{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:40:52Z","timestamp":1793234452312,"version":"4.5.0"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jad.2023.06.068","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T20:36:43Z","timestamp":1688157403000},"page":"526-545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Psychopharmacology of eating disorders: Systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"338","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9647-0853","authenticated-orcid":false,"given":"Michele","family":"Fornaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Mondin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Billeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"De Prisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Caiazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausta","family":"Micanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Calati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 F\u00e9rrer","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"de Bartolomeis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jad.2023.06.068_bb0005","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1176\/ajp.149.1.82","article-title":"Pharmacologic and cognitive-behavioural treatment for bulimia nervosa: a controlled comparison","volume":"149","author":"Agras","year":"1992","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.jad.2023.06.068_bb0010","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/ajcn\/53.4.865","article-title":"Effect of a tricyclic antidepressant and opiate antagonist on binge-eating behavior in normoweight bulimic and obese, binge-eating subjects","volume":"53","author":"Alger","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jad.2023.06.068_bb0015","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/eat.22173","article-title":"Dronabinol in severe, enduring anorexia nervosa: a randomized controlled trial","volume":"47","author":"Andries","year":"2014","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.jad.2023.06.068_bb0020","series-title":"Diagnostic and Statistical Manual of Mental Disorders-III","author":"APA","year":"1980"},{"key":"10.1016\/j.jad.2023.06.068_bb0025","series-title":"Diagnostic and Statistical Manual of Mental Disorders-IV","author":"APA","year":"1994"},{"key":"10.1016\/j.jad.2023.06.068_bb0030","series-title":"Diagnostic and Statistical Manual of Mental Disorders-5","author":"APA","year":"2013"},{"key":"10.1016\/j.jad.2023.06.068_bb0035","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1001\/archpsyc.60.11.1109","article-title":"A randomized, double-blind, placebo-controlled study of sibutramine in the treatment of binge-eating disorder","volume":"60","author":"Appolinario","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0040","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/archgenpsychiatry.2011.74","article-title":"Mortality rates in patients with anorexia nervosa and other eating disorders: a meta-analysis of 36 studies","volume":"68","author":"Arcelus","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0045","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1176\/ajp.155.4.548","article-title":"Does fluoxetine augment the inpatient treatment of anorexia nervosa?","volume":"155","author":"Attia","year":"1998","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0050","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1017\/S0033291711000390","article-title":"Olanzapine versus placebo for out-patients with anorexia nervosa","volume":"41","author":"Attia","year":"2011","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2023.06.068_bb0055","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1176\/appi.ajp.2018.18101125","article-title":"Olanzapine versus placebo in adult outpatients with anorexia nervosa: a randomized clinical trial","volume":"176","author":"Attia","year":"2019","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.jad.2023.06.068_bb0060","series-title":"An Inventory for Measuring Depression","first-page":"561","volume":"4","author":"Beck","year":"1961"},{"key":"10.1016\/j.jad.2023.06.068_bb0065","series-title":"An Inventory for Measuring Clinical Anxiety: Psychometric Properties","first-page":"893","volume":"56","author":"Beck","year":"1988"},{"key":"10.1016\/j.jad.2023.06.068_bb0070","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3109\/00048679709065073","article-title":"Intensive nutritional counselling in bulimia nervosa: a role for supplementation with fluoxetine?","volume":"31","author":"Beumont","year":"1997","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0075","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1176\/appi.ajp.2008.07121900","article-title":"Olanzapine in the treatment of low body weight and obsessive thinking in women with anorexia nervosa: a randomized, double-blind, placebo-controlled trial","volume":"165","author":"Bissada","year":"2008","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.jad.2023.06.068_bb0080","series-title":"Comprehensive Meta-analysis Version 2","first-page":"104","author":"Borenstein","year":"2005"},{"key":"10.1016\/j.jad.2023.06.068_bb0085","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000119215","article-title":"Combined cognitive-behavioral, psychopharmacological and nutritional therapy in bulimia nervosa","volume":"32","author":"Brambilla","year":"1995","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.jad.2023.06.068_bb0090","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000119213","article-title":"Combined cognitive-behavioral, psychopharmacological and nutritional therapy in eating disorders: 1. Anorexia nervosa \u2013 restricted type","volume":"32","author":"Brambilla","year":"1995","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.jad.2023.06.068_bb0095","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000119214","article-title":"Combined cognitive-behavioral, psychopharmacological and nutritional therapy in eating disorders: 2. Anorexia nervosa \u2013 binge-eating\/purging type","volume":"32","author":"Brambilla","year":"1995","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.jad.2023.06.068_bb0100","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/YIC.0b013e328080ca31","article-title":"Olanzapine therapy in anorexia nervosa: psychobiological effects","volume":"22","author":"Brambilla","year":"2007","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2023.06.068_bb0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.psyneuen.2007.02.005","article-title":"Olanzapine-induced weight gain in anorexia nervosa: involvement of leptin and ghrelin secretion?","volume":"32","author":"Brambilla","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jad.2023.06.068_bb0110","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/YIC.0b013e32832ac828","article-title":"Multivariate therapeutic approach to binge-eating disorder: combined nutritional, psychological and pharmacological treatment","volume":"24","author":"Brambilla","year":"2009","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2023.06.068_bb0115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00004850-200101000-00003","article-title":"Efficacy and tolerability of moclobemide in bulimia nervosa: a placebo-controlled trial","volume":"16","author":"Carruba","year":"2001","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2023.06.068_bb0120","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1177\/0269881120920453","article-title":"Pharmacological treatment of acute-phase anorexia nervosa: evidence from randomized controlled trials","volume":"34","author":"Cassioli","year":"2020","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jad.2023.06.068_bb0125","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jpsychires.2010.03.011","article-title":"Investigating the effectiveness, safety and tolerability of quetiapine in the treatment of anorexia nervosa in young people: a pilot study","volume":"44","author":"Court","year":"2010","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jad.2023.06.068_bb0130","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1037\/0022-006X.59.1.115","article-title":"Mechanisms of action in cognitive-behavioral and pharmacological interventions for obesity and bulimia nervosa","volume":"59","author":"Craighead","year":"1991","journal-title":"J. Consult. Clin. Psychol."},{"key":"10.1016\/j.jad.2023.06.068_bb0135","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s40429-014-0010-2","article-title":"Potential role of addiction pharmacotherapy in problematic eating behavior","volume":"1","author":"Edge","year":"2014","journal-title":"Curr. Addict. Rep."},{"key":"10.1016\/j.jad.2023.06.068_bb0140","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.jad.2023.06.068_bb0145","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1192\/bjp.162.5.597","article-title":"A placebo-controlled trial of d-fenfluramine in Bulimia nervosa","volume":"162","author":"Fahy","year":"1993","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0150","series-title":"Assessment of Eating Disorders: Interview or Self-report Questionnaire?","first-page":"363","volume":"16","author":"Fairburn","year":"1994"},{"key":"10.1016\/j.jad.2023.06.068_bb0155","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1001\/archpsyc.1993.01820180009001","article-title":"Psychotherapy and bulimia nervosa: longer-term effects of interpersonal psychotherapy, behavior therapy, and cognitive behavior therapy","volume":"50","author":"Fairburn","year":"1993","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0160","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0140-6736(99)09062-5","article-title":"Effect of decreasing afferent vagal activity with ondansetron on symptoms of bulimia nervosa: a randomised, double-blind trial","volume":"355","author":"Faris","year":"2000","journal-title":"Lancet (Lond. Engl.)"},{"key":"10.1016\/j.jad.2023.06.068_bb0165","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0924-977X(02)00058-5","article-title":"Efficacy of citalopram in anorexia nervosa: a pilot study","volume":"12","author":"Fassino","year":"2002","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jad.2023.06.068_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2007-1014424","article-title":"Fluoxetin versus placebo: a double-blind study with bulimic inpatients undergoing intensive psychotherapy","volume":"24","author":"Fichter","year":"1991","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0175","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1055\/s-2007-979488","article-title":"Effects of fluvoxamine on depression, anxiety, and other areas of general psychopathology in bulimia nervosa","volume":"30","author":"Fichter","year":"1997","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0180","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1001\/archpsyc.1992.01820020059008","article-title":"Fluoxetine in the treatment of bulimia nervosa. A multicenter, placebo-controlled, double-blind trial","volume":"49","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0185","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jad.2020.11.015","article-title":"The prevalence, odds and predictors of lifespan comorbid eating disorder among people with a primary diagnosis of bipolar disorders, and vice-versa: systematic review and meta-analysis","volume":"280","author":"Fornaro","year":"2021","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2023.06.068_bb0190","series-title":"The Eating Disorder Inventory Manual","author":"Garner DM","year":"1984"},{"key":"10.1016\/j.jad.2023.06.068_bb0195","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0005-7967(97)00041-7","article-title":"A randomized controlled trial of fluoxetine and cognitive behavioral therapy for bulimia nervosa: short-term outcome","volume":"35","author":"Goldbloom","year":"1997","journal-title":"Behav. Res. Ther."},{"key":"10.1016\/j.jad.2023.06.068_bb0200","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1192\/bjp.166.5.660","article-title":"Long-term fluoxetine treatment of bulimia nervosa. Fluoxetine Bulimia Nervosa Research Group","volume":"166","author":"Goldstein","year":"1995","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"key":"10.1016\/j.jad.2023.06.068_bb0205","series-title":"The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability","first-page":"1006","volume":"46","author":"Goodman","year":"1989"},{"key":"10.1016\/j.jad.2023.06.068_bb0210","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/eat.23078","article-title":"A double-blind, placebo-controlled study of vortioxetine in the treatment of binge-eating disorder","volume":"52","author":"Grant","year":"2019","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.jad.2023.06.068_bb0215","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.biopsych.2004.11.002","article-title":"Efficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: a randomized double-blind placebo-controlled comparison","volume":"57","author":"Grilo","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0220","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.clinthera.2020.10.010","article-title":"Naltrexone + bupropion combination for the treatment of binge-eating disorder with obesity: a randomized, controlled pilot study","volume":"43","author":"Grilo","year":"2021","journal-title":"Clin. Ther."},{"key":"10.1016\/j.jad.2023.06.068_bb0225","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/00004714-198111000-00005","article-title":"A double-blind controlled trial of lithium carbonate primary anorexia nervosa","volume":"1","author":"Gross","year":"1981","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2023.06.068_bb0230","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/YIC.0b013e328329c7b5","article-title":"Lamotrigine in the treatment of binge-eating disorder with obesity: a randomized, placebo-controlled monotherapy trial","volume":"24","author":"Guerdjikova","year":"2009","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2023.06.068_bb0235","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/eat.20946","article-title":"Duloxetine in the treatment of binge eating disorder with depressive disorders: a placebo-controlled trial","volume":"45","author":"Guerdjikova","year":"2012","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.jad.2023.06.068_bb0240","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/hup.2547","article-title":"Lisdexamfetamine dimesylate in binge eating disorder: a placebo controlled trial","volume":"31","author":"Guerdjikova","year":"2016","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.jad.2023.06.068_bb0245","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.jaac.2011.06.009","article-title":"A double-blind, placebo-controlled study of risperidone for the treatment of adolescents and young adults with anorexia nervosa: a pilot study","volume":"50","author":"Hagman","year":"2011","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0250","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0140-6736(82)92422-9","article-title":"Cyproheptadine for anorexia nervosa","volume":"319","author":"Halmi","year":"1982","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2023.06.068_bb0255","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1001\/archpsyc.1986.01800020087011","article-title":"Anorexia nervosa: treatment efficacy of cyproheptadine and amitriptyline","volume":"43","author":"Halmi","year":"1986","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0260","series-title":"A Rating Scale for Depression","author":"Hamilton","year":"1960"},{"key":"10.1016\/j.jad.2023.06.068_bb0265","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2498","article-title":"Effectiveness of olanzapine in the treatment of anorexia nervosa: a systematic review and meta-analysis","volume":"12","author":"Han","year":"2022","journal-title":"Brain Behav."},{"key":"10.1016\/j.jad.2023.06.068_bb0270","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/imj.14691","article-title":"Current approach to eating disorders: a clinical update","volume":"50","author":"Hay","year":"2020","journal-title":"Intern. Med. J."},{"issue":"4","key":"10.1016\/j.jad.2023.06.068_bb0275","article-title":"Psychological treatments for bulimia nervosa and binging","volume":"2009","author":"Hay","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jad.2023.06.068_bb0280","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1177\/0004867414555814","article-title":"Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of eating disorders","volume":"48","author":"Hay","year":"2014","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0285","series-title":"A Self-rating Scale for Bulimia the \u2018BITE\u2019","first-page":"18","volume":"150","author":"Henderson","year":"1987"},{"key":"10.1016\/j.jad.2023.06.068_bb0290","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.jad.2023.06.068_bb0295","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/eat.23297","article-title":"Meta-analysis on the long-term effectiveness of psychological and medical treatments for binge-eating disorder","volume":"53","author":"Hilbert","year":"2020","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.jad.2023.06.068_bb0300","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1176\/ajp.155.12.1756","article-title":"Fluvoxamine in the treatment of binge-eating disorder: a multicenter placebo-controlled, double-blind trial","volume":"155","author":"Hudson","year":"1998","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0305","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/cap.2010.0139","article-title":"A placebo-controlled pilot study of adjunctive olanzapine for adolescents with anorexia nervosa","volume":"21","author":"Kafantaris","year":"2011","journal-title":"J. Child Adolesc. Psychopharmacol."},{"issue":"4","key":"10.1016\/j.jad.2023.06.068_bb0310","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3109\/08039489509011912","article-title":"Fluoxetine in the treatment of anxiety, depressive symptoms, and eating-related symptoms in bulimia nervosa","volume":"49","author":"Kanerva","year":"1995","journal-title":"Nord. J. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0315","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0006-3223(00)01013-1","article-title":"Double-blind placebo-controlled administration of fluoxetine in restricting-and restricting-purging-type anorexia nervosa","volume":"49","author":"Kaye","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0320","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/00004714-199312000-00007","article-title":"Is there a role for selective monoamine oxidase inhibitor therapy in bulimia nervosa? A placebo-controlled trial of brofaromine","volume":"13","author":"Kennedy","year":"1993","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2023.06.068_bb0325","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/wps.20941","article-title":"The efficacy of psychotherapies and pharmacotherapies for mental disorders in adults: an umbrella review and meta-analytic evaluation of recent meta-analyses","volume":"21","author":"Leichsenring","year":"2022","journal-title":"World Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0330","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.pnpbp.2008.06.005","article-title":"A randomized, double-blind trial comparing sertraline and fluoxetine 6-month treatment in obese patients with binge eating disorder","volume":"32","author":"Leombruni","year":"2008","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0335","series-title":"Randomized Clinical Trial Comparing Family-based Treatment With Adolescent-focused Individual Therapy for Adolescents With Anorexia Nervosa","first-page":"1025","volume":"67","author":"Lock","year":"2010"},{"key":"10.1016\/j.jad.2023.06.068_bb0340","series-title":"The Yale-Brown-Cornell Eating Disorder Scale: Development, Use, Reliability and Validity","first-page":"425","volume":"28","author":"Mazure","year":"1994"},{"key":"10.1016\/j.jad.2023.06.068_bb0345","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1176\/appi.ajp.157.6.1004","article-title":"Placebo-controlled trial of sertraline in the treatment of binge eating disorder","volume":"157","author":"McElroy","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0350","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1176\/appi.ajp.160.2.255","article-title":"Topiramate in the treatment of binge eating disorder associated with obesity: a randomized, placebo-controlled trial","volume":"160","author":"McElroy","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0355","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.biopsych.2006.08.008","article-title":"Topiramate for the treatment of binge eating disorder associated with obesity: a placebo-controlled study","volume":"61","author":"McElroy","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0360","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/npp.2015.275","article-title":"Lisdexamfetamine dimesylate for adults with moderate to severe binge eating disorder: results of two pivotal phase 3 randomized controlled trials","volume":"41","author":"McElroy","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jad.2023.06.068_bb0365","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jamapsychiatry.2014.2162","article-title":"Efficacy and safety of lisdexamfetamine for treatment of adults with moderate to severe binge-eating disorder: a randomized clinical trial","volume":"72","author":"McElroy","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0370","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00004714-198408000-00003","article-title":"A placebo-controlled, double-blind trial of amitriptyline in bulimia","volume":"4","author":"Mitchell","year":"1984","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2023.06.068_bb0375","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/00004714-200106000-00008","article-title":"The relative efficacy of fluoxetine and manual-based self-help in the treatment of outpatients with bulimia nervosa","volume":"21","author":"Mitchell","year":"2001","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2023.06.068_bb0380","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.jad.2023.06.068_bb0385","first-page":"72","article-title":"Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa","volume":"13","author":"Mondraty","year":"2005","journal-title":"Australas. Psychiatry Bull. R. Aust. N. Z. Coll. Psychiatr."},{"key":"10.1016\/j.jad.2023.06.068_bb0390","series-title":"A New Depression Scale Designed to be Sensitive to Change","first-page":"382","volume":"134","author":"Montgomery","year":"1979"},{"key":"10.1016\/j.jad.2023.06.068_bb0395","series-title":"Personality Assessment Inventory (PAI): Professional Manual","author":"Morey","year":"2007"},{"key":"10.1016\/j.jad.2023.06.068_bb0400","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1073\/pnas.94.5.2036","article-title":"Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac)","volume":"94","author":"Ni","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jad.2023.06.068_bb0405","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/eat.20202","article-title":"Topiramate treatment in bulimia nervosa patients: a randomized, double-blind, placebo-controlled trial","volume":"38","author":"Nickel","year":"2005","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.jad.2023.06.068_bb0410","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00737-003-0172-8","article-title":"A double-blind, placebo-controlled trial of fluvoxamine in binge eating disorder: a high placebo response","volume":"6","author":"Pearlstein","year":"2003","journal-title":"Arch. Womens Ment. Health"},{"key":"10.1016\/j.jad.2023.06.068_bb0415","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1176\/ajp.140.5.554","article-title":"Bulimia treated with imipramine: a placebo-controlled, double-blind study","volume":"140","author":"Pope","year":"1983","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0420","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/00004714-198908000-00004","article-title":"A placebo-controlled study of trazodone in bulimia nervosa","volume":"9","author":"Pope","year":"1989","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jad.2023.06.068_bb0425","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/erv.2169","article-title":"Double-blind placebo-controlled trial of quetiapine in anorexia nervosa","volume":"20","author":"Powers","year":"2012","journal-title":"Eur. Eat. Disord. Rev."},{"key":"10.1016\/j.jad.2023.06.068_bb0430","series-title":"Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity","first-page":"1","article-title":"An update on the prevalence of eating disorders in the general population: a systematic review and meta-analysis","author":"Qian","year":"2021"},{"key":"10.1016\/j.jad.2023.06.068_bb0435","first-page":"385","article-title":"The CES-D scale applied psychological","volume":"1","author":"Radloff","year":"1977","journal-title":"Measurement"},{"key":"10.1016\/j.jad.2023.06.068_bb0440","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.clinthera.2020.10.006","article-title":"Psychotherapy and medications for eating disorders: better together?","volume":"43","author":"Reas","year":"2021","journal-title":"Clin. Ther."},{"key":"10.1016\/j.jad.2023.06.068_bb0445","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000056270","article-title":"Fluoxetine and fluvoxamine combined with individual cognitive-behaviour therapy in binge eating disorder: a one-year follow-up study","volume":"70","author":"Ricca","year":"2001","journal-title":"Psychother. Psychosom."},{"key":"10.1016\/j.jad.2023.06.068_bb0450","series-title":"Relapse in Anorexia and Bulimia Nervosa\u2014A 2.5-Year Follow-up Study","first-page":"180","volume":"13","author":"Richard","year":"2005"},{"key":"10.1016\/j.jad.2023.06.068_bb0455","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1176\/appi.ajp.159.1.96","article-title":"A placebo-controlled study of fluoxetine in continued treatment of bulimia nervosa after successful acute fluoxetine treatment","volume":"159","author":"Romano","year":"2002","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.jad.2023.06.068_bb0460","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/pmh.1533","article-title":"The impact of personality disorders and personality traits on psychotherapy treatment outcome of eating disorders: a systematic review","volume":"16","author":"Simpson","year":"2022","journal-title":"Personal. Ment. Health"},{"key":"10.1016\/j.jad.2023.06.068_bb0465","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.jad.2023.06.068_bb0470","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0022-3999(85)90010-8","article-title":"The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger","volume":"29","author":"Stunkard","year":"1985","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.jad.2023.06.068_bb0475","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1017\/S0033291718003525","article-title":"Efficacy of psychotherapies and pharmacotherapies for Bulimia nervosa","volume":"49","author":"Svaldi","year":"2019","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jad.2023.06.068_bb0480","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1751-9861.1999.tb00051.x","article-title":"Binge eating scale: further assessment of validity and reliability 1","volume":"4","author":"Timmerman","year":"1999","journal-title":"J. Appl. Biobehav. Res."},{"key":"10.1016\/j.jad.2023.06.068_bb0485","article-title":"Anorexia nervosa","volume":"1","author":"Treasure","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jad.2023.06.068_bb0490","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0140-6736(20)30059-3","article-title":"Eating disorders","volume":"395","author":"Treasure","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2023.06.068_bb0495","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1192\/bjp.144.3.288","article-title":"Neuroleptics in the short-term treatment of anorexia nervosa a double-blind placebo-controlled study with sulpiride","volume":"144","author":"Vandereycken","year":"1984","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jad.2023.06.068_bb0500","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1600-0447.1982.tb04501.x","article-title":"Pimozide combined with behavior therapy in the short-term treatment of anorexia nervosa: a double-blind placebo-controlled cross-over study","volume":"66","author":"Vandereycken","year":"1982","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jad.2023.06.068_bb0505","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1176\/ajp.148.9.1206","article-title":"Long-term outcome of antidepressant treatment for bulimia nervosa","volume":"148","author":"Walsh","year":"1991","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.jad.2023.06.068_bb0510","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1176\/appi.ajp.157.8.1332","article-title":"Fluoxetine for bulimia nervosa following poor response to psychotherapy","volume":"157","author":"Walsh","year":"2000","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.jad.2023.06.068_bb0515","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1176\/appi.ajp.161.3.556","article-title":"Treatment of bulimia nervosa in a primary care setting","volume":"161","author":"Walsh","year":"2004","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.jad.2023.06.068_bb0520","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1001\/jama.295.22.2605","article-title":"Fluoxetine after weight restoration in anorexia nervosa: a randomized controlled trial","volume":"295","author":"Walsh","year":"2006","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.jad.2023.06.068_bb0525","series-title":"Treatment of Binge Eating Disorder","first-page":"773","volume":"34","author":"Wilson","year":"2011"},{"key":"10.1016\/j.jad.2023.06.068_bb0530","series-title":"Eating Disorders and Obesity: A Comprehensive Handbook","first-page":"374","article-title":"The management of patients with intractable eating disorders","author":"Yager","year":"1995"},{"key":"10.1016\/j.jad.2023.06.068_bb0535","series-title":"Practice Guideline for the Treatment of Patients With Eating Disorders","author":"Yager","year":"2002"},{"key":"10.1016\/j.jad.2023.06.068_bb0540","series-title":"A Rating Instrument for Anxiety Disorders Psychosomatics","first-page":"10","volume":"371","author":"Zung","year":"1971"}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032723008339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032723008339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:19:17Z","timestamp":1759033157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032723008339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":108,"alternative-id":["S0165032723008339"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2023.06.068","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Psychopharmacology of eating disorders: Systematic review and meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2023.06.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}