{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:27:56Z","timestamp":1791293276265,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002636","name":"Inje University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jad.2022.12.089","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T22:14:36Z","timestamp":1671747276000},"page":"8-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"C","title":["Effects of liraglutide on depressive behavior in a mouse depression model and cognition in the probe trial of Morris water maze test"],"prefix":"10.1016","volume":"324","author":[{"given":"Mi Kyoung","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehoon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Hyun","family":"Seog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung An","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Hon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yena","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Goo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2022.12.089_bb0005","first-page":"S59","article-title":"Liraglutide: a review of the first once-daily GLP-1 receptor agonist","volume":"17","author":"Bode","year":"2011","journal-title":"Am. J. Manag. Care"},{"key":"10.1016\/j.jad.2022.12.089_bb0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12916-016-0560-3","article-title":"Cognitive remission: a novel objective for the treatment of major depression?","volume":"14","author":"Bortolato","year":"2016","journal-title":"BMC Med."},{"key":"10.1016\/j.jad.2022.12.089_bb0015","article-title":"Morris water maze test for learning and memory deficits in Alzheimer's disease model mice","volume":"53","author":"Bromley-Brits","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jad.2022.12.089_bb0020","article-title":"The mouse forced swim test","volume":"59","author":"Can","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jad.2022.12.089_bb0025","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2710.2007.00846.x","article-title":"Augmentation strategies for treatment-resistant depression: a literature review","volume":"32","author":"Carvalho","year":"2007","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.jad.2022.12.089_bb0030","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1007\/s11064-017-2250-8","article-title":"Liraglutide improves water maze learning and memory performance while reduces hyperphosphorylation of tau and neurofilaments in APP\/PS1\/Tau triple transgenic mice","volume":"42","author":"Chen","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jad.2022.12.089_bb0035","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1001\/jamapsychiatry.2019.1189","article-title":"Efficacy of esketamine nasal spray plus oral antidepressant treatment for relapse prevention in patients with treatment-resistant depression: a randomized clinical trial","volume":"76","author":"Daly","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2022.12.089_bb0040","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/da.22227","article-title":"Neurobiology of stress, depression, and rapid acting antidepressants: remodeling synaptic connections","volume":"31","author":"Duman","year":"2014","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2022.12.089_bb0045","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants","volume":"22","author":"Duman","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.jad.2022.12.089_bb0050","first-page":"1789","volume":"392","author":"Gbd","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2022.12.089_bb0055","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neubiorev.2020.11.020","article-title":"The effects of ketamine on cognition in treatment-resistant depression: a systematic review and priority avenues for future research","volume":"120","author":"Gill","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jad.2022.12.089_bb0060","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1177\/0897190012465985","article-title":"Clinical pearls for initiating and utilizing liraglutide in patients with type 2 diabetes","volume":"26","author":"Gross","year":"2013","journal-title":"J. Pharm. Pract."},{"key":"10.1016\/j.jad.2022.12.089_bb0065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jad.2013.01.004","article-title":"Risk factors for suicide in individuals with depression: a systematic review","volume":"147","author":"Hawton","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2022.12.089_bb0070","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1001\/jamapsychiatry.2020.0158","article-title":"The age of depression and its treatments","volume":"77","author":"Hofmann","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2022.12.089_bb0075","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/09513590.2018.1505848","article-title":"The effects of treatment with liraglutide on quality of life and depression in young obese women with PCOS and controls","volume":"35","author":"Kahal","year":"2019","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.jad.2022.12.089_bb0080","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2016.02.003","article-title":"Neurobehavioral effects of liraglutide and sitagliptin in experimental models","volume":"774","author":"Kamble","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jad.2022.12.089_bb0085","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.neuropharm.2018.01.001","article-title":"Liraglutide ameliorates cognitive decline by promoting autophagy via the AMP-activated protein kinase\/mammalian target of rapamycin pathway in a streptozotocin-induced mouse model of diabetes","volume":"131","author":"Kong","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jad.2022.12.089_bb0090","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.pnpbp.2007.05.002","article-title":"Effect of various classes of antidepressants in behavioral paradigms of despair","volume":"31","author":"Kulkarni","year":"2007","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2022.12.089_bb0095","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jad.2022.12.089_bb0100","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/jnc.13169","article-title":"Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice","volume":"135","author":"Li","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jad.2022.12.089_bb0105","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jad.2016.09.056","article-title":"Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: a pilot, open-label study","volume":"207","author":"Mansur","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2022.12.089_bb0110","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.euroneuro.2017.08.433","article-title":"Treatment with a GLP-1R agonist over four weeks promotes weight loss-moderated changes in frontal-striatal brain structures in individuals with mood disorders","volume":"27","author":"Mansur","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2022.12.089_bb0115","first-page":"2485","article-title":"Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression","volume":"367","author":"Massart","year":"2012","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.jad.2022.12.089_bb0120","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/da.22063","article-title":"Cognitive deficits and functional outcomes in major depressive disorder: determinants, substrates, and treatment interventions","volume":"30","author":"McIntyre","year":"2013","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jad.2022.12.089_bb0125","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s40263-015-0263-x","article-title":"The prevalence, measurement, and treatment of the cognitive dimension\/domain in major depressive disorder","volume":"29","author":"McIntyre","year":"2015","journal-title":"CNS Drugs"},{"key":"10.1016\/j.jad.2022.12.089_bb0130","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1176\/appi.ajp.2020.20081251","article-title":"Synthesizing the evidence for ketamine and esketamine in treatment-resistant depression: an international expert opinion on the available evidence and implementation","volume":"178","author":"McIntyre","year":"2021","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2022.12.089_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2021.113993","article-title":"The effect of intravenous ketamine on cognitive functions in adults with treatment-resistant major depressive or bipolar disorders: results from the Canadian rapid treatment center of excellence (CRTCE)","volume":"302","author":"McIntyre","year":"2021","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.jad.2022.12.089_bb0140","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fpsyt.2015.00006","article-title":"An efficient chronic unpredictable stress protocol to induce stress-related responses in C57BL\/6 mice","volume":"6","author":"Monteiro","year":"2015","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.jad.2022.12.089_bb0145","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.jad.2022.12.089_bb0150","doi-asserted-by":"crossref","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder","volume":"2","author":"Otte","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jad.2022.12.089_bb0155","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbr.2017.01.004","article-title":"Liraglutide prevents cognitive decline in a rat model of streptozotocin-induced diabetes independently from its peripheral metabolic effects","volume":"321","author":"Palleria","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jad.2022.12.089_bb0160","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3389\/fnins.2018.00756","article-title":"Liraglutide activates mTORC1 signaling and AMPA receptors in rat hippocampal neurons under toxic conditions","volume":"12","author":"Park","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jad.2022.12.089_bb0165","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2147\/NDT.S199746","article-title":"Cognitive impairment in depression: recent advances and novel treatments","volume":"15","author":"Perini","year":"2019","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.jad.2022.12.089_bb0170","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.2174\/13816128113196660736","article-title":"Signaling pathways involved in antidepressant-induced cell proliferation and synaptic plasticity","volume":"20","author":"Pilar-C\u00faellar","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jad.2022.12.089_bb0175","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.OT19037BR3","article-title":"Inadequate response to treatment in major depressive disorder: augmentation and adjunctive strategies","volume":"81","author":"Rafeyan","year":"2020","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2022.12.089_bb0180","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.amjmed.2015.01.007","article-title":"Antidepressant use and cognitive decline: the health and retirement study","volume":"128","author":"Saczynski","year":"2015","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jad.2022.12.089_bb0185","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/ijnp\/pyy083","article-title":"Making sense of rodent models of anhedonia","volume":"21","author":"Scheggi","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2022.12.089_bb0190","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/fcp.12664","article-title":"Improvement of cognitive function, glucose and lipid homeostasis and serum osteocalcin levels by liraglutide in diabetic rats","volume":"35","author":"Sedky","year":"2021","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jad.2022.12.089_bb0195","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s11011-014-9591-7","article-title":"GLP-1 receptor agonist liraglutide reverses long-term atypical antipsychotic treatment associated behavioral depression and metabolic abnormalities in rats","volume":"30","author":"Sharma","year":"2015","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jad.2022.12.089_bb0200","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S2215-0366(16)00012-2","article-title":"Effect of antidepressant treatment on cognitive impairments associated with depression: a randomised longitudinal study","volume":"3","author":"Shilyansky","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.jad.2022.12.089_bb0205","doi-asserted-by":"crossref","first-page":"279","DOI":"10.9758\/cpn.2016.14.3.279","article-title":"Differential effects of olanzapine and haloperidol on MK-801-induced memory impairment in mice","volume":"14","author":"Song","year":"2016","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"10.1016\/j.jad.2022.12.089_bb0210","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jad.2008.03.009","article-title":"Trends in antidepressant use in the older population: results from the LASA-study over a period of 10 years","volume":"111","author":"Sonnenberg","year":"2008","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2022.12.089_bb0215","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jad.2022.12.089_bb0220","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4088\/JCP.13m08852","article-title":"Ketamine safety and tolerability in clinical trials for treatment-resistant depression","volume":"76","author":"Wan","year":"2015","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2022.12.089_bb0225","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2018.04.031","article-title":"Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity","volume":"1694","author":"Weina","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.jad.2022.12.089_bb0230","article-title":"The role of depression course on life functioning and coping outcomes from baseline through 23-year follow-up","volume":"1\u20139","author":"Woodhead","year":"2020","journal-title":"J. Ment. Health"},{"key":"10.1016\/j.jad.2022.12.089_bb0235","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/FBP.0000000000000252","article-title":"Bilobalide alleviates depression-like behavior and cognitive deficit induced by chronic unpredictable mild stress in mice","volume":"27","author":"Wu","year":"2016","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.jad.2022.12.089_bb0240","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41398-019-0624-1","article-title":"Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites","volume":"9","author":"Yang","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jad.2022.12.089_bb0245","article-title":"The forced swim test as a model of depressive-like behavior","volume":"97","author":"Yankelevitch-Yahav","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jad.2022.12.089_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101180","article-title":"GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer's disease","volume":"47","author":"Zheng","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jad.2022.12.089_bb0255","doi-asserted-by":"crossref","first-page":"26859","DOI":"10.1038\/srep26859","article-title":"The neuroprotection of liraglutide against ischaemia-induced apoptosis through the activation of the PI3K\/AKT and MAPK pathways","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032722014495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032722014495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T03:30:23Z","timestamp":1759030223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032722014495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":51,"alternative-id":["S0165032722014495"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2022.12.089","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of liraglutide on depressive behavior in a mouse depression model and cognition in the probe trial of Morris water maze test","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2022.12.089","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}