{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T08:24:37Z","timestamp":1777796677972,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R279\\u20132018\\u20131145"],"award-info":[{"award-number":["R279\\u20132018\\u20131145"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jad.2021.11.046","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T11:10:43Z","timestamp":1637579443000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Response to antidepressants among patients with unipolar depression with and without comorbid epilepsy-a nation-wide population-based longitudinal study"],"prefix":"10.1016","volume":"299","author":[{"given":"Lars Vedel","family":"Kessing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon Christoffer","family":"Ziersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esben","family":"Budtz-J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gerds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2021.11.046_bib0001","first-page":"263","article-title":"The danish national hospital register. A valuable source of data for modern health sciences","volume":"46","author":"Andersen","year":"1999","journal-title":"Dan. Med. Bull."},{"key":"10.1016\/j.jad.2021.11.046_bib0002","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.biopsych.2006.09.023","article-title":"Seizure incidence in psychopharmacological clinical trials: an analysis of Food and Drug Administration (FDA) summary basis of approval reports","volume":"62","author":"Alper","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2021.11.046_bib0003","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.yebeh.2018.07.007","article-title":"Depressive, inflammatory, and metabolic factors associated with cognitive impairment in patients with epilepsy","volume":"86","author":"Arend","year":"2018","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2021.11.046_bib0005","first-page":"160","article-title":"Tricyclic antidepressant-induced seizures and plasma drug concentration","volume":"53","author":"Preskorn","year":"1992","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2021.11.046_bib0006","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1745-0179-5-4","article-title":"Validity of the diagnosis of a single depressive episode in a case register","volume":"5","author":"Bock","year":"2009","journal-title":"Clin. Pract. Epidemiol. Ment. Health"},{"key":"10.1016\/j.jad.2021.11.046_bib0007","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/wps.20630","article-title":"The symptom-specific efficacy of antidepressant medication vs. cognitive behavioral therapy in the treatment of depression: results from an individual patient data meta-analysis","volume":"18","author":"Boschloo","year":"2019","journal-title":"World Psychiatry"},{"key":"10.1016\/j.jad.2021.11.046_bib0008","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S1474-4422(07)70175-8","article-title":"Epilepsy and risk of suicide: a population-based case-control study","volume":"6","author":"Christensen","year":"2007","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jad.2021.11.046_bib0009","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/1535759720934787","article-title":"Network Dysfunction in Comorbid Psychiatric Illnesses and Epilepsy","volume":"20","author":"Colmers","year":"2020","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.jad.2021.11.046_bib0011","first-page":"181","article-title":"Psychiatric effects of antiepileptic drugs in adults","volume":"16","author":"Dussaule","year":"2018","journal-title":"Geriatr. Psychol. Neuropsychiatr. Vieil."},{"key":"10.1016\/j.jad.2021.11.046_bib0012","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/ana.25561","article-title":"A trial of sertraline or cognitive behavior therapy for depression in epilepsy","volume":"86","author":"Gilliam","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jad.2021.11.046_bib0013","first-page":"354","article-title":"The Danish registers of causes of death","volume":"46","author":"Juel","year":"1999","journal-title":"Dan. Med. Bull."},{"key":"10.1016\/j.jad.2021.11.046_bib0014","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0149-7634(00)00031-2","article-title":"Long-term amygdala kindling in rats as a model for the study of interictal emotionality in temporal lobe epilepsy","volume":"24","author":"Kalynchuk","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2021.11.046_bib0015","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.yebeh.2016.03.022","article-title":"Most antidepressant drugs are safe for patients with epilepsy at therapeutic doses: a review of the evidence","volume":"61","author":"Kanner","year":"2016","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2021.11.046_bib0016","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S1474-4422(12)70201-6","article-title":"Can neurobiological pathogenic mechanisms of depression facilitate the development of seizure disorders?","volume":"11","author":"Kanner","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jad.2021.11.046_bib0017","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s13311-014-0271-4","article-title":"Biomarkers of epileptogenesis: psychiatric comorbidities (?)","volume":"11","author":"Kanner","year":"2014","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jad.2021.11.046_bib0018","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/epi4.12278","article-title":"Bidirectional relations among common psychiatric and neurologic comorbidities and epilepsy: do they have an impact on the course of the seizure disorder?","volume":"3","author":"Kanner","year":"2018","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.jad.2021.11.046_bib0019","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0924-9338(99)80685-3","article-title":"Validity of diagnoses and other clinical register data in patients with affective disorder","volume":"13","author":"Kessing","year":"1998","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jad.2021.11.046_bib0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.yebeh.2007.03.012","article-title":"Increased rate of treatment with antidepressants in patients with epilepsy","volume":"11","author":"Kessing","year":"2007","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2021.11.046_bib0021","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/YIC.0b013e32834a5cd0","article-title":"Predictors of excellent response to lithium: results from a nationwide register-based study","volume":"26","author":"Kessing","year":"2011","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2021.11.046_bib0022","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.yebeh.2018.04.015","article-title":"Major depressive disorder in epilepsy clinics: a meta-analysis","volume":"84","author":"Kim","year":"2018","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2021.11.046_bib0023","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.yebeh.2015.07.003","article-title":"Epilepsy and bipolar disorder","volume":"52","author":"Knott","year":"2015","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2021.11.046_bib0024","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10803-009-0818-0","article-title":"Validity of childhood autism in the Danish Psychiatric Central Register: findings from a cohort sample born 1990-1999","volume":"40","author":"Lauritsen","year":"2010","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.jad.2021.11.046_bib0025","article-title":"Antidepressants for people with epilepsy and depression","volume":"4","author":"Maguire","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jad.2021.11.046_bib0026","unstructured":"Malig, C. (1996). The civil registration system in Denmark. Technical paper No 66."},{"key":"10.1016\/j.jad.2021.11.046_bib0027","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/bmb\/65.1.193","article-title":"Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment","volume":"65","author":"Mayberg","year":"2003","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.jad.2021.11.046_bib0028","first-page":"82","article-title":"The Danish psychiatric central register","volume":"44","author":"Munk-Jorgensen","year":"1997","journal-title":"Dan. Med. Bull."},{"key":"10.1016\/j.jad.2021.11.046_bib0029","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0165-0327(02)00061-7","article-title":"On the increased risk of developing late-onset epilepsy for patients with major affective disorder","volume":"76","author":"Nilsson","year":"2003","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2021.11.046_bib0030","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/bimj.201800298","article-title":"On the estimation of average treatment effects with right-censored time to event outcome and competing risks","volume":"62","author":"Ozenne","year":"2020","journal-title":"Biom. J."},{"key":"10.1016\/j.jad.2021.11.046_bib0032","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.yebeh.2017.02.032","article-title":"The impact of antidepressants on seizure frequency and depressive and anxiety disorders of patients with epilepsy: is it worth investigating?","volume":"70","author":"Ribot","year":"2017","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jad.2021.11.046_bib0010","unstructured":"Statistics Denmark. http:\/\/www.dst.dk."},{"key":"10.1016\/j.jad.2021.11.046_bib0033","unstructured":"World Health Organization (1992). The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. World Health Organisation: Genova."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721012696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032721012696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:20:16Z","timestamp":1777494016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032721012696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":31,"alternative-id":["S0165032721012696"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2021.11.046","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Response to antidepressants among patients with unipolar depression with and without comorbid epilepsy-a nation-wide population-based longitudinal study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2021.11.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}