{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:20:14Z","timestamp":1788884414352,"version":"build-2803163510"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jad.2022.10.003","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T06:07:01Z","timestamp":1665122821000},"page":"534-543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Melancholic features and typical neurovegetative symptoms of major depressive disorder show specific polygenic patterns"],"prefix":"10.1016","volume":"320","author":[{"given":"Vincenzo","family":"Oliva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Fanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Kasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Zohar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Souery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Albani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Forloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Ferentinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Rujescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Mendlewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"De Ronchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fabbri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Serretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2022.10.003_bb0005","doi-asserted-by":"crossref","DOI":"10.1038\/d41586-019-00857-9","article-title":"Scientists rise up against statistical significance","author":"Amrhein","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jad.2022.10.003_bb0010","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/nprot.2010.116","article-title":"Data quality control in genetic case-control association studies","volume":"5","author":"Anderson","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jad.2022.10.003_bb0015","article-title":"Depression with atypical neurovegetative symptoms shares genetic predisposition with immuno-metabolic traits and alcohol consumption","author":"Badini","year":"2020","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2022.10.003_bb0020","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/15622975.2019.1635270","article-title":"Results of the european Group for the Study of resistant depression (GSRD) - basis for further research and clinical practice","volume":"20","author":"Bartova","year":"2019","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0025","first-page":"51","article-title":"BIOS consortium, Social Science Genetic Association Consortium, Boomsma DI, de Geus EJC, Nivard MG and Bartels M, 2019. Multivariate genome-wide analyses of the well-being spectrum","author":"Baselmans","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0030","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s10519-019-09951-0","article-title":"A genetic investigation of the well-being Spectrum","volume":"49","author":"Baselmans","year":"2019","journal-title":"Behav. Genet."},{"issue":"24","key":"10.1016\/j.jad.2022.10.003_bb0035","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41380-019-0385-5","article-title":"Data-driven biological subtypes of depression: systematic review of biological approaches to depression subtyping","volume":"246","author":"Beijers","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0040","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1017\/S0033291719001004","article-title":"Characteristics, comorbidities, and correlates of atypical depression: evidence from the UK biobank mental health survey","volume":"50","author":"Brailean","year":"2020","journal-title":"Psychol. Med."},{"issue":"10","key":"10.1016\/j.jad.2022.10.003_bb0045","first-page":"1","article-title":"Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling","volume":"101","author":"Bralten","year":"2020","journal-title":"Transl. Psychiatry"},{"issue":"46","key":"10.1016\/j.jad.2022.10.003_bb0050","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1038\/s41386-021-01044-z","article-title":"Genetic underpinnings of sociability in the general population","volume":"469","author":"Bralten","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2022.10.003_bb0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/02699931.2013.837379","article-title":"Evolutionary mechanisms for loneliness","volume":"28","author":"Cacioppo","year":"2014","journal-title":"Cognit. Emot."},{"key":"10.1016\/j.jad.2022.10.003_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gigascience\/giz082","article-title":"PRSice-2: polygenic risk score software for biobank-scale data","volume":"8","author":"Choi","year":"2019","journal-title":"Gigascience"},{"key":"10.1016\/j.jad.2022.10.003_bb0065","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/s41596-020-0353-1","article-title":"Tutorial: a guide to performing polygenic risk score analyses","volume":"15","author":"Choi","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jad.2022.10.003_bb0070","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41588-019-0556-y","article-title":"Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression","volume":"52","author":"Craig","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0075","first-page":"9","article-title":"Elucidating the genetic basis of social interaction and isolation","author":"Day","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2022.10.003_bb0080","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/mp.2010.128","article-title":"Meta-analysis of genome-wide association studies for personality","volume":"17","author":"De Moor","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0085","first-page":"1","article-title":"Longitudinal associations between alcohol use, smoking, genetic risk scoring and symptoms of depression in the general population: a prospective 6-year cohort study","author":"DeBoer","year":"2021","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2022.10.003_bb0090","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41588-018-0269-7","article-title":"Discovery of the first genome-wide significant risk loci for attention-deficit\/hyperactivity disorder","volume":"51","author":"Demontis","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0095","series-title":"ensr: R Package for Simultaneous Selection of Elastic Net Tuning Parameters","author":"DeWitt","year":"2019"},{"key":"10.1016\/j.jad.2022.10.003_bb0100","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/ijnp\/pyy009","article-title":"Major depression and the degree of suicidality: results of the european group for the study of resistant depression (GSRD)","volume":"21","author":"Dold","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2022.10.003_bb0105","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.4088\/JCP.17m12090","article-title":"Psychotic features in patients with major depressive disorder: a report from the european Group for the Study of resistant depression","volume":"80","author":"Dold","year":"2019","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2021.110285","article-title":"Melancholic features in major depression \u2013 a european multicenter study","volume":"110","author":"Dold","year":"2021","journal-title":"Prog. Neuro-Psychopharmacology Biol. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/b91ba224-10be-409d-93f4-7423d502cba0","article-title":"Power and predictive accuracy of polygenic risk scores","volume":"9","author":"Dudbridge","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0120","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1017\/S0033291717002148","article-title":"Polygenic risk for severe psychopathology among europeans is associated with major depressive disorder in Han chinese women","volume":"48","author":"Edwards","year":"2018","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2022.10.003_bb0125","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jad.2020.02.036","article-title":"The biological face of melancholia: are there any reliable biomarkers for this depression subtype?","volume":"266","author":"Esposito","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2022.10.003_bb0130","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/YIC.0000000000000305","article-title":"Genetics and major depressive disorder: clinical implications for disease risk, prognosis and treatment","volume":"35","author":"Fabbri","year":"2020","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2022.10.003_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110170","article-title":"Higher polygenic risk scores for schizophrenia may be suggestive of treatment non-response in major depressive disorder","volume":"108","author":"Fanelli","year":"2021","journal-title":"Prog. Neuro-Psychopharmacology Biol. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0140","series-title":"Polygenic Risk Scores for Psychiatric, Inflammatory, and Cardio-metabolic Traits and Diseases Highlight Possible Genetic Overlaps With Suicide Attempt and Treatment-emergent Suicidal Ideation","author":"Fanelli","year":"2021"},{"key":"10.1016\/j.jad.2022.10.003_bb0145","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.euroneuro.2021.11.005","article-title":"A meta-analysis of polygenic risk scores for mood disorders, neuroticism, and schizophrenia in antidepressant response","volume":"55","author":"Fanelli","year":"2022","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2022.10.003_bb0150","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jad.2014.10.010","article-title":"Depression is not a consistent syndrome: an investigation of unique symptom patterns in the STAR*D study","volume":"172","author":"Fried","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2022.10.003_bb0155","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S2215-0366(20)30169-3","article-title":"The 341 737 ways of qualifying for the melancholic specifier","volume":"7","author":"Fried","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.jad.2022.10.003_bb0165","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s40273-021-01019-4","article-title":"The economic burden of adults with major depressive disorder in the United States (2010 and 2018)","volume":"39","author":"Greenberg","year":"2021","journal-title":"PharmacoEconomics"},{"key":"10.1016\/j.jad.2022.10.003_bb0170","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jad.2011.07.015","article-title":"Meta-review of depressive subtyping models","volume":"139","author":"Harald","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2022.10.003_bb0175","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41380-019-0463-8","article-title":"A polygenic resilience score moderates the genetic risk for schizophrenia","volume":"26","author":"Hess","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0180","first-page":"9","article-title":"Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways","author":"Howard","year":"2018","journal-title":"Nat. Commun"},{"key":"10.1016\/j.jad.2022.10.003_bb0185","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41593-018-0326-7","article-title":"Genome-wide meta-analysis of depression identifies 102 independentvariants and highlights the importance of the prefrontal brainregions","volume":"22","author":"Howard","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jad.2022.10.003_bb0190","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jad.2017.12.076","article-title":"Examining the latent structure mechanisms for comorbid posttraumatic stress disorder and major depressive disorder","volume":"229","author":"Hurlocker","year":"2018","journal-title":"J. Affect. Disord."},{"issue":"51","key":"10.1016\/j.jad.2022.10.003_bb0195","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41588-018-0333-3","article-title":"Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways","volume":"513","author":"Jansen","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0200","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1176\/appi.ajp.2018.17111251","article-title":"The genetic epidemiology of treated major depression in Sweden","volume":"175","author":"Kendler","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0205","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1176\/ajp.142.11.1259","article-title":"The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence","volume":"142","author":"Khantzian","year":"1985","journal-title":"Am. J. Psychiatry"},{"issue":"10","key":"10.1016\/j.jad.2022.10.003_bb0210","first-page":"1","article-title":"Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations","volume":"101","author":"Kranzler","year":"2019","journal-title":"Nat. Commun."},{"issue":"18","key":"10.1016\/j.jad.2022.10.003_bb0215","first-page":"692","article-title":"Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression","volume":"186","author":"Lamers","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0220","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1001\/jamapsychiatry.2014.411","article-title":"Depression with atypical features and increase in obesity, body mass index, waist circumference, and fat mass: a prospective, population-based study","volume":"71","author":"Lasserre","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0225","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/s41588-018-0147-3","article-title":"Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment","volume":"50","author":"Lee","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0230","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2019.11.020","article-title":"Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders","volume":"179","author":"Lee","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jad.2022.10.003_bb0235","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/gepi.20533","article-title":"MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes","volume":"34","author":"Li","year":"2010","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.jad.2022.10.003_bb0240","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41588-018-0307-5","article-title":"Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use","volume":"51","author":"Liu","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/157340009787315271","article-title":"Psychotic (Delusional) major depression: new vistas","volume":"5","author":"Lykouras","year":"2009","journal-title":"Curr. Psychiatry Rev."},{"key":"10.1016\/j.jad.2022.10.003_bb0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076295","article-title":"The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases","volume":"8","author":"Manchia","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jad.2022.10.003_bb0255","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/mp.2015.86","article-title":"Polygenic dissection of major depression clinical heterogeneity","volume":"21","author":"Milaneschi","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0260","doi-asserted-by":"crossref","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","author":"Montgomery","year":"1979","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0265","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41588-021-00857-4","article-title":"Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology","volume":"53","author":"Mullins","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0270","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1176\/appi.ajp.2020.19111195","article-title":"Polygenic risk and progression to bipolar or psychotic disorders among individuals diagnosed with unipolar depression in early life","volume":"177","author":"Musliner","year":"2020","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0275","series-title":"Largest Genome-wide Association Study for PTSD Identifies Genetic Risk Loci in European and African Ancestries and Implicates Novel Biological Pathways","first-page":"458562","volume":"48","author":"Nievergelt","year":"2018"},{"key":"10.1016\/j.jad.2022.10.003_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/YIC.0000000000000380","article-title":"Post-traumatic stress disorder and childhood emotional abuse are markers of subthreshold bipolarity and worse treatment outcome in major depressive disorder","volume":"37","author":"Olgiati","year":"2021","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2022.10.003_bb0285","first-page":"37","article-title":"Social withdrawal as a trans-diagnostic predictor of short-term remission: a meta-analysis of five clinical cohorts","author":"Oliva","year":"2022","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2022.10.003_bb0290","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/ajmg.b.32333","article-title":"A genome-wide approach to children\u2019s aggressive behavior: the EAGLE consortium","volume":"171","author":"Pappa","year":"2016","journal-title":"Am. J. Med. Genet. Part B Neuropsychiatr. Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0295","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41588-018-0059-2","article-title":"Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection","volume":"50","author":"Pardi\u00f1as","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0300","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/s41593-018-0206-1","article-title":"GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia","volume":"21","author":"Pasman","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jad.2022.10.003_bb0305","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1371\/journal.pgen.0020190","article-title":"Population structure and eigenanalysis","volume":"2","author":"Patterson","year":"2006","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1741-7015-11-129","article-title":"Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile","volume":"11","author":"Penninx","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.jad.2022.10.003_bb0315","doi-asserted-by":"crossref","first-page":"193","DOI":"10.30773\/pi.2019.0289","article-title":"Personalized psychiatry and depression: the role of sociodemographic and clinical variables","volume":"17","author":"Perna","year":"2020","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.jad.2022.10.003_bb0320","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1136\/bmj.316.7139.1236","article-title":"What\u2019s wrong with bonferroni adjustments","volume":"316","author":"Perneger","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.jad.2022.10.003_bb0325","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1176\/appi.ajp.2020.20060947","article-title":"Elevated C-reactive protein in patients with depression, independent of genetic, health, and psychosocial factors: results from the UK biobank","volume":"178","author":"Pitharouli","year":"2021","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0330","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/s41380-019-0559-1","article-title":"A major role for common genetic variation in anxiety disorders","volume":"25","author":"Purves","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0335","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/mpr.1388","article-title":"The structure of the Montgomery-\u00c5sberg depression rating scale over the course of treatment for depression","volume":"22","author":"Quilty","year":"2013","journal-title":"Int. J. Methods Psychiatr. Res."},{"key":"10.1016\/j.jad.2022.10.003_bb0340","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41398-020-01142-4","article-title":"Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms","volume":"11","author":"R\u00f8devand","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0345","series-title":"RStudio: integrated development for R","year":"2020"},{"key":"10.1016\/j.jad.2022.10.003_bb0350","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1038\/s41380-018-0326-8","article-title":"Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide","volume":"25","author":"Ruderfer","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0355","first-page":"22132","article-title":"The varied clinical presentations of major depressive disorder","volume":"68","author":"Rush","year":"2007","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0360","first-page":"2562","article-title":"Genome-wide association studies of impulsive personality traits (BIS-11 and UPPS-P) and drug experimentation in up to 22,861 adult research participants identify loci in the CACNA1I and CADM2 genes","volume":"39","author":"Sanchez-Roige","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jad.2022.10.003_bb0365","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s41588-018-0152-6","article-title":"Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence","volume":"50","author":"Savage","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9758\/cpn.2018.16.1.1","article-title":"The present and future of precision medicine in psychiatry: focus on clinical psychopharmacology of antidepressants","volume":"16","author":"Serretti","year":"2018","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"10.1016\/j.jad.2022.10.003_bb0375","first-page":"11980","article-title":"The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2022.10.003_bb0380","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/pst.1514","article-title":"Bonferroni-based correction factor for multiple, correlated endpoints","volume":"11","author":"Shi","year":"2012","journal-title":"Pharm. Stat."},{"key":"10.1016\/j.jad.2022.10.003_bb0385","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jad.2020.03.075","article-title":"Factors associated with loneliness: an umbrella review of observational studies","volume":"271","author":"Solmi","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2022.10.003_bb0390","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/pchj.344","article-title":"Social anhedonia and social functioning: loneliness as a mediator","volume":"9","author":"Tan","year":"2020","journal-title":"PsyCh J."},{"key":"10.1016\/j.jad.2022.10.003_bb0395","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s10519-015-9735-5","article-title":"Meta-analysis of genome-wide association studies for extraversion: findings from the genetics of personality consortium","volume":"46","author":"van den Berg","year":"2016","journal-title":"Behav. Genet."},{"issue":"21","key":"10.1016\/j.jad.2022.10.003_bb0400","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1038\/s41593-018-0275-1","article-title":"Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders","volume":"2112","author":"Walters","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jad.2022.10.003_bb0405","series-title":"WHO, 2017. Depression and Other Common Mental Disorders: Global Health Estimates","author":"WHO","year":"2017"},{"key":"10.1016\/j.jad.2022.10.003_bb0410","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41588-018-0090-3","article-title":"Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression","volume":"50","author":"Wray","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jad.2022.10.003_bb0415","article-title":"Genetic evidence suggests posttraumatic stress disorder as a subtype of major depressive disorder","author":"Zhang","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jad.2022.10.003_bb0420","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1467-9868.2005.00503.x","article-title":"Regularization and variable selection via the elastic net","volume":"67","author":"Zou","year":"2005","journal-title":"J. R. Stat. Soc. Ser. B Stat Methodol."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032722011867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032722011867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T20:30:57Z","timestamp":1723840257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032722011867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":84,"alternative-id":["S0165032722011867"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2022.10.003","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melancholic features and typical neurovegetative symptoms of major depressive disorder show specific polygenic patterns","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2022.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}