{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:32:01Z","timestamp":1785540721943,"version":"3.56.0"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014535","name":"Mayo Clinic Center for Individualized Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014535","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016227","name":"Assurex Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016227","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jad.2022.12.031","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T02:12:54Z","timestamp":1671415974000},"page":"77-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Early reduction in irritability is associated with improved outcomes among youth with depression: Findings from the AMOD study"],"prefix":"10.1016","volume":"324","author":[{"given":"Alaa K.","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Croarkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish K.","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Vande Voort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2022.12.031_bb0005","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"issue":"1","key":"10.1016\/j.jad.2022.12.031_bb0010","doi-asserted-by":"crossref","DOI":"10.1192\/bjo.2020.168","article-title":"Irritability through research domain criteria: an opportunity for transdiagnostic conceptualisation","volume":"7","author":"Bell","year":"2021","journal-title":"BJPsych Open"},{"issue":"4","key":"10.1016\/j.jad.2022.12.031_bb0015","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/mpr.321","article-title":"Psychometric properties of the quick inventory of depressive symptomatology in adolescents","volume":"19","author":"Bernstein","year":"2010","journal-title":"Int. J. Methods Psychiatr. Res."},{"key":"10.1016\/j.jad.2022.12.031_bb0020","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev-clinpsy-032816-044941","article-title":"Irritability in children and adolescents","volume":"13","author":"Brotman","year":"2017","journal-title":"Annu. Rev. Clin. Psychol."},{"issue":"7","key":"10.1016\/j.jad.2022.12.031_bb0025","first-page":"28","article-title":"The clinical global impressions scale: applying a research tool in clinical practice","volume":"4","author":"Busner","year":"2007","journal-title":"Psychiatry (Edgmont)"},{"issue":"2","key":"10.1016\/j.jad.2022.12.031_bb0030","doi-asserted-by":"crossref","first-page":"xiii-xvi","DOI":"10.1016\/S1056-4993(21)00003-1","article-title":"Emotion dysregulation and outbursts in children and adolescents: part I","volume":"30","author":"Carlson","year":"2021","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"issue":"5","key":"10.1016\/j.jad.2022.12.031_bb0035","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1176\/appi.ajp.2018.18030355","article-title":"Irritability and its clinical utility in major depressive disorder: prediction of individual-level acute-phase outcomes using early changes in irritability and depression severity","volume":"176","author":"Jha","year":"2019","journal-title":"Am. J. Psychiatry"},{"issue":"13","key":"10.1016\/j.jad.2022.12.031_bb0040","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1038\/s41386-020-0769-x","article-title":"Association between irritability and suicidal ideation in three clinical trials of adults with major depressive disorder","volume":"45","author":"Jha","year":"2020","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1016\/j.jad.2022.12.031_bb0045","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1097\/01.chi.0000242228.75516.21","article-title":"Remission and residual symptoms after short-term treatment in the Treatment of Adolescents with Depression Study (TADS)","volume":"45","author":"Kennard","year":"2006","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"12","key":"10.1016\/j.jad.2022.12.031_bb0050","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1177\/070674371205701211","article-title":"Predicting treatment response in major depressive disorder: the impact of early symptomatic improvement","volume":"57","author":"Kudlow","year":"2012","journal-title":"Can. J. Psychiatr."},{"issue":"7","key":"10.1016\/j.jad.2022.12.031_bb0055","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s40263-014-0171-5","article-title":"Early switching strategies in antidepressant non-responders: current evidence and future research directions","volume":"28","author":"Kudlow","year":"2014","journal-title":"CNS Drugs"},{"issue":"5","key":"10.1016\/j.jad.2022.12.031_bb0065","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1001\/jamapsychiatry.2018.0174","article-title":"Association of Childhood Irritability and Depressive\/Anxious mood profiles with adolescent suicidal ideation and attempts","volume":"75","author":"Orri","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2022.12.031_bb0070","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jad.2018.07.010","article-title":"Association between irritability and suicide-related outcomes across the life-course. Systematic review of both community and clinical studies","volume":"239","author":"Orri","year":"2018","journal-title":"J. Affect. Disord."},{"issue":"2","key":"10.1016\/j.jad.2022.12.031_bb0080","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00004583-198403000-00011","article-title":"Preliminary studies of the reliability and validity of the children's depression rating scale","volume":"23","author":"Poznanski","year":"1984","journal-title":"J. Am. Acad. Child Psychiatry"},{"key":"10.1016\/j.jad.2022.12.031_bb0090","article-title":"A randomized controlled trial of combinatorial pharmacogenetics testing in adolescent depression","author":"Vande Voort","year":"2021","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"issue":"7","key":"10.1016\/j.jad.2022.12.031_bb0095","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jaac.2016.04.014","article-title":"The status of irritability in psychiatry: a conceptual and quantitative review","volume":"55","author":"Vidal-Ribas","year":"2016","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"issue":"4","key":"10.1016\/j.jad.2022.12.031_bb0100","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1017\/S0033291703007414","article-title":"Evaluation of the clinical global impression scale among individuals with social anxiety disorder","volume":"33","author":"Zaider","year":"2003","journal-title":"Psychol. Med."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032722013921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032722013921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T03:32:45Z","timestamp":1759030365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032722013921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":17,"alternative-id":["S0165032722013921"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2022.12.031","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early reduction in irritability is associated with improved outcomes among youth with depression: Findings from the AMOD study","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2022.12.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}