.083_bib0031","article-title":"Depression, hippocampal volume changes, and cognitive decline in a clinical sample of older depressed outpatients and non-depressed controls","volume":"6","author":"Kathryn","year":"2012","journal-title":"Aging & mental health"},{"issue":"9","key":"10.1016\/j.jad.2021.10.083_bib0020","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/JGP.0b013e3181ad4d17","article-title":"Comorbidity of depressive and anxiety disorders for older Americans in the national comorbidity survey-replication. The American journal of geriatric psychiatry","volume":"17","author":"King-Kallimanis","year":"2009","journal-title":"official journal of the American Association for Geriatric Psychiatry"},{"issue":"12","key":"10.1016\/j.jad.2021.10.083_bib0024","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/da.20612","article-title":"Prevalence and risk factors for posttraumatic stress disorder: a cross-sectional study among survivors of the Wenchuan 2008 earthquake in China","volume":"26","author":"Kun","year":"2009","journal-title":"Depression and anxiety"},{"issue":"9","key":"10.1016\/j.jad.2021.10.083_bib0012","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/1099-1166(200009)15:9<824::AID-GPS207>3.0.CO;2-C","article-title":"Validation and comparison of three brief depression scales in an elderly Chinese population","volume":"15","author":"Lim","year":"2000","journal-title":"International journal of geriatric psychiatry"},{"key":"10.1016\/j.jad.2021.10.083_bib0035","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3389\/fpsyt.2020.00249","article-title":"Cognitive Reserve Moderates Effects of White Matter Hyperintensity on Depressive Symptoms and Cognitive Function in Late-Life Depression","volume":"11","author":"Lin","year":"2020","journal-title":"Frontiers in psychiatry"},{"key":"10.1016\/j.jad.2021.10.083_bib0034","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jad.2019.08.091","article-title":"Influence of comorbid anxiety symptoms on cognitive deficits in patients with major depressive disorder","volume":"260","author":"Liu","year":"2020","journal-title":"Journal of affective disorders"},{"key":"10.1016\/j.jad.2021.10.083_bib0008","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3389\/fpsyt.2020.00269","article-title":"Metabonomic profile and signaling pathway prediction of depression-associated suicidal behavior","volume":"11","author":"Liu","year":"2020","journal-title":"Frontiers in psychiatry"},{"issue":"23","key":"10.1016\/j.jad.2021.10.083_bib0027","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1093\/eurheartj\/ehl338","article-title":"Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies","volume":"27","author":"Nicholson","year":"2006","journal-title":"European heart journal"},{"issue":"8","key":"10.1016\/j.jad.2021.10.083_bib0006","first-page":"22","article-title":"Comorbid anxiety and depression","volume":"66","author":"P","year":"2005","journal-title":"The Journal of clinical psychiatry"},{"issue":"10","key":"10.1016\/j.jad.2021.10.083_bib0014","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1532-5415.1975.tb00927.x","article-title":"A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients","volume":"23","author":"Pfeiffer","year":"1975","journal-title":"Journal of the American Geriatrics Society"},{"issue":"6","key":"10.1016\/j.jad.2021.10.083_bib0017","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/JGP.0b013e31819b87b2","article-title":"The burden of late-life generalized anxiety disorder: effects on disability, health-related quality of life, and healthcare utilization","volume":"17","author":"Porensky","year":"2009","journal-title":"The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry"},{"issue":"8","key":"10.1016\/j.jad.2021.10.083_bib0021","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1037\/bul0000102","article-title":"Gender differences in depression in representative national samples: Meta-analyses of diagnoses and symptoms","volume":"143","author":"Salk","year":"2017","journal-title":"Psychological bulletin"},{"issue":"2","key":"10.1016\/j.jad.2021.10.083_bib0016","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0010-440X(00)80008-5","article-title":"Anxiety and anxiety disorders in the old and very old\u2013results from the Berlin Aging Study (BASE)","volume":"41","author":"Schaub","year":"2000","journal-title":"Comprehensive psychiatry"},{"issue":"12","key":"10.1016\/j.jad.2021.10.083_bib0019","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.jagp.2013.08.003","article-title":"The moderating effect of age on the 12-month prevalence of anxiety and depressive disorders in adults with a lifetime history of cancer","volume":"22","author":"Simning","year":"2014","journal-title":"The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry"},{"issue":"7526","key":"10.1016\/j.jad.2021.10.083_bib0001","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/515180a","article-title":"Mental health: A world of depression","volume":"515","author":"Smith","year":"2014","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jad.2021.10.083_bib0018","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1034\/j.1600-0447.2003.02056.x","article-title":"The association between age and depression in the general population: a multivariate examination","volume":"107","author":"Stordal","year":"2003","journal-title":"Acta psychiatrica Scandinavica"},{"issue":"6","key":"10.1016\/j.jad.2021.10.083_bib0013","first-page":"184","volume":"11","author":"Swinson","year":"2006","journal-title":"The GAD-7 scale was accurate for diagnosing generalised anxiety disorder. Evidence-based medicine"},{"key":"10.1016\/j.jad.2021.10.083_bib0010","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.comppsych.2016.05.005","article-title":"A cross-sectional study to investigate the correlation between depression comorbid with anxiety and serum lipid levels","volume":"69","author":"Wang","year":"2016","journal-title":"Comprehensive psychiatry"},{"issue":"5","key":"10.1016\/j.jad.2021.10.083_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156382","article-title":"Depression among Low-Income Female Muslim Uyghur and Kazakh Informal Caregivers of Disabled Elders in Far Western China: Influence on the Caregivers' Burden and the Disabled Elders' Quality of Life","volume":"11","author":"Wang","year":"2016","journal-title":"PloS one"},{"key":"10.1016\/j.jad.2021.10.083_bib0009","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-021-01176-0","article-title":"A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression","author":"Zacharias","year":"2021","journal-title":"Mol Psychiatry"},{"issue":"5-6","key":"10.1016\/j.jad.2021.10.083_bib0029","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1080\/15412555.2019.1679102","article-title":"Prevalence, Contribution to Disease Burden and Management of Comorbid Depression and Anxiety in Chronic Obstructive Pulmonary Disease: A Narrative Review","volume":"16","author":"Zareifopoulos","year":"2019","journal-title":"Copd"},{"key":"10.1016\/j.jad.2021.10.083_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jocn.2017.09.022","article-title":"Depression and cardiovascular disease in elderly: Current understanding","volume":"47","author":"Zhang","year":"2018","journal-title":"Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia"},{"key":"10.1016\/j.jad.2021.10.083_bib0002","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jad.2019.09.011","article-title":"Prevalence and recognition of depressive disorders among Chinese older adults receiving primary care: A multi-center cross-sectional study","volume":"260","author":"Zhong","year":"2020","journal-title":"Journal of affective disorders"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721011782?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721011782?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T02:25:12Z","timestamp":1759026312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032721011782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":37,"alternative-id":["S0165032721011782"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2021.10.083","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comorbid anxiety and depression, depression, and anxiety in comparison in multi-ethnic community of west China: prevalence, metabolic profile, and related factors","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2021.10.083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}