{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:36:07Z","timestamp":1792200967281,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jad.2021.10.101","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T19:23:08Z","timestamp":1635621788000},"page":"373-380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"PA","title":["Assessment of the relationships between genetic determinants of thyroid functions and bipolar disorder: A mendelian randomization study"],"prefix":"10.1016","volume":"298","author":[{"given":"Guoqing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honggang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanzheng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinguo","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2021.10.101_bib0001","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1210\/en.2004-0274","article-title":"A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration","volume":"145","author":"Aus\u00f3","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.jad.2021.10.101_bib0002","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.schres.2015.04.030","article-title":"Free thyroxine levels are associated with cognitive abilities in subjects with early psychosis","volume":"166","author":"Barbero","year":"2015","journal-title":"Schizophrenia Research"},{"key":"10.1016\/j.jad.2021.10.101_bib0003","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jad.2017.06.019","article-title":"Thyroid autoimmunity in bipolar disorder: A systematic review","volume":"221","author":"Barbuti","year":"2017","journal-title":"Journal of affective disorders"},{"key":"10.1016\/j.jad.2021.10.101_bib0004","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/mp.2014.186","article-title":"Levothyroxine effects on depressive symptoms and limbic glucose metabolism in bipolar disorder: a randomized, placebo-controlled positron emission tomography study","volume":"21","author":"Bauer","year":"2016","journal-title":"Molecular psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0005","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/sj.mp.4000963","article-title":"Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain","volume":"7","author":"Bauer","year":"2002","journal-title":"Molecular psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0006","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0404.2004.00262.x","article-title":"Cognitive and affective status in mild hypothyroidism and interactions with L-thyroxine treatment","volume":"110","author":"Bono","year":"2004","journal-title":"Acta neurologica Scandinavica"},{"key":"10.1016\/j.jad.2021.10.101_bib0007","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genetic Epidemiology"},{"key":"10.1016\/j.jad.2021.10.101_bib0008","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"International journal of epidemiology"},{"key":"10.1016\/j.jad.2021.10.101_bib0009","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/sim.7221","article-title":"A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization","volume":"36","author":"Bowden","year":"2017","journal-title":"Statistics in medicine"},{"key":"10.1016\/j.jad.2021.10.101_bib0010","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/ije\/dyt179","article-title":"Calculating statistical power in Mendelian randomization studies","volume":"42","author":"Brion","year":"2012","journal-title":"International journal of epidemiology"},{"key":"10.1016\/j.jad.2021.10.101_bib0011","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jad.2021.10.101_bib0012","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/schbul\/sby058","article-title":"Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study","volume":"44","author":"Charlson","year":"2018","journal-title":"Schizophrenia bulletin"},{"key":"10.1016\/j.jad.2021.10.101_bib0013","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1176\/appi.ajp.2020.19111158","article-title":"An Exposure-Wide and Mendelian Randomization Approach to Identifying Modifiable Factors for the Prevention of Depression","volume":"177","author":"Choi","year":"2020","journal-title":"The American journal of psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0014","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/0269881115581093","article-title":"Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines","volume":"29","author":"Cleare","year":"2015","journal-title":"Journal of psychopharmacology"},{"key":"10.1016\/j.jad.2021.10.101_bib0015","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1136\/bmj.330.7499.1076","article-title":"What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?","volume":"330","author":"Davey Smith","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.jad.2021.10.101_bib0016","doi-asserted-by":"crossref","first-page":"e34442","DOI":"10.1371\/journal.pone.0034442","article-title":"Novel associations for hypothyroidism include known autoimmune risk loci","volume":"7","author":"Eriksson","year":"2012","journal-title":"PloS one"},{"key":"10.1016\/j.jad.2021.10.101_bib0017","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/s12888-019-2354-6","article-title":"Rapid cycling bipolar disorder is associated with antithyroid antibodies, instead of thyroid dysfunction","volume":"19","author":"Gan","year":"2019","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0018","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(15)00241-X","article-title":"Bipolar disorder","volume":"387","author":"Grande","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2021.10.101_bib0019","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/15622970903555881","article-title":"The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the treatment of acute bipolar depression","volume":"11","author":"Grunze","year":"2010","journal-title":"The World Journal of Biological Psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0020","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1001\/jamapsychiatry.2017.3191","article-title":"Inflammatory Biomarkers and Risk of Schizophrenia: A 2-Sample Mendelian Randomization Study","volume":"74","author":"Hartwig","year":"2017","journal-title":"JAMA psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0021","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408.012","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","author":"Hemani","year":"2018","journal-title":"Elife 7"},{"key":"10.1016\/j.jad.2021.10.101_bib0022","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Jack","year":"2015","journal-title":"International Journal of Epidemiology"},{"key":"10.1016\/j.jad.2021.10.101_bib0023","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1093\/bioinformatics\/btz469","article-title":"PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations","volume":"35","author":"Kamat","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jad.2021.10.101_bib0024","article-title":"Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study","author":"Kappelmann","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0025","doi-asserted-by":"crossref","unstructured":"Ku\u015b, A., Kjaergaard, A.D., Marouli, E., Del Greco, M.F., Sterenborg, R., Chaker, L., Peeters, R.P., Bednarczuk, T., \u00c5svold, B.O., Burgess, S., Deloukas, P., Teumer, A., Ellervik, C., Medici, M., 2021. Thyroid Function and Mood Disorders: A Mendelian Randomization Study. Thyroid.","DOI":"10.1089\/thy.2020.0884"},{"key":"10.1016\/j.jad.2021.10.101_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110027","article-title":"Association of altered thyroid hormones and neurometabolism to cognitive dysfunction in unmedicated bipolar II depression","volume":"105","author":"Lai","year":"2021","journal-title":"Progress in neuro-psychopharmacology & biological psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0027","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/sim.3034","article-title":"Mendelian randomization: using genes as instruments for making causal inferences in epidemiology","volume":"27","author":"Lawlor","year":"2008","journal-title":"Stat Med"},{"key":"10.1016\/j.jad.2021.10.101_bib0028","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12888-018-2006-2","article-title":"Association between subclinical hypothyroidism and depression: an updated systematic review and meta-analysis","volume":"19","author":"Loh","year":"2019","journal-title":"BMC psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0029","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004123","article-title":"Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease","volume":"10","author":"Medici","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jad.2021.10.101_bib0030","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41588-021-00857-4","article-title":"Genome-wide association study of more than 40, 000 bipolar disorder cases provides new insights into the underlying biology","volume":"53","author":"Mullins","year":"2021","journal-title":"Nature genetics"},{"key":"10.1016\/j.jad.2021.10.101_bib0031","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fncel.2015.00194","article-title":"Possible role of glial cells in the relationship between thyroid dysfunction and mental disorders","volume":"9","author":"Noda","year":"2015","journal-title":"Frontiers in cellular neuroscience"},{"key":"10.1016\/j.jad.2021.10.101_bib0032","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1210\/jc.2008-0397","article-title":"A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine","volume":"93","author":"Panicker","year":"2008","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"10.1016\/j.jad.2021.10.101_bib0033","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3389\/fpsyt.2020.00775","article-title":"Glucose Metabolism, Thyroid Function, and Prolactin Level in Adolescent Patients With First Episode of Schizophrenia and Affective Disorders","volume":"11","author":"Petruzzelli","year":"2020","journal-title":"Frontiers in psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0034","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/ng.3570","article-title":"Detection and interpretation of shared genetic influences on 42 human traits","volume":"48","author":"Pickrell","year":"2016","journal-title":"Nature genetics"},{"key":"10.1016\/j.jad.2021.10.101_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003266","article-title":"A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function","volume":"9","author":"Porcu","year":"2013","journal-title":"PLoS genetics"},{"key":"10.1016\/j.jad.2021.10.101_bib0036","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fendo.2014.00062","article-title":"Thyroid hormone signaling and adult neurogenesis in mammals","volume":"5","author":"Remaud","year":"2014","journal-title":"Frontiers in endocrinology"},{"key":"10.1016\/j.jad.2021.10.101_bib0037","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.maturitas.2015.03.016","article-title":"Thyroid hormone: Influences on mood and cognition in adults","volume":"81","author":"Ritchie","year":"2015","journal-title":"Maturitas"},{"key":"10.1016\/j.jad.2021.10.101_bib0038","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/MED.0000000000000089","article-title":"Psychiatric and cognitive manifestations of hypothyroidism","author":"Samuels","year":"2014","journal-title":"Current opinion in endocrinology, diabetes, and obesity 21"},{"key":"10.1016\/j.jad.2021.10.101_bib0039","doi-asserted-by":"crossref","first-page":"E799","DOI":"10.1210\/jc.2014-4352","article-title":"A genetic risk score for thyroid peroxidase antibodies associates with clinical thyroid disease in community-based populations","volume":"100","author":"Schultheiss","year":"2015","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"10.1016\/j.jad.2021.10.101_bib0040","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41588-019-0397-8","article-title":"Genome-wide association study identifies 30 loci associated with bipolar disorder","volume":"51","author":"Stahl","year":"2019","journal-title":"Nature genetics"},{"key":"10.1016\/j.jad.2021.10.101_bib0041","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1093\/bioinformatics\/btw373","article-title":"PhenoScanner: a database of human genotype-phenotype associations","volume":"32","author":"Staley","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jad.2021.10.101_bib0042","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4088\/JCP.12m08305","article-title":"Supraphysiologic doses of levothyroxine as adjunctive therapy in bipolar depression: a randomized, double-blind, placebo-controlled study","volume":"75","author":"Stamm","year":"2014","journal-title":"The Journal of clinical psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0043","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Stephen","year":"2013","journal-title":"Genetic Epidemiology"},{"key":"10.1016\/j.jad.2021.10.101_bib0044","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.1038\/ncomms6681","article-title":"Whole-genome sequence-based analysis of thyroid function","volume":"6","author":"Taylor","year":"2015","journal-title":"Nature communications"},{"key":"10.1016\/j.jad.2021.10.101_bib0045","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1038\/s41467-018-06356-1","article-title":"Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation","volume":"9","author":"Teumer","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jad.2021.10.101_bib0046","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jpsychires.2018.09.014","article-title":"Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication","volume":"106","author":"Vedal","year":"2018","journal-title":"Journal of psychiatric research"},{"key":"10.1016\/j.jad.2021.10.101_bib0047","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nature Genetics"},{"key":"10.1016\/j.jad.2021.10.101_bib0048","first-page":"171","article-title":"Estimating the true global burden of mental illness. The lancet","volume":"3","author":"Vigo","year":"2016","journal-title":"Psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0049","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1001\/jamapsychiatry.2014.2502","article-title":"Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis","volume":"72","author":"Walker","year":"2015","journal-title":"JAMA psychiatry"},{"key":"10.1016\/j.jad.2021.10.101_bib0050","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/bdi.12657","article-title":"Adjunctive thyroid hormone treatment in rapid cycling bipolar disorder: A double-blind placebo-controlled trial of levothyroxine (L-T(4)) and triiodothyronine (T(3))","volume":"20","author":"Walshaw","year":"2018","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jad.2021.10.101_bib0051","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1365-2826.2008.01733.x","article-title":"Neurodevelopmental and neurophysiological actions of thyroid hormone","volume":"20","author":"Williams","year":"2008","journal-title":"Journal of neuroendocrinology"},{"key":"10.1016\/j.jad.2021.10.101_bib0052","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/bdi.12609","article-title":"Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder","volume":"20","author":"Yatham","year":"2018","journal-title":"Bipolar disorders"},{"key":"10.1016\/j.jad.2021.10.101_bib0053","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000497182","article-title":"Correlation between Intrinsic Brain Activity and Thyroid-Stimulating Hormone Level in Unmedicated Bipolar II Depression","volume":"108","author":"Zhong","year":"2019","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jad.2021.10.101_bib0054","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1038\/s41467-020-17718-z","article-title":"GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer","volume":"11","author":"Zhou","year":"2020","journal-title":"Nat Commun"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721011897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721011897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T02:24:36Z","timestamp":1759026276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032721011897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":54,"alternative-id":["S0165032721011897"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2021.10.101","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of the relationships between genetic determinants of thyroid functions and bipolar disorder: A mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2021.10.101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}