{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:33:49Z","timestamp":1789688029868,"version":"4.0.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jad.2021.11.007","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T09:40:17Z","timestamp":1636278017000},"page":"565-576","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"PA","title":["What not to use in bipolar disorders: A systematic review of non-recommended treatments in clinical practice guidelines"],"prefix":"10.1016","volume":"298","author":[{"given":"Fabiano A.","family":"Gomes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael O.","family":"Cerqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yena","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo B.","family":"Mansur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Kapczinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi N.","family":"Yatham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roumen","family":"Milev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Brietzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jad.2021.11.007_bib0046","first-page":"1","volume":"159","year":"2002","journal-title":"Am. J. Psychiatry"},{"issue":"10","key":"10.1016\/j.jad.2021.11.007_bib0041","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jcma.2013.06.013","article-title":"Taiwan consensus of pharmacological treatment for bipolar disorder","volume":"76","author":"Bai","year":"2013","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.jad.2021.11.007_bib0031","unstructured":"Bipolar disorder: assessment and management, 2014. Clinical Guideline [CG185] [internet]. National Institute for Health and Care Excellence, London Available from https:\/\/www.nice.org.uk\/guidance\/cg185."},{"key":"10.1016\/j.jad.2021.11.007_bib0048","unstructured":"[Bipolar disorder: clinical guidelines for investigation and treatment.] Stockholm: Swedish Psychiatric Association; 2014. Swedish. Available from: http:\/\/www.svenskpsykiatri.se\/wp-content\/uploads\/2017\/02\/SPF-kliniska-riktlinjer-om-Bipol%C3%A4r-sjukdom.pdf."},{"key":"10.1016\/j.jad.2021.11.007_bib0021","unstructured":"[Care standards: bipolar disorders.] [internet]. Utrecht: GGZ Standards for Dutch Association of Mental Health and Addiction Care; 2017. Dutch. Available from: https:\/\/www.ggzstandaarden.nl\/zorgstandaarden\/bipolaire-stoornissen."},{"issue":"1","key":"10.1016\/j.jad.2021.11.007_bib0013","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1034\/j.1399-5618.1999.10111.x","article-title":"Topiramate as add-on treatment for patients with bipolar mania","volume":"1","author":"Chengappa","year":"1999","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jad.2021.11.007_bib0030","series-title":"Chinese Guidelines For the Prevention and Treatment of Bipolar disorder, 2nd Version","year":"2014"},{"key":"10.1016\/j.jad.2021.11.007_bib0040","unstructured":"[Clinical guide: bipolar disorder in people 15 years and older. 1st ed.] Santiago: Ministry of Health of Chile; 2013. Spanish. Available from: http:\/\/www.repositoriodigital.minsal.cl\/handle\/2015\/1127."},{"key":"10.1016\/j.jad.2021.11.007_bib0032","unstructured":"[Clinical practice guideline for bipolar disorder: UAH\/AEN No. 2012\/1.] Madrid: Ministry of Health, Social Services and Equality of Spain; 2012. Spanish. Available from: https:\/\/portal.guiasalud.es\/wp-content\/uploads\/2018\/12\/GPC_510_Trastorno_Bipolar_compl.pdf."},{"key":"10.1016\/j.jad.2021.11.007_bib0027","unstructured":"Consensus treatment guidelines on bipolar mood disorder. Pasig City: Philippine Psychiatric Association; 2017."},{"issue":"12","key":"10.1016\/j.jad.2021.11.007_bib0009","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1017\/S0033291705005933","article-title":"Does provider adherence to a treatment guideline change clinical outcomes for patients with bipolar disorder? Results from the Texas Medication Algorithm Project","volume":"35","author":"Dennehy","year":"2005","journal-title":"Psychol. Med."},{"issue":"3","key":"10.1016\/j.jad.2021.11.007_bib0038","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4102\/sajpsychiatry.v19i3.942","article-title":"The south african society of psychiatrists (SASOP) treatment guidelines for psychiatric disorders","volume":"19","author":"Emsley","year":"2013","journal-title":"S. Afr. J. Psychiatr"},{"issue":"4","key":"10.1016\/j.jad.2021.11.007_bib0018","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/MLR.0b013e3181ca404e","article-title":"The rise and fall of gabapentin for bipolar disorder: a case study on off-label pharmaceutical diffusion","volume":"48","author":"Fullerton","year":"2010","journal-title":"Med. Care"},{"issue":"4","key":"10.1016\/j.jad.2021.11.007_bib0026","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/ijnp\/pyz064","article-title":"The CINP guidelines on the definition and evidence-based interventions for treatment-resistant bipolar disorder","volume":"23","author":"Fountoulakis","year":"2020","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"2","key":"10.1016\/j.jad.2021.11.007_bib0037","first-page":"180","article-title":"The international college of neuro-psychopharmacology (CINP) treatment guidelines for bipolar disorder in adults (CINP-BD-2017), part 3: the clinical guidelines","volume":"20","author":"Fountoulakis","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"6","key":"10.1016\/j.jad.2021.11.007_bib0007","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1177\/0269881116636545","article-title":"Evidence-based guidelines for treating bipolar disorder: revised third edition recommendations from the British Association for Psychopharmacology","volume":"30","author":"Goodwin","year":"2016","journal-title":"J. Psychopharmacol."},{"issue":"6","key":"10.1016\/j.jad.2021.11.007_bib0008","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/bdi.13114","article-title":"Why do medications with little or no efficacy continue to be prescribed in the management of patients with bipolar disorder?","volume":"23","author":"Gomes","year":"2021","journal-title":"Bipolar Disord."},{"issue":"2","key":"10.1016\/j.jad.2021.11.007_bib0036","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/15622970902823202","article-title":"The world federation of societies of biological psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: update 2009 on the treatment of acute mania","volume":"10","author":"Grunze","year":"2009","journal-title":"World J. Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.jad.2021.11.007_bib0045","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/15622970903555881","article-title":"WFSBP task force on treatment guidelines for bipolar disorders. The world federation of societies of biological psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: update 2010 on the treatment of acute bipolar depression","volume":"11","author":"Grunze","year":"2010","journal-title":"World J. Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2021.11.007_bib0047","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3109\/15622975.2013.770551","article-title":"Force on treatment guidelines for bipolar disorders. the world federation of societies of biological psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: update 2012 on the long-term treatment of bipolar disorder","volume":"14","author":"Grunze","year":"2013","journal-title":"World J. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2021.11.007_bib0049","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/15622975.2017.1384850","volume":"19","author":"Grunze","year":"2018","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2021.11.007_bib0022","unstructured":"[[Guideline: bipolar disorders] [internet]. Utrecht: federation of medical specialists and dutch association for psychiatry (NVvP); 2015. Dutch. Available from: https:\/\/richtlijnendatabase.nl\/richtlijn\/bipolaire_stoornissen\/bipolaire_stoornissen_-_startpagina.html."},{"issue":"1","key":"10.1016\/j.jad.2021.11.007_bib0051","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/15622975.2018.1557346","article-title":"WFSBP guideline task force chairs. WFSBP guidelines on how to grade treatment evidence for clinical guideline development","volume":"20","author":"Hasan","year":"2019","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2021.11.007_bib0020","series-title":"Clinical Practice Guidelines We Can Trust","article-title":"Committee on standards for developing trustworthy clinical practice guidelines","author":"Graham","year":"2011"},{"issue":"2","key":"10.1016\/j.jad.2021.11.007_bib0014","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11920-999-0019-8","article-title":"New treatments of bipolar disorder","volume":"1","author":"Janowsky","year":"1999","journal-title":"Curr. Psychiatry Rep."},{"issue":"5","key":"10.1016\/j.jad.2021.11.007_bib0039","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/pcn.12060","article-title":"Committee for treatment guidelines of mood disorders, japanese society of mood disorders, 2012 Guideline for treatment of bipolar disorder by the japanese society of mood disorders, 2012","volume":"67","author":"Kanba","year":"2013","journal-title":"Psychiatry Clin. Neurosci."},{"issue":"10","key":"10.1016\/j.jad.2021.11.007_bib0004","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2471\/BLT.20.251405","article-title":"Global alliance for chronic diseases (GACD) mental health guidelines working group development and implementation of guidelines for the management of depression: a systematic review","volume":"98","author":"Lee","year":"2020","journal-title":"Bull. World Health Organ."},{"issue":"1","key":"10.1016\/j.jad.2021.11.007_bib0042","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/0004867420979353","article-title":"The 2020 royal Australian and New Zealand college of psychiatrists clinical practice guidelines for mood disorders","volume":"55","author":"Malhi","year":"2021","journal-title":"Aust. N. Z. J. Psychiatry"},{"issue":"10265","key":"10.1016\/j.jad.2021.11.007_bib0001","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/S0140-6736(20)31544-0","article-title":"Bipolar disorders","volume":"396","author":"McIntyre","year":"2020","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jad.2021.11.007_bib0012","doi-asserted-by":"crossref","DOI":"10.11613\/BM.2017.030201","article-title":"Dealing with the positive publication bias: why you should really publish your negative results","volume":"27","author":"Mlinari\u0107","year":"2017","journal-title":"Biochem. Med."},{"issue":"7","key":"10.1016\/j.jad.2021.11.007_bib0019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.jad.2021.11.007_bib0024","series-title":"[Management of Bipolar Disorder in adults.]","year":"2014"},{"issue":"12","key":"10.1016\/j.jad.2021.11.007_bib0033","first-page":"914","article-title":"Ministry of health. ministry of health clinical practice guidelines: bipolar disorder","volume":"52","author":"Mok","year":"2011","journal-title":"Singapore Med. J."},{"issue":"3","key":"10.1016\/j.jad.2021.11.007_bib0005","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1185\/030079906X167444","article-title":"Use of treatment guidelines in clinical decision making in bipolar disorder: a pilot survey of clinicians","volume":"23","author":"Perlis","year":"2007","journal-title":"Curr. Med. Res. Opin."},{"issue":"9","key":"10.1016\/j.jad.2021.11.007_bib0016","article-title":"Topiramate for acute affective episodes in bipolar disorder in adults","volume":"9","author":"Pigott","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jad.2021.11.007_bib0029","unstructured":"[Recommended practices for psychiatric care.] Prague: Czech Psychiatric Society; 2014. Czech."},{"issue":"8","key":"10.1016\/j.jad.2021.11.007_bib0011","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1176\/appi.ajp.2020.19091000","article-title":"20-Year trends in the pharmacologic treatment of bipolar disorder by psychiatrists in outpatient care settings","volume":"177","author":"Rhee","year":"2020","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2021.11.007_bib0017","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1755-5949.2009.00089.x","article-title":"Is anticonvulsant treatment of mania a class effect? Data from randomized clinical trials","volume":"17","author":"Rosa","year":"2011","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jad.2021.11.007_bib53","article-title":"[Federal clinical recommendation for the diagnosis of bipolar disorder in adults.] St Petersburg","author":"Russian Society of Psychiatrists","year":"2013","journal-title":"Russian"},{"issue":"7183","key":"10.1016\/j.jad.2021.11.007_bib0003","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1136\/bmj.318.7183.593","article-title":"Clinical guidelines: developing guidelines","volume":"318","author":"Shekelle","year":"1999","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.jad.2021.11.007_bib0006","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/NMD.0b013e3182125d4c","article-title":"Adherence to guidelines by French psychiatrists in their real world of clinical practice","volume":"199","author":"Samalin","year":"2011","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.jad.2021.11.007_bib0010","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jad.2020.09.037","article-title":"Does guideline-concordant care predict naturalistic outcomes in youth with early stage bipolar I disorder?","volume":"278","author":"Sunder","year":"2021","journal-title":"J. Affect Disord."},{"issue":"1","key":"10.1016\/j.jad.2021.11.007_bib0028","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.4103\/0019-5545.196974","article-title":"Clinical practice guidelines for management of bipolar disorder","volume":"59","author":"Shah","year":"2017","journal-title":"Indian J. Psychiatry"},{"issue":"1","key":"10.1016\/j.jad.2021.11.007_bib0043","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.encep.2014.11.002","article-title":"[French society for biological psychiatry and neuropsychopharmacology task force formal consensus for the treatment of bipolar disorder: an update (2014)]","volume":"41","author":"Samalin","year":"2015","journal-title":"Encephale"},{"key":"10.1016\/j.jad.2021.11.007_bib0035","article-title":"G\u00fcnzburg: german society for bipolar disorder and german society of psychiatry","year":"2019","journal-title":"Psychother. Nerv. Dis."},{"key":"10.1016\/j.jad.2021.11.007_bib0044","article-title":"Romanian society of psychiatry and psychotherapy and romanian society of biological psychiatry and psychopharmachology; 2014","year":"2013","journal-title":"Romanian"},{"key":"10.1016\/j.jad.2021.11.007_bib0034","unstructured":"[Treatment guide for medical treatment of bipolar disorder.] Copenhagen: Council for the Use of Expensive Hospital Medicines (RADS); 2015. Danish. Available from: https:\/\/www.regioner.dk\/media\/1903\/beh-bipolar-okt-2015-221233.pdf."},{"key":"10.1016\/j.jad.2021.11.007_bib0025","series-title":"National Guidelines For Management of Common Conditions","year":"2016"},{"issue":"4","key":"10.1016\/j.jad.2021.11.007_bib0023","doi-asserted-by":"crossref","first-page":"434","DOI":"10.9758\/cpn.2018.16.4.434","article-title":"Korean medication algorithm project for bipolar disorder 2018 (KMAP-BP 2018): fourth revision","volume":"16","author":"Woo","year":"2018","journal-title":"Clin. Psychopharmacol. Neurosci."},{"issue":"6","key":"10.1016\/j.jad.2021.11.007_bib0050","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1600-0447.2007.01016.x","article-title":"Effects of implementation of psychiatric guidelines on provider performance and patient outcome: systematic review","volume":"115","author":"Weinmann","year":"2007","journal-title":"Acta Psychiatr. Scand."},{"issue":"2","key":"10.1016\/j.jad.2021.11.007_bib0002","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/bdi.12609","article-title":"Canadian network for mood and anxiety treatments (CANMAT) and international society for bipolar disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder","volume":"20","author":"Yatham","year":"2018","journal-title":"Bipolar Disord."},{"issue":"4","key":"10.1016\/j.jad.2021.11.007_bib0015","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4088\/JCP.v63n0402","article-title":"Third generation anticonvulsants in bipolar disorder: a review of efficacy and summary of clinical recommendations","volume":"63","author":"Yatham","year":"2002","journal-title":"J. Clin. Psychiatry"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721012258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721012258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T02:37:57Z","timestamp":1759027077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032721012258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":52,"alternative-id":["S0165032721012258"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2021.11.007","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What not to use in bipolar disorders: A systematic review of non-recommended treatments in clinical practice guidelines","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2021.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}