{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:18:53Z","timestamp":1791253133391,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"am","delay-in-days":343,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 CA197707"],"award-info":[{"award-number":["R35 CA197707"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007904","name":"Texas A and M University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007904","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008796","name":"Allen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008796","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.jad.2022.09.155","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T11:04:22Z","timestamp":1664881462000},"page":"213-220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Sex-dependent differences in the stress mitigating and antidepressant effects of selective aryl hydrocarbon receptor modulators"],"prefix":"10.1016","volume":"319","author":[{"given":"Caitlin A.","family":"Madison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roanna A.","family":"Debler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan I.","family":"Vardeleon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Hillbrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arul","family":"Jayaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Safe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Chapkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoshana","family":"Eitan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2022.09.155_bb0005","doi-asserted-by":"crossref","first-page":"R289","DOI":"10.1152\/ajpregu.00029.2019","article-title":"Acyloxyacyl hydrolase modulates depressive-like behaviors through aryl hydrocarbon receptor","volume":"317","author":"Aguiniga","year":"2019","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jad.2022.09.155_bb0010","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1503\/jpn.150205","article-title":"Why is depression more prevalent in women?","volume":"40","author":"Albert","year":"2015","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.jad.2022.09.155_bb0015","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbr.2013.05.035","article-title":"Use of the light\/dark test for anxiety in adult and adolescent male rats","volume":"256","author":"Arrant","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2022.09.155_bb0020","article-title":"Anxiety and depression assessments in a mouse model of congenital blindness","volume":"15","author":"Bouguiyoud","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jad.2022.09.155_bb0025","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0006-3223(01)01083-6","article-title":"Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication","volume":"50","author":"Chen","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2022.09.155_bb0030","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/toxsci\/kfw230","article-title":"Editor's highlight: microbial-derived 1,4-Dihydroxy-2-naphthoic acid and related compounds as aryl hydrocarbon receptor agonists\/antagonists: structure-activity relationships and receptor modeling","volume":"155","author":"Cheng","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jad.2022.09.155_bb0035","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2022.09.155_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001547","article-title":"Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010","volume":"10","author":"Ferrari","year":"2013","journal-title":"PLoS Med."},{"key":"10.1016\/j.jad.2022.09.155_bb0045","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.pbb.2014.08.010","article-title":"Alternative method of oral administration by peanut butter pellet formulation results in target engagement of BACE1 and attenuation of gavage-induced stress responses in mice","volume":"126","author":"Gonzales","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jad.2022.09.155_bb0050","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.physbeh.2005.02.007","article-title":"Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions","volume":"84","author":"Gr\u00f8nli","year":"2005","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jad.2022.09.155_bb0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jad.2013.01.004","article-title":"Risk factors for suicide in individuals with depression: a systematic review","volume":"147","author":"Hawton","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2022.09.155_bb0060","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/FBP.0b013e32832ec57e","article-title":"Extracellular signal-regulated kinase activation in the amygdala mediates elevated plus maze behavior during opioid withdrawal","volume":"20","author":"Hofford","year":"2009","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.jad.2022.09.155_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010404","article-title":"Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice","volume":"5","author":"Isingrini","year":"2010","journal-title":"PLoS One."},{"key":"10.1016\/j.jad.2022.09.155_bb0070","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.neuroscience.2008.10.045","article-title":"Aryl hydrocarbon receptor-mediated apoptosis of neuronal cells: a possible interaction with estrogen receptor signaling","volume":"158","author":"Kajta","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.jad.2022.09.155_bb0075","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/acps.12959","article-title":"Clinical factors predicting treatment resistant depression: affirmative results from the european multicenter study","volume":"139","author":"Kautzky","year":"2019","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2022.09.155_bb0080","doi-asserted-by":"crossref","first-page":"271","DOI":"10.31887\/DCNS.2008.10.3\/shkennedy","article-title":"Core symptoms of major depressive disorder: relevance to diagnosis and treatment","volume":"10","author":"Kennedy","year":"2008","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.jad.2022.09.155_bb0085","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ntt.2015.10.005","article-title":"Developmental origin of abnormal dendritic growth in the mouse brain induced by in utero disruption of aryl hydrocarbon receptor signaling","volume":"52","author":"Kimura","year":"2015","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.jad.2022.09.155_bb0090","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.brainres.2003.08.047","article-title":"Evaluation of the effects of chronic mild stressors on hedonic and physiological responses: sex and strain compared","volume":"992","author":"Konkle","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.jad.2022.09.155_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030481","article-title":"Stress leads to contrasting effects on the levels of brain derived neurotrophic factor in the hippocampus and amygdala","volume":"7","author":"Lakshminarasimhan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2022.09.155_bb0100","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1471-4159.2009.06364.x","article-title":"Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons","volume":"111","author":"Lin","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jad.2022.09.155_bb0105","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jad.2022.04.106","article-title":"3,3'-diindolylmethane and 1,4-dihydroxy-2-naphthoic acid prevent chronic mild stress induced depressive-like behaviors in female mice","volume":"309","author":"Madison","year":"2022","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2022.09.155_bb0110","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pbb.2016.11.005","article-title":"Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences","volume":"152","author":"Marco","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jad.2022.09.155_bb0115","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1186\/1471-2407-14-524","article-title":"Low levels of 3,3'-diindolylmethane activate estrogen receptor \u03b1 and induce proliferation of breast cancer cells in the absence of estradiol","volume":"14","author":"Marques","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jad.2022.09.155_bb0120","doi-asserted-by":"crossref","DOI":"10.1621\/nrs.04016","article-title":"Estrogen receptor and aryl hydrocarbon receptor signaling pathways","volume":"4","author":"Matthews","year":"2006","journal-title":"Nucl. Recept. Signal."},{"key":"10.1016\/j.jad.2022.09.155_bb0125","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1128\/MCB.25.13.5317-5328.2005","article-title":"Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters","volume":"25","author":"Matthews","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jad.2022.09.155_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2013.10.043","article-title":"Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach","volume":"156","author":"McIntyre","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2022.09.155_bb0135","series-title":"Suicide screening and prevention","author":"O'Rourke","year":"2022"},{"key":"10.1016\/j.jad.2022.09.155_bb0140","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cdp.2003.11.006","article-title":"Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3'-diindolylmethane and its parent compound indole-3-carbinol","volume":"28","author":"Parkin","year":"2004","journal-title":"Cancer Detect. Prev."},{"key":"10.1016\/j.jad.2022.09.155_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0810as14","article-title":"Rodent models of depression: forced swimming and tail suspension behavioral despair tests in rats and mice","author":"Porsolt","year":"2001","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.jad.2022.09.155_bb0150","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1523\/JNEUROSCI.4540-10.2011","article-title":"Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene","volume":"31","author":"Pruunsild","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2022.09.155_bb0155","series-title":"La psychologie des sentiments","author":"Ribot","year":"1896"},{"key":"10.1016\/j.jad.2022.09.155_bb0160","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1007\/s12035-015-9471-0","article-title":"Selective aryl hydrocarbon receptor modulator 3,3'-diindolylmethane impairs AhR and ARNT signaling and protects mouse neuronal cells against hypoxia","volume":"53","author":"Rzemieniec","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jad.2022.09.155_bb0165","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.psyneuen.2013.11.008","article-title":"Sex differences in response to chronic mild stress and congenital serotonin deficiency","volume":"40","author":"Sachs","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2022.09.155_bb0170","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cotox.2018.11.005","article-title":"Aryl hydrocarbon receptor (AhR) ligands as selective AhR modulators: genomic studies","volume":"11\u201312","author":"Safe","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"10.1016\/j.jad.2022.09.155_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21186654","article-title":"Aryl hydrocarbon receptor (AHR) ligands as selective AHR modulators (SAhRMs)","volume":"21","author":"Safe","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jad.2022.09.155_bb0180","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41575-021-00430-8","article-title":"AHR in the intestinal microenvironment: safeguarding barrier function","volume":"18","author":"Stockinger","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jad.2022.09.155_bb0185","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00008877-200605000-00008","article-title":"Selective effects of citalopram in a mouse model of stress-induced anhedonia with a control for chronic stress","volume":"17","author":"Strekalova","year":"2006","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.jad.2022.09.155_bb0190","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/17425255.2019.1569627","article-title":"Chemical activation of estrogen and aryl hydrocarbon receptor signaling pathways and their interaction in toxicology and metabolism","volume":"15","author":"Tarnow","year":"2019","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.jad.2022.09.155_bb0195","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1017\/S003329171800199X","article-title":"Effectiveness of psychotherapy for treatment-resistant depression: a meta-analysis and meta-regression","volume":"49","author":"van Bronswijk","year":"2019","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2022.09.155_bb0200","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1124\/dmd.120.000346","article-title":"3,3'-diindolylmethane (BioResponse DIM(\u00ae)) exhibits significant metabolism following Oral dosing in humans","volume":"49","author":"Vermillion Maier","year":"2021","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jad.2022.09.155_bb0205","author":"WHO"},{"key":"10.1016\/j.jad.2022.09.155_bb0210","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1158\/1541-7786.MCR-08-0396","article-title":"Estrogen receptor subtype- and promoter-specific modulation of aryl hydrocarbon receptor-dependent transcription","volume":"7","author":"Wihl\u00e9n","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jad.2022.09.155_bb0215","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ynstr.2016.08.002","article-title":"The chronic mild stress (CMS) model of depression: history, evaluation and usage","volume":"6","author":"Willner","year":"2017","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.jad.2022.09.155_bb0220","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1128\/MCB.23.6.1843-1855.2003","article-title":"The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes","volume":"23","author":"Wormke","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jad.2022.09.155_bb0225","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10072-013-1505-7","article-title":"Hippocampal expression of aryl hydrocarbon receptor nuclear translocator 2 and neuronal PAS domain protein 4 in a rat model of depression","volume":"35","author":"Zhang","year":"2014","journal-title":"Neurol. Sci."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032722011697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032722011697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T03:54:53Z","timestamp":1759031693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032722011697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":45,"alternative-id":["S0165032722011697"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2022.09.155","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-dependent differences in the stress mitigating and antidepressant effects of selective aryl hydrocarbon receptor modulators","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2022.09.155","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}